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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14365 |
AZ PFKFB3 26
|
Glucokinase | Metabolism |
AZ PFKFB3 26 是一种有效的特异性 PFKFB3 抑制剂,IC50 为 23 nM。 PFKFB1 和 PFKFB2 的 IC50 分别为 2.06 和 0.384 μM。 | |||
T67874 |
PFKFB3-IN-2
|
Glucokinase | Metabolism |
PFKFB3-IN-2是一种6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3)抑制剂。在体内,对PFKFB3进行反义治疗可降低肿瘤生长速度。 | |||
T26730 |
AZ-PFKFB3-67
|
Others | Others |
AZ-PFKFB3-67 is a novel, potent and selective inhibitor of PFKFB3. | |||
T23552 |
YZ9
|
Glucokinase | Metabolism |
Y29 是 PFKFB3抑制剂,IC50为 0.183 µM。Y29是 Fru-6-P 的竞争性抑制剂,Ki 为 0.094 µM。Y29 抑制 HeLa 细胞生长,GI50为 2.7 µM。 | |||
T62894 |
AZ-PFKFB3-67 quarterhydrate
|
Others | Others |
AZ-PFKFB3-67 quarterhydrate 是一种选择性的、高效的代谢激酶 PFKFB3 激酶抑制剂,作用于 PFKFB3 (IC50: 11 nM)、PFKFB2 (IC50: 159 nM) 和 PFKFB1 (IC50: 1130 nM)。 | |||
T3105 |
PFK-158
|
Apoptosis; Glucokinase; Autophagy | Apoptosis; Autophagy; Metabolism |
PFK158 是一种选择性的PFKFB3抑制剂,IC50值为 137 nM。它可减少癌细胞中葡萄糖的摄取,ATP 的产生,乳酸的释放,并诱导细胞凋亡和自噬。它还可以增强 Colistin 对细菌的抵抗力,具有广泛的抗肿瘤活性。 | |||
T2455 |
PFK-015
PFK15,PFK 015 |
Glucokinase; Autophagy | Autophagy; Metabolism |
PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。 | |||
T11741 |
KAN0438757
|
Glucokinase; Autophagy | Autophagy; Metabolism |
KAN0438757 是一种选择性强效的代谢激酶 PFKFB3 抑制剂,IC50值为 0.19 μM。 | |||
T3260 |
(E)-3PO
3PO |
Glucokinase | Metabolism |
(E)-3PO 是一种 PFKFB3(6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase)抑制剂。 | |||
T22223 |
3PO
|
Glucokinase; Autophagy | Autophagy; Metabolism |
3PO 是一种 PFKFB3 的小分子抑制剂,IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖,IC50在1.4到24 μM 之间。它抑制葡萄糖摄取,并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。 | |||
T40565 |
5MPN
|
Others | Others |
5MPN is a novel compound that functions as a highly potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). This compound demonstrates oral activity and serves as a first-in-class inhibitor. Through competitive inhibition of the F6P binding site, 5MPN effectively hinders the functionality of PFKFB4, with a Ki value of 8.6 μM. Importantly, it exhibits no inhibitory effects on PFK-1 or PFKFB3. By specifically targeting the sugar metabolism of tumors, 5MPN... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26346 |
YN1
YN-1,YN 1 |
||
YN1 is an inhibitor of PFKFB3. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00319 |
PFKFB3 Protein, Human, Recombinant (His)
PFK/FBPase 3,PFK2,IPFK2,iPFK-2 |
Human | E. coli |
Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic c... | |||
TMPY-04474 |
PFKFB3 Protein, Human, Recombinant (His & GST)
IPFK2,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase |
Human | Baculovirus Insect Cells |
Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of glycolysis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glycolysis. The concentration of PFK2 de... |