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Search Results for " pc1 "

Targets Recommended: NPC1L1 Others

9

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7495	Hexa-D-arginine	Others	Others
	Hexa-D-arginine 是稳定的furin 抑制剂，能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。
T83974	OPC18750 HCl	PDE	Metabolism
	OPC18750 HCl 是一种潜在的磷酸二酯酶抑制剂，具有正肌力作用，可用于研究哮喘、癌症、糖尿病和精神疾病。
T29112	VPC171 (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171	Adenosine Receptor	GPCR/G Protein; Neuroscience
	VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。
T24599	PC170942 Sodium PC170942 Sodium salt	Others	Others
	PC170942 Sodium is a water-soluble bacterial cytokinesis inhibitor that acts by inhibiting FtsZ.
T29109	VPC12249 VPC-12249,VPC 12249	Others	Others
	VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity.
T61274	PC190723	Others	Others
	PC190723 (Compound 2) 是一种细菌细胞分裂蛋白 FtsZ 抑制剂，IC50值为 55 ng/ml。FtsZ-IN-3 具有抗葡萄球菌活性，对 MSSA 和 MRSA 的MIC 值均为 1 μg/ml。
TP1160	Hexa-D-arginine TFA Furin Inhibitor II TFA
	Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
TP2038	Decanoyl-RVKR-CMK
	Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in
T78224	Histatin-3
	Histatin-3是一肽类物质，由32个氨基酸残基构成，表现出显著的抗菌活性。作为前蛋白转化酶1(PC1)的底物，Histatin-3在Arg25位点的羧基端被该蛋白酶特异性切割（HRGYR降低SN）。此外，Histatin-3亦作为中等效力的、可逆的以及具竞争性的抑制剂，能够抑制弗林蛋白酶介导的五肽pGlu-Arg-Thr-Lys-Arg-MCA荧光底物的裂解，其抑制常数Ki大约为1.98μM。

化合物

Hexa-D-arginine

Cat.No: T7495

Target: Others

Cat.No: T83974

Target: PDE

Cat.No: T29112

Synonym: (2-氨基-4-(3-(三氟甲基)苯基)噻吩-3-基)(苯基)甲酮,VPC 171,VPC-171

Target: Adenosine Receptor

PC170942 Sodium

Cat.No: T24599

Synonym: PC170942 Sodium salt

Target: Others

Cat.No: T29109

Synonym: VPC-12249,VPC 12249

Target: Others

Cat.No: T61274

Target: Others

Hexa-D-arginine TFA

Cat.No: TP1160

Synonym: Furin Inhibitor II TFA

Decanoyl-RVKR-CMK

Cat.No: TP2038

Cat.No: T78224

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01635	PCSK1 Protein, Human, Recombinant (His) proprotein convertase subtilisin/kexin type 1,S...	Human	HEK293 Cells
	Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav...
TMPK-00852	ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated E-NPP 1,NPPase,PC1,NPP1,...	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 98.29 kDa and the accession number is P22413.
TMPK-00854	ENPP1 Protein, Human, Recombinant (C-His) M6S1,E-NPP 1,PCA1,PDNP	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413.
TMPK-00853	ENPP1 Protein, Human, Recombinant (N-His) PDNP1,NPP1,NPPase,PCA1AR...	Human	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413.
TMPK-00781	ENPP1 Protein, Mouse, Recombinant (His) ENPP1,PC1,PCA1A...	Mouse	HEK293 Cells
	Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 95.99 kDa and the accession number is P06802-1.
TMPJ-00330	GPC1 Protein, Human, Recombinant (His) Glypican-1,GPC1	Human	HEK293 Cells
	The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 aa signal sequence, a 507 aa mature segment, and a 28 aa C-terminal prosegment. There are two potential N-linked and four potential O-linked sites for glycosylation or glycanation. There are potentially two heparan sulfate (HS) modifications on GPC1 that could contribute to a nati...
TMPH-00931	ANAPC15 Protein, Human, Recombinant (GST) Anaphase-promoting complex subunit 15,APC<...	Human	E. coli
	ANAPC15 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01885	PABPC1 Protein, Human, Recombinant (His & SUMO) Polyadenylate-binding protein 1,PABPC1...	Human	E. coli
	PABPC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 57.8 kDa and the accession number is P11940.
TMPY-00131	Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG) NPC,Niemann-Pick disease, type C1	Human	HEK293 Cells
	Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty...
TMPH-01407	Glypican 1/GPC1 Protein, Human, Recombinant (GST & His & Myc) GPC1,Glypican-1	Human	E. coli
	Glypican 1/GPC1 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli.
TMPJ-01368	GPC1 Protein, Mouse, Recombinant (His) Gpc1,Glypican-1	Mouse	HEK293 Cells
	Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. It is required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated sig...
TMPH-02905	TRPC1 Protein, Mouse, Recombinant (His) Transient receptor protein 1,Short transient recept...	Mouse	E. coli
	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. TRPC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 94.0 kDa and the accession number is Q61056.
TMPH-00093	GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc) NAD-dependent glyceraldehydephosphate dehydrogenase C subuni...	Arabidopsis thaliana	E. coli
	GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.4 kDa and the accession number is P25858.

重组蛋白

PCSK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01635

Species: Human

Expression System: HEK293 Cells

ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00852

Species: Human

Expression System: HEK293 Cells

ENPP1 Protein, Human, Recombinant (C-His)

Cat.No: TMPK-00854

Species: Human

Expression System: HEK293 Cells

ENPP1 Protein, Human, Recombinant (N-His)

Cat.No: TMPK-00853

Species: Human

Expression System: HEK293 Cells

ENPP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00781

Species: Mouse

Expression System: HEK293 Cells

GPC1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00330

Species: Human

Expression System: HEK293 Cells

ANAPC15 Protein, Human, Recombinant (GST)

Cat.No: TMPH-00931

Species: Human

Expression System: E. coli

PABPC1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01885

Species: Human

Expression System: E. coli

Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)

Cat.No: TMPY-00131

Species: Human

Expression System: HEK293 Cells

Glypican 1/GPC1 Protein, Human, Recombinant (GST & His & Myc)

Cat.No: TMPH-01407

Species: Human

Expression System: E. coli

GPC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01368

Species: Mouse

Expression System: HEK293 Cells

TRPC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02905

Species: Mouse

Expression System: E. coli

GAPC1, cytosolic Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00093

Species: Arabidopsis thaliana

Expression System: E. coli

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