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Search Results for " p-glycoprotein "

Targets Recommended: Adrenergic Receptor

117

抑制剂 & 化合物

35

天然产物

10

重组蛋白

7

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T21640	Talinolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talinolol 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂，具有心脏保护和抗高血压作用。它也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。
T12341	P-gp inhibitor 1	Others; P-gp	Membrane transporter/Ion channel; Neuroscience; Others
	P-gp inhibitor 1 抑制逆转 P-糖蛋白介导的多药耐药性，EC50 为 57.9 nM（K562/A02 细胞）。
T8596	Ceefourin 1	MRP	Immunology/Inflammation
	Ceefourin 1 是一种具有高度选择性的多药抗性蛋白 4 (MRP4) 抑制剂。它能够抑制多种 MRP4 底物的转运，但对其他 ABC 转运蛋白无影响。它是苯并噻唑，常作为高危神经母细胞瘤的化学增敏剂。
T16561	Polyoxyethylene stearate POES,聚氧乙烯硬脂酸酯	Antibacterial; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Polyoxyethylene stearate (POES) 是一种非离子乳化剂。
T11071	Dofequidar fumarate MS-209	P-gp	Membrane transporter/Ion channel; Neuroscience
	Dofequidar fumarate (MS-209) 是口服活性的喹啉化合物，通过抑制 ABCB1/P-gp 和 ABCC1/MDR 相关蛋白 1 来克服 MDR。
T8426	Encequidar HM30181,HM30181A	P-gp	Membrane transporter/Ion channel; Neuroscience
	Encequidar (HM30181A) 是一种选择性 P-糖蛋白抑制剂。
T6287	Tariquidar XR9576,他立喹达	P-gp	Membrane transporter/Ion channel; Neuroscience
	Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂，Kd 为 5.1 nM。
T4059	Selamectin UK-124114,司拉克丁,塞拉菌素	Chloride channel; P-gp; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Selamectin (UK-124114) 是半合成的大环内酯，是一种驱虫剂，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。它还是抗寄生虫剂，可激活神经元和咽肌中的谷氨酸门控氯离子通道，以预防恶丝虫，淋巴丝虫和线虫感染。它还是 P-糖蛋白底物和抑制剂，IC50为 120 nM。
T0351	Risperidone Risperidal,R 64 766,利培酮	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Risperidone (R 64 766) 是5-HT2受体阻断剂、P-糖蛋白抑制剂和多巴胺 D2受体的拮抗剂，对 5-HT2A 和多巴胺 D2受体的 Ki 值分别为 4.8 和 5.9 nM。
T11578L	Encequidar mesylate HM30181 mesylate,HM30181A mesylate	P-gp	Membrane transporter/Ion channel; Neuroscience
	Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。
T8389	Trifluoperazine 三氟拉嗪,trifluoroperazine	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine (trifluoroperazine) 是一种多巴胺 D2 受体抑制剂，可治疗精神分裂症。它是NUPR1抑制剂，具有抗癌活性。它是α1-adrenergic 受体拮抗剂，是流感病毒形态发生的可逆抑制剂。
TQ0311	GSK163090	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	GSK163090 是选择性和具有口服活性的5-HT1A/1B/1D 受体拮抗剂，pKi 值分别为 9.4、8.5 和 9.7。它抑制血清素再摄取转运蛋白的功能活性，pKi 值为 6.1，具有抗抑郁和抗焦虑活性。
T13383	Zamicastat BIA 5-1058	BCRP; Hydroxylase; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂，可透过血脑屏障引起中枢和周边效应，具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂，IC50值分别为 73.8 和 17.0 μM。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T0100L	Atazanavir Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂，可研究艾滋病毒感染。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 3.49 μM。它是CYP3A4的底物和抑制剂，也是P-糖蛋白的抑制剂和诱导剂。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T20656	Verapamil NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil (CP-16533-1) 是一种非二氢吡啶类钙通道阻滞剂，一种 P-gp 抑制剂，也是一种 CYP3A4 抑制剂，具有口服活性。Verapamil 可以用于治疗高血压、心绞痛、心肌梗塞等。
T1010	Verapamil hydrochloride Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T1222	Trifluoperazine dihydrochloride Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine dihydrochloride (SKF5019) 是一种抗精神病药物，靶向中枢多巴胺受体。它是流感病毒形态发生的可逆抑制剂，是NUPR1抑制剂，具有抗癌活性。它是钙调蛋白抑制剂，还可抑制 P-糖蛋白，可研究精神分裂症。
T0100	Atazanavir sulfate 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂，与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂，IC50为 3.49 μM。
T2657	Elacridar GW0918,依克立达,GW120918,GF120918,GG918	BCRP; P-gp	Membrane transporter/Ion channel; Neuroscience
	Elacridar (GG918) 是一种有效的 P-糖蛋白和BCRP 的抑制剂。
T6018	Zosuquidar trihydrochloride 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride	P-gp	Membrane transporter/Ion channel; Neuroscience
	Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂，Ki 值为 59 nM。
T1244	Celiprolol hydrochloride Selecor,Selectrol,盐酸塞利洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
T9173	HM-30181 mesylate monohydrate	P-gp	Membrane transporter/Ion channel; Neuroscience
