Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71172 |
U 80215
|
Others | Others |
U 80215 is an enzyme-competitive inhibitor. | |||
T71174 |
PBT434 HBr
|
Others | Others |
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g... | |||
T72280 |
PBT434 methanesulfonate
|
Others | Others |
PBT434 methanesulfonate 为一种有效、口服活性并能穿透血脑屏障的α-synuclein aggregation抑制剂,同时担任铁螯合剂和跨细胞铁运输的调节剂。该化合物抑制铁介导的氧化还原活性及α-synuclein聚集,可有效防止SNpc神经元丢失,显示出在PD研究中的应用潜力。 |