382
99
6
16
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Cat. No. | Product Name | ||
---|---|---|---|
L1300 | PI3K/Akt/mTOR 化合物库 | 420 compounds | |
420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选; | |||
L2195 | 抗前列腺癌化合物库 | 2070 compounds | |
2070 种与前列腺癌相关的化合物,可以用于高通量和高内涵筛选 | |||
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; | |||
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L3600 | 细胞因子抑制剂库 | 604 compounds | |
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64392 |
PI3K-IN-46
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-46 是 PI3Kγ的特异性抑制剂。 | |||
T12459 |
PI3K/mTOR Inhibitor-2
|
PI3K; mTOR | PI3K/Akt/mTOR signaling |
PI3K/mTOR Inhibitor-2 是一种有效的 PI3K 和 mTOR 泛抑制剂,对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 mTOR 的 IC50 分别为 3.4、34、16,1 和 4.7 nM。 PI3K/mTOR Inhibitor-2 具有抗肿瘤活性。 | |||
T12365 |
PARP/PI3K-IN-1
|
PARP; PI3K | Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PARP/PI3K-IN-1 是一种 新型双重聚(ADP-核糖)聚合酶(PARP)和磷酸肌醇 3-激酶(PI3K)双重抑制剂,具有抗癌、抗肿瘤和抗癌细胞增殖活性,可用于研究乳腺癌、胰腺癌和肺癌。 | |||
T1826 |
PI3K-IN-1
Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 |
DNA-PK; PI3K | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂,PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。 | |||
T24637 |
PI3K inhibitor C 96
PI3K IN C96,PI3K-IN-C96 |
Others | Others |
PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase. It shows effective activity against multiple myeloma in vitro and in vivo. | |||
T61618 |
PI3K-IN-38
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-38 是一种可口服且具有有效性的 PI3K 抑制剂,对 PI3K-α 的IC50 值为 0.541 µM。PI3K-IN-38 具有抗癌和抗炎的活性,可以抑制体内肿瘤的生长。 | |||
T2078 |
Fimepinostat
CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 |
Apoptosis; PI3K; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Fimepinostat (CUDC 907) 是一种 I 型PI3K 及 I 和 II 型HDAC 酶抑制剂,作用于 PI3Kα/PI3Kβ/PI3Kδ 和 HDAC1/HDAC2/HDAC3/HDAC10 ,IC50分别为 19/54/39 nM 和 1.7/5.0/1.8/2.8 nM。 | |||
T39581 |
PI3K-IN-19 hydrochloride
PI3K-IN-19 hydrochloride |
Others | Others |
PI3K-IN-19 hydrochloride (WO2017153220, step 5) acts as a phosphatidylinositol-3-kinase (PI3K) inhibitor. | |||
T60564 |
PI3K/Akt/mTOR-IN-2
|
Apoptosis; Akt; PI3K; mTOR | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用,并对 MDA-MB-231 细胞具有选择性,IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 具有抗癌活性,可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。 | |||
T2265 |
Bimiralisib
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 |
Others; PI3K; S6 Kinase; mTOR | MAPK; Others; PI3K/Akt/mTOR signaling |
Bimiralisib (PI3K-IN-2) 是一种有效的,可渗透脑的 mTOR/PI3K 抑制剂,是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR,IC50分别为 33 nM,451 nM,661 nM,708 nM 和 89 nM。 | |||
T12457 |
PI3K-IN-6
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively). | |||
T12458 |
PI3K-IN-9
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM). | |||
T12455 | PI3K/HDAC-IN-1 | PI3K | PI3K/Akt/mTOR signaling |
PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively). | |||
T12456 |
PI3K-IN-10
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-10 is a potent inhibitor of pan-PI3K . | |||
