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Search Results for " nmn "

Targets Recommended: Others

3

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13907	Sulfo-ara-F-NMN CZ-48	Others	Others
	Sulfo-ara-F-NMN 是一种具有细胞渗透性的烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 对激活 SARM1具有选择性，对 CD38具有抑制作用， IC50 约为 10 μM。Sulfo-ara-F-NMN 对具有更高的环化酶活性 CZ-48或 NMN 的激活会引起 SARM1的构象变化，导致 cADPR 的产生、NAD 的消耗和非凋亡细胞死亡。
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T37695	NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ
	NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ, an ACE2-related peptide, serves as a valuable research tool for comprehending ACE2 functions.

化合物

Sulfo-ara-F-NMN

Cat.No: T13907

Synonym: CZ-48

Target: Others

Cat.No: T12854

Target: NAMPT

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ

Cat.No: T37695

Cat. No.	Product Name	Target	Signaling Pathways
T4721	β-Nicotinamide mononucleotide NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。

天然产物

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,NT	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...
TMPK-00982	NTS1 Protein, Cynomolgus, Recombinant (His) NTR1,NT,NTRR,NTRH,NTS1,NTSR1,NT/N,NTS,NMN-125,NN,NT...	Cynomolgus	HEK293 Cells
	Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 18.84 kDa and the accession number is Q2PG57.
TMPK-01162	NTS1 Protein, Mouse, Recombinant (hFc) NTS1,NTRH,NN,NT,NTR1,NMN-125,NT/N,NTSR1,NTR,NTRR	Mouse	HEK293 Cells
	Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9D3P9.
TMPY-03406	NMNAT1 Protein, Human, Recombinant (His) PNAT1,LCA9,nicotinamide nucleotide adenylyltransferase 1,	Human	Baculovirus Insect Cells
	NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz...
TMPH-02811	NRK1 Protein, Mouse, Recombinant (His) Ribosylnicotinamide kinase 1,Nmrk1,Ribosylnicotinic acid kin...	Mouse	E. coli
	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
TMPH-00673	NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His) NAD-capped RNA hydrolase NudC,nudC,NADH pyrophosphatase	E. coli	E. coli
	mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates. NADH pyrophosphatase Protein, E. coli O157:H7, Recombina...

重组蛋白

Neurotensin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00561

Species: Human

Expression System: HEK293 Cells

NTS1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00982

Species: Cynomolgus

Expression System: HEK293 Cells

NTS1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01162

Species: Mouse

Expression System: HEK293 Cells

NMNAT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03406

Species: Human

Expression System: Baculovirus Insect Cells

NRK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02811

Species: Mouse

Expression System: E. coli

NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His)

Cat.No: TMPH-00673

Species: E. coli

Expression System: E. coli

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