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Search Results for " oab "

Targets Recommended: Others

25

抑制剂 & 化合物

11

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T33766	OAB-14 OAB 14,OAB14	Others	Others
	OAB-14 是一种 Bexarotene 衍生物，通过清除 APP/PS1 转基因小鼠的 β-淀粉样蛋白，改善其阿尔茨海默病相关的病理学和认知障碍。OAB-14 可有效改善 APP/PS1 转基因小鼠内体自噬溶酶体（EAL）途径的功能障碍。
T4612	NS309	EGFR; Potassium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂，在 BK 通道上没有激活作用。
T9419	Fesoterodine (R) Fesoterodine,弗斯特罗定	AChR	Neuroscience
	Fesoterodine ((R) Fesoterodine) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T1049L	Oxybutynin Oxytrol,奥昔布宁,Ditropan,Oxibutyninum	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin (Ditropan) 是一种抗胆碱能药，抑制血管 Kv 通道，IC50为 11.51 μM，可用于治疗尿失禁和膀胱过度活动症。
T1049	Oxybutynin chloride Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T19783	Dehydroabiethylamine NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺	P450; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dehydroabiethylamine (NSC-2955) 是肝脏 CYP2B 活性的诱导剂。 Dehydroabiethylamine 抑制丙酮酸脱氢酶激酶 (PDK) 和细胞内胆固醇转运，具有抗肿瘤活性。
T125012	7-Oxodehydroabietinol	Others	Others
	7-Oxodehydroabietinol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125012。
T126441	Methyl 7β,15-dihydroxydehydroabietate	Others	Others
	Methyl 7β,15-dihydroxydehydroabietate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126441。
T39306	7-Oxodehydroabietic acid	Others	Others
	7-Oxodehydroabietic acid is a diterpene resin acid found in the roots of Pinus densiflora pine. It acts as a defensive compound against herbivorous insects by disrupting their endocrine system.
T124573	Methyl 15-hydroxy-7-oxodehydroabietate	Others	Others
	Methyl 15-hydroxy-7-oxodehydroabietate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124573。
T40564	Neoabietic acid	Others	Others
	Neoabietic acid is an abietic-type acid isolated from the oleoresin and rosin of Pinus palustris . Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity in vitro.
T126227	16-Nor-7,15-dioxodehydroabietic acid	Others	Others
	16-Nor-7,15-dioxodehydroabietic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126227。
T126378	Isoabsouline	Others	Others
	Isoabsouline 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126378。
T16370	OABK hydrochloride	Others	Others
	OABK hydrochloride is a small-molecule switch. It also can be used to control protein activity.
T40750	12,14-Dichlorodehydroabietic acid	Others	Others
	12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity. It effectively inhibits GABA-dependent chloride influx in the mammalian brain, functioning as a non-competitive antagonist of GABA A receptors. Moreover, 12,14-Dichlorodehydroabietic acid induces an elevation in cytosolic free calcium levels and promotes the release of neurotransmitters.
T74094	5,6-Dihydroabiraterone	Others	Others
	5,6-Dihydroabiraterone 是 Abiraterone 的代谢物。Abiraterone 是一种强效且不可逆的 CYP17A1抑制剂，具有抗雄激素活性，并在 CRPC (去势抵抗性前列腺癌) 中显示出抗肿瘤活性。
T40751	12-Chlorodehydroabietic acid	Others	Others
	12-Chlorodehydroabietic acid is a chlorinated resin acid.
T5023	Propiverine hydrochloride	Others; Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Propiverine hydrochloride 是一种痉挛剂，具有钙拮抗和抗胆碱能特性，用于研究膀胱过度活动和尿失禁。
T29208	ZD-0947 AZD0947,AZD-0947,ZD 0947,AZD 0947	Others	Others
	ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB).
T11275	Fesoterodine L-mandelate	Others	Others
	Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB).
T35052	Vibegron MK4618,MK 4618,MK-4618	Others	Others
	Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB).
T34774	TAK-259 HCl TAK-259,TAK259	Others	Others
	TAK-259 is a novel, selective, and orally active α1D adrenergic receptor antagonist (α1D, Ki = 1.1 nM) that represents a promising new therapeutic agent for the treatment of symptoms of OAB. It has an anti-frequency effect and reduces the burden of the hu
T61438	Propiverine	Others	Others
	Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2].
T61357	EP3 antagonist 3	Others	Others
	EP3 antagonist 3 (compound 2) is a highly effective and specific antagonist of the EP3 receptor. It displays significant oral bioavailability and exhibits a strong pKi value of 8.3. Furthermore, EP3 antagonist 3 possesses excellent pharmacokinetic characteristics, making it a suitable candidate for experimental investigations involving overactive bladder (OAB) research [1].

