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Search Results for " pam "

Targets Recommended: Dopamine Receptor TRP/TRPV Channel

258

抑制剂 & 化合物

12

天然产物

10

重组蛋白

17

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T37428	TRPC6-PAM-C20 TRPC6-PAM-C20,3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPC6-PAM-C20 是一种选择性 TRPC6 正变构调节剂。 TRPC6-PAM-C20 在表达 TRPC6 的 HEK 细胞中诱导胞内 Ca2+ 瞬时增加，EC50 为 2.37 μM。 TRPC6-PAM-C20 增强 OAG 诱导的血小板聚集。
T37075	CB2R PAM Ec2la	Cannabinoid Receptor	GPCR/G Protein
	CB2R PAM 是一种口服活性大麻素 2 型受体（CB2Rs）阳性突变调节剂，它能增强 CP 55940 和 2-Arachidonylglycerol 刺激的 [35S]GTPγS 与 CB2 受体的结合，但在没有激动剂的情况下没有作用。CB2R PAM 在神经病理性疼痛小鼠模型中显示出抗损伤活性。
T1111	Pralidoxime Chloride 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)	AChE	Neuroscience
	Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物，对中毒乙酰胆碱酯酶具有恢复作用，可用于有机磷中毒的研究。
T33872	Pam 1392 AI3 52841,AI352841,AI3-52841	Others	Others
	Pam 1392 is a chemotherapeutic agent.
TP1067	Pam3CSK4 TFA (112208-00-1 free base) Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA	TLR	Immunology/Inflammation
	Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) 是 Toll 样受体 1/2 激动剂，对人 TLR1/2 的EC50为 0.47 ng/mL。
T22404	Pralidoxime Iodide 2-PAM,碘解磷定	Others	Others
	Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
TP2399	Palmitoyl tetrapeptide Pam-ser-ser-asn-ala
	Palmitoyl tetrapeptide is an analog of the N-terminal part of lipoprotein from the outer membrane of E. coli.
T9177	BPAM344	iGluR	Membrane transporter/Ion channel; Neuroscience
	BPAM344 是一种红藻氨酸受体亚基GluK1b、GluK2a 和GluK3a 的正变构调节剂。
T9021	Ro0711401 Ro-0711401,Ro 0711401	GluR	Neuroscience
	Ro0711401 是一种可口服的 mGlu1受体选择性正变构调节剂，EC50为 56 nM。
T29123	VU0152099 VU 0152099,VU-0152099	AChR	Neuroscience
	VU0152099 是选择性和可透过血脑屏障的 mAChR M4正变构调节剂，可增强 M4 对乙酰胆碱的反应，对大鼠 M4 受体的 EC50为 0.4 µM。
T28069	ML380 ML 380,ML-380	AChR	Neuroscience
	ML380 是一种高效的中枢神经系统渗透剂 M5 正变构调节剂，对人和大鼠 M5 的 EC50值分别为 190 和 610 nM。它对 M1 和 M3 mAChR 亚型具有中等选择性，可增加 Ach 对 M5 mAChR 的亲和力。
T23514	VU-1545 VU 1545	GluR	Neuroscience
	VU-1545 是一种代谢型谷氨酸受体 5 正变构调节剂，Ki 为 156 nM，EC50为 9.6 nM。
T29137	VU0453595 VU 0453595,VU-0453595	AChR	Neuroscience
	VU0453595 是有效的、高选择性的、全身活性的M1正变构调节剂 (PAM, EC50=2140 nM)，在精神分裂症方面有研究价值。
T8991	BMS986187	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM)，其 EC50= 0.03 μM，pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。
TP1962	Pam2CSK4
	Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
T7699	AZD7325 AZD-7325	P450; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂，Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和强效 CYP3A4诱导剂，有用于焦虑和 dravet 综合征相关的研究潜力。
TP2282	Pam2CSK4 Biotin	Others	Others
	biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist
T70460	HM5023507	Others	Others
	HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays and in primary human immune cells with an exquisite selectivity against other targets.
T81559	Pam3-Cys-Ala-Gly
	Pam3-Cys-Ala-Gly为合成细菌脂肽，具备激活巨噬细胞与B细胞的高效能力。
TP2282L	Pam2CSK4 TFA PUL-042 TFA,ODN-M362 TFA,Pam2CSK4 trifluoroacetate-salt,Pam2CSK4 TFA(868247-72-7 Free base）	TLR; Antifungal	Immunology/Inflammation; Microbiology/Virology
	Pam2CSK4 TFA (PUL-042 TFA) 是一种有效的 TLR2 和 TLR6 双重激动剂，是一种模拟细菌脂蛋白的多肽。Pam2CSK4 TFA 可促进血小板聚集，可用来研究脂蛋白对牙周的影响。
TP1068	Pam3CSK4 Pam3Cys-Ser-(Lys)4
	Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
TP1066	Pam3CSK4-Biotin Pam3Cys-Ser-(Lys)4-Biotin
	Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.
T60047	V-0219	Glucagon Receptor	GPCR/G Protein
	V-0219 是 GLP-1 的正变构调节剂，可用于肥胖相关糖尿病的研究。
T34896	Tofisopam Emandaxin,托非索洋,Grandaxin	Others	Others
	Tofisopam (Grandaxin) 是2,3-苯二氮卓类化合物，具有抗焦虑活性，可口服。
T13957	Verilopam	Others	Others
