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Search Results for " novobiocin "

Targets Recommended: Apoptosis Virus Protease HSP DNA gyrase Antibacterial Antibiotic

4

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20510	Novobiocin U-6391,U 6391,U6391,Cathomycin,Albamycin	Apoptosis; Virus Protease; HSP; DNA gyrase; Antibacterial; Antibiotic	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Novobiocin 是一种具有口服活性和有效性的的抗生素。Novobiocin 是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂，对促旋酶和Hsp90 具有抑制作用。 Novobiocin 具有抗正痘活性，可用于研究高度耐药性肺炎球菌感染。
T37721	Dihydronovobiocin	Others	Others
	Dihydronovobiocin is a coumarin antibiotic and derivative of novobiocin .1It is active against the bacteriaS. aureus,S. haemolyticus,D. pneumoniae,S. typhosa,K. pneumoniae, andP. multocida(MICs = 0.6, 2, 0.6, 10, 10, and 3 μg/ml, respectively).2Dihydronovobiocin inhibits DNA gyrase subunit B with an IC50value of 64.5 nM.3 1.Berger, J., and Batcho, A.D.Coumarin - glycoside antibioticsJ. Chromatogr. Lib.15101-158(1978) 2.Hoeksema, H.Dihydronovobiocin and derivatives thereof3,175,9441-9(1965) 3.Gev...
T15671	KU-32	HSP	Cytoskeletal Signaling; Metabolism
	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
T83705	BING TFA Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria
	BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽，由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时，对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应，并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内，BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。

化合物

Cat.No: T20510

Synonym: U-6391,U 6391,U6391,Cathomycin,Albamycin

Target: Apoptosis, Virus Protease, HSP, DNA gyrase, Antibacterial, Antibiotic

Dihydronovobiocin

Cat.No: T37721

Target: Others

Cat.No: T15671

Target: HSP

Cat.No: T83705

Synonym: Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria

Cat. No.	Product Name	Target	Signaling Pathways
T0974	Novobiocin Sodium Albamycinsodium,新生霉素钠,Cathomycin,Albamycin	Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。

天然产物

Novobiocin Sodium

Cat.No: T0974

Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy

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