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Targets Recommended: EGFR

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Cat. No. Product Name Target Signaling Pathways
T2041 PD153035

NSC 669364,SU-5271,ZM 252868,AG1517

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
PD153035 (NSC-669364) 是一种EGFR 抑制剂,Ki 和IC50值分别为6和25 pM。
T1761 PD153035 hydrochloride

ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
PD153035 hydrochloride (ZM 252868) 是有效地EGFR 抑制剂,Ki 和IC50值分别为6和25 pM。
T69055 PD153035 nitrate

Others Others
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T69985 Lifirafenib HCl

Others Others
Lifirafenib, also known as Beigene-283, is a Novel potent and selective RAF Kinase and EGFR inhibitor. BGB-283-displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 potently inhibits B-RAFV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harbouring B-RAFV600E and EGFR mutation/amplification. In B-RAFV600E CRC cell lines, BGB-283 effectively inhibits the ...
T3558 EBE-A22

PD153035 Analog 63

EGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
EBE-A22 (PD153035 Analog 63) 是 PD153035 衍生物,PD153035 能够抑制 ErbB-1 磷酸化,但对 EBE-A22 则无抑制作用。

化合物

PD153035
Cat.No: T2041
Synonym: NSC 669364,SU-5271,ZM 252868,AG1517
Target: EGFR
PD153035 hydrochloride
Cat.No: T1761
Synonym: ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868
Target: EGFR
PD153035 nitrate
Cat.No: T69055
Synonym:
Target: Others
Lifirafenib HCl
Cat.No: T69985
Synonym:
Target: Others
EBE-A22
Cat.No: T3558
Synonym: PD153035 Analog 63
Target: EGFR
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