	Verilopam 具有镇痛作用，可用于疼痛研究。
T15645	Pamicogrel KBT3022,帕米格雷	COX	Immunology/Inflammation; Neuroscience
	Pamicogrel (KBT3022) 是一种环氧合酶 (COX) 抑制剂。
T0053	Hydroxyzine Pamoate Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine Pamoate (Bobsule) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。
T1230	Pamabrom 巴马溴,帕马溴	Others	Others
	Pamabrom 是一种利尿剂，有效成分为8-bromotheophylline，能够缓解月经相关症状。
T7333	Pyrvinium pamoate Pyrvinium embonate,扑蛲灵	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Pyrvinium pamoate (Pyrvinium embonate) 是一种古老的驱虫药，用于治疗蛲虫病，由于其在某些类型的癌症中抑制 Wnt/β-catenin 通路，它作为抗癌药物再次引起人们的关注。
T28159	Nerisopam EGIS-6775,GYKI 52322,GYKI52322,EGIS6775,GYKI-52322	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Nerisopam 是一种γ-氨基丁酸（GABA）受体激动剂。
T60075	Dopamine D2 receptor agonist-2 Dopamine D2 Receptor	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) 是靶向多巴胺D2受体的配体。
T68081	Girisopam	Others	Others
	Girisopam 是一种用于2，3-苯二氮卓结合位点的新型选择性苯二氮卓类化合物，是一种非典型精神安定药，具有抗焦虑作用。
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T11077	Dopamine D2 receptor antagonist-1	Others	Others
	Dopamine D2 receptor antagonist-1，一种对多巴胺D2受体（D2R）表现出亚毫摩尔级别亲和力的负变构调节剂（NAM）。
T1576	Iopamidol SQ-13396,Niopam,Iopamiron,Iopamiro,碘帕醇,B-15000,Isovue	Others	Others
	Iopamidol (SQ-13396) 是一种 benzenedicarboxamide 化合物。它具有放射性不透明介质、环境污染物和异种生物的作用。
T15257	Etripamil MSP-2017,(-)-MSP-2017	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂，可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入，显示房室结传导并延长房室结不应期
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T6835	Fenoldopam mesylate Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fenoldopam mesylate (Corlopam mesylate) 是一种多巴胺受体D1选择性激动剂。
T13257	Upamostat	PAI-1; Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Upamostat 是一种丝氨酸蛋白酶抑制剂，也是一种具有口服活性的 WX-UK1 前药，是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
T13512	5-Hydroxydopamine hydrochloride	Antifungal	Microbiology/Virology
	5-Hydroxydopamine hydrochloride 是人体尿液中的一种天然胺,对卢克斯普受体的 IC50 值为 22 µM 。5-Hydroxydopamine hydrochloride 具有潜在的抗菌活性和抗癌活性。
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T6549	Isepamicin sulfate Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate	Antibacterial; Antibiotic	Microbiology/Virology
	Isepamicin sulfate (sch21420) Sulphate) 是一种广谱氨基糖苷类抗生素，对产生 I 型 6-乙酰转移酶的菌株具有良好的活性，通过靶向细菌 30S 核糖体亚基来抑制细菌蛋白质合成。
T1337	Pamidronate Disodium 帕米膦酸钠,CGP 23339A,CGP 23339AE,Pamidronate disodium salt	Others; HBV	Microbiology/Virology; Others
	Pamidronate Disodium (CGP 23339A) 是一种具有强化骨骼作用的物质。
T24064	Fipamezole JP-1730,BVF-025,JP 1730,JP1730	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fipamezole 是一种有效的 α2肾上腺素能受体拮抗剂，可能用于研究帕金森病自主神经功能障碍。
T68055	Devapamil Devapamilo,Devapamilum	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Devapamil (Devapamilo) 是一种苯烷基胺，以使用依赖性方式阻断来自膜细胞内侧的 L 型钙电流。
TP1880L1	PAMP-12 (human, porcine) acetate PAMP-12 (human, porcine) acetate(196305-05-2 free base)	Others	Others
	PAMP-12 (human, porcine) acetate (PAMP-12 (human, porcine) acetate (196305-05-2 free base)) 是 ir-PAMP 的主要成分，由 AM 前体加工而成，PAMP-20 也是如此，并且可能参与心血管控制。
T7809L	Ipamorelin 2 Pivalic acid NNC-26-0161	Others	Others
	Ipamorelin 2 Pivalic acid (NNC-26-0161) 是一种生长激素释放肽，可诱导大鼠纵向骨生长。
T1010	Verapamil hydrochloride Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T76804	Pamrevlumab FG-3019	Apoptosis	Apoptosis
	Pamrevlumab (FG-3019) 是一种对缔组织生长因子（CTGF）有亲和力的人源抗体，参与抗结缔组织生长因子疗法，可用于治疗特发性肺纤维化 (IPF) 。
T11353	Gallopamil Methoxyverapamil,戈洛帕米	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Gallopamil (Methoxyverapamil) 是一种苯烷基胺钙拮抗剂，以浓度依赖性方式抑制酸分泌 (IC50 = 10.9 μM)。Gallopamil 显示出抗心律失常和血管扩张剂的功效。

