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Targets Recommended: Others

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1880L1	PAMP-12 (human, porcine) acetate PAMP-12 (human, porcine) acetate(196305-05-2 free base)	Others	Others
	PAMP-12 (human, porcine) acetate (PAMP-12 (human, porcine) acetate (196305-05-2 free base)) 是 ir-PAMP 的主要成分，由 AM 前体加工而成，PAMP-20 也是如此，并且可能参与心血管控制。
TP1880	PAMP-12(human, porcine) PAMP-12 (human, porcine)
	Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.
T83697	PAMP-12 (human, mouse, rat, porcine, bovine) TFA Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
	Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段，源自人体肾上腺髓质，对应人类PAMP-20的9-20氨基酸，涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中，PAMP-12抑制forskolin诱导的cAMP积累（EC50 = 57.2 nM），特异性诱导表达MRGPRX2的CHO细胞的钙离子动员（EC50 = 41 nM），而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应（在1 µM浓度下）。PAMP-12还能作为烟碱型乙酰胆碱受体（nAChRs）的拮抗剂，抑制carbachol诱导的儿茶酚胺释放（IC50 = 1.3 µM）及钙和钠的流入（IC50分别为0.39 µM和0.87 µM），但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入（IC50 >1 µM），在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时，PAMP-12能降低平均动脉血压。
T78027	PAMP-12 (unmodified)
	PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂，其EC50值为20-50 nM。作为内源性肽，它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。
T80080	PAMP-12 (unmodified) (TFA)
	PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂，展现出高效性（EC50=20-50 nM）。该化合物为内源性肽，能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。
T81557	PAMP-12(human, porcine) TFA
	PAMP-12(human, porcine) TFA，免疫反应性PAMP(ir-PAMP)的关键成分，源自肾上腺髓质素前体，具有调节心血管功能和显著降压作用的生物活性肽。

化合物

PAMP-12 (human, porcine) acetate

Cat.No: TP1880L1

Synonym: PAMP-12 (human, porcine) acetate(196305-05-2 free base)

Target: Others

PAMP-12(human, porcine)

Cat.No: TP1880

Synonym: PAMP-12 (human, porcine)

Target:

PAMP-12 (human, mouse, rat, porcine, bovine) TFA

Cat.No: T83697

Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Target:

PAMP-12 (unmodified)

Cat.No: T78027

Synonym:

Target:

PAMP-12 (unmodified) (TFA)

Cat.No: T80080

Synonym:

Target:

PAMP-12(human, porcine) TFA

Cat.No: T81557

Synonym:

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Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His) Mas-related G-protein coupled receptor member X2,MRGPRX2	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c...
TMPY-02642	UBE2W Protein, Human, Recombinant (His) UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative)	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th...
TMPY-00479	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) ARIA,neuregulin 1,GGF2,MSTP131,GGF,MST131,HGL,NDF,SMDF,HRG1,...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.
TMPY-00031	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) HRG1,GGF2,HRG,NDF,MSTP131,HRGA,GGF,neuregulin 1,HGL,SMDF,ARI...	Human	HEK293 Cells
	Neuregulin-1/NRG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.3 kDa and the accession number is Q02297-12.
TMPY-03797	Neurofascin Protein, Human, Recombinant (His) neurofascin,NF,NRCAML	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104.4 kDa and the accession number is O94856-12.
TMPY-04620	Neurofascin Protein, Human, Recombinant (hFc) neurofascin,NRCAML,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-12.