T36087 |
PI3K-IN-22
CAY10626 |
Others | Others |
PI3K-IN-22 是 PI3Kα 和 mTOR 双重激酶抑制剂,IC50s 分别为 0.9、0.6 nM。PI3K-IN-22 可用于癌症研究。 | |||
T5831 |
Selective PI3Kδ Inhibitor 1
|
PI3K | PI3K/Akt/mTOR signaling |
Selective PI3Kδ Inhibitor 1 是一种 PI3Kδ 抑制剂 (IC50 = 0.9 nM)。 | |||
T12460 |
PI3K/mTOR Inhibitor-1
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM) | |||
T6330 |
Linperlisib
PI3Kδ-IN-2 |
PI3K | PI3K/Akt/mTOR signaling |
Linperlisib (PI3Kδ-IN-2) 是一种有效的,效选择性的,具有口服活性的 PI3Kδ的抑制剂,其 IC50=6.4 nM。 | |||
T71272 |
PI3K/Akt-IN-C89
|
Others | Others |
PI3K/Akt-IN-C89 is a novel Inhibitor of the PI3K-Akt Pathway, Inducing Autophagy of Female Germline Stem Cells. | |||
T62997 |
PI3K/AKT-IN-1
|
Others | Others |
PI3K/AKT-IN-1 是一种有效的、双重的 PI3K/AKT 抑制剂,能够作用于 PI3Kγ (IC50: 6.99 μM)、PI3Kδ (IC50: 4.01 μM) 和 AKT (IC50: 3.36 μM)。PI3K/AKT-IN-1 通过抑制 PI3K/AKT 通路,诱导 caspase 3 依赖性凋亡,表现出抗癌作用。 | |||
T63470 |
PI3K/mTOR Inhibitor-8
|
Others | Others |
PI3K/mTOR Inhibitor-8 是 PI3K (PI3Kα IC50: 0.46 nM) 和 mTOR (mTOR IC50: 12 nM) 双重抑制剂。PI3K/mTOR Inhibitor-8 能够将 HCT-116 细胞的细胞周期阻滞在G1/S 期,并诱导其凋亡 (apoptosis)。 | |||
T62580 |
PI3K-IN-37
|
Others | Others |
PI3K-IN-37 (Example 84.1) 是一种 PI3K α (IC50: 6 nM) /β (IC50: 8 nM) /δ (IC50: 4 nM) 抑制剂。PI3K-IN-37 对 mTOR 具有抑制作用,其 IC50 值为4 nM。 | |||
T61966 |
PI3K-IN-26
|
Others | Others |
PI3K-IN-26 是有效的PI3K 抑制剂。PI3K-IN-26抑制 SU-DHL-6 细胞增殖,IC50为 36 nM。 | |||
T79701 |
PI3K-IN-48
|
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
PI3K-IN-48,PI3K抑制剂,对A549细胞系表现出1.55 ± 0.18 μM的IC50值。该化合物能够诱导G0/G1期细胞周期阻滞与细胞凋亡,并可下调p-PI3K与p-Akt的表达水平,适用于人类肺癌研究。 | |||
T72713 |
PI3K/VEGFR2-IN-1
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K/VEGFR2-IN-1是一种具有双重抑制效应的化合物,对PI3K和VEGFR2的IC50分别为2.21 μM和68 μM,能够诱导细胞凋亡(apoptosis),在癌症研究中应用。 | |||
T72408 |
PI3K/mTOR Inhibitor-5
|
Others | Others |
PI3K/mTOR Inhibitor-5 是一种有效的 PI3K 和mTOR 双抑制剂,其IC50值分别为 86.9 nM 和 14.6 nM。 | |||
T62392 |
PI3K-IN-34
|
Others | Others |
PI3K-IN-34 (Compound 6g) 是一种 PI3K 的高选择性抑制剂,能够作用于 PI3K-α (IC50: 11.73 μM),PI3K-β (IC50: 6.09 μM) 和 PI3K-δ (IC50: 11.18 μM)。PI3K-IN-34 能够将细胞周期阻滞在 G2/M 期,并诱导细胞凋亡。PI3K-IN-34 能够用于研究白血病。 | |||
T63957 |
PI3K-IN-29
|
Others | Others |
PI3K-IN-29 是一种有效的 PI3K 抑制剂。PI3K-IN-29 对 U87MG、HeLa 和 HL60 细胞具有较好的抑制作用,IC50值分别为 0.264、2.04 和 1.14 µM。PI3K-IN-29 通过抑制PI3K 催化的Akt 的磷酸化来抑制PI3K/Akt 通路。 | |||
T73118 |
PI3K-IN-28
|
Others | Others |
PI3K-IN-28 是一种有效的PI3K 抑制剂。PI3K-IN-28 显示出有效的活性,对 MCF-10a 的毒性作用较低。PI3K-IN-28 的 IC50, μM 值为 5.8、2.3 和 7.9 μM。PI3K-IN-28 是有效的一种,选择性指数 (SI) 为 39,被认为是进一步优化抗癌药物的潜在先导。 | |||
T63682 |
PI3K-IN-2
|
Others | Others |
PI3K-IN-2 是口服具有活力的 PI3Kβ/δ 抑制剂,他们的 IC50 值分别为7.1 nM、8.6 nM,且选择性高于 PI3Kσ (IC50: 13 nM)、PI3Kγ (IC50: 190 nM) 高。 | |||
T72880 |
PI3K/AKT-IN-2
|
Others | Others |
PI3K/AKT-IN-2 是一种 PI3K 和 AKT 抑制剂。PI3K/AKT-IN-2 阻断上皮-间质转化 (EMT),诱导细胞凋亡 (apoptosis)。PI3K/AKT-IN-2 抑制微管蛋白 (tubulin) 的聚合。 | |||
T62912 |
PI3K/HDAC-IN-2
|
Others | Others |
PI3K/HDAC-IN-2 是一种有效的 PI3K/HDAC 双重抑制剂,能够作用于 PI3Kα (IC50: 226 nM)、PI3Kβ (IC50: 279 nM)、PI3Kγ (IC50: 467 nM)、PI3Kδ (IC50: 29 nM)、HDAC1 (IC50: 1.3 nM)、HDAC2 (IC50: 3.4 nM)、HDC4 (IC50: 973 nM)、HDAC6 (IC50: 17 nM)、HDAC8 (IC50: 12 nM)。PI3K/HDAC-IN-2 具有 PI3Kδ 和 I 类和 IIb 类 HDAC 选择性,并表现出显着的抗癌作用。 | |||
