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Targets Recommended: NADPH-oxidase Others

2

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T22990 ML-090

Fluoflavine

NADPH-oxidase; Others Immunology/Inflammation; Others
ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM),对 NOX1 的特异性高于 NOX2、NOX3NOX4(所有 IC50 > 10 μM)100倍。
T10353 APX-115 free base

Ewha-18278 free base

NADPH-oxidase; NADPH Immunology/Inflammation; Metabolism
APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂,对 Nox1,Nox2和 Nox4的 Ki 分别为 1.08 μM,0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。

化合物

ML-090
Cat.No: T22990
Synonym: Fluoflavine
Target: NADPH-oxidase, Others
APX-115 free base
Cat.No: T10353
Synonym: Ewha-18278 free base
Target: NADPH-oxidase, NADPH
Cat. No. Product Name Species Expression System
TMPH-02106 SH3PXD2A Protein, Human, Recombinant (His & Myc)

SH3PXD2A,SH3 multiple domains protein 1,SH...

Human E. coli
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.

重组蛋白

SH3PXD2A Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02106
Species: Human
Expression System: E. coli
TargetMol Loading
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