	HM-30181 mesylate monohydrate 是一种口服 P-糖蛋白 (P-gp) 抑制剂，用于提高 P-gp 底物药物的口服生物利用度。
T28396	PGP-4008 PGP 4008,PGP4008	P-gp	Membrane transporter/Ion channel; Neuroscience
	PGP-4008 是一种具有选择性和有效性的 P-糖蛋白 (Pgp) 抑制剂,通过与Doxorubicin联合给药来抑制肿瘤生长。
T35262	YM 534 YM-534,YM534	Others	Others
	YM 534 具有抗肿瘤活性和血小板凝集活性，抑制去糖基化P-糖蛋白的光亲和标记，可用于研究白血病。
T17216	Valspodar PSC 833	P-gp	Membrane transporter/Ion channel; Neuroscience
	Valspodar (PSC 833) 是一种特异性的 P-糖蛋白抑制剂和MDR调节剂，常被用作化学增敏剂，可用于研究晚期上皮卵巢癌。
T68124	Pafenolol	Adrenergic Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Pafenolol 是一种 P-糖蛋白调节剂，Ki 值为5.5 µM。Pafenolol 是一种可口服的且具有选择性的β肾上腺素受体拮抗剂。
T1782	Canagliflozin 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754	SGLT	GPCR/G Protein
	Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂，在表达 mSGLT2，rSGLT2 和 hSGLT2 的 CHO 细胞上，IC50分别为 2 nM，3.7 nM 和 4.4 nM。
T6200	Ledipasvir GS-5885,雷迪帕韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。
T2060	ELR510444 LR-510444,LR510444,LR 510444	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	ELR510444 (LR510444) 是一种新型微管破坏剂，抑制 MDA-MB-231 细胞增殖，IC50 为 30.9 nM。
T77575	P-gb-IN-1	P-gp	Membrane transporter/Ion channel; Neuroscience
	P-gb-IN-1 是一种有效的 P-糖蛋白 (P-gp) 抑制剂，通过抑制 P-gp 外流展现出逆转活性。P-gb-IN-1 通过与残基 Asn 721 和 Met 986 形成氢键相互作用从而显示出对 P-gp 的抑制作用。P-gb-IN-1 在 MCF-7/ADR 细胞中显示出低毒性。
T4595	YHO-13177 YHO 13177,YHO13177	BCRP	Membrane transporter/Ion channel
	YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。
T72055	FM04	P-gp	Membrane transporter/Ion channel; Neuroscience
	FM04 是一种具有口服活性和高效性的 P-糖蛋白 (P-gp) 抑制剂，EC50 值为 83 nM。FM04 可以与人P-gp核苷酸结合域2（NBD2）中的Q1193和I1115相互作用。从而破坏 R262-Q1081-Q1118 相互作用口袋并解偶联 ICL2-NBD2 相互作用，从而抑制 P-gp。FM04 可用于癌症和肿瘤的治疗。
T64133L	Laniquidar TFA Laniquidar TFA(197509-46-9 Free base),R101933	P-gp	Membrane transporter/Ion channel; Neuroscience
	Laniquidar TFA (R101933) 是一种新型口服非竞争性P-糖蛋白(P-gp)抑制剂，IC50 值为 0.51 μM。Laniquidar的生物利用度有限，可用于调节多药耐药性转运体。Laniquidar可用于研究急性髓性白血病(AML)和骨髓增生异常综合征(MDS)。
T1434	Clarithromycin A-56268,克拉霉素	P450; ribosome; MRP; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Clarithromycin (A-56268) 具有广谱的抗菌活性。它抑制 CYP3A4催化的三唑仑 α-羟基化，IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流。
T15713	Larotaxel XRP9881	P-gp	Membrane transporter/Ion channel; Neuroscience
	Larotaxel (XRP9881) 是一种紫杉烷类似物，具有抗癌活性，通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用，并通过细胞凋亡诱导细胞死亡。Larotaxel (XRP9881) 是一种可穿过血脑屏障的化合物，对 Docetaxel 的亲和力比 P-糖蛋白 1 高，可用于研究乳腺癌和膀胱癌。
T6075	Epothilone B 帕妥匹隆,Patupilone,EPO 906	Apoptosis; Microtubule Associated; Antibiotic; Antifungal	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Epothilone B (EPO 906) 是微管稳定剂，Ki 为0.71 μM。它与αβ-微管蛋白异二聚体亚基结合，使αβ-微管蛋白解离减少。
T1146	Nifedipine BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat	CaMK; Potassium Channel; Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂，可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞，导致主要冠状动脉和全身动脉扩张，降低心肌收缩力。它常用于心肌功能不全的相关研究。
T14616	Biricodar VX-710	Others	Others
	Biricodar is a P-glycoprotein and MRP-1 modulator.
T27985	MC-70 MC70,MC 70	Others	Others
	MC-70 is a potent P-glycoprotein (P-gp) inhibitor (EC50 = 0.69 μM).
T69515	R 101933	Others	Others
	R 101933 is a P-glycoprotein (P-gp) inhibitor.
T12340	P-gp modulator 1	Others	Others
	P-gp modulator 1 is a high affinity and orally available P-glycoprotein (Pgp) modulator
T16352	NSC23925	Nrf2	Immunology/Inflammation
	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
T26803	Bibw 22 Bibw22,Bibw-22	Others	Others
	Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport.
T6287L	Tariquidar dimesylate D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576	Others	Others
	Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs.
T12646	(R)-Verapamil hydrochloride (R)-(+)-Verapamil hydrochloride	Others	Others
	(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a inhibitor of P-Glycoprotein.
T69115	Nutlin-1	Others	Others
	Nutlin-1 is a p53-MDM2 binding inhibitor, p-Glycoprotein (p-gp) transport substrate, and antitumor agent.
T29169	XR9051 Hydrochloride	Others	Others
	XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein.

