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Search Results for " notch1 "

Targets Recommended: Mitophagy Gamma-secretase HIV Protease GABA Receptor HDAC Autophagy

8

抑制剂 & 化合物

2

天然产物

8

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T6474	Divalproex Sodium Valproate semisodium,Epival,双丙戊酸钠	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶，其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成，具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
T14680	BMS-906024 Osugacestat,AL-101,BM-0018	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS-906024 (Osugacestat) 是一种可口服且具有选择性的γ 分泌酶抑制剂，是一种小分子 Notch 抑制剂。BMS-906024 对多种人类癌症异种移植具有广谱抗肿瘤活性。BMS-906024 可阻止所有四种 Notch 受体的激活，对 Notch1、-2、-3 和 -4 受体的 IC50 分别为 1.6、0.7、3.4 和 2.9 nM。
T72984	(Rac)-SHIN2	Others	Others
	(Rac)-SHIN2 是一种丝氨酸羟甲基转移酶 (SHMT) 抑制剂，可提高 NOTCH1 驱动的小鼠原代 T-ALL 在体内的存活率，可用于研究 T 细胞急性淋巴细胞白血病（T-ALL）。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T3633	Crenigacestat LY3039478	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T76785	Brontictuzumab
	Brontictuzumab (OMP 52M51) 是一种针对 Notch1 信号抑制作用的单克隆抗体 (MAb)，其通过选择性结合 Notch1 负调控区域而发挥作用。该化合物有效抑制肿瘤细胞增殖，并被应用于白血病和淋巴瘤的研究中。
T16341	Notch inhibitor 1	Others	Others
	Notch inhibitor 1 is an effective Notch inhibitor (IC50s: 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively). Notch inhibitor 1 is also used in the research of cancer.

化合物

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Divalproex Sodium

Cat.No: T6474

Synonym: Valproate semisodium,Epival,双丙戊酸钠

Target: HDAC

Cat.No: T14680

Synonym: Osugacestat,AL-101,BM-0018

Target: Gamma-secretase

Cat.No: T72984

Target: Others

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

Cat.No: T3633

Synonym: LY3039478

Target: Gamma-secretase

Cat.No: T76785

Notch inhibitor 1

Cat.No: T16341

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3399	Psoralidin	Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial	Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。

天然产物

Cat.No: T3399

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00467	Notch 1 Protein, Human, Recombinant (His & Avi) Notch-1,Mis6,lin-12,99301	Human	HEK293 Cells
	Notch 1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 56.5 kDa and the accession number is P46531.
TMPY-02663	Notch 1 Protein, Mouse, Recombinant (His) Notch1,notch 1,Mis6,Tan<...	Mouse	Baculovirus Insect Cells
	Notch 1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q01705-1.
TMPY-00415	Notch 1 Protein, Mouse, Recombinant (hFc) lin-12,Tan1,Mis6,993011<...	Mouse	CHO Cells
	Notch 1 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 80.6 kDa and the accession number is Q01705-1.
TMPK-00468	Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated lin-12,Mis6,N1,993011	Human	HEK293 Cells
	Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 56.5 kDa and the accession number is P46531.
TMPJ-01452	Notch 1 Protein, Mouse, Recombinant (aa 18-526, His) mT14,Neurogenic locus notch homolog protei...	Mouse	HEK293 Cells
	Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain ...
TMPH-01512	HIF1AN Protein, Human, Recombinant (His) Hypoxia-inducible factor asparagine hydroxylase,Hypoxia-indu...	Human	P. pastoris (Yeast)
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and severa...
TMPK-00360	DLL4 Protein, Human, Recombinant (His & Avi) notch ligand DLL4,MGC126344,δ-like 4,Delta...	Human	HEK293 Cells
	Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibit...
TMPY-03308	ADAM17 Protein, Rat, Recombinant (His) ADAM metallopeptidase domain 17	Rat	HEK293 Cells
	ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1...

重组蛋白

Notch 1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00467

Species: Human

Expression System: HEK293 Cells

Notch 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02663

Species: Mouse

Expression System: Baculovirus Insect Cells

Notch 1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00415

Species: Mouse

Expression System: CHO Cells

Notch 1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00468

Species: Human

Expression System: HEK293 Cells

Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)

Cat.No: TMPJ-01452

Species: Mouse

Expression System: HEK293 Cells

HIF1AN Protein, Human, Recombinant (His)

Cat.No: TMPH-01512

Species: Human

Expression System: P. pastoris (Yeast)

DLL4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00360

Species: Human

Expression System: HEK293 Cells

ADAM17 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03308

Species: Rat

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0120	Valproic Acid-d15
	Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMIJ-0163	Valproic Acid-d4
	Valproic Acid-d4 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。
TMIJ-0431	2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid
	2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid 是 2-pentanoic Acid 的氘代化合物。2-pentanoic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂，可抑制HDAC1的活性，同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。

同位素标记化合物

Valproic Acid-d15

Cat.No: TMID-0120

Valproic Acid-d4

Cat.No: TMIJ-0163

2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid

Cat.No: TMIJ-0431

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