Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5850 |
Benzamil
Benzamil (hydrochloride) |
Na+/Ca2+ Exchanger; Sodium Channel | Membrane transporter/Ion channel |
Benzamil 是 Amiloride 类似物,是 Na+/Ca2+交换体抑制剂,抑制 TRPP3 介导的 Ca2+激活电流,IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂,能增强肌源性血管收缩。 | |||
T5457 |
SN 6
SN6 |
Calcium Channel; Na+/Ca2+ Exchanger | Membrane transporter/Ion channel; Metabolism |
SN 6 (SN6) 是选择性NCX 抑制剂,可抑制 NCX1、NCX2 和 NCX3 对45Ca2+的吸收,IC50值分别为 2.9、16 和 8.6 μM。 | |||
T1266 |
Terfenadine
(±)-Terfenadine,特非那定,MDL-991 |
Apoptosis; Potassium Channel; 5-HT Receptor; Caspase; Na+/Ca2+ Exchanger; HER; AChR; Histamine Receptor | Angiogenesis; Apoptosis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂,IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂,通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡,同时激活Caspase-4,-2,-9。 | |||
T3508 |
SEA0400
SEA 0400,2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA-0400 |
Calcium Channel; Na+/Ca2+ Exchanger | Membrane transporter/Ion channel; Metabolism |
SEA0400 是 Na+/Ca2+ 交换剂的选择性抑制剂,在培养的神经元、星形胶质细胞和小胶质细胞中,能够抑制 Na+-依赖性 Ca2+的吸收,IC50值为 5-33 nM。 | |||
T14941 |
CGP37157
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one |
Na+/Ca2+ Exchanger | Membrane transporter/Ion channel |
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) 是一种 Na+/Ca2+ 交换抑制剂,抑制 Na+ 诱导的豚鼠心脏线粒体中 Ca2+ 的释放,IC50 为 0.8 μM。 | |||
T6144 |
KB-R7943 mesylate
KB-R7943 |
Na+/Ca2+ Exchanger; Autophagy | Autophagy; Membrane transporter/Ion channel |
KB-R7943 mesylate 是一种广泛使用的反向 Na+/Ca2+ 交换剂 (NCXrev) 抑制剂,IC50 为 5.7±2.1 µM。它通过激活JNK 通路和抑制自噬通量来诱导癌细胞死亡。 | |||
T39195 |
YM-244769 dihydrochloride
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。 | |||
T9888 |
YM-244769
3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 对神经元和肾脏具有有效的保护作用。 | |||
T11319 |
FR183998 free base
|
Na+/Ca2+ Exchanger | Membrane transporter/Ion channel |
FR183998 free base 是 Na+/Ca2+ 交换剂的抑制剂。 | |||
T12321 |
ORM-10103
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ORM-10103 是一种新型有效且具有选择性的 Na+/Ca2+ 交换体 (NCX) 抑制剂。ORM-10103 对 NCX 电流有抑制作用,在 -80 和 20 mV 下的 IC50 的估算值分别为 55 和 67 nM,可减少犬心脏的早期和延迟后去极化。 | |||
T68320 |
L594881 HCl
|
Others | Others |
L594881, also known as 3',4'-Dichlorobenzamil or DCB, is an inhibitor of Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. L594881 can inhibit Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels. | |||
T26383 |
3',4'-Dichlorobenzamil HCl
|
Others | Others |
3',4'-Dichlorobenzamil HCl is an inhibitor of Na+ transport, Na+/Ca2+ exchanger, sarcoplasmic reticulum Ca2+ release channels. | |||
T14857 |
Caldaret
MCC-135 |
Others | Others |
Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. |