6
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1880L1 |
PAMP-12 (human, porcine) acetate
PAMP-12 (human, porcine) acetate(196305-05-2 free base) |
Others | Others |
PAMP-12 (human, porcine) acetate (PAMP-12 (human, porcine) acetate (196305-05-2 free base)) 是 ir-PAMP 的主要成分,由 AM 前体加工而成,PAMP-20 也是如此,并且可能参与心血管控制。 | |||
TP1880 |
PAMP-12(human, porcine)
PAMP-12 (human, porcine) |
||
Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin. | |||
T83697 |
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20) |
||
Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段,源自人体肾上腺髓质,对应人类PAMP-20的9-20氨基酸,涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中,PAMP-12抑制forskolin诱导的cAMP积累(EC50 = 57.2 nM),特异性诱导表达MRGPRX2的CHO细胞的钙离子动员(EC50 = 41 nM),而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应(在1 µM浓度下)。PAMP-12还能作为烟碱型乙酰胆碱受体(nAChRs)的拮抗剂,抑制carbachol诱导的儿茶酚胺释放(IC50 = 1.3 µM)及钙和钠的流入(IC50分别为0.39 µM和0.87 µM),但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入(IC50 >1 µM),在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时,PAMP-12能降低平均动脉血压。 | |||
T78027 |
PAMP-12 (unmodified)
|
||
PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂,其EC50值为20-50 nM。作为内源性肽,它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。 | |||
T80080 |
PAMP-12 (unmodified) (TFA)
|
||
PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂,展现出高效性(EC50=20-50 nM)。该化合物为内源性肽,能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。 | |||
T81557 |
PAMP-12(human, porcine) TFA
|
||
PAMP-12(human, porcine) TFA,免疫反应性PAMP(ir-PAMP)的关键成分,源自肾上腺髓质素前体,具有调节心血管功能和显著降压作用的生物活性肽。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01640 |
MRGPRX2 Protein, Human, Recombinant (His)
Mas-related G-protein coupled receptor member X2,MRGPRX2 |
Human | E. coli |
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c... | |||
TMPY-02642 |
UBE2W Protein, Human, Recombinant (His)
UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative) |
Human | E. coli |
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th... | |||
TMPY-00479 |
Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc)
ARIA,neuregulin 1,GGF2,MSTP131,GGF,MST131,HGL,NDF,SMDF,HRG1,... |
Human | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12. | |||
TMPY-00031 |
Neuregulin-1/NRG1 Protein, Human, Recombinant (His)
HRG1,GGF2,HRG,NDF,MSTP131,HRGA,GGF,neuregulin 1,HGL,SMDF,ARI... |
Human | HEK293 Cells |
Neuregulin-1/NRG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is Q02297-12. | |||
TMPY-03797 |
Neurofascin Protein, Human, Recombinant (His)
neurofascin,NF,NRCAML |
Human | HEK293 Cells |
Neurofascin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.4 kDa and the accession number is O94856-12. | |||
TMPY-04620 |
Neurofascin Protein, Human, Recombinant (hFc)
neurofascin,NRCAML,NF |
Human | HEK293 Cells |
Neurofascin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-12. |