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Targets Recommended: GPR

298

抑制剂 & 化合物

22

天然产物

1

化合物库

9

重组蛋白

13

同位素标记化合物

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Cat. No.	Product Name
L8700	铁死亡化合物库		779 compounds
	779 种与铁死亡通路相关的化合物，可用于高通量和高内涵筛选；

化合物库

铁死亡化合物库

Cat.No: L8700

Compounds: 779

Cat. No.	Product Name	Target	Signaling Pathways
T83972	NOX-6-18 GPR132 antagonist 1,GPR132-B-160	GPR	Endocrinology/Hormones; GPCR/G Protein
	NOX-6-18 (GPR132-B-160) 是一种具有高效性和选择性的 GPR132 拮抗剂，具有促进胰岛素分泌活性，可以调节胰岛内的巨噬细胞重编程，减少体重增加。
T73718	MDCG sodium NOX 100 sodium,N-methyl-N-dithiocarboxyglucamine sodium	Endogenous Metabolite	Metabolism
	MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) 是一种金属螯合剂，可促进Cd的胆道排泄。
T33716	Norathiol NOX-100,NOX100,NOX 100	Endogenous Metabolite	Metabolism
	Norathiol (N-methyl-N-dithiocarboxyglucamine) 是一种镉中毒解毒剂，也是一种金属螯合剂，可促进 109Cd 的排泄，可以用于治疗镉中毒。
T4359	VAS2870	NADPH	Metabolism
	VAS2870 是一种NADPH 氧化酶抑制剂。
T8107	GLX351322	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GLX351322 抑制 NADPH 氧化酶 4 (Nox4) 。在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50值为 5 μM。
T15433	GSK2795039	Apoptosis; Reactive Oxygen Species; ROS; NADPH	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	GSK2795039 是一种 NADPH 氧化酶 2 抑制剂，可抑制活性氧产生和 NADPH 消耗，同时可减少细胞凋亡。
T6099	Setanaxib GKT137831	NADPH-oxidase; Ferroptosis; NADPH	Apoptosis; Immunology/Inflammation; Metabolism
	Setanaxib (GKT137831) 是一种有效的特异性双重 NADPH 氧化酶 (NOX1/4) 抑制剂，Ki 分别为140和110nM。
T22990	ML-090 Fluoflavine	NADPH-oxidase; Others	Immunology/Inflammation; Others
	ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM)，对 NOX1 的特异性高于 NOX2、NOX3、NOX4（所有 IC50 > 10 μM）100倍。
T68796	Thr101	Others	Others
	Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor.
T7191	Diphenyleneiodonium chloride 二苯基氯化碘盐,DPI	NOS; Reactive Oxygen Species; NADPH; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂，也是 TRPA1激活剂，EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T81647	NOX2-IN-2	Others	Others
	NOX2-IN-2（化合物33）作为一种高效的NOX2抑制剂，其作用机制是针对p47phox-p22phox的蛋白-蛋白相互作用，具有0.24 μM的Ki值。该化合物能够抑制NOX2在细胞内产生的ROS。
T81648	NOX2-IN-1	Others	Others
	NOX2-IN-1 是 NOX2 (烟酰胺腺嘌呤二核苷酸磷酸氧化酶异构体 2) 的抑制剂。该化合物旨在针对 p47phox-p22phox 蛋白间相互作用，展现出优秀的结合亲和力及细胞活性。
T10353	APX-115 free base Ewha-18278 free base	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T1586	Tenoxicam Ro-12-0068,替诺昔康,Tenoxicamum,Mobiflex,Tilcotil	COX	Immunology/Inflammation; Neuroscience
	Tenoxicam (Tilcotil) 是一种抗炎化合物，具有退热止痛作用。
T25944	Phenoxyacetone 苯氧乙酮,NSC-1876,NSC 1876,NSC1876	Others	Others
	Phenoxyacetone (NSC-1876) 可抑制乙酰胆碱酯酶。
T50115	3-phenoxy-8-azabicyclo[3.2.1]octane HCl	Others	Others
	3-phenoxy-8-azabicyclo[3.2.1]octane hydrochloride 是一种合成化合物，属于氮杂双环辛烷类。它是多巴胺D2受体的强效和选择性激动剂，被广泛用于研究多巴胺信号传导的机制及其在各种生理和病理过程中的作用。
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid 3,5-二(4-硝基苯氧基)苯甲酸,Compound W	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) 是 γ-secretase 抑制剂。它导致 Aβ42 和 notch-1 Aβ-like peptide 25 (Nβ25) 的释放水平降低。它是母体血清中 3,3’-diiodothyronine sulfate (T2S) 的交叉反应物质，可作为胎儿甲状腺功能减退的标志物。
