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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6603 |
Nelarabine
GW 506U78,Nelzarabine,奈拉滨,506U78 |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Nelarabine (GW 506U78) 是一种嘌呤核苷酸类似物,为DNA 合成抑制剂,对肿瘤细胞的IC50为0.067-2.15 μM,可作用于T 细胞急性淋巴细胞白血病。 | |||
T67737 |
gp120-α4β7 binding inhibitor 11
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
gp120-α4β7 binding inhibitor 11是一种抗HIV 药物。gp120-α4β7 binding inhibitor 11干扰HIV 相关糖蛋白gp12G 与整合素α4β7的结合(IC50=1.64nM)。 | |||
T9691L |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate 是一种高效的甲状旁腺激素 (PTH) 拮抗剂,在牛肾皮质膜中的 Ki 值为 69 nM。 | |||
T76537 |
GP120, HIV-1 MN
|
||
GP120,HIV-1MN 是一种肽。GP120,HIV-1MN 可用于 HIV 感染的研究。 | |||
T78846 |
EP12
|
Apoptosis | Apoptosis |
EP12是一种c-Myc抑制剂及c-MycG4稳定剂,能够诱导多发性骨髓瘤细胞的细胞凋亡(apoptosis)及DNA损伤,并通过干扰NF-κB信号通路破坏P65/P50的核转位,从而抑制多发性骨髓瘤的生长。 | |||
T2415 |
PP121
|
Apoptosis; VEGFR; Bcr-Abl; PDGFR; Src; mTOR; Hck | Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
PP121是一种多靶点激酶抑制剂,抑制 PDGFR、Hck、mTOR、VEGFR2、Src、Abl、DNK-PK 的 IC50值分别为2、8、10、12、14、18、60 nM。 | |||
T28993 |
TOP1210
TOP 1210,TOP-1210 |
Others | Others |
TOP1210, a narrow spectrum kinase inhibitor, potently inhibits P38α, Src, and Syk kinase activities. | |||
T11292 |
FKBP12 PROTAC dTAG-7
dTAG-7 |
Epigenetic Reader Domain; PROTACs | Chromatin/Epigenetic; PROTAC |
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein. | |||
T60871 |
gp120-IN-1
|
Others | Others |
gp120-IN-1 (compound 4e) 是 HIV-1 gp120蛋白的有效抑制剂,CC50值为 100.90 μM,IC50值为 2.2 μM。gp120-IN-1 抑制 gp120 蛋白介导的病毒进入细胞。gp120-IN-1 具有抗 HIV-1 活性。gp120-IN-1 在 SUP-T1 细胞中具有剂量依赖性细胞毒性。 | |||
T76586 |
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
|
||
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) 是一种有效的 PTH-1R 拮抗剂。 | |||
T13694 |
FKBP12 PROTAC RC32
RC32 |
Others; PROTACs | Others; PROTAC |
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. | |||
T9691 |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
|
||
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 在生命科学相关研究中具有广泛的应用。 | |||
T60714 |
gp120-IN-2
|
Others | Others |
gp120-IN-2 (compound 4i) 显示出抗 HIV-1 活性。它是 HIV-1 gp120的有效抑制剂,IC50值为 7.5 μM,CC50值为 112.93 μM。gp120-IN-2 在癌细胞 SUP-T1 中表现出剂量依赖性的细胞毒性。 | |||
T83735 |
Pap12-6 TFA
|
||
Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌(MIC50s = 4-8 µM)以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126(MRSA-3126)、B. subtilis和S. epidermidis(MIC50s = 4-8 µM)具有活性,但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6(10 µM)预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮(NO2-)、Tnf-α和Il-6的分泌水平。在体内,Pap12-6(10 mg/kg)可以提高感染E. coli的小鼠的存活率,并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位(CFUs)的数量。Pap12-6(1 mg/kg)在E. co... | |||
T61287 |
CYP121A1-IN-1
|
Others | Others |
CYP121A1-IN-1 是一种有效的CYP121A1抑制剂,对抗结核分枝杆菌具有良好的活性 (H37RvMIC90~6.25 μM, ~2.2 μg/mL)。CYP121A1-IN-1 通过抑制 CYP121A1 介导的环(l-酪氨酸-l-酪氨酸)转化为真菌环素,可显著减少真菌环素的产生。 | |||
T69965 |
TP1287
|
Others | Others |
TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib. | |||
T70613 |
SLP120701 HCl
|
Others | Others |
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease. | |||
T71840 |
FKBP12-IN-Q2
|
Others | Others |
FKBP12-IN-Q2 is an inhibitor of FKBP12. | |||
T83851 |
Tat-QFNP12 TFA
|
||
Tat-QFNP12 是一种含有转录激活因子 (Tat) 跨膜结构域和抑制N-Myc下游调节基因2 (NDRG2) 与蛋白磷酸酶Mg2+/Mn2+依赖性1A (PPM1A) 蛋白-蛋白相互作用的肽。在以20 mg/kg剂量给药的内脑血管穿刺诱导的小鼠蛛网膜下腔出血模型中,它能减少由基质金属蛋白酶-9 (MMP-9) 浓度增高引起的血脑屏障内皮紧密连接的损失,减轻脑水肿,并且提高自发活动及肢体运动的对称性。 | |||
T11291 |
FKBP12 PROTAC dTAG-13
dTAG-13 |
Epigenetic Reader Domain; PROTACs | Chromatin/Epigenetic; PROTAC |
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19329 |
Fructo-oligosaccharide DP12/GF11
蔗果十二糖 |
Others | Others |
Fructo-oligosaccharide DP12/GF11 is a member of fructooligosaccharides (FOS) characterized by a degree of polymerization (DP) of 12. FOS compounds consist of 11 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00034 |
ASFV (isolate Tick/South Africa/Pretoriuskop Pr4/1996) p12 Protein (His)
Protein p12,Pret-110,Inner membrane protein p12... |
ASFV | E. coli |
Virus attachment protein. ASFV (isolate Tick/South Africa/Pretoriuskop Pr4/1996) p12 Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 12.7 kDa and the accession number is P0C9Y3. | |||
TMPH-02897 |
SPINK1 Protein, Mouse, Recombinant (His)
Serine protease inhibitor Kazal-type 3,Serine protease inhib... |
Mouse | P. pastoris (Yeast) |
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. SPINK1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 8.1 kDa and the accession number is P09036. | |||
TMPY-01373 |
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is I6TSC9. | |||
TMPY-01558 |
HIV-1 (group N, strain 06CM-U14296) gp160 (gp120 subunit) Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group N, strain 06CM-U14296) gp160 (gp120 subunit) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.4 kDa. | |||
