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Search Results for " p 64 "

Targets Recommended: Dopamine Receptor 5-HT Receptor Adrenergic Receptor P-gp

13

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0351	Risperidone Risperidal,R 64 766,利培酮	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Risperidone (R 64 766) 是5-HT2受体阻断剂、P-糖蛋白抑制剂和多巴胺 D2受体的拮抗剂，对 5-HT2A 和多巴胺 D2受体的 Ki 值分别为 4.8 和 5.9 nM。
T62661	Risperidone hydrochloride	Others	Others
	Risperidone hydrochloride (R 64 766 hydrochloride) 是一种 5-HT2 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂和 dopamine D2 受体的拮抗剂，其能够作用于 5-HT2A (Ki: 4.8 nM) 和 dopamine D2 (Ki: 5.9 nM)受体。
T78673	Antibacterial agent 135	Others	Others
	Antibacterialagent 135（示例7）是一种针对多种细菌具有抑制作用的有效抗菌剂，包括铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌和肺炎克雷伯菌，其最小抑菌浓度（MIC）大于64 μg/mL。
T39790	LpxC-IN-5	Others	Others
	LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.
T83717	Cys-Pexiganan TFA
	Cys-pexiganan是一种抗微生物肽，是pexiganan的衍生物，具有N-末端的半胱氨酸。它对P. aeruginosa和S. aureus具有活性（MICs分别为64和16 µg/ml）。Cys-pexiganan与含醋酸纤维素的聚乙烯醇电纺垫结合，可以加速隔离的重钙化人类血浆的凝血。
T38259	Phenelfamycin E	Others	Others
	Phenelfamycin E is an antibiotic originally isolated from Streptomyces. It is active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus128 μg/ml). Phenelfamycin E (4-64 mg/kg) increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens.
T75001	Antibacterial agent 128	Others	Others
	Antibacterial agent 128 是一种带有可裂解接头的铁载体类似物-环丙沙星 (Ciprofloxacin (Ciprofloxacin )) 偶联物。Antibacterial agent 128 显示出针对铜绿假单胞菌 (MIC 值为 0.25-64 μg/mL) 和类鼻疽伯克氏菌 (MIC 值为 1-32 μg/mL) 的抗生素活性。
T36746	Leoidin	Others	Others
	Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM...
T83705	BING TFA Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria
	BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽，由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时，对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应，并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内，BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。
T35680	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide	Others	Others
	2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is an antimicrobial agent.1It is active against the Gram-negative bacteriaE. coli,P. aeruginosa, andS. marcescens(MICs = 64, 100, and 70 μg/ml, respectively), the Gram-positive bacteriaS. aureus,M. luteus, andB. cereus(MICs = 130, 100, and 50 μg/ml, respectively), and the fungiC. albicans,G. candidum,T. rubrum,F. oxysporum,A. flavus, andS. brevicaulis(MICs = 69-120 μg/ml). 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is also a prec...
T36649	AN3661	Others	Others
	AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1]. AN3661 is active at nanomolar (IC50=20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is simi...
T37313	ITH15004	Others	Others
	ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor when used at a concentration of 100 μM. ITH15004 (1 μM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA). 1.Calzaferri, F., Narros-Fernández, P., de Pa...
T36729	Urotensin II (goby) (trifluoroacetate salt)	Others	Others
	Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ...

化合物

Cat.No: T0351

Synonym: Risperidal,R 64 766,利培酮

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, P-gp

Risperidone hydrochloride

Cat.No: T62661

Target: Others

Antibacterial agent 135

Cat.No: T78673

Target: Others

Cat.No: T39790

Target: Others

Cys-Pexiganan TFA

Cat.No: T83717

Phenelfamycin E

Cat.No: T38259

Target: Others

Antibacterial agent 128

Cat.No: T75001

Target: Others

Cat.No: T36746

Target: Others

Cat.No: T83705

Synonym: Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria

2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide

Cat.No: T35680

Target: Others

Cat.No: T36649

Target: Others

Cat.No: T37313

Target: Others

Urotensin II (goby) (trifluoroacetate salt)

Cat.No: T36729

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。

天然产物

Cat.No: T8433

Target: Mitochondrial Metabolism

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02926	IL-2RG Protein, Human, Recombinant (hFc) SCIDX1,interleukin 2 receptor, gamma,CIDX,SCIDX,CD1...	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.4 kDa and the accession number is P31785.
TMPY-05692	IL-2RG Protein, Human, Recombinant (His) IL-2RG,SCIDX1,P64,interleukin 2 recep<...	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.72 kDa and the accession number is P31785-1.
TMPY-06359	IL-2RG Protein, Human, Recombinant (His & Avi), Biotinylated IMD4,CIDX,IL-2RG,SCIDX,P64,CD132,interleuk...	Human	HEK293 Cells
	IL-2RG Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 31.53 kDa and the accession number is NP_000197.1.
TMPK-00986	IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His) SCIDX1,IL2RG,gammaC,γC,CIDX,IL-2 R γ/CD132,IL-2 R gamma,SCID...	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant...
TMPK-00239	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated SCIDX,IMD4,IL-2 R gamma,CD132,SCIDX1,IL-2 R γ/CD132,γC,CIDX,...	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His...
TMPK-00987	IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated IL-2 R γ/CD132,IL-2 R gamma,IMD4,gammaC,SCIDX1,CD132,SCIDX,I...	Cynomolgus	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein (Primary Amine Labeling)...
TMPK-00238	IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi) CD132,gammaC,γC,IMD4,IL2RG,SCIDX1,CIDX,IL-2 R γ,P	Human	HEK293 Cells
	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. IL-2 R gamma/CD132 Protein, Human, Recombinant (His...

重组蛋白

IL-2RG Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02926

Species: Human

Expression System: HEK293 Cells

IL-2RG Protein, Human, Recombinant (His)

Cat.No: TMPY-05692

Species: Human

Expression System: HEK293 Cells

IL-2RG Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06359

Species: Human

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00986

Species: Cynomolgus

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00239

Species: Human

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00987

Species: Cynomolgus

Expression System: HEK293 Cells

IL-2 R gamma/CD132 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00238

Species: Human

Expression System: HEK293 Cells

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