化合物

Cat.No: T21640

Target: Adrenergic Receptor

P-gp inhibitor 1

Cat.No: T12341

Target: Others, P-gp

Cat.No: T8596

Target: MRP

Polyoxyethylene stearate

Cat.No: T16561

Synonym: POES,聚氧乙烯硬脂酸酯

Target: Antibacterial, P-gp

Dofequidar fumarate

Cat.No: T11071

Synonym: MS-209

Target: P-gp

Cat.No: T8426

Synonym: HM30181,HM30181A

Target: P-gp

Cat.No: T6287

Synonym: XR9576,他立喹达

Target: P-gp

Cat.No: T4059

Synonym: UK-124114,司拉克丁,塞拉菌素

Target: Chloride channel, P-gp, Parasite

Cat.No: T0351

Synonym: Risperidal,R 64 766,利培酮

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp

Encequidar mesylate

Cat.No: T11578L

Synonym: HM30181 mesylate,HM30181A mesylate

Target: P-gp

Trifluoperazine

Cat.No: T8389

Synonym: 三氟拉嗪,trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Cat.No: TQ0311

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T0100L

Synonym: Zrivada,Reyataz,Latazanavir,阿扎那韦,BMS-232632

Target: P450, SARS-CoV, HIV Protease, P-gp

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

Cat.No: T20656

Synonym: NSC 135784,维拉帕米,NSC-135784,CP-16533-1,(±)-Verapamil

Target: P450, Calcium Channel, P-gp

Verapamil hydrochloride

Cat.No: T1010

Synonym: Manidon,盐酸维拉帕米,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Trifluoperazine dihydrochloride

