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Search Results for " notch4 "

Targets Recommended: Gamma-secretase

1

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14680	BMS-906024 Osugacestat,AL-101,BM-0018	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS-906024 (Osugacestat) 是一种可口服且具有选择性的γ 分泌酶抑制剂，是一种小分子 Notch 抑制剂。BMS-906024 对多种人类癌症异种移植具有广谱抗肿瘤活性。BMS-906024 可阻止所有四种 Notch 受体的激活，对 Notch1、-2、-3 和 -4 受体的 IC50 分别为 1.6、0.7、3.4 和 2.9 nM。

化合物

Cat.No: T14680

Synonym: Osugacestat,AL-101,BM-0018

Target: Gamma-secretase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00868	Notch 4 Protein, Mouse, Recombinant (His) Notch-4,Int-3,Notch4,Int...	Mouse	HEK293 Cells
	The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells.
TMPY-05054	Notch 4 Protein, Human, Recombinant (His) INT3,notch 4	Human	Baculovirus Insect Cells
	NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is involved in the development and patterning of the central nervous systems. It regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possibl...
TMPK-00360	DLL4 Protein, Human, Recombinant (His & Avi) notch ligand DLL4,MGC126344	Human	HEK293 Cells
	Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibit...

重组蛋白

Notch 4 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00868

Species: Mouse

Expression System: HEK293 Cells

Notch 4 Protein, Human, Recombinant (His)

Cat.No: TMPY-05054

Species: Human

Expression System: Baculovirus Insect Cells

DLL4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00360

Species: Human

Expression System: HEK293 Cells

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