化合物

Cat.No: T33766

Synonym: OAB 14,OAB14

Target: Others

Cat.No: T4612

Target: EGFR, Potassium Channel, HER

Cat.No: T9419

Synonym: (R) Fesoterodine,弗斯特罗定

Target: AChR

Cat.No: T1049L

Synonym: Oxytrol,奥昔布宁,Ditropan,Oxibutyninum

Target: Potassium Channel, AChR

Oxybutynin chloride

Cat.No: T1049

Synonym: Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl

Target: Potassium Channel, AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Dehydroabiethylamine

Cat.No: T19783

Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine,脱氢松香胺

Target: P450, PDK

7-Oxodehydroabietinol

Cat.No: T125012

Target: Others

Methyl 7β,15-dihydroxydehydroabietate

Cat.No: T126441

Target: Others

7-Oxodehydroabietic acid

Cat.No: T39306

Target: Others

Methyl 15-hydroxy-7-oxodehydroabietate

Cat.No: T124573

Target: Others

Neoabietic acid

Cat.No: T40564

Target: Others

16-Nor-7,15-dioxodehydroabietic acid

Cat.No: T126227

Target: Others

Cat.No: T126378

Target: Others

OABK hydrochloride

Cat.No: T16370

Target: Others

12,14-Dichlorodehydroabietic acid

Cat.No: T40750

Target: Others

5,6-Dihydroabiraterone

Cat.No: T74094

Target: Others

12-Chlorodehydroabietic acid

Cat.No: T40751

Target: Others

Propiverine hydrochloride

Cat.No: T5023

Target: Others, Calcium Channel, AChR

Cat.No: T29208

Synonym: AZD0947,AZD-0947,ZD 0947,AZD 0947

Target: Others

Fesoterodine L-mandelate

Cat.No: T11275

Target: Others

Cat.No: T35052

Synonym: MK4618,MK 4618,MK-4618

Target: Others

Cat.No: T34774

Synonym: TAK-259,TAK259

Target: Others

Cat.No: T61438

Target: Others

EP3 antagonist 3

Cat.No: T61357

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN3790	Dehydroabietinol Pomiferin A,Dehydroabietyl alcohol	Antifection	Microbiology/Virology
	Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫，IC50为26-27 μM.
TCS1772	Dehydroabietic acid Dehydroabietate,脱氢松香酸	Antifection	Microbiology/Virology
	Dehydroabietic acid (Dehydroabietate) 是 EBV-EA 活化抑制剂。它是食物衍生化合物，可通过降低血浆葡萄糖、胰岛素水平、血浆甘油三酯 (TG) 和肝 TG 水平来治疗肥胖相关疾病。它的衍生物在动物模型中表现出抗分泌和抗胃蛋白酶作用。
T8278	(+)-Dehydroabietic acid	Others	Others
	(+)-Dehydroabietic acid 是一种可用于合成丙烯酰胺水凝胶的二萜。
TN2638	15-Hydroxy-7-oxodehydroabietic acid	Others	Others
	15-Hydroxy-7-oxodehydroabietic acid是一种天然产物，属于松科松属，其产品编号为 TN2638，CAS号为 95416-25-4。15-Hydroxy-7-oxodehydroabietic acid可用作对照参考。
TN5583	Methyl 7α,15-dihydroxydehydroabietate
	Methyl 7α,15-dihydroxydehydroabietate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5583，CAS号为 155205-65-5。
TN2648	16-Nor-15-oxodehydroabietic acid	Others	Others
	16-Nor-15-oxodehydroabietic acid is a natural product from Pinus massoniana.
TN3252	7alpha,15-Dihydroxydehydroabietic acid	p53	Apoptosis
	7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
TN4393	Koaburaside monomethyl ether	Others	Others
	Koaburaside monomethyl ether是一种天然产物，属于大戟科巴豆属，其产品编号为 TN4393，CAS号为 41514-64-1。Koaburaside monomethyl ether可用作对照参考。
TMA0164	15-Hydroxydehydroabietic acid	P450; Antifection	Metabolism; Microbiology/Virology
	15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
T82591	Dehydroabietal
	Dehydroabietal，一种白松及大西洋雪松等生物中的天然产物。

天然产物

Dehydroabietinol

Cat.No: TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

Dehydroabietic acid

Cat.No: TCS1772

Synonym: Dehydroabietate,脱氢松香酸

Target: Antifection

(+)-Dehydroabietic acid

Cat.No: T8278

Target: Others

15-Hydroxy-7-oxodehydroabietic acid

Cat.No: TN2638

Target: Others

Methyl 7α,15-dihydroxydehydroabietate

Cat.No: TN5583

16-Nor-15-oxodehydroabietic acid

Cat.No: TN2648

Target: Others

7alpha,15-Dihydroxydehydroabietic acid

Cat.No: TN3252

Target: p53

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Koaburaside monomethyl ether

Cat.No: TN4393

Target: Others

15-Hydroxydehydroabietic acid

Cat.No: TMA0164

Target: P450, Antifection

Cat.No: T82591

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00188	BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) Adenosylmethionine-8-amino-7-oxononanoate aminotransferase B...	Bacteroides fragilis	E. coli
	Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p...

重组蛋白

BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc)

Cat.No: TMPH-00188

Species: Bacteroides fragilis

Expression System: E. coli

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