Cat.No: T1222

Synonym: Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Atazanavir sulfate

Cat.No: T0100

Synonym: 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦

Target: P450, SARS-CoV, HIV Protease, P-gp

Cat.No: T2657

Synonym: GW0918,依克立达,GW120918,GF120918,GG918

Target: BCRP, P-gp

Zosuquidar trihydrochloride

Cat.No: T6018

Synonym: 唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride

Target: P-gp

Celiprolol hydrochloride

Cat.No: T1244

Synonym: Selecor,Selectrol,盐酸塞利洛尔

Target: Adrenergic Receptor

HM-30181 mesylate monohydrate

Cat.No: T9173

Target: P-gp

Cat.No: T28396

Synonym: PGP 4008,PGP4008

Target: P-gp

Cat.No: T35262

Synonym: YM-534,YM534

Target: Others

Cat.No: T17216

Synonym: PSC 833

Target: P-gp

Cat.No: T68124

Target: Adrenergic Receptor, P-gp

Cat.No: T1782

Synonym: 卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754

Target: SGLT

Cat.No: T6200

Synonym: GS-5885,雷迪帕韦

Target: HCV Protease, SARS-CoV

Cat.No: T2060

Synonym: LR-510444,LR510444,LR 510444

Target: Apoptosis, Microtubule Associated

Cat.No: T77575

Target: P-gp

Cat.No: T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Cat.No: T72055

Target: P-gp

Cat.No: T64133L

Synonym: Laniquidar TFA(197509-46-9 Free base),R101933

Target: P-gp

Cat.No: T1434

Synonym: A-56268,克拉霉素

Target: P450, ribosome, MRP, Antibacterial, Antibiotic, Autophagy

Cat.No: T15713

Synonym: XRP9881

Target: P-gp

Cat.No: T6075

Synonym: 帕妥匹隆,Patupilone,EPO 906

Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal

Cat.No: T1146

Synonym: BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

Cat.No: T14616

Synonym: VX-710

Target: Others

Cat.No: T27985

Synonym: MC70,MC 70

Target: Others

Cat.No: T69515

Target: Others

P-gp modulator 1

Cat.No: T12340

Target: Others

Cat.No: T16352

Target: Nrf2

Cat.No: T26803

Synonym: Bibw22,Bibw-22

Target: Others

Tariquidar dimesylate

Cat.No: T6287L

Synonym: D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576

Target: Others

(R)-Verapamil hydrochloride

Cat.No: T12646

Synonym: (R)-(+)-Verapamil hydrochloride

Target: Others

Cat.No: T69115

Target: Others

XR9051 Hydrochloride

Cat.No: T29169

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4761	Phellamurin	P-gp	Membrane transporter/Ion channel; Neuroscience
	Phellamurin 是一种来自黄檗叶的黄酮糖苷，可诱导细胞凋亡，具有抗肿瘤活性。它抑制肠道 P-糖蛋白，还抑制凤蝶的产卵。
TN1651	Furanodiene	Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome
	Furanodiene 是从姜黄中提取的一种萜类天然产物，可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。
T3S0012	coniferyl ferulate	P-gp; GST	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Coniferyl ferulate 是从川芎中提取的一种天然产物，是强效的谷胱甘肽 S-转移酶抑制剂，强抑制人胎盘型谷胱甘肽 S-转移酶，IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。
T2S0223	Isosinensetin 异橙黄酮,6-Demethoxynobiletin	Antioxidant; HIV Protease; Antibacterial; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; oxidation-reduction; Proteases/Proteasome
	Isosinensetin (6-Demethoxynobiletin) 是从青皮中提取的一种甲氧基黄酮，具有抗氧化和抑制 HIV-1 蛋白酶的活性。
T3002	Piperine 胡椒碱,1-Piperoylpiperidine,Bioperine	P450; Endogenous Metabolite; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Piperine (Bioperine) 是从胡椒中分离的一种生物碱，可以抑制P-糖蛋白和 CYP3A4 的活性，在HeLa 细胞中的IC50值为61.94±0.054 μg/mL。它已用于研究治疗多发性骨髓瘤和吞咽障碍的试验。
TJS1159	Chrysosplenetin 猫眼草黄素,Chrysosptertin B	P450; Ferroptosis; P-gp	Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Chrysosplenetin 是青蒿和其他几种中草药中的一种多甲氧基化黄酮类天然产物，抑制 P-gp 活性并逆转由青蒿素诱导的上调的 P-gp 和 MDR1 水平。
T2S0271	Voacamine 老刺木胺,Voacanginine	Cannabinoid Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱，可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用，具有强效的大麻素 CB1受体拮抗活性。
