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Search Results for " pi 14 "

Targets Recommended: PI3K

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T79658	PI3Kδ-IN-14	PI3K	PI3K/Akt/mTOR signaling
	PI3Kδ-IN-14（化合物（S）-29）是一种高选择性PI3Kδ抑制剂，具有出色的靶点亲和力（IC50为0.8 nM，Kd为84.8 nM）。该化合物特异性结合至PI3Kδ激酶的ATP结合位点，并通过抑制PI3K/AKT信号通路发挥抗炎作用。此外，PI3Kδ-IN-14在改善急性肺损伤（ALI）方面显示出潜在效果。
T81469	PI3Kα-IN-14	PI3K	PI3K/Akt/mTOR signaling
	PI3Kα-IN-14（复合物F8）是一款高度选择性的PI3Kα抑制剂，其IC50值为0.14 nM 。此化合物能显著降低线粒体膜的完整性，并在U87-MG细胞中引起G1期细胞周期的停滞以及凋亡现象。此外，PI3Kα-IN-14在不同来源的肿瘤细胞系中均展现出明显的抗增殖能力，其中PC-3的IC50为0.28 μM，HCT-116的IC50为0.57 μM，以及U87-MG的IC50为1.37 μM。
T81470	PI3K/mTOR Inhibitor-14	PI3K	PI3K/Akt/mTOR signaling
	PI3K/mTOR Inhibitor-14（化合物 Y-2）是一种针对PI3K和mTOR的双重抑制剂，其IC50值分别为171.4 nM 和10.1 nM ，具备抗肿瘤活性。
T25809	MI-14 MI14	Others	Others
	MI-14 is a potent and selective inhibitor of PI 4-K IIIß.

化合物

Cat.No: T79658

Target: PI3K

Cat.No: T81469

Target: PI3K

PI3K/mTOR Inhibitor-14

Cat.No: T81470

Target: PI3K

Cat.No: T25809

Synonym: MI14

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00022	LGALS7 Protein, Human, Recombinant Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ...
TMPY-01841	Serpin I2 Protein, Human, Recombinant (His) PI14,TSA2004,PANCPIN,MEPI	Human	HEK293 Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chy...

重组蛋白

LGALS7 Protein, Human, Recombinant

Cat.No: TMPJ-00022

Species: Human

Expression System: E. coli

Serpin I2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01841

Species: Human

Expression System: HEK293 Cells

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