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Search Results for " ns5a "

Targets Recommended: HCV Protease

41

抑制剂 & 化合物

1

天然产物

1

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T73834	NS5A-IN-2	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NS5A-IN-2 (Compound 33)为一种高效的NS5A抑制剂，对HCV基因型1b展现出极高效力，并对基因型3a (GT 3a) 亦具备增强活性与良好的代谢稳定性。
T74403	NS5A-IN-1	Others	Others
	NS5A-IN-1 是一种丙型肝炎病毒NS5A 抑制剂 Pibrentasvir（ABT-530）的前体。
T73223	NS5A-IN-3	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NS5A-IN-3 (Compound 15) 为高效NS5A抑制剂，对HCV基因型1b显示出高效力，并对基因型3a (GT 3a) 活性提升以及展现出良好的代谢稳定性。NS5A-IN-3相较于daclatasvir，对基因型1b具有更高的耐药门槛。
T74495	NS5A-IN-4	Others	Others
	NS5A-IN-4 (Compound 1.12) 是一种具有口服活性的泛基因型丙型肝炎病毒 (HCV)NS5A 抑制剂，对gT1b、gT1a、gT2a、gT3a,gT4a 和gT5a 的IC50分别为 1.2、2296、4.6、362、10.3 和 693 pM。
T11541	HCV-IN-30	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂（基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM）。
T9567	Samatasvir ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) 是 NS5A HCV 复制抑制剂。它能够有效的选择复制子及感染性 HCV，在基因型 1至5 复制子中，EC50= 2~24 pM。
T25268L	Coblopasvir dihydrochloride Coblopasvir dihydrochloride(1312608-46-0 Free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T1786	Daclatasvir dihydrochloride BMS-790052 dihydrochloride,盐酸达拉他韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50范围为 9-146 pM。
T25268	Coblopasvir	Others	Others
	Coblopasvir 是一种泛基因型非结构蛋白5A(NS5A)抑制剂。它可以用于研究慢性丙型肝炎病毒的感染。
T5127	ABT530 ABT 530,ABT-530,哌仑他韦,Pibrentasvir	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	ABT530 (Pibrentasvir) 是一种 HCV NS5A 抑制剂，针对含有 NS5A 基因型 1-6 的 HCV 复制子，EC50 范围为 1.4-5.0 pM。
T6200	Ledipasvir GS-5885,雷迪帕韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。
T4544	Elbasvir MK-8742	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Elbasvir (MK-8742) 是丙型肝炎病毒的非结构蛋白 5A 抑制剂，可用于治疗慢性 HCV 感染。
T68015	Ruzasvir MK8408,MK-8408,MK 8408	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ruzasvir (MK-8408) 是一种新型有效的丙型肝炎病毒NS5A的泛基因型抑制剂，具有抗病毒活性。
T10493	Beclabuvir BMS-791325	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Beclabuvir (BMS-791325) 是一种高效的 NS5A 复制复合物抑制剂，抑制 HCV 基因型 1，2，4，5 表达的 NS5B 蛋白活性，可用于研究 HCV 感染。
T4203	Ledipasvir (acetone) Ledipasvir acetone,雷迪帕韦单丙酮溶剂化物,GS-5885 acetone,雷迪帕韦单丙酮	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ledipasvir (acetone) (GS-5885 acetone) 是 Ledipasvir 的活性药物成分。Ledipasvir 是一种 HCV NS5A 聚合酶抑制剂，用于治疗丙型肝炎病毒感染。
T24480	MK-8325 MK 8325,MK8325	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	MK-8325是一种有效且可口服的HCV NS5A 抑制剂，对多种基因型具有复制活性。MK-8325在体外和体内试验显示生物利用度且具有良好的总体ADME 特征。
T3334	Velpatasvir GS-5816,维帕他韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T7158	Ombitasvir 奥比他韦,ABT-267	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Ombitasvir (ABT-267) 是丙型肝炎病毒非结构蛋白 5A 的口服生物可利用的强效抑制剂。对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，对基因型 6a 的 EC50 为 366 pM。
T11548L	HCV-IN-7 hydrochloride	Others	Others
	HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.
T11548	HCV-IN-7	Others	Others
	HCV-IN-7 is an orally active and potent pan-genotypic HCV NS5A inhibitor (IC50s: 3-47 pM). It shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake.