T2S1200	Sinapine	Antioxidant; P-gp; AChE	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T12540	Pristinamycin IA Mikamycin IA,普利霉素IA,Mikamycin B	Others; Antibiotic; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Pristinamycin IA (Mikamycin B) 是 P-糖蛋白的底物，也是一种环肽类大环内酯抗生素。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T4034	Solamargine Solamargin,δ-Solanigrine,澳洲茄边碱	Apoptosis; p38 MAPK; P-gp; STAT	Apoptosis; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Neuroscience; Stem Cells
	Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物，诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭，在多种癌症中均表现出抗癌活性。
TN1525	Convallatoxin K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷	NF-κB; P-gp; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Convallatoxin 是从铃兰分离得到的一种强心苷。它是 P-糖蛋白底物，并识别 Val982 是参与其转运的重要氨基酸。它是配体诱导的 MOR 胞吞作用的增强剂，通过激活PPARγ和抑制NF-κB 改善结肠炎，具有抗炎和抗增殖特性。
T2799	(20S)-Protopanaxadiol 20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇	Apoptosis; Reactive Oxygen Species; P-gp	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物，是一种凋亡诱导剂，抑制Akt 活性并诱导多种肿瘤细胞凋亡。
TN1757	Hypophyllanthin 叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂	Potassium Channel; Calcium Channel; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Hypophyllanthin 是珠子草中的一种木脂素，能直接抑制 P-gp 的活性，具有很强的抗炎活性。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
TCS2336	Evodine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Evodine 是吴茱萸中的主要柠檬苦素，是P-gp 有效抑制剂，可通过保留抗氧化剂防御系统，针对谷氨酸诱导的毒性具有保护作用。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T3S2019	Lathyrol	Others	Others
	Lathyrol 是一种具有抗癌功能的天然产物。
TN5118	Taxol C	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxol C 可以减少与 P-糖蛋白转运蛋白的相互作用，从而增加紫杉烷类向大脑的渗透。
T6S1842	Tenacissoside G Tenacissimoside A,通关藤苷G	Others; P-gp	Membrane transporter/Ion channel; Neuroscience; Others
	Tenacissoside G 是一种 C21 甾体，来自于Marsdenia tenacissima茎部。它可逆转 P-糖蛋白过度表达的多药耐药癌细胞的多药耐药。
T3868	Agnuside 牡荆油,穗花牡荆苷,chasteberry oil	COX; Prostaglandin Receptor; P-gp	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Agnuside (chasteberry oil) 是从黄荆中分离得到的一种天然产物，可下调炎性介质PGE2和LTB4，减少细胞因子的表达，具有抗关节炎活性。
TMA2270	Alisol F 24-acetate	P-gp	Membrane transporter/Ion channel; Neuroscience
	Alisol F 24-acetate 是一种从 Alisma plantago-aquatica Linn [1] 中分离出来的天然产物。 Alisol F 24 Acetate 通过抑制 P-糖蛋白介导的药物流出来增强 MCF-7/DOX 细胞的化学敏感性和凋亡。
TN2256	Taccalonolide B 根薯酮内酯B,根薯酮内酯 B	Microtubule Associated	Cytoskeletal Signaling
	Taccalonolide B 是从广西裂果薯中分离得到的一种微管稳定剂，具有抗肿瘤活性。它抑制 SK-OV-3 细胞的生长，IC50 为 208 nM，在体外对过表达 P-糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系有效。
T15097	Deoxynivalenol Vomitoxin,4-Deoxynivalenol
	Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素，常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
T6S0119	Dauricine 蝙蝠葛碱	Apoptosis; Others; NF-κB	Apoptosis; NF-κB; Others
	Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱，具有抗炎活性。它通过抑制NF-κB 激活，剂量依赖性地抑制结肠癌细胞的增值和侵袭，并诱导凋亡。
TN5124	Taxuspine X	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxuspine X may have p-glycoprotein inhibitory activity.
TN5114	Taxinine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
T72735	Coleon-U-quinone	Others	Others
	Coleon-U-quinone 是一种有效的P-gp 抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对Doxorubicin 的敏感性。
TN1099	Dihydroevocarpine	MAO; P-gp; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.
T75524	Mutabilol	Others	Others
	Mutabilol (compound 1) 是一种有效的 p-糖蛋白 (P-gp) 调节剂。Mutabilol 是一种可以从Plectranthus mutabilis 叶中分离得到的天然产物。Mutabilol 增加 NCI-H460/R 细胞中P-gp 的表达。
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
T72802	Spongionellol A	Others	Others
	Spongionellol A 是一种 MDR1(p-糖蛋白) 抑制剂。Spongionellol A 通过诱导 caspase 依赖性的凋亡 (apoptosis) 而对前列腺癌细胞具有较强的细胞毒活性和选择性。Spongionellol A 可用于癌症的研究，如前列腺癌。
T37810	6',7'-Epoxybergamottin	Others	Others
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo...

