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Search Results for " nsclc "

Targets Recommended: PI3K

119

抑制剂 & 化合物

10

天然产物

1

化合物库

13

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2190	抗肺癌化合物库		1702 compounds
	1702 种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；

化合物库

抗肺癌化合物库

Cat.No: L2190

Compounds: 1702

Cat. No.	Product Name	Target	Signaling Pathways
T9460	iMDK	PI3K	PI3K/Akt/mTOR signaling
	iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。
T9929	Ramucirumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ramucirumab 是一种人 VEGFR-2 拮抗剂，具有抗实体瘤活性。它是人源化单克隆抗体，能够与 VEGFR-2 结合，阻碍 VEGFR 配体 VEGF-A，VEGF-C 和 VEGF-D 结合。
T6455	CP-91149	Phosphorylase	Metabolism
	CP91149 是GP (糖原磷酸化酶)的抑制剂，能够促进糖原的重新合成，但不会造成糖原的过度积累。它对2型糖尿病具有潜在的研究价值。
T6734	WZ8040	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	WZ8040 是一种新型突变选择性不可逆 EGFRT790M 抑制剂，可抑制EGFR 磷酸化。它对突变型EGFR 的活性是野生型EGFR 的100倍以上。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T40254	MRTX-1719	Histone Methyltransferase	Chromatin/Epigenetic
	MRTX-1719 是有效的PRMT5/MTA 复合体选择性抑制剂，其对PRMT5/MTAMTAPDELSDMA 细胞系的IC50值为 <10 nM。
T10777	CG347B	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CG347B 是一种选择性HDAC6抑制剂。
T11224	Rineterkib ERK-IN-1	ERK; Raf	MAPK
	Rineterkib (ERK-IN-1) 是口服有效的RAF 和ERK1/2的抑制剂，与 KRAS-突变型非小细胞肺癌、BRAF-突变型非小细胞肺癌、KRAS-突变型胰腺癌、KRAS -突变型结肠癌和 KRAS-突变型卵巢癌尤为相关。
T13176	TNO155 Batoprotafib	Phosphatase	Metabolism
	TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。
T12695	RBN-2397	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂，IC50 小于 3 nM。它选择性结合 PARP7 ，Kd 为0.001 μM，可恢复干扰素 I 型信号转导，有用于晚期或转移性实体肿瘤的研究潜力。
T5414	Glumetinib SCC244	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Glumetinib (SCC244) 是一种高选择性、ATP 竞争性的、口服具有活力的 c-Met 抑制剂。它对 c-Met 的选择性超过 312 种激酶，包括 c-Met 家族成员 RON 和高度同源的激酶 Axl、Mer、TyrO3。它具有抗肿瘤作用。
T8684	Sotorasib AMG-510	Ras	GPCR/G Protein; MAPK
	Sotorasib (AMG-510) 是一种 KRAS G12C 共价抑制剂，具有口服活性和选择性。Sotorasib 与 KRAS G12C 非活性构象的 GDP 状态结合，抑制 KRAS 及其下游信号的传导。Sotorasib 对 KRAS G12C 突变肿瘤具有抑制活性。
T22318	Taletrectinib DS-6051b,AB-106	Trk receptor; ROS; ROS Kinase	Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Taletrectinib (AB-106) 是具有口服活力的、选择性的 ROS1/NTRK 抑制剂。它对重组 ROS1、NTRK1、NTRK2 和 NTRK3 有较强的抑制作用，IC50值分别为 0.207、0.622、2.28 和 0.98 nM。它还抑制 ROS1 G2032R 和其他抗 Crizotinib 的 ROS1 突变体。
T8327	ONO-7475	Trk receptor; TAM Receptor	Tyrosine Kinase/Adaptors
	ONO-7475 是一种选择性的、有效的、具有口服活性的Axl/Mer 抑制剂。它使 AXL 过表达的EGFR 突变型 NSCLC 细胞对 EGFR-TKIs 敏感，抑制耐药细胞的产生和耐药性的维持。它与 Osimertinib 联合使用，具有用于 EGFR 突变非小细胞肺癌的潜力。
T39275	Befotertinib D-0316,Befotertinib	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Befotertinib (D-0316) 是一种 EGFR 酪氨酸激酶抑制剂，可用于 EGFR T790M 阳性非小细胞肺癌的研究。
T8151	Mobocertinib tak788	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Mobocertinib (tak788) 是可口服的EGFR 和HER2突变的抑制剂，具有抗肿瘤活性。
T22254	Alflutinib AST2818,ASK120067	EGFR; P450	Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Alflutinib (ASK120067) 是 EGFR 抑制剂。它对 T790M 的性耐药突变以及 EGFR 活性突变具有抑制作用。它对于癌症疾病，特别是非小细胞肺癌(NSC-LC)方面具有研究潜力。
T16996	TAS6417	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	TAS6417 是一种高效的、具有口服活性的 EGFR 突变型抑制剂，可独特的结合到 EGFR 铰链区的 ATP 结合位点，其 IC50值为 1.1-8.0 nM。
T5462	Almonertinib HS-10296,阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib (HS-10296) 是EGFR 激活突变抑制剂和EGFR T790M 耐受突变抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性，用于非小细胞肺癌的研究。它对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
TQ0255	Olafertinib CK-101,EGFR-IN-3,RX-518	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Olafertinib (RX-518) 是新型突变选择性、不可逆、可口服的EGFR 酪氨酸酶抑制剂，可克服 NSCLC 中 T790M 介导的耐药性。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T16545	Pivanex Pivalyloxymethyl butyrate,AN-9	Apoptosis; HDAC; Bcr-Abl	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
T7175	Alflutinib mesylate 甲磺酸伏美替尼,AST2818 mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Alflutinib mesylate (AST2818 mesylate) 是一种不可逆的酪氨酸激酶抑制剂，可选择性抑制 EGFR 突变。
T15735	Leptomycin B CI 940,LMB,来普霉素B	CRM1; Antibiotic; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Leptomycin B (LMB) 是一种抗真菌抗生素，可阻断真核细胞周期，抑制蛋白出核转运。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1失活。它