化合物

TRPC6-PAM-C20

Cat.No: T37428

Synonym: TRPC6-PAM-C20,3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

Target: TRP/TRPV Channel

Cat.No: T37075

Synonym: Ec2la

Target: Cannabinoid Receptor

Pralidoxime Chloride

Cat.No: T1111

Synonym: 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)

Target: AChE

Cat.No: T33872

Synonym: AI3 52841,AI352841,AI3-52841

Target: Others

Pam3CSK4 TFA (112208-00-1 free base)

Cat.No: TP1067

Synonym: Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA

Target: TLR

Pralidoxime Iodide

Cat.No: T22404

Synonym: 2-PAM,碘解磷定

Target: Others

Palmitoyl tetrapeptide

Cat.No: TP2399

Synonym: Pam-ser-ser-asn-ala

Cat.No: T9177

Target: iGluR

Cat.No: T9021

Synonym: Ro-0711401,Ro 0711401

Target: GluR

Cat.No: T29123

Synonym: VU 0152099,VU-0152099

Target: AChR

Cat.No: T28069

Synonym: ML 380,ML-380

Target: AChR

Cat.No: T23514

Synonym: VU 1545

Target: GluR

Cat.No: T29137

Synonym: VU 0453595,VU-0453595

Target: AChR

Cat.No: T8991

Target: Opioid Receptor

Cat.No: TP1962

Cat.No: T7699

Synonym: AZD-7325

Target: P450, GABA Receptor

Pam2CSK4 Biotin

Cat.No: TP2282

Target: Others

Cat.No: T70460

Target: Others

Pam3-Cys-Ala-Gly

Cat.No: T81559

Cat.No: TP2282L

Synonym: PUL-042 TFA,ODN-M362 TFA,Pam2CSK4 trifluoroacetate-salt,Pam2CSK4 TFA(868247-72-7 Free base）