天然产物

Cat.No: TN4761

Target: P-gp

Cat.No: TN1651

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

coniferyl ferulate

Cat.No: T3S0012

Target: P-gp, GST

Cat.No: T2S0223

Synonym: 异橙黄酮,6-Demethoxynobiletin

Target: Antioxidant, HIV Protease, Antibacterial, P-gp

Cat.No: T3002

Synonym: 胡椒碱,1-Piperoylpiperidine,Bioperine

Target: P450, Endogenous Metabolite, P-gp, Autophagy

Chrysosplenetin

Cat.No: TJS1159

Synonym: 猫眼草黄素,Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Cat.No: T2S0271

Synonym: 老刺木胺,Voacanginine

Target: Cannabinoid Receptor, P-gp

Cat.No: T2S1200

Target: Antioxidant, P-gp, AChE

Pristinamycin IA

Cat.No: T12540

Synonym: Mikamycin IA,普利霉素IA,Mikamycin B

Target: Others, Antibiotic, P-gp

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Cat.No: T4034

Synonym: Solamargin,δ-Solanigrine,澳洲茄边碱

Target: Apoptosis, p38 MAPK, P-gp, STAT

Cat.No: TN1525

Synonym: K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷

Target: NF-κB, P-gp, PPAR

(20S)-Protopanaxadiol

Cat.No: T2799

Synonym: 20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇

Target: Apoptosis, Reactive Oxygen Species, P-gp

Hypophyllanthin

Cat.No: TN1757

Synonym: 叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂

Target: Potassium Channel, Calcium Channel, P-gp

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Cat.No: TCS2336

Target: P-gp

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T3S2019

Target: Others

Cat.No: TN5118

Target: P-gp

Tenacissoside G

Cat.No: T6S1842

Synonym: Tenacissimoside A,通关藤苷G

Target: Others, P-gp

Cat.No: T3868

Synonym: 牡荆油,穗花牡荆苷,chasteberry oil

Target: COX, Prostaglandin Receptor, P-gp

Alisol F 24-acetate

Cat.No: TMA2270

Target: P-gp

Taccalonolide B

Cat.No: TN2256

Synonym: 根薯酮内酯B,根薯酮内酯 B

Target: Microtubule Associated

Cat.No: T15097

Synonym: Vomitoxin,4-Deoxynivalenol

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Cat.No: T6S0119

Synonym: 蝙蝠葛碱

Target: Apoptosis, Others, NF-κB

Cat.No: TN5124

Target: P-gp

Cat.No: TN5114

Target: P-gp

Coleon-U-quinone

Cat.No: T72735

Target: Others

Dihydroevocarpine

Cat.No: TN1099

Target: MAO, P-gp, Antifection

Cat.No: T75524

Target: Others

Cat.No: TN5113

Target: Others

Spongionellol A

Cat.No: T72802

Target: Others

6',7'-Epoxybergamottin

Cat.No: T37810

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00257	PSGL-1/CD162 Protein, Human, Recombinant (hFc) Selectin P ligand,P-selectin glycop	Human	HEK293 Cells
	PSGL-1 (CD162), is a mucintype glycoprotein that plays a key role in leukocyte adhesion. Human PSGL-1 cDNA encodes 412 amino acids (aa). It expressed on neutrophils, monocytes and most lymphocytes. The mature PSGL-1 (aa 42-412) is expressed as a disulfide-linked homodimer that signals intracellularly and promotes integrin activation. PSGL-1 is found on virtually all leukocytes, dendritic cells, platelets, and some endothelial cells. It is primarily responsible for early events in extravasation, ...
TMPJ-01145	ABCB5 Protein, Human, Recombinant (Trx) ABCB5 P-gp,ATP-binding cassette s...	Human	E. coli
	ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FL...
TMPH-00981	ABCB1 Protein, Human, Recombinant (His) Multidrug resistance protein 1,P-glyco...	Human	E. coli
	ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPK-00830	P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated FLJ45155,CD62P,GRMP,CD62,P-Select...	Human	HEK293 Cells
	Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
TMPJ-00612	PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc) CLA,PSGL1,CD162,PSGL-1	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 ...