T3061	Lorlatinib 劳拉替尼,PF-6463922,PF-06463922,Loratinib	Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase	Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Lorlatinib (PF-6463922) 是一种具有口服活性，选择性，脑渗透性和 ATP 竞争性的ROS1/ALK 抑制剂，具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。
T20168	Aurothiomalate sodium 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂，可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂，也是一种抗风湿剂。
T8656	CAY10404 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis; Akt; COX	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。
T21312	Afatinib 阿法替尼,Afatinib free base,BIBW 2992	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib (BIBW 2992) 是一种不可逆的 EGFR 家族抑制剂，抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T16492	PF-06459988	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PF-06459988 是一种新型的的、有效的、具有口服活性的、不可逆的和选择性的表皮生长因子受体（ EGFR）突变体抑制剂。PF-06459988 对含 T790M 的 EGFRs 双突变体具有高效性和高亲和力，对 WT EGFR 具有极小的活性。PF-06459988 使治疗癌症的候选药物。
T6804	Chetomin Chaetomin,NSC289491,BRN0077366	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T1773	Afatinib Dimaleate 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR; HER; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Afatinib Dimaleate (BIBW 2992MA2) 是一种可口服的苯胺基-喹唑啉衍生物和受体酪氨酸激酶表皮生长因子受体家族的抑制剂，具有抗肿瘤活性。它抑制 EGFRwt、EGFRL858R、EGFRL858R/T790M 和 HER2的 IC50分别为0.5 nM、0.4 nM、10 nM 和 14 nM。
T5675	Almonertinib hydrochloride HS-10296 hydrochloride,盐酸阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib hydrochloride (HS-10296 hydrochloride) 是一种 EGFR 激活突变和 T790M 耐药突变的小分子抑制剂，用于非小细胞肺癌的研究，对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
T11162	EGFR-IN-8	EGFR; c-Met/HGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-8 是 EGFR 和 c-Met 的双重抑制剂。 EGFR-IN-8可用于靶向 EGFR TKI 耐药的 NSCLC 的研究。
T6269	Bemcentinib R428,BGB324	TAM Receptor	Tyrosine Kinase/Adaptors
	Bemcentinib (R428) 是具有选择性的、高效的 Axl 抑制剂，其 IC50=14 nM。
T9601	Tepotinib hydrochloride(1 : x)	c-Met/HGFR; P-gp; ABC	Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Tepotinib hydrochloride(1 : x) 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。
T9901A-002	Enoblituzumab MGA271,TJ-271	Others	Others
	Enoblituzumab 是一种人源化 IgG1κ 单克隆抗体，可以识别人 B7-H3 蛋白，可用于研究非小细胞肺癌（NSCLC）等实体肿瘤。
T3181	SW044248	Topoisomerase	DNA Damage/DNA Repair
	SW044248 是非典型拓扑异构酶 I 抑制剂，对 NSCLC 细胞具有选择性毒性。
T67934	MRT-2359	Others	Others
	MRT-2359 是一种有效的且可口服的 GSPT1 降解剂，具有抗肿瘤活性。MRT-2359 对耐药非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 细胞的生长具有抑制作用。MRT-2359 在 MYC 驱动的细胞系中表现出优先活性。
T36404L	PRLX-93936 HCL PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	PRLX-93936 HCL 是 erastin 的类似物，并显示出与顺铂对非小细胞肺癌 (NSCLC) 细胞的协同作用。
T6092	Sapitinib 沙普替尼,AZD-8931	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sapitinib (AZD-8931) 是可逆的 ATP 竞争型 EGFR 抑制剂，对 EGFR、ErbB2 和 ErbB3的IC50值分别为4、3 和 4 nM。
T72043	SCFSkp2-IN-2	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SCFSkp2-IN-2 是一种 Skp2抑制剂，其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T76873	Nidanilimab CAN04	IL Receptor	Immunology/Inflammation
	Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体，其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性，切断 IL1α 和 IL1β 信号通路，并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T61016	EMI1	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EMI1 是 EGFR 三重突变体 (EGFR ex19del/T790M/C797S, EGFR L858R/T790M/C797S) 的有效抑制剂。EMI1 可用于 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。
T9754	BLU-945 BLU945,BLU 945	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BLU-945 是一种强效的、高选择性的、口服有效的、可逆的表皮生长因子受体酪氨酸激酶抑制剂 (TKIs)。BLU-945 可有效抑制具有 L858R 和/或外显子 19 缺失突变、T790M 突变和 C797S 突变的 EGFR。BLU-945 可用于肺癌包括非小细胞肺癌（NSCLC）的研究。
T35391	Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT)	Others	Others
	Vibostolimab 是一种抗 T 细胞免疫蛋白和 ITIM 域的单克隆抗体。Vibostolimab 在体外实验中显示出抗肿瘤活性，可用于研究非小细胞肺癌 (NSCLC) 和黑色素瘤。
T4605	NT157	IGF-1R; STAT	JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	NT157 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T15384	Glesatinib MGCD265	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC.

