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Search Results for " nurr1 "

Targets Recommended: Others

20

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T77549	Nurr1 agonist 2	Others	Others
	Nurr1 agonist 2 是一种 Nurr1 激动剂，EC50 值为 0.07 μM。Nurr1 agonist 2 增加 Nurr1 调节基因酪氨酸羟化酶 (TH) 和囊泡氨基酸转运蛋白 2 (VMAT2) 的 mRNA 表达。Nurr1 agonist 2 与重组 Nurr1 配体结合域 (LBD) 结合，Kd 值为 0.14 μM。Nurr1 agonist 2 可用于研究帕金森综合征。
T81632	Nurr1 agonist 8	Others	Others
	Nurr1 agonist 8 是一种低亲和力的 Nurr1 激动剂，可用于研究帕金森等神经系统疾病。
T81633	Nurr1 agonist 7	Others	Others
	Nurr1 agonist 7 是 Nurr1 的激动剂（EC50：0.12 μM），可用于研究帕金森等神经系统疾病。
T81635	Nurr1 agonist 5	Others	Others
	Nurr1 agonist 5 (compound 5o)为具神经保护性的Nurr1转录因子激动剂，其Kd值为0.5 μM，EC50值为3 μM。
T81634	Nurr1 agonist 6	Others	Others
	Nurr1 agonist 6 (compound 13)作为Nurr1激动剂，展现了Kd 1.5 μM和EC50 3 μM的亲和力与效应浓度。
T60443	Nurr1 agonist 1	Others	Others
	Nurr1 agonist 1 是一种神经保护的转录因子Nurr1的反向激动剂工具，Nurr1 是治疗神经退行性疾病的有吸引力的靶点。
T78088	Nurr1 agonist 4	Others	Others
	Nurr1激动剂4（化合物8）是一种具有高亲和力的化合物，其EC50值为2.1μM。
T78049	Nurr1 inverse agonist-1	Others	Others
	Nurr1 inverse agonist-1为Nurr1, 一种具有神经保护功能的转录因子, 的反向激动剂。
T8381	Amodiaquine	Others; Histone Methyltransferase; Parasite	Chromatin/Epigenetic; Microbiology/Virology; Others
	Amodiaquine 是一种合成的4-氨基喹啉类抗疟剂，是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂，有抗炎活性，可特异性结合Nurr1的配体结合域，EC50约为20 μM。
T83894	4A7C-301-Nurr1 Agonist 4A7C-301-Nuclear Receptor-Related 1
	4A7C-301-Nurr1激动剂是一种核受体相关1（Nurr1）的激动剂。它通过与Nurr1配体结合域（LBD；IC50 = 48.22 nM）结合，增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性（EC50s = 6.53 和 50-70 µM，分别）。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡，并减少运动和嗅觉缺陷，而不诱发类似运动障碍的行为。
T27620	IP7e IP 7e,IP-7e,isoxazolo-pyridinone 7e	Others	Others
	IP7e (isoxazolo-pyridinone 7e) 是一种 Nurr1 激活剂，EC50 值为 3.9 nM。
T0381	Amodiaquine dihydrochloride dihydrate Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase; Parasite; Histamine Receptor	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) 是一种具有口服活性的组胺 N-甲基转移酶抑制剂，也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM。它是 4-氨基喹啉衍生物，具有抗疟和抗炎特性。
T3106	C-DIM12	Apoptosis; Others	Apoptosis; Others
	C-DIM12是一种人工合成的Nurr1激活剂，可诱导Nurr1和DA 基因表达。
T84298	LTGO-33	Sodium Channel	Membrane transporter/Ion channel
	LTGO-33 是一种具有物种特异性的电压门控钠通道 NaV1.8 抑制剂，抑制 NaV1.8、 NaV1.1-NaV1.7 和 NaV1.9。LTGO-33 抑制野生型和多重 NaV1.8 与人类疼痛疾病相关的变异，可用于研究疼痛。
T22242	Amodiaquine hydrochloride	Others	Others
	Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂，是一种有效的口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂，Ki 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM，具有抗炎作用。
T84542	Prostaglandin E2-biotin PGE2-biotin	Others	Others
	Prostaglandin E2-biotin，一种前列腺素类似物，用于研究与Nurr1相关的疾病，包括癌症和自身免疫性疾病。
T35159	XCT0135908 XCT 0135908,XCT-0135908	Others	Others
	XCT0135908 is a selectivity agonist of RXR -Nurr1 over a broad range of other RXR dimerization partners but with a rather low potency.
T70237	HX-600	Others	Others
	HX-600 is a synthetic agonist for the RXR-Nurr1 heterodimer complex. HX-600 prevents ischemia-induced neuronal damage.
T83328	4A7C-301	Others	Others
	4A7C-301是一种Nurr1激动剂，体外显示出强大的神经保护能力。在AAV2介导的α-突触核蛋白过表达雄鼠模型中，该化合物能显著纠正神经病理学异常，并改善运动及嗅觉功能障碍。此外，4A7C-301适用于帕金森病相关研究。
T69921	BRF110	Others	Others
	BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.

化合物

Nurr1 agonist 2

Cat.No: T77549

Target: Others

Nurr1 agonist 8

Cat.No: T81632

Target: Others

Nurr1 agonist 7

Cat.No: T81633

Target: Others

Nurr1 agonist 5

Cat.No: T81635

Target: Others

Nurr1 agonist 6

Cat.No: T81634

Target: Others

Nurr1 agonist 1

Cat.No: T60443

Target: Others

Nurr1 agonist 4

Cat.No: T78088

Target: Others

Nurr1 inverse agonist-1

Cat.No: T78049

Target: Others

Cat.No: T8381

Target: Others, Histone Methyltransferase, Parasite

4A7C-301-Nurr1 Agonist

Cat.No: T83894

Synonym: 4A7C-301-Nuclear Receptor-Related 1

Cat.No: T27620

Synonym: IP 7e,IP-7e,isoxazolo-pyridinone 7e

Target: Others

Amodiaquine dihydrochloride dihydrate

Cat.No: T0381

Synonym: Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate

Target: Histone Methyltransferase, Parasite, Histamine Receptor

Cat.No: T3106

Target: Apoptosis, Others

Cat.No: T84298

Target: Sodium Channel

Amodiaquine hydrochloride

Cat.No: T22242

Target: Others

Prostaglandin E2-biotin

Cat.No: T84542

Synonym: PGE2-biotin

Target: Others

Cat.No: T35159

Synonym: XCT 0135908,XCT-0135908

Target: Others

Cat.No: T70237

Target: Others

Cat.No: T83328

Target: Others

Cat.No: T69921

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01797	NR4A2 Protein, Human, Recombinant (His) NR4A2,Immediate-early response protein NOT,Nuclear receptor ...	Human	P. pastoris (Yeast)
	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. NR4A2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is P43354.
TMPH-01796	NR4A1 Protein, Human, Recombinant (His & Myc) ST-59,NR4A1,Nuclear hormone receptor NUR/77,Orphan ...	Human	E. coli
	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expre...

重组蛋白

NR4A2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01797

Species: Human

Expression System: P. pastoris (Yeast)

NR4A1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01796

Species: Human

Expression System: E. coli

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