Target: TLR, Antifungal

Cat.No: TP1068

Synonym: Pam3Cys-Ser-(Lys)4

Pam3CSK4-Biotin

Cat.No: TP1066

Synonym: Pam3Cys-Ser-(Lys)4-Biotin

Cat.No: T60047

Target: Glucagon Receptor

Cat.No: T34896

Synonym: Emandaxin,托非索洋,Grandaxin

Target: Others

Cat.No: T13957

Target: Others

Cat.No: T15645

Synonym: KBT3022,帕米格雷

Target: COX

Hydroxyzine Pamoate

Cat.No: T0053

Synonym: Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose

Target: Histamine Receptor

Cat.No: T1230

Synonym: 巴马溴,帕马溴

Target: Others

Pyrvinium pamoate

Cat.No: T7333

Synonym: Pyrvinium embonate,扑蛲灵

Target: Wnt/beta-catenin

Cat.No: T28159

Synonym: EGIS-6775,GYKI 52322,GYKI52322,EGIS6775,GYKI-52322

Target: GABA Receptor

Dopamine D2 receptor agonist-2

Cat.No: T60075

Synonym: Dopamine D2 Receptor

Target: Dopamine Receptor

Cat.No: T68081

Target: Others

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

Dopamine D2 receptor antagonist-1

Cat.No: T11077

Target: Others

Cat.No: T1576

Synonym: SQ-13396,Niopam,Iopamiron,Iopamiro,碘帕醇,B-15000,Isovue

Target: Others

Cat.No: T15257

Synonym: MSP-2017,(-)-MSP-2017

Target: Calcium Channel

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

Fenoldopam mesylate

Cat.No: T6835

Synonym: Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐

Target: Dopamine Receptor

Cat.No: T13257

Target: PAI-1, Serine/threonin kinase, Serine Protease

5-Hydroxydopamine hydrochloride

Cat.No: T13512

Target: Antifungal

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

Isepamicin sulfate

Cat.No: T6549

Synonym: Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate

Target: Antibacterial, Antibiotic

Pamidronate Disodium

Cat.No: T1337

Synonym: 帕米膦酸钠,CGP 23339A,CGP 23339AE,Pamidronate disodium salt

Target: Others, HBV

Cat.No: T24064

Synonym: JP-1730,BVF-025,JP 1730,JP1730

Target: Adrenergic Receptor

Cat.No: T68055

Synonym: Devapamilo,Devapamilum

Target: Calcium Channel

PAMP-12 (human, porcine) acetate

Cat.No: TP1880L1

Synonym: PAMP-12 (human, porcine) acetate(196305-05-2 free base)