T5200	Indirubin-3'-monoxime 靛玉红-3' -单肟,Indirubin-3'-oxime	GSK-3; Lipoxygenase; CDK	Cell Cycle/Checkpoint; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3'-monoxime (Indirubin-3'-oxime) 是一种有效的 GSK3β 抑制剂，IC50值为 22 nM。它对 CDK5/p25、CDK1/cyclin B 和CDk2/cyclin E 也有作用，IC50值分别为 100、180 和 250 nM。
T0274	Cinoxacin 西诺沙星,Compound 64716	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Cinoxacin (Compound 64716) 是一种喹诺酮类的合成抗生素, 与Oxolinic acid 和 Nalidixic acid 活性相似。
T16961	Supinoxin RX-5902	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂，是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长，IC50的范围为 10 nM 至 20 nM。
T2222	Carbinoxamine Maleate Salt Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Carbinoxamine Maleate Salt (Lergefin) 是一种乙醇胺类 H1 抗组胺药，具有温和的抗毒蕈碱和镇静作用。
T3431	Pardoprunox hydrochloride SLV-308 hydrochloride,DU-126891 hydrochloride,帕多芦诺盐酸盐	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Pardoprunox hydrochloride (SLV-308 hydrochloride) 是多巴胺受体 D2、D3部分激动剂和5-HT1A 激动剂，pEC50分别为 8、9.2 和 6.3。
T68166	Traxanox	Others	Others
	Traxanox 是一种可口服的利尿剂。Traxanox 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox 对抑制BALB/c小鼠抗体产生的恢复作用。
T7564	Chlorphenoxamine Contristamine,氯苯沙明	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Chlorphenoxamine (Contristamine) 是一种抗组胺药和抗胆碱能药，用作止痒药和抗帕金森病药。
T14955	Chlorthenoxazine 氯西诺嗪,Chlorethylbenzmethoxazone	Immunology/Inflammation related	Immunology/Inflammation
	Chlorthenoxazine (Chlorethylbenzmethoxazone) 是非甾体抗炎药。
T33479	Monoxerutin Z 12007,MonoHER,7-Monohydroxyethylrutosid	Antioxidant	oxidation-reduction
	Monoxerutin (MonoHER) 是一种血管扩张剂，具有抗氧化活性，可防止阿霉素诱导的小鼠心脏毒性，可用于研究急性呼吸系统综合征。
T20672	Quinoxyfen DE-795,DE795,Legend,DE 795	Antifungal	Microbiology/Virology
	Quinoxyfen 具有抗菌活性，可用用于研究白粉病。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T68161L	Tienoxolol FA Tienoxolol FA (90055-97-3 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tienoxolol FA 是一种小分子 β-肾上腺素能受体拮抗剂，可用于治疗心血管疾病和研究高血压、心机缺血。
T16522	Phenoxodiol 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E	Apoptosis; IAP; Caspase; Topoisomerase; p53	Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
	Phenoxodiol (Idronoxil) 是合成genestein 的类似物，激活线粒体caspase 系统，抑制XIAP，使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II，从而阻止DNA 复制。
T20293	Phenoxyethanol NSC 1864,乙二醇苯醚,NSC-1864,NSC1864	Others; Antibacterial	Microbiology/Virology; Others
	Phenoxyethanol (NSC-1864) 是广谱抗菌剂，被用作化妆品、疫苗和纺织品中的防腐剂。它是呼吸作用氧化磷酸化的解偶联剂，竞争性地抑制苹果酸脱氢酶。
T1190	Cefmenoxime hydrochloride Cefmenoxime hemihydrochloride,SCE-1365 hemihydrochloride,盐酸头孢甲肟	Antibacterial; Antibiotic; Antifection	Microbiology/Virology
	Cefmenoxime hydrochloride (Cefmenoxime hemihydrochloride) 是一种头孢类抗生素，可通过静脉内或肌肉内给药。它对大多数常见的革兰氏阳性和革兰氏阴性微生物有活性，是一种肠杆菌科抑制剂，并且对 β-内酰胺酶的水解具有高度抗性。
T0917	Sulfaquinoxaline sodium salt SQ-Na,磺胺喹恶啉钠盐,Sulfaquinoxaline sodium,磺胺喹啉钠	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Sulfaquinoxaline sodium salt (SQ-Na) 是一种兽用广谱抗菌剂，有抗革兰氏阴性菌和革兰氏阳性菌活性。Sulfaquinoxaline 能用于预防球虫病和细菌感染。