T30262	AZD-7295 A 831,A-831,AZD7295,A831	Others	Others
	AZD-7295 (A-689) is an NS5A inhibitor that may be used to treat HCV infection.
T24475	MK-4882 MK 4882,MK4882	Others	Others
	MK-4882 is an effective inhibitor of HCV NS5A.
T70731	Odalasvir	Others	Others
	Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C.
T27461	GSK2336805 GSK 2336805,GSK-2336805,JNJ-56914845,GSK-805,GSK805	Others	Others
	GSK-2336805 is a HCV NS5A inhibitor. GSK2336805 retained activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6.
T38858	GSK2818713	Others	Others
	GSK2818713 is a novel Hepatitis C NS5A replication complex inhibitor.
T71964	Ravidasvir HCl	Others	Others
	Ravidasvir, also known as PPI-668 and ASC16, is a second-generation, orally active, potent and selective HCV NS5A protein inhibitor.
T11832	Ledipasvir D-tartrate GS-5885 D-tartrate,雷迪帕韦 D-酒石酸	Others	Others
	Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.
T74589	Yimitasvir	Others	Others
	Yimitasvir (Emitasvir) 是一种口服活性丙肝病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂，用于慢性丙型肝炎病毒感染研究。
T78669	(1R,4S)-Yimitasvir diphosphate (1R,4S)-DAG-181 diphosphate,(1R,4S)-Emitasvir diphosphate	Others	Others
	Yimitasvir (Emitasvir) diphosphate是一口服活性HCV NS5A抑制剂，适用于研究慢性丙型肝炎病毒感染。
T37915	Monodes(N-carboxymethyl)valine Daclatasvir	Others	Others
	Monodes(N-carboxymethyl)valine Daclatasvir, also known as Daclatasvir Impurity A, is the principal degradation product of Daclatasvir.Daclatasvir is a potent inhibitor of the HCV NS5A protein[1].
T74007	Daclatasvir Impurity C	Others	Others
	Daclatasvir Impurity C 是 Daclatasvir 的一种杂质。Daclatasvir 是一种有效的 HCVNS5A 蛋白抑制剂。
T24476	MK-6169 MK6169	Others	Others
	MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.
T74588	Yimitasvir diphosphate	Others	Others
	Yimitasvir (Emitasvir) diphosphate，一种针对丙型肝炎病毒(HCV)非结构蛋白5A (NS5A)的口服活性抑制剂，适用于慢性丙型肝炎病毒感染的研究。
T74006	Daclatasvir Impurity B	Others	Others
	Daclatasvir Impurity B为Daclatasvir杂质之一，后者为一种高效的HCV NS5A蛋白抑制剂。
T27125	DBPR-110 MB110,MB 110,MB-110	Others	Others
	DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with
T76524	Hepatitis C Virus S5A/5B
	Hepatitis C Virus S5A/5B是一种合成肽底物，模拟非结构蛋白(NS)的NS5A/5B连接，用于研究HCVNS3蛋白酶活性。
T71085	BMS-824	Others	Others
	BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
TP1468	HCV-IN-4
	HCV-IN-4, a potent and orally active inhibitor of HCV NS5A, demonstrates significant efficacy against genotypes GT1a, GT2b, GT3a, and the GT1a mutations Y93H and L31V. Its half-maximal effective concentrations (EC90s) are 3 pM, 0.3 nM, 0.01 nM, 0.5 nM, and 0.02 nM, respectively[1].
T75241	Ledipasvir hydrochloride GS-5885 hydrochloride	Others	Others
	Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂，对GT1a 和 GT1b 复制子抑制作用显著，其EC50值仅为34 pM 和 4 pM。此外，Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro， IC50 为1.62 μM。
T63090	SMCypI C31	Others	Others
	SMCypIC31 是一种非肽类 cyclophilin 抑制剂，能够有效抑制肽基-脯氨酰顺/反异构酶 (PPIase) (IC50: 0.1 μM)。SMCypI C31 可以破坏亲环蛋白 A-NS5A 相互作用。SMCypI C31 具有泛基因型抗 HCV 效果，对基因型 1a，1b，2a，3a 和 5a HCV-SGRs 和嵌合基因型 2a/4a HCV-SGRs 的 EC50 范围为 1.20-7.76 μM。

