36
5
2
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12268 |
NTP42
|
Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism |
NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂,IC50为 3.278 nM,可用于肺动脉高压的相关研究。 | |||
T8900 |
Seralutinib
GB002 |
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂,可用于研究肺动脉高压。 | |||
T14782 |
Brilaroxazine
RP5063 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Brilaroxazine (RP5063) 是一种有效的多模式多巴胺/5-HT 调节剂。 Brilaroxazine 是多巴胺 D2、D3 和 D4 受体、5-HT1A (Ki = 1.5 nM) 和 5-HT2A (Ki = 2.5 nM) 的部分激动剂,具有拮抗活性 5-HT2B 和 5-HT7 受体,Ki 分别为 0.19 nM 和 2.7 nM。 Brilaroxazine 可用于研究神经精神和神经系统疾病的认知障碍。 | |||
T8840 |
PF-543 hydrochloride
PF-543 |
Apoptosis; S1P Receptor; Autophagy; LPL Receptor | Apoptosis; Autophagy; GPCR/G Protein |
PF-543 hydrochloride (PF-543) 是一种选择性可逆和鞘氨醇竞争性SPHK1抑制剂,对SPHK1的选择性是 SPHK2 的 100 倍以上。它还是全血中 1-磷酸鞘氨醇形成的有效抑制剂,诱导细胞凋亡、坏死和自噬。 | |||
T6085 |
PF-543
Sphingosine Kinase 1 Inhibitor II,PF 543 |
Apoptosis; S1P Receptor; Autophagy; LPL Receptor | Apoptosis; Autophagy; GPCR/G Protein |
PF-543 (Sphingosine Kinase 1 Inhibitor II) 是一种选择性可逆和鞘氨醇竞争性 SPHK1抑制剂,可诱导细胞凋亡、坏死和自噬。它对 SPHK1的选择性是 SPHK2 的 100 倍以上。它还抑制全血中 1-磷酸鞘氨醇形成,IC50为 26.7 nM。 | |||
T34746 |
Sulfo-SANPAH Crosslinker
Sulfo-SANPAH Cross-linker,Sulfo-SANPAH Cross linker,6-[(4-叠氮-2-硝基苯基)氨基]己酸磺酸基琥珀酰亚胺酯 |
Others | Others |
Sulfo-SANPAH Crosslinker (Sulfo-SANPAH Cross linker) 是一种水溶性同双功能蛋白质交联剂。 | |||
T23178 |
PPAHV
|
Others | Others |
vanilloid TRPV1 (VR1) receptor agonist | |||
T35447 |
10(S)-PAHSA
|
Others | Others |
10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T84407 |
13-PAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids influenced by dietary changes, playing a crucial role in insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid (for example, palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxy fatty acid with the same carbon chain length. 13-PAHSA, a derivative where palmitic acid is esterified to 13-hydroxy stearic acid, is notably prevalent in the adipose tissue of glucose-tolerant AG4OX mice, wh... | |||
T36588 |
9(R)-PAHSA
|
Others | Others |
9(R)-PAHSA is a stereoisomer of 9-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T36586 |
12-PAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs ar... | |||
T36590 |
9-PAHSA
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as whi... | |||
T35446 |
10(R)-PAHSA
|
Others | Others |
10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). | |||
T36142 |
10-PAHSA
|
Others | Others |
10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-... | |||
T73841 |
9-PAHPA
|
Others | Others |
9-PAHPA,一种羟基脂肪酸的脂肪酸酯 (FAHFA),属于一类新的内源性脂质家族,显示出抗糖尿病和抗炎特性。 | |||
T126416 |
Homopahutoxin
|
Others | Others |
Homopahutoxin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126416。 | |||
T125133 |
Pahutoxin
|
Others | Others |
Pahutoxin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125133。 | |||
T84423 |
5-PAHSA
5-PAHSA,5-(palmitoyloxy)octadecanoic acid |
Others | Others |
5-PAHSA, a FAHFA formed through the formal condensation of the carboxy group of palmitic acid with the hydroxy group of 5-hydroxystearic acid, serves as a human metabolite, possesses anti-inflammatory and hypoglycemic properties, and is categorized as a long-chain fatty acid. This compound, deriving from hexadecanoic acid and octadecanoic acid, is the conjugate acid of a 5-PAHSA(1-). | |||
T85061 |
1-Palmitoyl-2-12-PAHSA-3-Oleoyl-sn-glycerol
TG(16:0/12-PAHSA/18:1),16:0-12-PAHSA-18:1-TG |
Others | Others |
1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol, an endogenous triacylglycerol, comprises palmitic acid (at the sn-1 position), the fatty acid ester of hydroxy fatty acids (FAHFA), 12-PAHSA (at the sn-2 position), and oleic acid (at the sn-3 position). Identified in the lipid extract of mouse adipose tissue, this triacylglycerol demonstrates that levels of FAHFA-containing triacylglycerols are over 100-fold higher than those of non-esterified FAHFAs, suggesting their role as intracellular storage re... | |||
T84415 |
9-PAHSA 13C4
|
Others | Others |
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets, and they play a role in insulin sensitivity. These compounds consist of a fatty acid—either a C-16 or C-18, such as palmitoleic, palmitic, oleic, or stearic acid—esterified to a hydroxylated C-16 or C-18 lipid. One notable FAHFA, 9-PAHSA, features an ester linkage between palmitic acid and 9-hydroxy stearic acid. PAHSAs, with 9-PAHSA being the most... | |||
T2561 |
Macitentan
马西替坦,ACT-064992 |