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	SC-1 是一种 Sorafenib 的衍生物，可抑制 STAT3磷酸化，通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡，具有抗癌作用。
T19633	Ionox 330 Antioxidant 40,BRN 2034522,Ahydol,Antioxidant 330,抗氧剂 330,AO-40	Others	Others
	Ionox 330 (Ahydol) 是一种用作抗氧化剂的烷基酚化合物。
T64388	3-Phenoxybenzaldehyde	Complement System	Immunology/Inflammation
	3-Phenoxybenzaldehyde 是补体经典途径抑制剂，IC50= 1388μM。
T27417L	Glutathione arsenoxide hydrochloride GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)	Apoptosis; AChR	Apoptosis; Neuroscience
	Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) 是一种潜在的抗癌活性分子和肿瘤代谢抑制剂。Glutathione arsenoxide hydrochloride 靶向线粒体内膜腺嘌呤核苷酸转移酶 (ANT)，对细胞增殖有抑制作用，促进细胞凋亡。Glutathione arsenoxide hydrochloride 可用于识别如蛋白质二硫异构酶一样的细胞表面蛋白质。
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)	NADPH-oxidase	Immunology/Inflammation
	NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T9434	3-Phenoxybenzaldehyde cyanohydrin 三苯氧基苯甲醛,2-Hydroxy-2-(3-phenoxyphenyl)acetonitrile	Others	Others
	3-Phenoxybenzaldehyde cyanohydrin (2-Hydroxy-2-(3-phenoxyphenyl)acetonitrile) 是拟除虫菊酯类杀虫剂如氯菊酯的中间体。
T50113	(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid	Others	Others
	(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid 可用于化学和生命科学领域的研究。
T20824	Cyanox CY 1790 Lowinox 1790,Irganox 3790,抗氧化剂 TH-1790,Antioxidant 1790,Irganox-3790,DN 90	Others	Others
	Cyanox CY 1790 (Irganox-3790) 是一种具有抗氧化活性的试剂。
T0717	Enoxacin hydrate CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Enoxacin hydrate (AT-2266 hydrate) 是氟喹诺酮，可干扰DNA 复制，抑制细菌 DNA 促旋酶 (IC50=126 µg/ml) 和拓扑异构酶 IV (IC50=26.5 µg/ml)。它是特异性癌症生长抑制剂，抑制革兰氏阳性和阴性细菌。
T10459	Banoxantrone dihydrochloride AQ4N dihydrochloride,AZD1689 2HCl	NOS	Immunology/Inflammation
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。
T9058	Bisphenoxyethanolfluorene	Others	Others
	Bisphenoxyethanolfluorene 是一种高稳定性的新型有机化工原料，主要用于合成耐热、透明性和高折射率的高分子单体。
T1639	Amlexanox 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673	IL Receptor; FGFR; Others; IκB/IKK	Angiogenesis; Immunology/Inflammation; NF-κB; Others; Tyrosine Kinase/Adaptors
	Amlexanox (AA673) 是一种特异性的 IKKε和 TBK1抑制剂，其 IC50=1-2 μM。
T19679	Benoxaprofen 氧苯恶唑丙酸,NSC 299582,LY-90459,Benoxaphen. Compound 90459	COX	Immunology/Inflammation; Neuroscience
	Benoxaprofen (NSC-299582) 是长效的、强效的抗炎和解热化合物，在体外具有较弱的对环氧合酶的抑制作用，也可以抑制脂氧合酶，在一些炎症动物模型中抑制单核细胞迁移。
T5938	4-Phenoxybenzylamine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能，对 HCV NS3/4a 的 IC50 约为 500 μM。
T1401	Meclofenoxate hydrochloride Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl	Lipoxygenase; COX; AChR; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Meclofenoxate hydrochloride (Lucidril) 是二甲基氨基乙醇和对氯苯氧乙酸的酯，有刺激记忆和提高认知的活性。
T3263	(6R,7S)-Cefminox sodium heptahydrate Meicelin,头孢米诺钠,Cefminox Sodium,Alteporina,Tencef	Antibiotic	Microbiology/Virology
	(6R,7S)-Cefminox sodium heptahydrate (Meicelin) 是一种 Cefminox sodium heptahydrate 的异构体。它也是一种具有广谱抗菌活性的 β-内酰胺头孢菌素抗生素。

