2
1
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5196 |
DIM-C-pPhCO2Me
|
Others | Others |
DIM-C-pPhCO2Me 是一种核受体 4A1 拮抗剂,具有抗肿瘤作用。 | |||
T4400 |
DIM-C-pPhOH
CDIM8 |
Apoptosis; Others | Apoptosis; Others |
DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂,可降低细胞增殖,对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导,诱导细胞凋亡和细胞应激。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3976 |
Cytosporone B
Csn-B,Dothiorelone G |
Others | Others |
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01796 |
NR4A1 Protein, Human, Recombinant (His & Myc)
ST-59,NR4A1,Nuclear hormone receptor NUR/7... |
Human | E. coli |
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expre... | |||
TMPH-02733 |
IFI27L2A Protein, Mouse, Recombinant (His)
Interferon-stimulated gene 12 protein,Ifi27l2a,Interferon al... |
Mouse | E. coli |
May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors. Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury. IFI27L2A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 7.3 kDa and the accession number is Q8R412. |