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Cat. No. | Product Name | ||
---|---|---|---|
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9010 |
IMM-H007
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
IMM-H007 是一种新型降脂剂,可增加 abca1 蛋白的表达。 | |||
T75150 |
GIP/GLP-1 dual receptor agonist-1
|
Others | Others |
GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病,包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。 | |||
T74132 |
GLP-1 receptor agonist 8
|
Others | Others |
GLP-1 receptoragonist 8 是一种有效的GLP-1R 激动剂。GLP-1 receptoragonist 8 具有研究糖尿病、肥胖和非酒精性脂肪肝 (NAFLD) 的潜力。 | |||
T78313 |
Fazpilodemab
BFKB8488A |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Fazpilodemab (BFKB8488A) 是靶向 FGFR1c 和 Klothoβ 的激动性人源化双特异性抗体,适用于T2DM或NAFLD的研究。 | |||
T62277 |
PPARδ agonist 8
|
Others | Others |
Pparδ agonist 8 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族,在体内代谢稳态、炎症、细胞生长和分化的调节中具有关键作用。Pparδ agonist 8 具有潜力进行非酒精性脂肪肝 (NAFLD) 的研究。 | |||
T82719 |
Cisd2 agonist 2
|
Others | Others |
Cisd2 agonist 2(compound 6)是Cisd2激活剂,具有191 nM的EC50值,其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠(杂合子肝细胞特异性Cisd2敲除)中,Cisd2 agonist 2未显示出显著的体内毒性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00386 |
GLT8D2 Protein, Human, Recombinant (His)
glycosyltransferase 8 domain containing 2,UNQ1901/PRO4347 |
Human | Baculovirus Insect Cells |
GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic fatty liver disease (NAFLD) pathogenesis possibly by negatively regulating MTP expression. |