化合物

Cat.No: T83972

Synonym: GPR132 antagonist 1,GPR132-B-160

Target: GPR

Cat.No: T73718

Synonym: NOX 100 sodium,N-methyl-N-dithiocarboxyglucamine sodium

Target: Endogenous Metabolite

Cat.No: T33716

Synonym: NOX-100,NOX100,NOX 100

Target: Endogenous Metabolite

Cat.No: T4359

Target: NADPH

Cat.No: T8107

Target: NADPH-oxidase, NADPH

Cat.No: T15433

Target: Apoptosis, Reactive Oxygen Species, ROS, NADPH

Cat.No: T6099

Synonym: GKT137831

Target: NADPH-oxidase, Ferroptosis, NADPH

Cat.No: T22990

Synonym: Fluoflavine

Target: NADPH-oxidase, Others

Cat.No: T68796

Target: Others

Diphenyleneiodonium chloride

Cat.No: T7191

Synonym: 二苯基氯化碘盐,DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Cat.No: T81647

Target: Others

Cat.No: T81648

Target: Others

APX-115 free base

Cat.No: T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Cat.No: T1586

Synonym: Ro-12-0068,替诺昔康,Tenoxicamum,Mobiflex,Tilcotil

Target: COX

Cat.No: T25944

Synonym: 苯氧乙酮,NSC-1876,NSC 1876,NSC1876

Target: Others

3-phenoxy-8-azabicyclo[3.2.1]octane HCl

Cat.No: T50115

Target: Others

3,5-Bis(4-nitrophenoxy)benzoic acid

Cat.No: T22678

Synonym: 3,5-二(4-硝基苯氧基)苯甲酸,Compound W

Target: Gamma-secretase

Indirubin-3'-monoxime

Cat.No: T5200

Synonym: 靛玉红-3' -单肟,Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

Cat.No: T0274

Synonym: 西诺沙星,Compound 64716

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T16961

Synonym: RX-5902

Target: Apoptosis, DNA/RNA Synthesis

Carbinoxamine Maleate Salt

Cat.No: T2222

Synonym: Lergefin,马来酸罗托沙敏,CarbinoxaMine Maleate

Target: Histamine Receptor

Pardoprunox hydrochloride

Cat.No: T3431

Synonym: SLV-308 hydrochloride,DU-126891 hydrochloride,帕多芦诺盐酸盐

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T68166

Target: Others

Chlorphenoxamine

Cat.No: T7564

Synonym: Contristamine,氯苯沙明

Target: Histamine Receptor

Chlorthenoxazine

Cat.No: T14955

Synonym: 氯西诺嗪,Chlorethylbenzmethoxazone

Target: Immunology/Inflammation related

Cat.No: T33479

Synonym: Z 12007,MonoHER,7-Monohydroxyethylrutosid

Target: Antioxidant

Cat.No: T20672

Synonym: DE-795,DE795,Legend,DE 795

Target: Antifungal

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T68161L

Synonym: Tienoxolol FA (90055-97-3 Free base)

