Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T81546 |
PARG-IN-4
|
Others | Others |
PARG-IN-4(公式 (A))是一款具备口服活性与细胞渗透能力的PARG抑制剂,能在小鼠模型中有效地抑止肿瘤生长,适用于癌症研究。 | |||
T83799 |
6-alkyne NAD+ sodium
β-Nicotinamide-N6-propargyladenine dinucleotide,6-Parg NAD,6-alkyne Nicotinamide adenine dinucleotide,Click Tag™ 6-alkyne NAD |
||
6-炔基NAD+是一种可点击的信号分子及酶辅因子NAD+形式。它与荧光标签联用,用于检测聚(ADP-核糖)聚合酶(PARP)蛋白质底物。 | |||
T1440 |
Ethacridine lactate monohydrate
乳酸依沙吖啶一水物,利凡诺 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ethacridine lactate monohydrate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂,有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。它也是抗菌剂和流产剂。 | |||
T5967 |
Ethacridine lactate
乳酸依沙吖啶,Acrinol,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE |
Others; Antibacterial | Microbiology/Virology; Others |
Ethacridine lactate (Acrinol) 是一种聚 (ADP-核糖) 糖水解酶 (PARG) 抑制剂,也是一种抗菌剂和流产剂。它有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。 | |||
T12284 |
O-Propargyl-Puromycin
OP-puro,O-Propargylpuromycin |
Others | Others |
O-Propargyl-Puromycin (OP-puro) 是一种高效的蛋白质合成抑制剂,是一种嘌呤霉素炔类似物。 | |||
T38173 |
Propargylcholine
Propargylcholine (bromide) |
Antibacterial | Microbiology/Virology |
Propargylcholine (Propargylcholine (bromide)) 是一种炔烃修饰的胆碱类似物,在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。 | |||
T1578 |
Pargyline hydrochloride
优降宁盐酸盐,Pargylamine hydrochloride |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline hydrochloride (Pargylamine hydrochloride) 是不可逆的单胺氧化酶抑制剂,可作用于 MAO-A (Ki=13 μM) 和 MAO-B (Ki=0.5 μM) ,具有降压和抗癌作用。 | |||
T18566 |
Propargyl-PEG12-bromide
|
Others; PROTAC Linker | Others; PROTAC |
Propargyl-PEG12-bromide 是 PEG 类PROTAC linker,可用于合成 PROTAC 分子。 | |||
T18831 |
Thalidomide-propargyl
|
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到含 IMiD 的 PROTAC。 | |||
T38079 |
DL-Propargylglycine HCl
DL-Propargyl Glycine HCl,DL-Propargyl Glycine hydrochloride |
Others | Others |
DL-Propargylglycine HCl (DL-Propargyl Glycine HCl)是一种有效的胱硫氨酸 γ-裂解酶的不可逆抑制剂,可用于研究心力衰竭。 | |||
T39849 |
Propargite
|
Parasite | Microbiology/Virology |
Propropgite 通过诱导 DNA 损伤来诱导 β 细胞坏死。它诱导 MIN6 细胞死亡的 IC50为 1 μM.。它可用于杀死螨虫。 | |||
T20129 |
L-Propargylglycine
(S)-Propargylglycine,(S)-alpha.Propargylglycine,Propargylglycine,L-炔丙基甘氨酸 |
Others | Others |
L-Propargylglycine ((S)-Propargylglycine) 是一种脯氨酸酶抑制剂。 | |||
T9389 |
Thalidomide-PEG4-Propargyl
Thalidomide-O-PEG4-Propargyl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T16605 |
Propargyl-PEG3-acid
丙炔基-二聚乙二醇-羧酸 |
PROTAC Linker; ADC Linker | Antibody-drug Conjugate/ADC Related; PROTAC |
Propargyl-PEG3-acid 是一种不可切割的,含 3 个单元 PEG 的 ADC 接头,也是一种基于 PEG 的 PROTAC 接头,可用于合成 6-OHDA-PEG3-yne。 6-OHDA-PEG3-yne 包含 6-OHDA 和炔丙基-PEG3-酸。 | |||
T18574 |
Propargyl-PEG17-methane
MPEG16-Propyne |
Others; PROTAC Linker | Others; PROTAC |
Propargyl-PEG17-methane (MPEG16-Propyne) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T0300 |
Pargyline
Pargylamine,Paragyline,优降宁 |
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Pargyline (Pargylamine) 是不可逆的单胺氧化酶抑制剂,对MAO-A 和MAO-B 的Ki 分别为 13 μM 和 0.5 μM,具有降压和抗癌作用。 | |||
T15694 |
L-Homopropargylglycine
|
Others | Others |
L-Homopropargylglycine 是一种蛋氨酸类似物,常用于生物正交非经典氨基酸标记中来检测细菌活性和检测蛋白合成。 | |||
T18568 |
Propargyl-PEG11-methane
|
Others; PROTAC Linker | Others; PROTAC |
Propargyl-PEG11-methane 是 PEG 类 PROTAC linker。可用于合成 PROTAC 分子。 | |||
T16326 |
Cipargamin
KAE609,NITD609 |
Parasite | Microbiology/Virology |
Cipargamin (NITD609) 是一种有效的抗疟药物,对恶性疟原虫的IC50值约为 1 nM。 | |||
T18588 |
Propargyl-PEG5-Ms
Propargyl-PEG6-Ms |
Others; PROTAC Linker | Others; PROTAC |
Propargyl-PEG5-Ms (Propargyl-PEG6-Ms) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T18560 |
Propargyl-C1-NHS ester
4-戊炔酸琥珀亚胺酯,4-Pentynoic Acid Succinimidyl Ester |
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Propargyl-C1-NHS ester (4-Pentynoic Acid Succinimidyl Ester) 是一种不可切割的 ADC 接头,可用于合成抗体偶联药物。 | |||
T18823 | Thalidomide-O-amido-PEG4-propargyl | Others | Others |
Thalidomide-O-amido-PEG4-propargyl is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1]. | |||
T14020 | (2-Pyridyldithio)-PEG4-propargyl | Others | Others |
(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) [1]. | |||
T15884 |
m-PEG4-propargyl
|
Others | Others |
m-PEG4-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18591 |
Propargyl-PEG8-SH
|
Others | Others |
Propargyl-PEG8-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14758 |
