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Search Results for " pge1 "

Targets Recommended: Others

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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T84595	2,3-dinor Prostaglandin E1 2,3-dinor PGE1	Others	Others
	Prostaglandin E1 (PGE1), though not predominantly found in nature, plays a significant role in clinical treatments, addressing conditions such as peripheral occlusive vascular disease, erectile dysfunction, and neonatal cardiology issues. The metabolism of PGE1 primarily begins with the oxidation at C-15, producing 13,14-dihydro-15-keto PGE1 as its major metabolite. Alternatively, inhibiting this pathway or overwhelming it with too much PGE1 could potentially enhance the production of 2,3-dinor ...
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium	Others	Others
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T29908	Alprostadil ethyl ester Prostaglandin E1 ethyl ester,PGE1 ethyl ester	Others	Others
	Alprostadil ethyl ester is a biochemical used in the treatment of scleroderma.
T84527	13,14-dihydro-15(R)-Prostaglandin E1 13,14-dihydro-15(R)-PGE1	Others	Others
	13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)-PGE1)为13,14-二氢-PGE1的同分异构体，特点在于其C-15位的羟基呈R构型，非自然形态。
T15757	Limaprost 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206	PGE Synthase	Immunology/Inflammation
	Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。
T85025	tetranor-Prostaglandin E1 Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1	Others	Others
	Tetranor-Prostaglandin E1 (tetranor-PGE1), a metabolite of PGE1 and PGE2, undergoes formation through β-oxidation.
T34550	SC 31391 SC31391,SC-31391	Others	Others
	SC 31391 is a PGE1 analog.
T36147	13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1	Others	Others
	13,14-dihydro-15-keto Prostaglandin E1 可抑制 ADP 诱导的人离体富血小板血浆中的血小板聚集（IC50=14.8 μg/mL），也是 PGE1 代谢物。
T84592	Prostaglandin E1 ethanolamide Alprostadil Ethanolamide	Others	Others
	Prostaglandin E1 ethanolamide，前列腺素E1 (PGE1) 的类似物，可能有效抑制GLI2诱导的靶基因表达（包括Gli1和Ptch1）和肿瘤生长。
T36775	13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1	Others	Others
	13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hyb...
T84513	13,14-dihydro-16,16-difluoro Prostaglandin E1 15-hydroxy Lubiprostone	Others	Others
	Prostaglandin E1 (PGE1), synthesized through cyclooxygenase-mediated metabolism of dihomo-γ-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability...
T73346	SC 34301 Enisoprost	Others	Others
	SC 34301 (Enisoprost)为有效的口服活性PGE1类似物，显著降低细菌移位并提升烧伤小鼠存活率。
T84528	13,14-dihydro-19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy PGE0	Others	Others
	13,14-Dihydro-19(R)-hydroxy Prostaglandin E1 (13,14-dihydro-19(R)-hydroxy PGE1) is posited as a theoretical metabolite resulting from the action of ω-1 hydroxylase on 13,14-dihydro PGE1. Its biosynthesis and biological activity remain unreported in scientific literature.
T36726	6-keto Prostaglandin E1 6-keto Prostaglandin E1	Others	Others
	6-keto Prostaglandin E1 是 PGE1 的生物活性衍生物，在抗血小板聚集和解聚作用方面发挥作用。
T36214	16,16-dimethyl Prostaglandin E1 16,16-dimethyl Prostaglandin E1	Others	Others
	16,16-dimethyl Prostaglandin E1 是 PGE1 (T1626) 类似物，可诱导支气管收缩和血管平滑肌收缩，并抑制吲哚美辛诱导的细胞伸长。
T36157	8-iso Prostaglandin A1 8-iso Prostaglandin A1	Others	Others
	8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.
T36154	15(S)-15-methyl Prostaglandin E2 15(S)-15-methyl Prostaglandin E2	Others	Others
	15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
T36209	15-keto Prostaglandin A1 15-keto Prostaglandin A1	Others	Others
	Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.
T37773	tetranor-PGEM tetranor-Prostaglandin E Metabolite,tetranor-PGEM	Others	Others
	tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 μg of tetranor-PGEM over a 24-hour period.[1]
T70865	BMY-42393	Others	Others
	BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. B...
T37233	(±)14(15)-EpEDE	Others	Others
	8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of fatty acid elongases. It can be metabolized by the cyclooxygenase pathway to produce 1-series prostaglandins (PGs) (e.g., PGE1). (±)14(15)-EpEDE is an EpEDE acid formed from 8,11,14-eicosatrienoic acid. This monoepoxide can be generated from the PUFA, in vitro, by the action of a strong oxidizing agent. Alternatively, this compound may be pro...
T84643	Dihomo-γ-Linolenic Acid ethyl ester ethyl 20:3ω6	Others	Others
	Ethyl dihomo-γ-linolenic acid ethyl ester (ethyl DGLA), an ω-6 fatty acid intermediate ester form, elevates prostaglandin E1(PGE1) and PGE2 secretion in rabbit renal papilla when administered dietarily at a dosage of 1 g/kg per day for 25 days. Additionally, this dosage of ethyl DGLA increases triglyceride levels and enhances the proportion of 20:3ω6 and 20:4ω6 phospholipids in the renal medulla of rabbits. Ethyl DGLA formulations have been employed in managing eczema and inflammatory disorders.
T36167	8-iso-15-keto Prostaglandin F2β 8-iso-15-keto Prostaglandin F2β	Others	Others
	8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8...
T83807	Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium Rp-ATP-α-S	Others	Others
	Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。
T84995	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA 1-Hexadecanoyl-d9-2-hydroxy-sn-glycero-3-phosphate	Others	Others
	1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by pro...
T62532	MRS2395	Others	Others
	MRS2395 是一种二戊酰衍生物，是一种 P2Y12 受体的有效拮抗剂。MRS2395 抑制 ADP 诱导的血小板活化 (Ki: 3.6 μM)。MRS2395 在 PGE1 存在下，对大鼠血小板中 ADP 诱导的 cAMP 具有抑制作用 (IC50: 7 μM)。MRS2395 增强血小板致密颗粒释放以响应 TRAP-6。
T37441	KMN-80	Others	Others
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...