T64041 |
PI3K/mTOR Inhibitor-7
|
Others | Others |
PI3K/mTOR Inhibitor-7 是有效的 PI3K/mTOR 双重抑制剂。PI3K/mTOR Inhibitor-7 的作用比 gedatolisib 高 4.7 倍,他们的 IC50 值分别为 1.4 μM 和 0.3 μM。10 μM 的 PI3K/mTOR Inhibitor-7 能够明显抑制 PI3K/Akt/mTOR 信号通路。PI3K/mTOR Inhibitor-7 对癌症疾病表现出研究潜力。 | |||
T63770 |
PI3K/mTOR Inhibitor-4
|
Others | Others |
PI3K/mTOR Inhibitor-4 是一种口服具有活力的泛 I 类 PI3K/mTOR 抑制剂。PI3K/mTOR Inhibitor-4 具有酶抑制作用,能够作用于 PI3Kα (IC50: 0.63 nM)、PI3Kγ (IC50: 22 nM)、PI3Kδ (IC50: 9.2 nM) 和 mTOR (IC50: 13.85 nM)。PI3K/mTOR Inhibitor-4 能够用于研究癌症。 | |||
T61516 |
PI3K/mTOR Inhibitor-3
|
Others | Others |
PI3K/mTOR Inhibitor-3 (compound 12) is an imidazoline compound with potent dual inhibitory effects on PI3K and mTOR. This compound exhibits notable anti-cancer activity [1]. | |||
T81470 |
PI3K/mTOR Inhibitor-14
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K/mTOR Inhibitor-14(化合物 Y-2)是一种针对PI3K和mTOR的双重抑制剂,其IC50值分别为171.4 nM 和10.1 nM ,具备抗肿瘤活性。 | |||
T72374 | PI3K/mTOR Inhibitor-12 | PI3K | PI3K/Akt/mTOR signaling |
PI3K/mTOR Inhibitor-12为口服有效且选择性的PI3K/mTOR抑制剂,对PI3Kα和mTOR的IC50分别为0.06 nM及3.12 nM,表现出抗肿瘤活性且肝毒性较低。 | |||
T64219 |
PI3K/mTOR Inhibitor-6
|
Others | Others |
PI3K/mTOR Inhibitor-6 (Compound 19c) 是一种有效的 PI3K/mTOR 双重抑制剂,在人工胃液中的稳定性比 gedatolisib 更高。10 μM 的 PI3K/mTOR Inhibitor-6 能够明显抑制 PI3K/Akt/mTOR 信号通路。PI3K/mTOR Inhibitor-6 对癌症疾病表现出研究潜力。 | |||
T72380 |
PI3K/mTOR Inhibitor-13
|
Others | Others |
PI3K/mTOR Inhibitor-13 是一种具有口服活性的磷酸肌醇 3-激酶 (PI3K) 和mTOR 激酶双重抑制剂。PI3K/mTOR Inhibitor-13 在性疾病、实体瘤和特发性肺纤维化 (IPF) 中有潜在应用。 | |||
T62438 |
PI3K/mTOR Inhibitor-9
|
Others | Others |
PI3K/mTOR Inhibitor-9 (Compound 1) 是一种 mTOR 和 PI3K 的有效抑制剂,能够作用于 mTOR (IC50: 38 nM)、PI3Kα (IC50: 6.6 nM)、PI3Kγ (IC50: 6.6 nM) 和 PI3Kδ (IC50: 0.8 nM)。 | |||
T62779 |
PI3K-IN-35
|
Others | Others |
PI3K-IN-35 (Compound 6l) 是一种 PI3K 的高选择性抑制剂,作用于 PI3K-α (IC50: 13.98 μM)、PI3K-β (IC50: 7.22 μM) 和 PI3K-δ (IC50: 10.94 μM)。PI3K-IN-35 可将细胞周期阻滞于 G2/M 期,并诱导细胞凋亡。PI3K-IN-35 能够用于研究白血病。 | |||
T79566 |
PI3K-IN-41
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-41(compound 2)是一种具抗癌特性的光笼PI3K抑制剂(IC50=18.92 nM),适用于精确控制的癌症治疗。在紫外线照射下,PI3K-IN-41能有效抑制PI3K活性,并增强其抗癌效果。 | |||
T62696 |
PI3K-IN-30
|
Others | Others |
PI3K-IN-30 (compound 6d) 是一种 PI3K 的有效抑制剂,能够作用于 PI3Kα (IC50: 5.1 nM)、PI3Kβ (IC50: 136 nM)、PI3Kγ (IC50: 30.7 nM) 和 PI3Kδ (IC50: 8.9 nM)。 | |||
T78853 |
PI3K-IN-47
|
PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-47 (Compound 27) 是一款高度选择性的二价PI3K抑制剂,对PI3Kα具有极低的半抑制浓度(IC50: 0.44 nM), 同时对PI3Kβ、PI3Kγ、PI3Kδ也表现出良好的抑制活性(IC50分别为7.18 nM、13.92 nM、22.83 nM)。此化合物能够有效诱导细胞周期在G1期发生暂停,并且在体外抑制集落形成和细胞迁移。对于HGC-27异种移植的小鼠模型,PI3K-IN-47能够显著抑制肿瘤生长。 | |||
T63323 |
PI3K-IN-33
|
Others | Others |
PI3K-IN-33 是高度选择性的 PI3K 抑制剂,能够作用于 PI3K-α (IC50: 11.73 μM),PI3K-β (IC50: 6.09 μM) 和 PI3K-δ (IC50: 11.18 μM)。PI3K-IN-33 能够将细胞周期阻滞在 G2/M 期,并可以诱导细胞凋亡,能够用于研究白血病。 | |||
T73150 |
PI3K-IN-36
|
Others | Others |
PI3K-IN-36 是一种有效的 PI3K 抑制剂。PI3K-IN-36 可用于滤泡性淋巴瘤 (FL) 的研究。 | |||
T62470 |
PI3K-IN-31
|
Others | Others |
PI3K-IN-31 (Compound 6b) 是一种 PI3K 的有效抑制剂,能够作用于 PI3Kα (IC50: 3.7 nM)、PI3Kβ (IC50: 74 nM)、PI3Kγ (IC50: 14.6 nM)和 PI3Kδ (IC50: 9.9 nM)。PI3K-IN-31 显示出抗癌活性。 | |||