Target: Adrenergic Receptor

Cat.No: T16522

Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Cat.No: T20293

Synonym: NSC 1864,乙二醇苯醚,NSC-1864,NSC1864

Target: Others, Antibacterial

Cefmenoxime hydrochloride

Cat.No: T1190

Synonym: Cefmenoxime hemihydrochloride,SCE-1365 hemihydrochloride,盐酸头孢甲肟

Target: Antibacterial, Antibiotic, Antifection

Sulfaquinoxaline sodium salt

Cat.No: T0917

Synonym: SQ-Na,磺胺喹恶啉钠盐,Sulfaquinoxaline sodium,磺胺喹啉钠

Target: Antibacterial, Antibiotic, Parasite

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

Cat.No: T22424

Target: Apoptosis, STAT

Cat.No: T19633

Synonym: Antioxidant 40,BRN 2034522,Ahydol,Antioxidant 330,抗氧剂 330,AO-40

Target: Others

3-Phenoxybenzaldehyde

Cat.No: T64388

Target: Complement System

Glutathione arsenoxide hydrochloride

Cat.No: T27417L

Synonym: GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)

Target: Apoptosis, AChR

NoxA1ds acetate(1435893-78-9 free base)

Cat.No: TP1886L1

Target: NADPH-oxidase

3-Phenoxybenzaldehyde cyanohydrin

Cat.No: T9434

Synonym: 三苯氧基苯甲醛,2-Hydroxy-2-(3-phenoxyphenyl)acetonitrile

Target: Others

(4R)-3-[2-(4-chlorophenoxy)-2-methylpropanoyl]-1,3-thiazolidine-4-carboxylic acid

Cat.No: T50113

Target: Others

Cat.No: T20824

Synonym: Lowinox 1790,Irganox 3790,抗氧化剂 TH-1790,Antioxidant 1790,Irganox-3790,DN 90

Target: Others

Enoxacin hydrate

Cat.No: T0717

Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,依诺沙星半水合物,AT-2266 hydrate,依诺沙星倍半水合物

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic

Banoxantrone dihydrochloride

Cat.No: T10459

Synonym: AQ4N dihydrochloride,AZD1689 2HCl

Target: NOS

Bisphenoxyethanolfluorene

Cat.No: T9058

Target: Others

Cat.No: T1639

Synonym: 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Cat.No: T19679

Synonym: 氧苯恶唑丙酸,NSC 299582,LY-90459,Benoxaphen. Compound 90459

Target: COX

4-Phenoxybenzylamine

Cat.No: T5938

Target: HCV Protease

Meclofenoxate hydrochloride

Cat.No: T1401

Synonym: Meclofenoxate (Centrophenoxine) HCl,Lucidril,盐酸甲氯芬酯,Cerutil,盐酸甲氯酚酯,Meclofenoxate HCl