化合物

2,3-dinor Prostaglandin E1

Cat.No: T84595

Synonym: 2,3-dinor PGE1

Target: Others

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Target: Others

Alprostadil ethyl ester

Cat.No: T29908

Synonym: Prostaglandin E1 ethyl ester,PGE1 ethyl ester

Target: Others

13,14-dihydro-15(R)-Prostaglandin E1

Cat.No: T84527

Synonym: 13,14-dihydro-15(R)-PGE1

Target: Others

Cat.No: T15757

Synonym: 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206

Target: PGE Synthase

tetranor-Prostaglandin E1

Cat.No: T85025

Synonym: Tetranor PGE1,7α,11-Dihydroxy-5-ketotetranorprost-9-enoic Acid,Tetranorprostaglandin E1

Target: Others

Cat.No: T34550

Synonym: SC31391,SC-31391

Target: Others

13,14-dihydro-15-keto Prostaglandin E1

Cat.No: T36147

Synonym: 13,14-dihydro-15-keto Prostaglandin E1

Target: Others

Prostaglandin E1 ethanolamide

Cat.No: T84592

Synonym: Alprostadil Ethanolamide

Target: Others

13,14-dihydro Prostaglandin E1

Cat.No: T36775

Synonym: 13,14-dihydro Prostaglandin E1

Target: Others

13,14-dihydro-16,16-difluoro Prostaglandin E1

Cat.No: T84513

Synonym: 15-hydroxy Lubiprostone

Target: Others

Cat.No: T73346

Synonym: Enisoprost

Target: Others

13,14-dihydro-19(R)-hydroxy Prostaglandin E1

Cat.No: T84528

Synonym: 19(R)-hydroxy PGE0

Target: Others

6-keto Prostaglandin E1

Cat.No: T36726

Synonym: 6-keto Prostaglandin E1

Target: Others

16,16-dimethyl Prostaglandin E1

Cat.No: T36214

Synonym: 16,16-dimethyl Prostaglandin E1

Target: Others

8-iso Prostaglandin A1

Cat.No: T36157

Synonym: 8-iso Prostaglandin A1

Target: Others

15(S)-15-methyl Prostaglandin E2

Cat.No: T36154

Synonym: 15(S)-15-methyl Prostaglandin E2

Target: Others

15-keto Prostaglandin A1

Cat.No: T36209

Synonym: 15-keto Prostaglandin A1

Target: Others

tetranor-PGEM

Cat.No: T37773

Synonym: tetranor-Prostaglandin E Metabolite,tetranor-PGEM

Target: Others

Cat.No: T70865

Target: Others

(±)14(15)-EpEDE

Cat.No: T37233

Target: Others

Dihomo-γ-Linolenic Acid ethyl ester

Cat.No: T84643

Synonym: ethyl 20:3ω6

Target: Others

8-iso-15-keto Prostaglandin F2β

Cat.No: T36167

Synonym: 8-iso-15-keto Prostaglandin F2β

Target: Others

Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83807

Synonym: Rp-ATP-α-S

Target: Others

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA

Cat.No: T84995

Synonym: 1-Hexadecanoyl-d9-2-hydroxy-sn-glycero-3-phosphate

Target: Others

Cat.No: T62532

Target: Others

Cat.No: T37441

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02125	SLCO2B1 Protein, Human, Recombinant (His & Myc) Solute carrier family 21 member 9,Solute carrier or...	Human	E. coli
	Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

重组蛋白

SLCO2B1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02125

Species: Human

Expression System: E. coli

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