Apoptosis; Endothelin Receptor | Apoptosis; GPCR/G Protein |
Macitentan (ACT-064992) 是一种内皮素受体拮抗剂,用于治疗肺动脉高压。 | |||
T3216 |
Selexipag
NS-304,ACT-293987,赛乐西帕,Uptravi |
Others; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Others |
Selexipag (ACT-293987) 是前列环素受体激动剂,可引起肺血管舒张,用于治疗肺动脉高压。 | |||
T0352 |
Dibenzothiophene
二苯并噻吩,Imino semicarbazide,Diphenylene sulfide |
Others | Others |
Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体,是由两个苯环稠合到一个中心的噻吩环。 | |||
T13193 |
TPN171
|
PDE | Metabolism |
TPN171是一种有效的 PDE5抑制剂,对 PDE5具有亚纳摩尔效价,对 PDE5比对 PDE6具有良好的选择性,具有治疗肺动脉高压(PAH)的潜力。在动物模型中,TPN171被证明具有比西地那非更持久的作用,为临床使用每日一次口服提供了基础。 | |||
T78835 |
Phosphatase-IN-1
|
Antifungal | Microbiology/Virology |
Phosphatase-IN-1(compound II-8)是Propranolol的衍生物,充当磷脂酸磷酸酶(Pah)的抑制剂。Phosphatase-IN-1能够与 MoPah1结合,展现出19.8 μM的亲和常数。Phosphatase-IN-1能够抑制植物病原体的生长,并显示出抗真菌特性,同时对稻苗和麦穗表现出无毒性。 | |||
T1655 |
Ambrisentan
BSF-208075,BSF 208075,安倍生坦,LU 208075 |
Endothelin Receptor | GPCR/G Protein |
Ambrisentan (BSF 208075) 是 ET A 型受体选择性拮抗剂。 | |||
TP1016L |
Aviptadil Acetate
醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt |
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物,具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。 | |||
T79573 |
ET receptor antagonist 1
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
ET receptor antagonist 1 (compound 16h),作为ET受体拮抗剂(IC50=0.18 nM),主要用于肺动脉高压(PAH)的研究。该化合物能缓解大鼠模型中由野百合碱引发的PAH症状。 | |||
T79575 |
ET receptor antagonist 3
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
ET receptor antagonist 3 (compound 17d)为ET受体拮抗剂,其IC50值为0.26 nM,主要用于肺动脉高压(PAH)的研究应用。在大鼠模型中,该化合物能有效减轻由野百合碱诱导的PAH症状。 | |||
T16779 |
Rodatristat ethyl
RVT-014,KAR5585,RVT-1201 |
5-HT Receptor; Hydroxylase | GPCR/G Protein; Metabolism; Neuroscience |
Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂,低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH), | |||
T71847 |
Terguride
|
Others | Others |
Terguride is 5-HT receptor antagonist. Terguride is a drug used to treat hyperprolactinemia that antagonizes 5-HT2A and 5-HT2B and activates dopamine receptors. It has also been extensively studied for the treatment of PAH. | |||
T79574 |
ET receptor antagonist 2
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
ET receptor antagonist 2 (compound 16j) 作为一种ET受体拮抗剂,具有0.22 nM的IC50,主要应用于肺动脉高压(PAH)的研究。在大鼠模型中,它能够有效减缓野百合碱诱导的PAH症状。 | |||
T78076 |
PBR28
|
Others | Others |
PBR28是一种TSPO调节剂,适用于肺动脉高压(PAH)预防研究。通过增加放射性标记的PBR28能够示踪18KDa转运蛋白(TSPO),在脑正电子发射断层扫描(PET)成像中具有关键作用。 | |||
T11935 |
Macitentan (n-butyl analogue)
|
Others | Others |
Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications. | |||
TP2096 |
ELA-21 (human)
|
||
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP produc | |||
T65598 |
Cefminox sodium
|
Others | Others |
Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most activ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN5358 |
Eupahualin C
|
||
Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS). | |||
T14961 |
Chrysene
䓛,屈 |
Others | Others |
Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
T7914 |
Acenaphthylene
|
Others | Others |
Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中,并由有机质的不完全燃烧得到。 | |||
T5290 |
(S)-2-Hydroxy-3-phenylpropanoic acid
L-(−)-3-Phenyllactic acid,L-3-苯乳酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。 | |||
T82897 |
Benzo[e]pyrene
|
||
Benzo[e]pyrene为化石燃料中检出的多环芳烃(PAHs)类剧毒成员。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02707 |
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
phenylalanine hydroxylase,PH,PKU1,PKU |
Human | Baculovirus Insect Cells |
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg... | |||
TMPH-03508 |
IpaH9.8 Protein, Shigella flexneri, Recombinant (His)
E3 ubiquitin-protein ligase ipaH9.8,ipaH9.... |
Shigella flexneri | P. pastoris (Yeast) |
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0389 |
Chrysene-d12
|
||
Chrysene-d12 是 Chrysene 的氘代化合物。Chrysene 的 CAS 号为 218-01-9。Chrysene 是高分子量 (HMW) 多环芳烃,有极强的顽固性和致癌性。 | |||
TMID-0210 |
Sildenafil-13C-d3
|
||
Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 | |||
TMIH-0520 |
Selexipag-d7
|
||
Selexipag-d7 是 Selexipag 的氘代化合物。Selexipag 的 CAS 号为 475086-01-2。Selexipag 是前列环素受体激动剂,可引起肺血管舒张,用于治疗肺动脉高压。 | |||
TMIJ-0529 |
Acenaphthylene-d8
|
||
Acenaphthylene-d8 是 Acenaphthylene 的氘代化合物。Acenaphthylene 的 CAS 号为 208-96-8。Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中,并由有机质的不完全燃烧得到。 | |||
TMID-0043 |
Sildenafil-d8
|
||
Sildenafil-d8 是 Sildenafil 的氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 |