T64052 |
PI3K-IN-27
|
Others | Others |
PI3K-IN-27 是 PI3K 的有效抑制剂。PI3K 是脂质信号激酶大家族,在细胞生长、分化、迁移和细胞凋亡等细胞过程中发挥着关键作用。PI3K-IN-27 对癌症和炎症等过度增殖性疾病或免疫和自身免疫性疾病表现出研究潜力。 | |||
T62409 |
PI3K-IN-23
|
Others | Others |
PI3K-IN-23 是一种 (E)-9-oxooctadec-10-en-12-ynoic acid 类似物,能够促进葡萄糖摄取 (EC50: 7.00 μM)。 | |||
T78836 |
IHMT-PI3K-455
|
PI3K | PI3K/Akt/mTOR signaling |
IHMT-PI3K-455(Compound 15u)为一种高效、选择性且具口服活性的PI3Kγ/δ双重抑制剂,其针对PI3Kγ与PI3Kδ的IC50值分别为7.1 nM和0.57 nM。该化合物能够抑制AKT磷酸化,并通过促进CD8+杀伤性T细胞的招募与激活,抑制肿瘤生长,适用于肿瘤学研究领域。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5654 |
Musk ketone
|
Others | Others |
Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性,因此可能被证明是有用的癌症化学保护剂。 | |||
TN1891 |
Lupiwighteone
|
Apoptosis; BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮。它通过抑制 PI3K/Akt/mTOR 通路,诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡,具有抗氧化、抗菌和抗癌作用。 | |||
T4S1796 |
Heterophyllin B
|
PI3K | PI3K/Akt/mTOR signaling |
Heterophyllin B 是一种活性环肽,从 Pseudostellaria heterophylla 中分离得到,可用于研究食管癌。 | |||
TN1134 |
Euscaphic acid
|
Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling |
Euscaphic acid 是来源于枣的一种三萜,是DNA 聚合酶抑制剂,可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。 | |||
TN4673 |
(+)-Nortrachelogenin
Wikstromol,荛花酚 |
Apoptosis; HIV Protease; PI3K; Antifection | Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
(+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer (百里香科)中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。 | |||
T6630 |
Quercetin Dihydrate
槲皮素,Sophoretin |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Quercetin Dihydrate (Sophoretin) 是一种黄酮类天然产物,可激活或抑制许多蛋白质的活性。它可激活 SIRT1,也可抑制PI3K,抑制 PI3K γ、PI3K δ和PI3K β 的IC50值分别为 2.4 μM、3.0 μM 和 5.4 μM。 | |||
T5S1982 |
Periplocin
Periplocoside,杠柳毒苷 |
Apoptosis; Others | Apoptosis; Others |
Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径,具有促进伤口愈合的潜力。 | |||
TN1079 |
Deoxyelephantopin
|
NF-κB | NF-κB |
Deoxyelephantopin 是来自Elephantopus scaber 的,具有生物活性的天然倍半萜烯内酯,能够抑制NF-κB,MAPK,PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。 | |||
T6677 |
Sophocarpine
|
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
T2174 |
Quercetin
槲皮素,Sophoretin |
Apoptosis; Mitophagy; Reactive Oxygen Species; PI3K; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Quercetin 属于黄酮类天然产物,是 SIRT1 的激动剂;Quercetin 也是一种 PI3K 抑制剂,抑制 PI3Kγ、PI3Kδ 和 PI3Kβ (IC50=2.4/3.0/5.4 μM)。Quercetin 作为公认的热休克蛋白抑制剂,也可通过下调Hsp70或Hsp90来显著减少TII模型中的外泌体释放。 | |||
TN1644 |
Flavanomarein
|
Others | Others |
Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物,对糖尿病性肾病具有保护作用。它具有很好的抗氧化,降糖,降压和降血脂作用。 | |||
T2791 |
Pectolinarin
柳穿鱼叶苷,大蓟苷 |
Apoptosis; Others; NO Synthase; Prostaglandin Receptor; Interleukin | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Others |
Pectolinarin 抑制 IL-6和 IL-8分泌以及 PGE2和 NO 产生,可通过抑制 PI3K/Akt 途径来抑制细胞增殖和炎症反应并诱导凋亡,具有抗炎活性。 | |||
T2798 |
Esculetin
秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin |
Lipoxygenase; Akt; PI3K | Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling |
Esculetin (Cichorigenin) 是主要提取自水曲柳的树皮中的活性成分。它能够抑制PI3K/Akt 途径,阻碍血小板衍生生长因子诱导的气道平滑肌细胞表型转换。它具有抗氧化,抗炎和抗肿瘤的活性。 | |||
T3780 |
Oroxin B
Hypocretin-2,木蝴蝶苷B |
Apoptosis; PTEN; Antioxidant; PI3K; Autophagy | Apoptosis; Autophagy; oxidation-reduction; PI3K/Akt/mTOR signaling |
Oroxin B (Hypocretin-2) 是从传统中草药木蝴蝶中分离出来的黄酮类天然产物,在恶性淋巴瘤细胞中诱导肿瘤抑制性 ER 应激。它通过上调 PTEN,下调 COX-2,VEGF,PI3K 和 p-AKT,对肝癌细胞具有明显的抑制作用,诱导细胞早期凋亡。 | |||
TN4761 |
Phellamurin
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Phellamurin 是一种来自黄檗叶的黄酮糖苷,可诱导细胞凋亡,具有抗肿瘤活性。它抑制肠道 P-糖蛋白,还抑制凤蝶的产卵。 | |||
T4867 |
Erucic acid
Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid |
PI3K; Endogenous Metabolite | Metabolism; PI3K/Akt/mTOR signaling |
Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸,分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障,使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。 | |||
T2746 |
Sophocarpine monohydrate
槐果碱,Sophocarpine,槐果碱水合物 |
Apoptosis; Influenza Virus; Akt; PI3K; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Sophocarpine monohydrate 是从传统草药苦参中提取的一种重要生物碱,具有抗肿瘤活性,可用于肝细胞癌,前列腺癌和结肠直肠癌。苦参具有抗病毒,抗肿瘤和抗炎等多种药理作用。 | |||
T1879 |
3-Methyladenine
3-MA,3-甲基腺嘌呤,NSC 66389 |
Mitophagy; PI3K; Endogenous Metabolite; Autophagy | Autophagy; Metabolism; PI3K/Akt/mTOR signaling |
3-Methyladenine (3-MA) 是一种 PI3K 抑制剂,选择性抑制 IB 类 PI3Kγ (IC50=60 μM) 和 III 类 VPS34 (IC50=25 μM)。3-Methyladenine 具有自噬抑制活性。 | |||
T4727 |
Taurolithocholic acid sodium salt
牛磺石胆酸钠,Sodium taurolithocholate |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
TN1405 |
Arnicolide D
山金车内酯 D,山金车内酯D |
Akt; Caspase; PI3K; STAT; mTOR | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯,以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期,激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T3675 |
1-Deoxynojirimycin
Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin |
PI3K; Glucosidase | Metabolism; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖,预防糖尿病。 | |||
T5740 |
25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元,(25RS)-Ruscogenin |
Others; HIF | Angiogenesis; Chromatin/Epigenetic; Others |
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。 | |||
TL0006 |
Cichoric Acid
菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid |
Reactive Oxygen Species; HIV Protease | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物,具有抗氧化作用。 | |||
T2836 |
Isorhamnetin
3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin |
MEK; PI3K; Endogenous Metabolite | MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。 | |||
T8160 |
EGCG Octaacetate
乙酰化表没食子儿茶素没食子酸酯,乙酰化EGCG |
Others; Antibacterial | Microbiology/Virology; Others |
EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药,对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平,减少小鼠结肠炎引起的结肠癌。 | |||
TN1299 |
Desmethylglycitein
4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone |
PI3K; CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。 | |||
TN3500 |
beta-Amyrone
β-Amyron,β-香树脂酮 |
COX; AChR; PPAR; Antifection | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。 | |||
T2P2806 |
Hederacolchiside A1
黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13 |
Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。 | |||
TN2019 |
Orobol
3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮 |
BCL; Caspase; PI3K | Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K,对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。 | |||
T3P2904 |
α-Linolenic acid
Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸 |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸,人体无法合成,从种子油中分离得到。它可调节 PI3K/Akt 信号传导,影响血栓形成过程。它具有抗心律失常的特性,并且与心血管疾病和癌症等有关。 | |||
T3208 |
Brevianamide F
Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp) |
BCRP; PI3K; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素,属于天然存在的 2,5-二酮哌嗪类,具有抗菌活性。它具有PI3Kα抑制活性,IC50值为 4.8 µM。 | |||
T21344 |
1-Deoxynojirimycin hydrochloride
Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin |
PI3K; Antibacterial; Antibiotic; Glucosidase | Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂,具有降血糖、减肥和抗病毒的作用,可抑制餐后血糖,预防糖尿病。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
T4S1499 |
Ginsenoside Rk1
人参皂苷RK1,人参皂苷 |
Apoptosis; Others; NF-κB; PI3K; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; PI3K/Akt/mTOR signaling; Stem Cells |
Ginsenoside Rk1 是人参的高温加工提取物,抑制Jak2/Stat3信号通路和NF-κB 的激活。它具有抗肿瘤、抗血小板聚集活性、抗炎、抗胰岛素抵抗、肾保护和抗菌作用,可使认知功能增强,脂质积聚减少和预防骨质疏松症,还诱导细胞凋亡。 | |||
T5736 |
1,3-Dicaffeoylquinic acid
CYNARIN,1,3-二咖啡酰奎宁酸,Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid |
Reactive Oxygen Species; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
1,3-Dicaffeoylquinic acid (CYNARIN) 是一种咖啡酰奎宁酸衍生物,具有抗氧化、自由基清除作用。 | |||
T6817 |
Deguelin
鱼藤素,(-)-Deguelin,(-)-cis-Deguelin,魚藤素 |
Apoptosis; Akt; PI3K; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Deguelin ((-)-Deguelin) 是一种 PI3K/AKT 抑制剂,从 Mundulea sericea 家族植物中分离出来的鱼藤酮类天然产物。 | |||
T16324 |
Nimbolide
|
Apoptosis; NF-κB; CDK | Apoptosis; Cell Cycle/Checkpoint; NF-κB |
Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。 | |||
TN1507 |
Clematichinenoside AR
|
TNF; Autophagy | Apoptosis; Autophagy |
Clematichinenoside AR 是从中药威灵仙中提取的一种天然产物,具有抗炎和免疫抑制特性,对 PI3K/Akt 信号通路和与胶原诱导的关节炎相关的 TNF-α± 具有抗关节炎作用。 | |||
T3890 |
Verbenalin
Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin |
Others | Others |
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。 | |||
T3385 |
Gypenoside XVII
GP-17,Gynosaponin S,七叶胆苷XVII |
Estrogen Receptor/ERR; GSK-3; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
Gypenoside XVII (Gynosaponin S) 是一种绞股蓝皂甙类的新型植物雌激素,能够激活雌激素受体。 | |||
TN2259 |
Taurocholic acid
N-Choloyltaurine |
TNF; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Taurocholic acid (N-Choloyltaurine) 是一种胆汁酸,参与脂肪的乳化。Taurocholic acid 具有细胞保护作用,可通过 PI3K 介导的途径防止肿瘤坏死因子-α 诱导的胆管细胞损伤。 | |||
TN1346 |
Oxypalmatine
8-Oxypalmatine |
Apoptosis | Apoptosis |
Oxypalmatine (8-Oxypalmatine) 是在 Phellodendron amurense 中分离出来的小檗碱型生物碱,通过抑制 PI3K/AKT 信号传导及其对乳腺癌类器官的功效来调节乳腺癌细胞的增殖和凋亡。 | |||
T6S1844 |
Tenacissoside H
Tenacissimoside C,通关藤苷H |
Others | Others |
Tenacissoside H (Tenacissimoside C) 是一种分离自通关藤中的天然产物,具有抗肿瘤作用。 | |||
T2S0410 |
Euphorbia factor L1
Euphorbiasteroid,大戟因子L1,大戟因子 L1 |
Apoptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2,PI3K,AKT 和 mTOR 蛋白和 mRNA 水平,上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬,具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。 | |||
T2S2382 |
3'-Hydroxypterostilbene
3’-羟基紫檀茋,3'-羟基紫檀茋,3'-HPT |
Apoptosis; Autophagy | Apoptosis; Autophagy |
3'-Hydroxypterostilbene (3'-HPT) 是天然紫檀芪类似物,通过诱导细胞凋亡和自噬,有效抑制人结肠癌细胞的生长。它抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK 途径。 | |||
T11685 |
Isolongifolene
异长叶烯,(-)-Isolongifolene |
Apoptosis; Others | Apoptosis; Others |
Isolongifolene ((-)-Isolongifolene) 是一种从调料九里香中分离的三环倍半萜烯,具有抗氧化,抗炎,抗癌和神经保护的特性。它通过调节 PI3K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激,线粒体功能障碍和细胞凋亡。 | |||
T3330 |
trans-Trimethoxyresveratrol
trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物,与Resveratrol(RSV)相比,它可能是一个更有效的抗炎、抗血管新生的化合物。 | |||
T3S1701 |
Dihydrocurcumin
|
PPAR; Fatty Acid Synthase | DNA Damage/DNA Repair; Metabolism |
Dihydrocurcumin 是姜黄素的主要代谢物,具有减少脂肪积累和减少氧化应激反应的作用。Dihydrocurcumin 可调控SREBP-1C,PNPLA3 和 PPARα 的 mRNA 和蛋白表达水平,使pAKT 和 PI3K 的蛋白表达水平增高,通过 Nrf2 信号通路使细胞胞内 NO 和 ROS 的含量减少。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01857 |
PIK3CG Protein, Human, Recombinant (His & Myc)
p120-PI3K,Phosphoinositide-3-kinase cataly... |
Human | E. coli |
PIK3CG Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is P48736. | |||
TMPJ-00059 |
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素 |
Human | HEK293 Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... | |||
TMPH-01348 |
FSHR Protein, Human, Recombinant (His)
Follitropin receptor,FSHR,Follicle-stimulating horm... |
Human | HEK293 Cells |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945. | |||
TMPK-01034 |
SEMA4B Protein, Mouse, Recombinant (His)
SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE... |
Mouse | HEK293 Cells |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC. | |||
TMPH-03365 |
REG3A Protein, Rat, Recombinant (E.coli, His)
Lithostathine 3,Reg3a,RegIII,Regenerating islet-derived prot... |
Rat | E. coli |
Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P35231. | |||
TMPH-01347 |
FSHR Protein, Human, Recombinant (E. coli, His)
Follicle-stimulating hormone receptor,Follitropin r... |
Human | E. coli |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945. | |||
TMPH-02019 |
REG3A Protein, Human, Recombinant (GST)
Regenerating islet-derived protein 3-alpha,REG3A,Regeneratin... |
Human | E. coli |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.6 kDa and the accession number is Q06141. | |||
TMPK-00136 |
ULBP-2 Protein, Human, Recombinant (His & Avi)
ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,N2DL2,ULBP-2/5/6,R... |
Human | HEK293 Cells |
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity. | |||
TMPH-02538 |
Beclin-1 Protein, Mouse, Recombinant (His & SUMO)
Beclin-1,GT197,Coiled-coil myosin-like BCL2-interacting prot... |
Mouse | E. coli |
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential f... | |||
TMPJ-01271 |
PIK3IP1 Protein, Human, Recombinant (His)
Kringle domain-containing protein HGFL,PIK3IP1,HGFL |
Human | HEK293 Cells |
Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. The gene encoding PIK3IP1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibrom... | |||
