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Search Results for " nqo2 "

Targets Recommended: Others Thrombin

4

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10951	Dabigatran ethyl ester hydrochloride N-[[2-[[[4-(氨基亚氨甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-(2-吡啶基)-BETA-丙氨酸乙酯盐酸盐	Others; Thrombin	Others; Proteases/Proteasome
	Dabigatran ethyl ester hydrochloride 是一种核糖基二氢烟酰胺脱氢酶抑制剂，IC50=0.8 μM，也是一种凝血酶的抑制剂。
T6798	Tretazicar 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Tretazicar (NSC-115829) 是一种抗肿瘤前药，由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂，可以形成 DNA-DNA 链间交联。
T68942	Caricotamide	Others	Others
	Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over...
T60402	Tubulin inhibitor 14	Others	Others
	Tubulin inhibitor 14 是一种有效的 NQO2（醌氧化还原酶 2）抑制剂，IC50 为 1.0 μM，也抑制微管蛋白聚合和内皮细胞毛细管样管的形成。Tubulin inhibitor 14 是一种微管去稳定剂，具有潜在的肿瘤选择性以及抗血管生成和血管破坏的功能[1]。

化合物

Dabigatran ethyl ester hydrochloride

Cat.No: T10951

Synonym: N-[[2-[[[4-(氨基亚氨甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-(2-吡啶基)-BETA-丙氨酸乙酯盐酸盐

Target: Others, Thrombin

Cat.No: T6798

Synonym: 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cat.No: T68942

Target: Others

Tubulin inhibitor 14

Cat.No: T60402

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02882	NQO2 Protein, Mouse, Recombinant (His) Ribosyldihydronicotinamide dehydrogenase [quinone],Quinone r...	Mouse	P. pastoris (Yeast)
	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

重组蛋白

NQO2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02882

Species: Mouse

Expression System: P. pastoris (Yeast)

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