TMPH-03690 |
VEEV (strain 3880) P1234 Protein (His)
Polyprotein P1234,Non-structural polyprotein |
VEEV | E. coli |
VEEV (strain 3880) P1234 Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 55.7 kDa and the accession number is P36327. | |||
TMPH-01273 |
TRIP12 Protein, Human, Recombinant (His & Myc)
Thyroid receptor-interacting protein 12,E3 ubiquitin-protein... |
Human | E. coli |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag... | |||
TMPY-00328 |
Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.8 kDa and the accession number is P12492. | |||
TMPY-00302 |
HIV-1 (group M, subtype A, isolate 92RW020) gp160 (gp120 subunit) Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype A, isolate 92RW020) gp160 (gp120 subunit) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.2 kDa and the accession number is Q6BC58. | |||
TMPY-05175 |
Rift Valley fever virus (RVFV) (strain MP12) glycoprotein/G1 Protein (His)
|
RVFV | Baculovirus Insect Cells |
Rift Valley fever virus (RVFV) (strain MP12) glycoprotein/G1 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 47.8 kDa and the accession number is A2T077. | |||
TMPY-05943 |
Influenza A H1N2 (A/Swine/Indiana/P12439/00) Neuraminidase/NA Protein (His)
|
H1N2 | HEK293 Cells |
Influenza A H1N2 (A/Swine/Indiana/P12439/00) Neuraminidase/NA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.8 kDa and the accession number is Q8QT79. | |||
TMPY-06486 |
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is AFM77980.1. | |||
TMPY-00316 |
HIV-1 (group M, subtype B, isolate BAL) gp120 Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype B, isolate BAL) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is Q03805. | |||
TMPY-01662 |
FKBP12 Protein, Mouse, Recombinant (His)
FK506 binding protein 1A,Fkbp1,FKBP12,Fkbp |
Mouse | E. coli |
FKBP12 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.7 kDa and the accession number is P26883. | |||
TMPY-00336 |
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is E2EXP2. | |||
TMPY-00309 |
HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is O11407. | |||
TMPY-00427 |
HIV-1 (group P, strain RBF168) gp120 Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group P, strain RBF168) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.2 kDa and the accession number is D0VTQ8. | |||
TMPJ-01313 |
HIV-1 gp120 Protein (His)
Envelope glycoprotein gp120,Surface protein gp1... |
HIV | HEK293 Cells |
Envelope glycoprotein gp160 is single-pass type I membrane protein. The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. It is cleaved into the following 2 chains: glycoprotein 120 and transmembrane protein gp41. The resulting complex protrudes from the virus surface as a spike. The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequ... | |||
TMPY-00331 |
Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is D7PU90. | |||
TMPY-00808 |
FKBP12 Protein, Human, Recombinant (His)
FKBP12,FKBP1,FKBP-1A,PKCI2,FK506 binding protein 1A... |
Human | E. coli |
FKBP12 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.9 kDa and the accession number is P62942. | |||
TMPY-04915 |
HIV-1 (group M, subtype B, Isolate MN) gp120 Protein (His)
|
HIV | HEK293 Cells |
HIV-1 (group M, subtype B, Isolate MN) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is Q9YUL5. | |||
TMPY-05194 |
Rift Valley fever virus (RVFV) (strain MP12) glycoprotein/G2 Protein (His)
|
RVFV | Baculovirus Insect Cells |
Rift Valley fever virus (RVFV) (strain MP12) glycoprotein/G2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.1 kDa and the accession number is A2T077. | |||
TMPJ-01007 |
HRSP12 Protein, Human, Recombinant (His)
p14.5,UK114 Antigen Homolog,Heat-Responsive Protein 12,Ribon... |
Human | E. coli |
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels ... | |||
TMPH-01941 |
PARP12 Protein, Human, Recombinant (His & Myc)
Protein mono-ADP-ribosyltransferase PARP12,PARP... |
Human | E. coli |
PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-01256 |
Caspase-10 Protein, Human, Recombinant (His)
CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co... |
Human | E. coli |
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca... | |||
TMPY-00261 |
Meprin beta Protein, Human, Recombinant (His)
meprin A, β,Meprin β,meprin A, beta |
Human | HEK293 Cells |
MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are cell membrane, oligomeric metalloendopeptidases composed of two distinct but evolutionarily related subunits, alpha, and beta. MEP1A is mapped to the short arm of chromosome 6 by the use of radiation and som... | |||
TMPH-01267 |
RNF13 Protein, Human, Recombinant (His & Myc)
RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,... |
Human | E. coli |
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist... |