TMPK-00524 |
CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His)
CAIX,CA9,P54/58N,RCC,G250,EC 4.2.1.1,PMW1,CA-IX,MN |
Cynomolgus | HEK293 Cells |
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred... | |||
TMPK-00283 |
CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi)
RCC,EC 4.2.1.1,CA9,P54/58N,MN,CA-IX,CAIX,G250,PMW1 |
Human | HEK293 Cells |
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The... | |||
TMPJ-00352 |
CD98 Protein, Human, Recombinant (mFc)
Lymphocyte activation antigen 4F2 large subunit,4F2 cell-sur... |
Human | HEK293 Cells |
CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. CD98 can interact with CD147 to induce integrin 1 function to promote cyclosporine B-induced cell adhesion and p44/p42 MAPK activation following PI3K activation. CD98 heavy chain has been studied to be a key player in tumorigenesis due to its role in activating integrin signaling to promote tumor progression via angiogenesis,... | |||
TMPJ-00181 |
PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Programmed cell death protein 1,PDCD1,CD279,hPD-1 |
Human | HEK293 Cells |
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been sugg... | |||
TMPY-05250 |
CLEC3A Protein, Mouse, Recombinant (His)
C-type lectin domain family 3, member A,Gm796,1110019O10Rik,... |
Mouse | Baculovirus Insect Cells |
C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicated a poor prognosis in breast IDC. CLEC3A knockdown inhibited BC cell growth and metastasis might be through suppressing PI3K/AKT signaling activity. That CLEC3A is a promising therapeutic target for BC in the future. Matrilysin (MMP-7) plays important roles in tumor progression. ... | |||
TMPY-03795 |
EIF5A2 Protein, Human, Recombinant (His)
eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2 |
Human | E. coli |
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIH-0618 |
Quercetin-d5
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Quercetin-d5 是 Quercetin 的氘代化合物。Quercetin 的 CAS 号为 117-39-5。Quercetin 是一种存在于蔬菜、水果和葡萄酒中的天然黄酮,可激活或抑制许多蛋白质的活性。它是重组 SIRT1 的刺激剂,也是 PI3K 抑制剂,抑制 PI3Kγ,PI3Kδ,PI3Kβ 的IC50分别为 2.4 μM, 3.0 μM, 5.4 μM。 | |||
TMIJ-0110 |
Clarithromycin-13C-d3
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Clarithromycin-13C-d3 是 Clarithromycin 的 13C 和氘代化合物。Clarithromycin 的 CAS 号为 81103-11-9。Clarithromycin 具有广谱的抗菌活性。它抑制CYP3A4催化的三唑仑 α-羟基化,IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流 。 | |||
T35519 |
Aflatoxin B2-13C17
Aflatoxin B2-13C17 |
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Aflatoxin B2-13C17(AFB2-13C17) is intended for use as an internal standard for the quantification of AFB2by GC- or LC-MS. AFB2is a mycotoxin that has been found inA. terricola.1It induces hepatic autophagy and apoptosis in broiler chickens when administered at doses of 0.2, 0.4, and 0.8 mg/kg.2AFB2(0.5 and 1 mg/animal) also induces parenchymal cell hyperplasia in rats.3 1.Moubasher, A.H., el-Kady, I.A., and Shoriet, A.Toxigenic Aspergilli isolated from different sources in EgyptAnn. Nutr. Alimen... |