Target: Others

Ipamorelin 2 Pivalic acid

Cat.No: T7809L

Synonym: NNC-26-0161

Target: Others

Verapamil hydrochloride

Cat.No: T1010

Synonym: Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Cat.No: T76804

Synonym: FG-3019

Target: Apoptosis

Cat.No: T11353

Synonym: Methoxyverapamil,戈洛帕米

Target: Calcium Channel

Cat. No.	Product Name	Target	Signaling Pathways
TN1970	N-trans-p-coumaroyloctopamine N-p-Coumaroyloctopamine,N-对香豆酰真蛸胺,p-coumaroylnoradrenaline	Others	Others
	N-trans-p-coumaroyloctopamine (p-coumaroylnoradrenaline) 来源于马铃薯的块茎组织。
T0469	Octopamine hydrochloride 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐	Dopamine Receptor; Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质，在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。
T2825	Cyclopamine 环巴胺,11-Deoxojervine	Hedgehog/Smoothened; Endogenous Metabolite; Smo	GPCR/G Protein; Metabolism; Stem Cells
	Cyclopamine (11-Deoxojervine) 是Hedgehog 通路的拮抗剂，细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。
TN1968	N-Feruloyloctopamine N-Feruloyloctopamine,N-阿魏酰章鱼胺	p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	N-Feruloyloctopamine 是从木本曼陀罗提取的一种天然产物，有抗氧化作用，可显著降低Akt 和p38 MAPK 磷酸化水平。
T13108	Pamufetinib H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Pamufetinib (TAS-115) 是VEGFR 和c-Met/HGFR 抑制剂，能够抑制 rVEGFR2 (IC50:30 nM)和 rMET (IC50:32 nM)的活性。
T1644	Dopamine hydrochloride 盐酸多巴胺,Dopamine HCl,ASL279	Ferroptosis; Dopamine Receptor; 5-HT Receptor; Endogenous Metabolite	Apoptosis; GPCR/G Protein; Metabolism; Neuroscience
	Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺，由二羟基苯丙氨酸脱羧形成，是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用，有促进血管生成活性。
T1537	Rapamycin Sirolimus,AY 22989,雷帕霉素,NSC-2260804	Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Rapamycin (AY 22989) 属于大环内酯类天然产物，是一种 mTOR 抑制剂，具有特异性（HEK293 细胞：IC50=0.1 nM）。Rapamycin 具有免疫抑制活性，并能诱导自噬。
T73775	Dopamine 3-O-sulfate	Others	Others
	Dopamine 3-O-sulfate，一种主要存在于血浆中的化合物，可作为芳香族氨基酸脱羧酶(AADC)缺乏症的生物标志物。
T40158	N-acetyldopamine NADA,N-乙酰多巴胺	Others	Others
	N-acetyldopamine (NADA) is a catecholamine utilized by insects as a precursor for sclerotization, a process that strengthens their cuticle.
TN6456	N-trans-caffeoyloctopamine
	N-trans-Caffeoyltyramine has both arginase inhibitory property and antioxidant capacity.
T25305	Demethoxyrapamycin AY 24668,AY24668,AY-24668	Others	Others
	Demethoxyrapamycin is a new antifungal antibiotic agent which is co-produced with rapamycin by Streptomyces hygroscopicus.
T81710	N-Acetyldopamine dimer-3	Others	Others
	N-Acetyldopamine dimer-3 (compound 11)为Aspongopus chinensis中检出的天然化合物。

天然产物

N-trans-p-coumaroyloctopamine

Cat.No: TN1970

Synonym: N-p-Coumaroyloctopamine,N-对香豆酰真蛸胺,p-coumaroylnoradrenaline

Target: Others

Octopamine hydrochloride

Cat.No: T0469

Synonym: 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐

Target: Dopamine Receptor, Endogenous Metabolite, Adrenergic Receptor

Cat.No: T2825

Synonym: 环巴胺,11-Deoxojervine

Target: Hedgehog/Smoothened, Endogenous Metabolite, Smo

N-Feruloyloctopamine

Cat.No: TN1968

Synonym: N-Feruloyloctopamine,N-阿魏酰章鱼胺

Target: p38 MAPK, Akt

Cat.No: T13108

Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

Target: VEGFR, c-Met/HGFR

Dopamine hydrochloride

Cat.No: T1644

Synonym: 盐酸多巴胺,Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

Cat.No: T1537

Synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Dopamine 3-O-sulfate

Cat.No: T73775

Target: Others

N-acetyldopamine

Cat.No: T40158

Synonym: NADA,N-乙酰多巴胺

Target: Others

N-trans-caffeoyloctopamine

Cat.No: TN6456

Demethoxyrapamycin

Cat.No: T25305

Synonym: AY 24668,AY24668,AY-24668

Target: Others

N-Acetyldopamine dimer-3

Cat.No: T81710

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00392	PAM Protein, Human, Recombinant (His) PAL,peptidylglycine alpha-amidating monooxygenase,peptidylgl...	Human	HEK293 Cells
	PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2.
TMPK-00188	JAM-A Protein, Mouse, Recombinant (His) F11R,JCAM1,PAM-1,PAM-1KAT,JAM-1,JAM,JCAM,J...	Mouse	HEK293 Cells
	junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyon...
TMPY-00149	PAM Protein, Human, Recombinant (hFc) peptidylglycine alpha-amidating monooxygenase,PHM,peptidylgl...	Human	HEK293 Cells
	PAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 104 kDa and the accession number is P19021-2.
TMPY-00865	JAM-A Protein, Human, Recombinant (hFc) F11 receptor,JAM1,JAMA,KAT,CD321,JCAM,JAM,PAM-1	Human	HEK293 Cells
	JAM-A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50 kDa and the accession number is Q9BQB4-1.
TMPY-01035	JAM-A Protein, Human, Recombinant (His) PAM-1,F11 receptor,JAMA,JAM1,KAT,CD321,JCAM,JAM	Human	HEK293 Cells
	JAM-A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Y624-1.
TMPJ-00965	TIM16 Protein, S. cerevisiae, Recombinant TIM16,Mitochondrial import inner membrane translocase subuni...	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM16 is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. TIM16 may act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase s...
TMPJ-01087	TIM14 Protein, S. cerevisiae, Recombinant Mitochondrial import inner membrane translocase subunit TIM1...	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM14 is required to stimulate activity of mtHSP70 (SSC1). TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as p...
TMPY-03852	Dopamine beta-Hydroxylase Protein, Human, Recombinant (His) dopamine β-hydroxylase (dopamine β-monooxy...	Human	HEK293 Cells
	DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ...
TMPH-01509	SPAM1 Protein, Human, Recombinant (His) Sperm adhesion molecule 1,Hyaluronidase PH-20,Sperm surface ...	Human	E. coli
	Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
TMPH-01690	TIM14 Protein, Human, Recombinant (GST) Mitochondrial import inner membrane translocase subunit TIM1...	Human	E. coli
	Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.

重组蛋白

PAM Protein, Human, Recombinant (His)

Cat.No: TMPY-00392

Species: Human

Expression System: HEK293 Cells

JAM-A Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00188

Species: Mouse

Expression System: HEK293 Cells

PAM Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00149

Species: Human

Expression System: HEK293 Cells

JAM-A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00865

Species: Human

Expression System: HEK293 Cells

JAM-A Protein, Human, Recombinant (His)

Cat.No: TMPY-01035

Species: Human

Expression System: HEK293 Cells

TIM16 Protein, S. cerevisiae, Recombinant

Cat.No: TMPJ-00965

Species: S. cerevisiae

Expression System: E. coli

TIM14 Protein, S. cerevisiae, Recombinant

Cat.No: TMPJ-01087

Species: S. cerevisiae

Expression System: E. coli

Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)