Boc-NH-PEG8-propargyl
|
Others | Others |
Boc-NH-PEG8-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T16300 |
NH-bis(PEG2-propargyl)
|
Others | Others |
NH-bis(PEG2-propargyl) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14740 |
Boc-aminooxy-PEG2-propargyl
Boc-NH-PEG2-propargyl |
Others | Others |
Boc-NH-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
T16249 |
N-(Propargyl-PEG4)-N-bis(PEG4-acid)
|
Others | Others |
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker extensively utilized in the synthesis of PROTACs (proteolysis targeting chimeras)[1]. | |||
T16612 |
Propargyl-PEG3-phosphonic acid
|
Others | Others |
Propargyl-PEG3-phosphonic acid, a PEG-based PROTAC linker, is utilized for PROTAC synthesis[1]. | |||
T16610 |
Propargyl-PEG3-OCH2-Boc
|
Others | Others |
Propargyl-PEG3-OCH2-Boc is a polyethylene glycol (PEG)-derived linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T16631 |
Propargyl-PEG4-sulfonic acid
|
Others | Others |
Propargyl-PEG4-sulfonic acid is a PEG4-based linker compound utilized in PROTAC synthesis[1]. | |||
T16246 |
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester
|
Others | Others |
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs) [1]. | |||
T17633 |
Bis-propargyl-PEG11
|
Others | Others |
Bis-propargyl-PEG11 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T14660 |
Bis-propargyl-PEG7
|
Others | Others |
Bis-propargyl-PEG7 is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). It is particularly employed for the synthesis of polymer-linked multimers of guanosine-3',5'-cyclic monophosphates[1]. | |||
T16603 |
Propargyl-PEG2-OH
|
Others | Others |
Propargyl-PEG2-OH is a polyethylene glycol (PEG)-based PROTAC linker, specifically designed for efficient synthesis of Thalidomide-O-PEG2-propargyl. | |||
T16604 |
Propargyl-PEG2-Tos
|
Others | Others |
Propargyl-PEG2-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T16248 |
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
n-propargyl-peg4-carbonyl-n-bis-peg1-methyl-ester |
Others | Others |
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a polyethylene glycol (PEG) based linker, employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T18589 |
Propargyl-PEG6-SH
|
Others | Others |
Propargyl-PEG6-SH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18189 |
m-PEG3-Sulfone-PEG4-propargyl
|
Others | Others |
m-PEG3-Sulfone-PEG4-propargyl is a polyethylene glycol (PEG)-based prodrug-induced degradation (PROTAC) linker. It is utilized in the efficient synthesis of PROTACs, a class of heterobifunctional molecules designed to selectively target and degrade specific protein targets[1]. | |||
T18452 |
N-methyl-N'-(propargyl-PEG4)-Cy5
|
Others | Others |
N-methyl-N'-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker suitable for PROTAC synthesis[1]. | |||
T18176 |
m-PEG25-Propargyl
|
Others | Others |
m-PEG25-Propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17634 |
Bis-propargyl-PEG13
|
Others | Others |
Bis-propargyl-PEG13 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18567 |
Propargyl-PEG12-methane
|
Others | Others |
Propargyl-PEG12-methane is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis, specifically for PEG-based proteolysis-targeting chimeras (PROTACs)[1]. | |||
T18070 |
Lenalidomide-propargyl-C2-NH2 hydrochloride
|
Others | Others |
Lenalidomide-propargyl-C2-NH2 hydrochloride is a compound that features a cereblon (CRBN) ligand for the E3 ubiquitin ligase, as well as a linker. It is utilized in the development of the PROTAC MD-224[1] system. | |||
T39398 |
Propargyl-PEG6-Br
Propargyl-PEG6-Br |
Others | Others |
Propargyl-PEG6-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T69217 |
Pargolol
|
Others | Others |
Pargolol is a beta adrenergic receptor antagonist. | |||
T38580 |
Azido-PEG4-propargyl
Azido-PEG4-propargyl |
Others | Others |
Azido-PEG4-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T24666 |
Propargyl-PEG14-alcohol
|
Others | Others |
Propargyl-PEG14-alcohol is a PEG derivative containing a hydroxyl group and a propargyl group. PEG Linkers are useful in the development of antibody drug conjugates. The hydroxyl group enables further derivatization or replacement with other reactive func | |||
T38689 |
Propargyl-PEG5-Br
Propargyl-PEG5-Br |
Others | Others |
Propargyl-PEG5-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |