7
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T63088 |
NOD2 antagonist 1
|
Others | Others |
NOD2 antagonist 1 (compound 32) 是一种有效的、选择性的 NOD2 拮抗剂 (IC50: 5.23 μM)。NOD2 antagonist 1 在 THP-1 细胞,对 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌表现出抑制作用。NOD2 antagonist 1 在 PBMCs 细胞,可以抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。 | |||
T38361 |
GSK717
|
IL Receptor; NOD | Immunology/Inflammation; NF-κB |
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。 | |||
T16159 |
Muramyl dipeptide
MDP |
NOD | Immunology/Inflammation; NF-κB |
Muramyl dipeptide (MDP) 是合成的免疫反应肽,由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达,直接促进成骨细胞分化,通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子,也是NLRP1激动剂。 | |||
T3587 |
NOD-IN-1
Compound 4 |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
NOD-IN-1 (Compound 4) 是核苷酸结合寡聚化结构域样受体 NOD1(IC50:5.74 μM)和 NOD2 (IC50:6.45 μM)的抑制剂。 | |||
T72473 |
NOD1/2 antagonist-1
|
Others | Others |
NOD1/2 antagonist-1 是一种有效的NOD1/2双拮抗剂,其IC50值分别为 1.13 (NOD1) 和 0.77 μM (NOD2)。NOD1/2 antagonist-1 有可接受的 T1/2(67.6 min)。NOD1/2 antagonist-1 可提高紫杉醇 (PTX) 的抗肿瘤作用。 | |||
T74089 |
Mifamurtide TFA
|
Others | Others |
Mifamurtide TFA (MTP-PE TFA) 是穆拉基二肽 (MDP) 的类似物,一种非特异性免疫调节剂,通过刺激激活巨噬细胞和单核细胞的免疫应答而发挥作用。Mifamurtide TFA 是一种孤儿药,是 NOD2的特异性配体,用作胰岛素增敏剂。Mifamurtide TFA 具有用于骨肉瘤研究的潜力。 | |||
T62783 |
RIPK2-IN-1
|
Others | Others |
RIPK2-IN-1 (compound 18f) 是一种 RIPK2 的有效抑制剂 (IC50: 51 nM),也能够抑制 ALK2 (IC50: 5 nM)。RIPK2-IN-1 在细胞试验中对 RIPK2/NOD2 的 IC50 为 390 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00289 |
NOD2 Protein, Bovine, Recombinant (His & KSI)
Caspase recruitment domain-containing protein 15,Nucleotide-... |
Bovine | E. coli |
NOD2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 36.8 kDa and the accession number is Q6E804. | |||
TMPH-02521 |
PYCARD Protein, Mouse, Recombinant (His & Myc)
Pycard,PYD and CARD domain-containing protein,Apoptosis-asso... |
Mouse | E. coli |
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ... |