Cat.No: TMPY-03852

Species: Human

Expression System: HEK293 Cells

SPAM1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01509

Species: Human

Expression System: E. coli

TIM14 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01690

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0401	Octopamine-d3
	Octopamine-d3 是 Octopamine 的氘代化合物。
TMIH-0484	Ractopamine-d6 Hydrochloride (Mixture of Diastereomers)
	Ractopamine-d6 Hydrochloride (Mixture of Diastereomers) 是 Ractopamine Hydrochloride (Mixture of Diastereomers) 的氘代化合物。
TMIH-0399	Norverapamil-d7 HCl
	Norverapamil-d7 HCl 是 Norverapamil HCl 的氘代化合物。Norverapamil HCl 的 CAS 号为 67812-42-4。Norverapamil hydrochloride是 Verapamil 的 N-去甲基代谢物，是L型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
TMIJ-0285	Verapamil-d7 Hydrochloride
	Verapamil-d7 Hydrochloride 是 Verapamil Hydrochloride 的氘代化合物。Verapamil Hydrochloride 的 CAS 号为 152-11-4。Verapamil hydrochloride 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
TMIH-0547	S-Verapamil-d7 HCL
	S-Verapamil-d7 HCL 是 S-Verapamil HCL 的氘代化合物。S-Verapamil HCL 的 CAS 号为 1188265-55-5。
T12243	Norverapamil-d7 D591 D7,(±)-Norverapamil D7	Others	Others
	Norverapamil D7 is a deuterium labeled Norverapamil . Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
TMIH-0482	Ractopamine-d5 Hydrochloride
	Ractopamine-d5 Hydrochloride 是 Ractopamine Hydrochloride 的氘代化合物。
TMIH-0508	R-Verapamil-d7 HCL
	R-Verapamil-d7 HCL 是 R-Verapamil HCL 的氘代化合物。R-Verapamil HCL 的 CAS 号为 1188265-55-5。
TMIH-0481	Ractopamine-d5
	Ractopamine-d5 是 Ractopamine 的氘代化合物。Ractopamine 的 CAS 号为 97825-25-7。
TMID-0019	Ractopamine-d3 hydrochloride
	Ractopamine-d3 hydrochloride 是 Ractopamine hydrochloride 的氘代化合物。Ractopamine hydrochloride 的 CAS 号为 90274-24-1。
T19453	N-Desmethylnefopam D5 hydrochloride	Others	Others
	N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.
TMIH-0483	Ractopamine-d6 (Mixture of Diastereomers)
	Ractopamine-d6 (Mixture of Diastereomers) 是 Ractopamine (Mixture of Diastereomers) 的氘代化合物。
TMIH-0047	3-Methoxy Dopamine-d4 Hydrochloride
	3-Methoxy Dopamine-d4 Hydrochloride 是 3-Methoxy Dopamine Hydrochloride 的氘代化合物。
TMIH-0002	(+/-)-Verapamil hydrochloride-d7
	(+/-)-Verapamil hydrochloride-d7 是 (+/-)-Verapamil hydrochloride 的氘代化合物。(+/-)-Verapamil hydrochloride 的 CAS 号为 152-11-4。Verapamil hydrochloride 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
TMIH-0185	Desmethyl Nefopam-d5 HCl
	Desmethyl Nefopam-d5 HCl 是 Desmethyl Nefopam HCl 的氘代化合物。Desmethyl Nefopam HCl 的 CAS 号为 147656-98-2。
TMID-0252	Diazepam-d5
	Diazepam-d5 是 Diazepam 的氘代化合物。Diazepam 的 CAS 号为 439-14-5。
T12691	Rapamycin-d3 AY-22989-d3,Sirolimus-d3	Others	Others
	Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).

同位素标记化合物

Cat.No: TMIH-0401

Ractopamine-d6 Hydrochloride (Mixture of Diastereomers)

Cat.No: TMIH-0484

Norverapamil-d7 HCl

Cat.No: TMIH-0399

Verapamil-d7 Hydrochloride

Cat.No: TMIJ-0285

S-Verapamil-d7 HCL

Cat.No: TMIH-0547

Norverapamil-d7

Cat.No: T12243

Synonym: D591 D7,(±)-Norverapamil D7

Target: Others

Ractopamine-d5 Hydrochloride

Cat.No: TMIH-0482

R-Verapamil-d7 HCL

Cat.No: TMIH-0508

Cat.No: TMIH-0481

Ractopamine-d3 hydrochloride

Cat.No: TMID-0019

N-Desmethylnefopam D5 hydrochloride

Cat.No: T19453

Target: Others

Ractopamine-d6 (Mixture of Diastereomers)

Cat.No: TMIH-0483

3-Methoxy Dopamine-d4 Hydrochloride

Cat.No: TMIH-0047

(+/-)-Verapamil hydrochloride-d7

Cat.No: TMIH-0002

Desmethyl Nefopam-d5 HCl

Cat.No: TMIH-0185

Cat.No: TMID-0252

Cat.No: T12691

Synonym: AY-22989-d3,Sirolimus-d3

Target: Others

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