化合物

Cat.No: T73834

Target: HCV Protease

Cat.No: T74403

Target: Others

Cat.No: T73223

Target: HCV Protease

Cat.No: T74495

Target: Others

Cat.No: T11541

Target: Others, HCV Protease

Cat.No: T9567

Synonym: ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719

Target: HCV Protease

Coblopasvir dihydrochloride

Cat.No: T25268L

Synonym: Coblopasvir dihydrochloride(1312608-46-0 Free base)

Target: HCV Protease

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

Daclatasvir dihydrochloride

Cat.No: T1786

Synonym: BMS-790052 dihydrochloride,盐酸达拉他韦

Target: HCV Protease

Cat.No: T25268

Target: Others

Cat.No: T5127

Synonym: ABT 530,ABT-530,哌仑他韦,Pibrentasvir

Target: HCV Protease

Cat.No: T6200

Synonym: GS-5885,雷迪帕韦

Target: HCV Protease, SARS-CoV

Cat.No: T4544

Synonym: MK-8742

Target: HCV Protease

Cat.No: T68015

Synonym: MK8408,MK-8408,MK 8408

Target: HCV Protease

Cat.No: T10493

Synonym: BMS-791325

Target: HCV Protease

Ledipasvir (acetone)

Cat.No: T4203

Synonym: Ledipasvir acetone,雷迪帕韦单丙酮溶剂化物,GS-5885 acetone,雷迪帕韦单丙酮

Target: HCV Protease

Cat.No: T24480

Synonym: MK 8325,MK8325

Target: HCV Protease

Cat.No: T3334

Synonym: GS-5816,维帕他韦

Target: HCV Protease, SARS-CoV

Cat.No: T7158

Synonym: 奥比他韦,ABT-267

Target: HCV Protease

HCV-IN-7 hydrochloride

Cat.No: T11548L

Target: Others

Cat.No: T11548

Target: Others

Cat.No: T30262

Synonym: A 831,A-831,AZD7295,A831

Target: Others

Cat.No: T24475

Synonym: MK 4882,MK4882

Target: Others

Cat.No: T70731

Target: Others

Cat.No: T27461

Synonym: GSK 2336805,GSK-2336805,JNJ-56914845,GSK-805,GSK805

Target: Others

Cat.No: T38858

Target: Others

Cat.No: T71964

Target: Others

Ledipasvir D-tartrate

Cat.No: T11832

Synonym: GS-5885 D-tartrate,雷迪帕韦 D-酒石酸

Target: Others

Cat.No: T74589

Target: Others

(1R,4S)-Yimitasvir diphosphate

Cat.No: T78669

Synonym: (1R,4S)-DAG-181 diphosphate,(1R,4S)-Emitasvir diphosphate

Target: Others

Monodes(N-carboxymethyl)valine Daclatasvir

Cat.No: T37915

Target: Others

Daclatasvir Impurity C

Cat.No: T74007

Target: Others

Cat.No: T24476

Synonym: MK6169

Target: Others

Yimitasvir diphosphate

Cat.No: T74588

Target: Others

Daclatasvir Impurity B

Cat.No: T74006

Target: Others

Cat.No: T27125

Synonym: MB110,MB 110,MB-110

Target: Others

Hepatitis C Virus S5A/5B

Cat.No: T76524

Cat.No: T71085

Target: Others

Cat.No: TP1468

Ledipasvir hydrochloride

Cat.No: T75241

Synonym: GS-5885 hydrochloride

Target: Others

Cat.No: T63090

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN3809	Dehydrojuncusol	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure.

天然产物

Dehydrojuncusol

Cat.No: TN3809

Target: HCV Protease

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) NS3	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t...

重组蛋白

Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)

Cat.No: TMPY-00323

Species: HCV

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0297	Ledipasvir-d6
	Ledipasvir-d6 是 Ledipasvir 的氘代化合物。Ledipasvir 的 CAS 号为 1256388-51-8。Ledipasvir 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。

同位素标记化合物

Cat.No: TMIH-0297

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