TMPK-00565	PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) PSGL-1,CD162,SELPLG,PSGL1,Selecti...	Cynomolgus	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.57 kDa and the accession number is A0A7N9CVJ8.
TMPK-01033	PSGL-1/CD162 Protein, Mouse, Recombinant (His) CLA,SELPLG,Selpl,Selectin P ligan...	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.74 kDa and the accession number is Q62170.
TMPJ-00382	P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated PADGEM,CD62 antigen-like family member P,G...	Mouse	HEK293 Cells
	P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes...
TMPY-03611	PMM2 Protein, Human, Recombinant (His) CDG1a,phosphomannomutase 2,PMM2,C...	Human	E. coli
	Phosphomannomutase 2, also known as PMM2 and CDG1, belongs to the eukaryotic PMM family. Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mannose 1-phosphate is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. GDP-mannose can transfer its small sugar molecule called mannose to the growing oligosaccharide chain. Once the correct number of small sugar molecules are linked together to form the oligosaccharide, it c...
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosp...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...

重组蛋白

PSGL-1/CD162 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00257

Species: Human

Expression System: HEK293 Cells

ABCB5 Protein, Human, Recombinant (Trx)

Cat.No: TMPJ-01145

Species: Human

Expression System: E. coli

ABCB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00981

Species: Human

Expression System: E. coli

P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPK-00830

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)

Cat.No: TMPJ-00612

Species: Mouse

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00565

Species: Cynomolgus

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01033

Species: Mouse

Expression System: HEK293 Cells

P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00382

Species: Mouse

Expression System: HEK293 Cells

PMM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03611

Species: Human

Expression System: E. coli

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12243	Norverapamil-d7 D591 D7,(±)-Norverapamil D7	Others	Others
	Norverapamil D7 is a deuterium labeled Norverapamil . Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
TMIH-0399	Norverapamil-d7 HCl
	Norverapamil-d7 HCl 是 Norverapamil HCl 的氘代化合物。Norverapamil HCl 的 CAS 号为 67812-42-4。Norverapamil hydrochloride是 Verapamil 的 N-去甲基代谢物，是L型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T73715	Risperidone-d4
	Risperidone-d4是 Risperidone 的氘代物。Risperidone 是5-HT2受体的阻断剂，P-糖蛋白(P-Glycoprotein)的抑制剂和dopamine D2受体的拮抗剂，其对 5-HT2A 和 dopamine D2受体的Ki 值分别为 4.8，5.9 nM。
TMIH-0297	Ledipasvir-d6
	Ledipasvir-d6 是 Ledipasvir 的氘代化合物。Ledipasvir 的 CAS 号为 1256388-51-8。Ledipasvir 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
TMIJ-0326	Cyclosporin A-d4 (Major)
	Cyclosporin A-d4 (Major) 是 Cyclosporin A 的氘代化合物。Cyclosporin A 的 CAS 号为 59865-13-3。Cyclosporine A 是一种能与亲环素结合的抑制剂。根据它的作用机制可作为钙调神经磷酸酶抑制剂、细胞色素 P450 3A4 抑制剂和 P-糖蛋白抑制剂。
TMIJ-0110	Clarithromycin-13C-d3
	Clarithromycin-13C-d3 是 Clarithromycin 的 13C 和氘代化合物。Clarithromycin 的 CAS 号为 81103-11-9。Clarithromycin 具有广谱的抗菌活性。它抑制CYP3A4催化的三唑仑 α-羟基化，IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流。

同位素标记化合物

Norverapamil-d7

Cat.No: T12243

Synonym: D591 D7,(±)-Norverapamil D7

Target: Others

Norverapamil-d7 HCl

Cat.No: TMIH-0399

Cat.No: T73715

Cat.No: TMIH-0297

Cat.No: T70808

Cyclosporin A-d4 (Major)

Cat.No: TMIJ-0326

Clarithromycin-13C-d3

Cat.No: TMIJ-0110

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