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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7693 |
Thiorphan
|
Neprilysin | Metabolism |
Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。 | |||
TQ0106 |
Sacubitrilat
LBQ-657 |
Neprilysin | Metabolism |
Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。 | |||
T1176 |
Racecadotril
Acetorphan,消旋卡多曲 |
Neprilysin; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂,具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性,Ki 分别为 4500 和 6.1 nM。 | |||
T2318 |
Sacubitril/Valsartan
Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696 |
Apoptosis; RAAS; Neprilysin | Apoptosis; Endocrinology/Hormones; Metabolism |
Sacubitril/Valsartan (LCZ696),以1:1摩尔比由Valsartan(一种ARB)和Sacubitril(AHU377)组成,为创新口服血管紧张素受体-脑啡肽酶(ARN)双重抑制剂,旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡,有助于改善糖尿病心肌病。 | |||
T4574 |
Sacubitril
AHU 377,AHU377,沙库必曲,AHU-377 |
Neprilysin | Metabolism |
Sacubitril (AHU-377) 是一种有效的NEP 抑制剂,IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。 | |||
T4200 |
Sacubitril hemicalcium salt
AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt |
Neprilysin | Metabolism |
Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂,IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。 | |||
TP2045 |
CH 275
|
||
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens | |||
T19114L |
Sacubitril-(2S,4S)-Isomer
(2S,4S)-Sacubitril,LCZ 696杂质C |
Others | Others |
Sacubitril-(2S,4S)-Isomer ((2S,4S)-Sacubitril) 是 Sacubitril 的异构体,它是一种脑啡肽酶抑制剂。 | |||
T19112L |
Sacubitril Enantiomer
2R,4S-Sacubitril,LCZ 696杂质A,ahu377 isomer 2 |
Others | Others |
Sacubitril Enantiomer (ahu377 isomer 2) 是 Sacubitril 的对映体,它是一种脑啡肽酶抑制剂。 | |||
T28005 |
MDL-100240
|
Others | Others |
MDL-100240 is a dual inhibitor of angiotensin-converting enzyme (ACE) and neprilysin with a balanced activity. MDL 100240 shows an impressive effectiveness both in preventing and in regressing hypertension-induced vascular remodeling and cardiac hypertrop | |||
T19112 |
2R,4S-Sacubitril
LCZ 696杂质A,Sacubitril Enantiomer,ahu377 isomer 2 |
Others | Others |
2R,4S-Sacubitril (Sacubitril Enantiomer) 是 Sacubitri 杂质。其中 Sacubitril 与缬沙坦联合使用,表现出抗心力衰竭的活性。 | |||
T13125 |
TD-0212
|
Others | Others |
TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP). | |||
T13125L |
TD-0212 TFA
|
Others | Others |
TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP). | |||
T25316 |
Dexecadotril
Retorphan |
Others | Others |
Dexecadotril is a powerful and selective neprilysin inhibitor. It behaves as a prodrug of the enantiomer of thiorphan. | |||
T4574L |
Sacubitril sodium
AHU377,AHU-377,LCZ696,AHU 377 |
Others | Others |
Sacubitril is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. | |||
T71118 |
NEP-28
|
Others | Others |
NEP-28 is an AR agonist. NEP28 is a new SARM exhibiting high selectivity for androgen receptor. NEP28 showed tissue-selective effect equivalent to or higher than existing SARMs. In addition, the administration of NEP28 increased the activity of neprilysin, a known Aβ-degrading enzyme. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6627 |
Phosphoramidon Disodium
Phosphoramidon Disodium Salt,磷酰胺二钠 |
RAAS; Neprilysin; Others | Endocrinology/Hormones; Metabolism; Others |
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ,0.034 和 78 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00782 |
Amyloid Precursor Protein, Human, Recombinant (hFc)
Amyloid Precursor,Amyloid Precursor Protein 695,APP695 |
Human | HEK293 Cells |
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0295 |
LBQ657-d4
|
||
LBQ657-d4 是 LBQ657 的氘代化合物。LBQ657 的 CAS 号为 149709-44-4。Sacubitrilat 是活性的脑啡肽酶 (NEP) 抑制剂。 | |||
T71145 |
Racecadotril-d5
|
||
Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan. In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively. It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-indu... |