Target: Lipoxygenase, COX, AChR, iGluR

(6R,7S)-Cefminox sodium heptahydrate

Cat.No: T3263

Synonym: Meicelin,头孢米诺钠,Cefminox Sodium,Alteporina,Tencef

Target: Antibiotic

Cat. No.	Product Name	Target	Signaling Pathways
T7732	Carbenoxolone Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral	Dehydrogenase; Gap Junction Protein	Cytoskeletal Signaling; Metabolism
	Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。
T5S0658	Corynoxine 柯诺辛,柯诺辛碱	Autophagy	Autophagy
	Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
TN1527	(-)-Corynoxidine Corynoxidine	Antibacterial; AChE; Antifection	Microbiology/Virology; Neuroscience
	(-)-Corynoxidine 是一种源自 Stephania succifera 块茎的 AChE 抑制剂。 Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌具有不同程度的抗菌活性。
T0073	Octinoxate 2-Ethylhexyl 4-methoxycinnamate,ethylhexyl methoxycinnamate,Octyl 4-methoxycinnamate,甲氧基肉桂酸辛酯,Octyl methoxycinnamate,对甲氧基肉桂酸辛酯	Others	Others
	Octyl 4-methoxycinnamate 是一种有机化合物，能够吸收来自太阳的UV-B射线，保护皮肤免受损伤，也可用于减少疤痕的外观，常用于是防晒霜和唇膏等化妆品中。Octinoxate 具有雄激素和雌激素作用。
T9932	2(1H)-Quinoxalinone	Others	Others
	2(1H)-Quinoxalinone 是从 Clitoria ternatea 和 Hibiscus rosa sinensis 等食用花卉中提取的天然产物。
TN3110	5-Geranoxy-7-methoxycoumarin	Anti-infection; Antibacterial; Antifungal	Microbiology/Virology
	5-Geranoxy-7-methoxycoumarin 是一种香豆素。它诱导细胞凋亡，具有抗癌、抗真菌和抗菌活性。
T1468	Lornoxicam Ro 13-9297,Chlortenoxicam,TS110,氯诺昔康	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	Lornoxicam (Chlortenoxicam) 是一种新型非甾体抗炎药，是高活性 COX-1 和 COX-2 抑制剂，IC50 分别为 5 和 8 nM。
T7932	[(2-Methoxyphenoxy)Methyl]Oxirane	Others	Others
	[(2-Methoxyphenoxy)Methyl]Oxirane 是一种天然产物。
T6S0655	Corynoxeine	ERK	MAPK
	Corynoxeine 是从钩藤中分离的一种天然产物，是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的 ERK1/ERK2抑制剂。
T9894	2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate	Others	Others
	2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate 是一种天然产物，可作为参考标准。
T5143	Corynoxine hydrochloride(6877-32-3(free base))	Autophagy	Autophagy
	Corynoxine hydrochloride(6877-32-3(free base)) 是一种天然羟吲哚生物碱，可在不同的神经元细胞系（包括 N2a 和 SHSY-5Y 细胞）中诱导自噬。
TQ0258	Corynoxine B 柯诺辛碱 B,柯诺辛碱B	Autophagy	Autophagy
	Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese).
T75438	Corynoxine hydrochloride	Others	Others
	Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。
TN1607	Epicorynoxidine	Others	Others
	Epicorynoxidine 是一种从 Corydalis tashiroi 植物中提取的生物碱。
TN3801	methoxyphenoxy]oxane-3,4,5-triol Dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside	Others	Others
	Dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside is a natural product from Ligusticopsis wallichiana (DC) Pimenov & Kljuykov.
T10010	1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol	Others	Others
	1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol is an endogenous metabolite.
T19091	2-(2',3',4'-Trihydroxybutyl)quinoxaline	Others	Others
	2-(2',3',4'-Trihydroxybutyl)quinoxaline is a food metabolite.
T81458	Pinofuranoxin A
	Pinofuranoxin A 对Athelia rolfsii和Phytophthora cambivora的生长展现出了完全抑制效果。
T35359	3-Phenoxybenzoic acid 3-Phenoxybenzoic acid,m-phenoxybenzoic acid,3-PBA	Others	Others
	3-phenoxybenzoic acid (3-PBA) 是拟除虫菊酯的中间代谢产物，比其母体化合物毒性更高，并已在牛奶、土壤和人类尿液中检测到。
T3834	8-Epideoxyloganic acid 8-表去氧马钱酸	ROS; Immunology/Inflammation related	Immunology/Inflammation
	8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。

天然产物

Cat.No: T7732

Synonym: Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral

Target: Dehydrogenase, Gap Junction Protein

Cat.No: T5S0658

Synonym: 柯诺辛,柯诺辛碱

Target: Autophagy

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

(-)-Corynoxidine

Cat.No: TN1527

Synonym: Corynoxidine

Target: Antibacterial, AChE, Antifection

Cat.No: T0073

Synonym: 2-Ethylhexyl 4-methoxycinnamate,ethylhexyl methoxycinnamate,Octyl 4-methoxycinnamate,甲氧基肉桂酸辛酯,Octyl methoxycinnamate,对甲氧基肉桂酸辛酯

Target: Others

2(1H)-Quinoxalinone

Cat.No: T9932

Target: Others

5-Geranoxy-7-methoxycoumarin

Cat.No: TN3110

Target: Anti-infection, Antibacterial, Antifungal

Cat.No: T1468

Synonym: Ro 13-9297,Chlortenoxicam,TS110,氯诺昔康

Target: COX, Endogenous Metabolite

[(2-Methoxyphenoxy)Methyl]Oxirane

Cat.No: T7932

Target: Others

Cat.No: T6S0655

Target: ERK

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

Cat.No: T9894

Target: Others

Corynoxine hydrochloride(6877-32-3(free base))