化合物

Cat.No: T9460

Target: PI3K

Cat.No: T9929

Target: VEGFR

Cat.No: T6455

Target: Phosphorylase

Cat.No: T6734

Target: EGFR

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

Cat.No: T40254

Target: Histone Methyltransferase

Cat.No: T10777

Target: HDAC

Cat.No: T11224

Synonym: ERK-IN-1

Target: ERK, Raf

Cat.No: T13176

Synonym: Batoprotafib

Target: Phosphatase

Cat.No: T12695

Target: PARP

Cat.No: T5414

Synonym: SCC244

Target: c-Met/HGFR

Cat.No: T8684

Synonym: AMG-510

Target: Ras

Cat.No: T22318

Synonym: DS-6051b,AB-106

Target: Trk receptor, ROS, ROS Kinase

Cat.No: T8327

Target: Trk receptor, TAM Receptor

Cat.No: T39275

Synonym: D-0316,Befotertinib

Target: EGFR

Cat.No: T8151

Synonym: tak788

Target: EGFR

Cat.No: T22254

Synonym: AST2818,ASK120067

Target: EGFR, P450

Cat.No: T16996

Target: Apoptosis, EGFR

Cat.No: T5462

Synonym: HS-10296,阿美替尼

Target: EGFR

Cat.No: TQ0255

Synonym: CK-101,EGFR-IN-3,RX-518

Target: EGFR

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Cat.No: T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Alflutinib mesylate

