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Search Results for " pip2 "

Targets Recommended: Others

10

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23498	UNC3230 UNC 3230	Others	Others
	UNC3230 是一种 ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 选择性抑制剂，其IC50约为 41 nM。它还可抑制PIP4K2C，但对其他调节磷酸肌醇水平的脂质激酶无抑制作用。它具有缓解疼痛和抗癌特性。
T70683	NA 382	Others	Others
	NA 382 is a staurosporine derivative that inhibits multidrug resistance.
T15375	Inavolisib GDC-0077,RG6114	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	Inavolisib (GDC-0077) 是一种可口服的选择性PI3Kα抑制剂，IC50值为0.038 nM。Inavolisib 通过与 PI3K 的 ATP 结合位点结合而发挥其活性，从而抑制了 PIP2 到 PIP3 的磷酸化。
TP1948L	PBP 10 acetate(794466-43-6 Free base)
	PBP 10 acetate(794466-43-6 Free base) 是一种选择性甲酰肽受体 2 (FPR2) 拮抗剂。 PBP 10 acetate 选择性抑制 FPR2 介导的 NADPH 氧化酶活性，但对中性粒细胞中的 FPR1 信号传导没有影响。 PBP 10 acetate 在体外表现出 PIP2 结合活性并阻断细胞运动。 PBP 10 acetate 通过抑制病毒诱导的 ERK 激活而表现出针对流感病毒的抗病毒活性。
TP1977	187-1, N-WASP inhibitor
	Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
TP1948	PBP10 PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh
T75777	187-1, N-WASP inhibitor TFA
	187-1, N-WASP inhibitor TFA，一种14-aa 环肽及N-WASP 抑制剂，能有效阻止由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 触发的肌动蛋白装配，IC50 值达 2 μM。该化合物通过维持蛋白质自身的抑制状态，进而抑制N-WASP 激活Arp2/3 复合体。
T36938	PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)	Others	Others
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (Ptd...
T37030	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)	Others	Others
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ...
T36937	PtdIns-(1,2-dioctanoyl) (sodium salt)	Others	Others
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this anal...

化合物

Cat.No: T23498

Synonym: UNC 3230

Target: Others

Cat.No: T70683

Target: Others

Cat.No: T15375

Synonym: GDC-0077,RG6114

Target: Apoptosis, PI3K

PBP 10 acetate(794466-43-6 Free base)

Cat.No: TP1948L

187-1, N-WASP inhibitor

Cat.No: TP1977

Cat.No: TP1948

Synonym: PBP 10

187-1, N-WASP inhibitor TFA

Cat.No: T75777

PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Cat.No: T36938

Synonym: PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Target: Others

PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Cat.No: T37030

Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Target: Others

PtdIns-(1,2-dioctanoyl) (sodium salt)

Cat.No: T36937

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00943	Profilin 2 Protein, Human, Recombinant Profilin-II,PFN2,PFL,Profilin-2	Human	E. coli
	Profilin-II (PFN2) is ubiquitous protein which belongs to the profilin family. PFN2 binds to actin, thenaffects the structure of the cytoskeleton. At high concentrations, profiling prevents the polymerization of actin, while increases that at low concentrations. PFN2 is a ubiquitous actin monomer-binding protein. It regulates actin polymerization in response to extra cellular signals. PFN2 binds to PIP2; it inhibits the formation of IP3 and DG.
TMPH-03096	Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc) Pollen allergen Phl p 12,Allergen Phl p 11,Profilin...	Phleum pratense	E. coli
	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.5 kDa and the accession number is O24650.
TMPY-03657	Profilin 2 Protein, Human, Recombinant (His) profilin 2,PFL,D3S1319E	Human	E. coli
	Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. Profilin 2 binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. Profilin 2 is thought to regulate actin polymerization in response to extracellular ...
TMPJ-00858	Ezrin Protein, Human, Recombinant Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin	Human	E. coli
	Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele...

重组蛋白

Profilin 2 Protein, Human, Recombinant

Cat.No: TMPJ-00943

Species: Human

Expression System: E. coli

Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc)

Cat.No: TMPH-03096

Species: Phleum pratense

Expression System: E. coli

Profilin 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03657

Species: Human

Expression System: E. coli

Ezrin Protein, Human, Recombinant

Cat.No: TMPJ-00858

Species: Human

Expression System: E. coli

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