Cat.No: T5143

Target: Autophagy

Cat.No: TQ0258

Synonym: 柯诺辛碱 B,柯诺辛碱B

Target: Autophagy

Corynoxine hydrochloride

Cat.No: T75438

Target: Others

Epicorynoxidine

Cat.No: TN1607

Target: Others

methoxyphenoxy]oxane-3,4,5-triol

Cat.No: TN3801

Synonym: Dehydrodiconiferyl alcohol 4-O-beta-D-glucopyranoside

Target: Others

1-(2-Quinoxalinyl)-1,2,3,4-butanetetrol

Cat.No: T10010

Target: Others

2-(2',3',4'-Trihydroxybutyl)quinoxaline

Cat.No: T19091

Target: Others

Pinofuranoxin A

Cat.No: T81458

3-Phenoxybenzoic acid

Cat.No: T35359

Synonym: 3-Phenoxybenzoic acid,m-phenoxybenzoic acid,3-PBA

Target: Others

8-Epideoxyloganic acid

Cat.No: T3834

Synonym: 8-表去氧马钱酸

Target: ROS, Immunology/Inflammation related

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01276	ENOX1 Protein, Human, Recombinant (His) Ecto-NOX disulfide-thiol exchanger 1,ENOX1...	Human	E. coli
	Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.
TMPJ-00848	NCF1 Protein, Human, Recombinant (His) Nox-organizing protein 2/SH3 and PX domain-containi...	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and ...
TMPH-01277	ENOX2 Protein, Human, Recombinant ENOX2,APK1 antigen,Cytosolic ovarian carcinoma anti...	Human	E. coli
	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPH-01278	ENOX2 Protein, Human, Recombinant (His & Myc) Cytosolic ovarian carcinoma antigen 1,Ecto-NOX disu...	Human	E. coli
	May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biol...
TMPH-01744	NOX1 Protein, Human, Recombinant (His) NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH oxidase 1...	Human	E. coli
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t...
TMPH-01745	NOX4 Protein, Human, Recombinant (Cell-Free, His) NOX4,Kidney oxidase-1,Renal NAD(P)H-oxidase,Kidney ...	Human	E. coli
	NOX4 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 69.8?kDa and the accession number is Q9NPH5.
TMPH-01746	NOX4 Protein, Human, Recombinant (E. coli, His) Kidney superoxide-producing NADPH oxidase,NOX4,NADP...	Human	E. coli
	NOX4 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q9NPH5.
TMPH-00361	Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) Toxin 2,Beta-mammal toxin Cn2,Toxin II.9.2.2	Centruroides noxius	P. pastoris (Yeast)
	Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals. Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.6 kDa and the accession number is P01495.
TMPY-02391	SUMO1 Protein, Human, Recombinant (His) small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP2...	Human	E. coli
	Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act...

重组蛋白

ENOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01276

Species: Human

Expression System: E. coli

NCF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00848

Species: Human

Expression System: E. coli

ENOX2 Protein, Human, Recombinant

Cat.No: TMPH-01277

Species: Human

Expression System: E. coli

ENOX2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01278

Species: Human

Expression System: E. coli

NOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01744

Species: Human

Expression System: E. coli

NOX4 Protein, Human, Recombinant (Cell-Free, His)

Cat.No: TMPH-01745

Species: Human

Expression System: E. coli

NOX4 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01746

Species: Human

Expression System: E. coli

Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His)

Cat.No: TMPH-00361

Species: Centruroides noxius

Expression System: P. pastoris (Yeast)

