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Search Results for " oxaliplatin "

Targets Recommended: DNA Alkylator/Crosslinker DNA/RNA Synthesis Autophagy

9

抑制剂 & 化合物

3

天然产物

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0164	Oxaliplatin L-OHP,奥沙利铂	DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。
T61870	(rel)-Oxaliplatin	Others	Others
	(rel)-Oxaliplatin is a DNA synthesis inhibitor that induces DNA crosslinking damage, inhibits DNA replication and transcription, and stimulates apoptosis. This compound has applications in cancer research [1] [2] [3].
T71992	ML-077	Others	Others
	ML-077, also known as VU0255011, is a highly selective, potent, saline soluble, best in class" KCC2 antagonist for high fidelity in vitro studies on KCC2 function with IC(50)=537 nM. ML-077 is cell permeable and exhibits submicromolar potency
T67981	Copper histidine	Others	Others
	Copper histidine 抑制了Ctr1介导的奥沙利铂在体外的细胞摄取，而不会改变奥沙利铂在体内DRG 组织中的铂或神经毒性的积累。Copper histidine 通过口服治疗 Menkes 疾病。
T39664	Ethaselen BBSKE	Others	Others
	Ethaselen (BBSKE) 是具有口服活性和选择性的硫氧还蛋白还原酶1 (TrxR) 抑制剂，具有抗癌活性，直接抑制 TrxR1 活性，常用奥沙利铂联合使用来抑制肿瘤生长。Ethaselen 可诱导癌细胞凋亡，抑制结直肠癌细胞增殖。
T28398	Phenanthriplatin cis-[Pt(NH3)2-(phenanthridine)Cl]NO3	Others	Others
	Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso
T81594	Osemitamab TST001
	Osemitamab是一种针对人类claudin-18.2的IgG1单克隆抗体。它由来自人鼠嵌合体TST001的γ-1链与κ链通过二硫键连接而成的二聚体(ACI)构成。该化合物与Capecitabine和Oxaliplatin联合应用，适用于胃(G)及胃食管结合部(GEJ)癌症的研究。
T83881	4-(3,4-Difluorobenzo)curcumin CDF	Others	Others
	4-(3,4-Difluorobenzo)curcumin（CDF）是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量（EC50s分别为0.8和0.37 µM）。CDF（4和8 µM）通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。
T36745	cDPCP	Others	Others
	cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad...

化合物

Cat.No: T0164

Synonym: L-OHP,奥沙利铂

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

(rel)-Oxaliplatin

Cat.No: T61870

Target: Others

Cat.No: T71992

Target: Others

Copper histidine

Cat.No: T67981

Target: Others

Cat.No: T39664

Synonym: BBSKE

Target: Others

Phenanthriplatin

Cat.No: T28398

Synonym: cis-[Pt(NH3)2-(phenanthridine)Cl]NO3

Target: Others

Cat.No: T81594

Synonym: TST001

4-(3,4-Difluorobenzo)curcumin

Cat.No: T83881

Synonym: CDF

Target: Others

Cat.No: T36745

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S0537	Neoline Bullatine B,雪上一枝蒿乙素	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Neoline 是一种乌头根 (PA) 的活性成分，可改善奥沙利铂引起的小鼠周围神经病变。Neoline 通对Nav1.7 电压门控钠通道电流 (VGSC)有抑制作用。它可用作标记化合物，从而测定用于研究神经性疼痛的 PA 产品的质量。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。

天然产物

Cat.No: T4S0537

Synonym: Bullatine B,雪上一枝蒿乙素

Target: Others, Sodium Channel

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Cat. No.	Product Name	Target	Signaling Pathways
T71401	Oxaliplatin-d10
	Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2....

同位素标记化合物

Oxaliplatin-d10

Cat.No: T71401

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