Cat.No: T7175

Synonym: 甲磺酸伏美替尼,AST2818 mesylate

Target: EGFR

Cat.No: T15735

Synonym: CI 940,LMB,来普霉素B

Target: CRM1, Antibiotic, Antifungal

Cat.No: T3061

Synonym: 劳拉替尼,PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Aurothiomalate sodium

Cat.No: T20168

Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

Cat.No: T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Cat.No: T21312

Synonym: 阿法替尼,Afatinib free base,BIBW 2992

Target: EGFR, Autophagy

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Cat.No: T16492

Target: EGFR

Cat.No: T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

Afatinib Dimaleate

Cat.No: T1773

Synonym: 马来酸阿法替尼,双马来酸盐阿法替尼,BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate

Target: EGFR, HER, Autophagy

Almonertinib hydrochloride

Cat.No: T5675

Synonym: HS-10296 hydrochloride,盐酸阿美替尼

Target: EGFR

Cat.No: T11162

Target: EGFR, c-Met/HGFR

Cat.No: T6269

Synonym: R428,BGB324

Target: TAM Receptor

Tepotinib hydrochloride(1 : x)

Cat.No: T9601

Target: c-Met/HGFR, P-gp, ABC

Cat.No: T9901A-002

Synonym: MGA271,TJ-271

Target: Others

Cat.No: T3181

Target: Topoisomerase

Cat.No: T67934

Target: Others

Cat.No: T36404L

Synonym: PRLX-93936 hcl(903499-49-0 Free base)

Target: Ferroptosis, Reactive Oxygen Species

Cat.No: T6092

Synonym: 沙普替尼,AZD-8931

Target: EGFR

Cat.No: T72043

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T76873

Synonym: CAN04

Target: IL Receptor

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Cat.No: T61016

Target: EGFR

Cat.No: T9754

Synonym: BLU945,BLU 945

Target: EGFR

Vibostolimab (anti-TIGIT)

Cat.No: T35391

Synonym: Vibostolimab (anti-TIGIT)

Target: Others

Cat.No: T4605

Target: IGF-1R, STAT

Cat.No: T10745

Target: CDK

Cat.No: T15384

Synonym: MGCD265

Target: c-Met/HGFR

Cat. No.	Product Name	Target	Signaling Pathways
TN2108	Protohypericin	Others	Others
	Protohypericin 是一种从贯叶连翘中提取的天然石脑粉。放射性碘化 Protohypericin 能用于肿瘤坏死靶向放射研究。
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
TN1153	Polyporenic acid C 猪苓酸C,聚孔酸C	Apoptosis; PARP; Caspase; PI3K	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Polyporenic acid C 是从茯苓中分离出的一种羊毛甾烷型三萜，可通过死亡受体介导的凋亡途径诱导细胞凋亡，有用于肺癌的研究潜力。
T34394	Rotenolone 12ALPHA-羟基鱼藤酮,Rotenolone I,12alpha-HYDROXYROTENONE	Others	Others
	Rotenolone (12alpha-HYDROXYROTENONE) 是鱼藤酮的代谢物，鱼藤酮是一种源自藤本植物和龙果属植物的天然化合物。
T3S0153	Xanthatin 苍耳亭,叶黄制菌素	Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors
	Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物，可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
TN1642	Ferruginol 铁锈罗汉柏醇	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.
T81132	Soladulcoside A	Others	Others
	Soladulcoside A，一种甾体糖苷及抗肿瘤剂，源自龙葵全株。该化合物可抑制A549细胞，并展示对治疗非小细胞肺癌(NSCLC)等癌症的潜在应用。
T35895	Ingenol 3,20-dibenzoate	Others	Others
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].
TN3525	Boehmenan	ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell

天然产物

Cat.No: TN2108

Target: Others

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Polyporenic acid C

Cat.No: TN1153

Synonym: 猪苓酸C,聚孔酸C

Target: Apoptosis, PARP, Caspase, PI3K

Cat.No: T34394

Synonym: 12ALPHA-羟基鱼藤酮,Rotenolone I,12alpha-HYDROXYROTENONE

Target: Others

Cat.No: T3S0153

Synonym: 苍耳亭,叶黄制菌素

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Cat.No: TN1642

Synonym: 铁锈罗汉柏醇

Target: BCL, PARP, Caspase

Soladulcoside A

Cat.No: T81132

Target: Others

Ingenol 3,20-dibenzoate

Cat.No: T35895

Target: Others

Cat.No: TN3525

Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03958	TGF alpha Protein, Human, Recombinant transforming growth factor α,转化生长因子,transforming growth fact...	Human	E. coli
	The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (...
TMPY-00476	ITGB1 Protein, Human, Recombinant (His) VLAB,integrin, beta 1 (fibronectin receptor, beta polypeptid...	Human	HEK293 Cells
	ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe...
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His) SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE...	Mouse	HEK293 Cells
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
TMPK-00341	ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated ALCAM,KG-CAM,MEMD,CD166,CD6L	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed ...
TMPY-04985	TMPRSS11D Protein, Human, Recombinant (His) transmembrane protease, serine 11D,HAT	Human	HEK293 Cells
	TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. Both TMPRSS11D mRNA and protein expression levels were significantly higher in NSCLC tumorous tissues than in adjacent normal tissues. High TMPRSS11D protein expression was associated with high TNM stages, and hi...
TMPY-02259	FKBP25/FKBP3 Protein, Human, Recombinant (GST) FKBP-25,PPIase,FKBP25,FK506 binding protein 3,FKBP-3	Human	E. coli
	FKBP3 is a member of FK506-binding proteins (FKBPs). miR-145-5p overexpression suppressed cell proliferation of NSCLC cells which was abrogated by FKBP3 overexpression, that FKBP3/Sp1/HDAC2/p27 control cell proliferation during NSCLC development.
TMPK-00340	ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated CD166,CD6L,KG-CAM,ALCAM,MEMD	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPK-00339	ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated CD6L,ALCAM,MEMD,KG-CAM,CD166	Mouse	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPY-02210	Serpin B9 Protein, Human, Recombinant (His) CAP-3,PI-9,CAP3,PI9,serpin peptidase inhibitor, clade B (ova...	Human	Baculovirus Insect Cells
	SerpinB9, also known as Cytoplasmic antiproteinase 3, CAP-3, Peptidase inhibitor 9, SERPINB9 and PI-9, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protect these cells against the actions of gran...
TMPY-02399	TRF1 Protein, Human, Recombinant (His) TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...	Human	Baculovirus Insect Cells
	Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc) IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...

重组蛋白

TGF alpha Protein, Human, Recombinant

Cat.No: TMPY-03958

Species: Human

Expression System: E. coli

ITGB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00476

Species: Human

Expression System: HEK293 Cells

SEMA4B Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01034

Species: Mouse

Expression System: HEK293 Cells

ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00341

Species: Human

Expression System: HEK293 Cells

TMPRSS11D Protein, Human, Recombinant (His)

Cat.No: TMPY-04985

Species: Human

Expression System: HEK293 Cells

FKBP25/FKBP3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02259

Species: Human

Expression System: E. coli

ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00340

Species: Human

Expression System: HEK293 Cells

ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00339

Species: Mouse

Expression System: HEK293 Cells

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

Serpin B9 Protein, Human, Recombinant (His)

Cat.No: TMPY-02210

Species: Human

Expression System: Baculovirus Insect Cells

TRF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02399

Species: Human

Expression System: Baculovirus Insect Cells

CADM1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T72818	Dosimertinib-d3
	Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。

同位素标记化合物

Dosimertinib-d3

Cat.No: T72818

Cat.No: TMIH-0413

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