SUMO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02391

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T19201	Banoxantrone-d12 dihydrochloride AQ4N D12 dihydrochloride	Others	Others
	Banoxantrone D12 (AQ4N D12) dihydrochloride is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.
TMIH-0418	Ozenoxacin-d3
	Ozenoxacin-d3 是 Ozenoxacin 的氘代化合物。Ozenoxacin 的 CAS 号为 245765-41-7。Ozenoxacin是一种新型喹诺酮类抗生素，能够抵抗大多数从在皮肤和软组织感染中分离的微生物。
TMIJ-0027	3-Methyl-2-quinoxalinecarboxylic Acid-d4 MQCA-d4
	3-Methyl-2-quinoxalinecarboxylic Acid-d4 是 3-Methyl-2-quinoxalinecarboxylic Acid 的氘代化合物。3-Methyl-2-quinoxalinecarboxylic Acid 的 CAS 号为 74003-63-7。3-Methyl-2-quinoxalinecarboxylic acid 在生命科学相关研究中具有广泛的应用。
TMID-0030	4-Bromophenoxybenzene-d5
	4-Bromophenoxybenzene-d5 是 4-Bromophenoxybenzene 的氘代化合物。4-Bromophenoxybenzene 的 CAS 号为 101-55-3。
TMID-0268	Enoxacin-d8 HCl
	Enoxacin-d8 HCl 是 Enoxacin HCl 的氘代化合物。Enoxacin HCl 的 CAS 号为 74011-31-7。
T10458	Banoxantrone (D12) Banoxantrone D12,AQ4N D12	Others	Others
	Banoxantrone D12 (AQ4N D12) is the deuterium-labeled Banoxantrone. Banoxantrone is a bioreductive agent that can be reduced to a stable, DNA-affinity compound AQ4, which is a topoisomerase II inhibitor.
TMID-0127	MINOXIDIL-d10
	MINOXIDIL-d10 是 MINOXIDIL 的氘代化合物。MINOXIDIL 的 CAS 号为 38304-91-5。Minoxidil 是一种是 ATP 敏感的钾通道 (KATP) 开放剂，可作为有效的口服降压药和外周血管舒张药，促进血管扩张并促进头发的生长。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，IC50为 20 μM。
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
TMID-0054	2-Quinoxalinecarboxylic acid-d4
	2-Quinoxalinecarboxylic acid-d4 是 2-Quinoxalinecarboxylic acid 的氘代化合物。2-Quinoxalinecarboxylic acid 的 CAS 号为 879-65-2。
TMIH-0542	Sulfaquinoxaline-d4
	Sulfaquinoxaline-d4 是 Sulfaquinoxaline 的氘代化合物。
TMIJ-0433	2,4,5-Trichlorophenoxyacetic Acid-d4
	2,4,5-Trichlorophenoxyacetic Acid-d4 是 2,4,5-Trichlorophenoxyacetic Acid 的氘代化合物。2,4,5-Trichlorophenoxyacetic Acid 的 CAS 号为 93-76-5。
TMIH-0230	Ezetimibe-d4 Phenoxy ß-D-Glucuronide Ezetimibe Phenoxy Glucuronide-d4
	Ezetimibe-d4 Phenoxy ß-D-Glucuronide 是 Ezetimibe Phenoxy ß-D-Glucuronide 的氘代化合物。Ezetimibe Phenoxy ß-D-Glucuronide 的 CAS 号为 190448-57-8。
TMID-0272	Cinoxacino-d8
	Cinoxacino-d8 是 Cinoxacino 的氘代化合物。Cinoxacino 的 CAS 号为 28657-80-9。Cinoxacin是一种喹诺酮类的合成抗生素, 与Oxolinic acid和 Nalidixic acid活性相似。

同位素标记化合物

Banoxantrone-d12 dihydrochloride

Cat.No: T19201

Synonym: AQ4N D12 dihydrochloride

Target: Others

Cat.No: TMIH-0418

3-Methyl-2-quinoxalinecarboxylic Acid-d4

Cat.No: TMIJ-0027

Synonym: MQCA-d4

4-Bromophenoxybenzene-d5

Cat.No: TMID-0030

Enoxacin-d8 HCl

Cat.No: TMID-0268

Banoxantrone (D12)

Cat.No: T10458

Synonym: Banoxantrone D12,AQ4N D12

Target: Others

Cat.No: TMID-0127

Cat.No: T71212

2-Quinoxalinecarboxylic acid-d4

Cat.No: TMID-0054

Sulfaquinoxaline-d4

Cat.No: TMIH-0542

2,4,5-Trichlorophenoxyacetic Acid-d4

Cat.No: TMIJ-0433

Ezetimibe-d4 Phenoxy ß-D-Glucuronide

Cat.No: TMIH-0230

Synonym: Ezetimibe Phenoxy Glucuronide-d4

Cat.No: TMID-0272

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