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Search Results for " nlrp3 inflammasome "

Targets Recommended: NOD-like Receptor (NLR) NOD

53

抑制剂 & 化合物

12

天然产物

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重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3230	NLRP3-IN-2 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物，对心肌细胞中NLRP3炎症小体的形成具有抑制作用，在小鼠心肌缺血/再灌注后限制梗死面积，且对代谢无影响。
T9222	Emlenoflast MCC7840	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Emlenoflast (MCC7840) 是一种 NLRP3炎症小体 (NLRP3 inflammasome) 的选择性抑制剂(IC50<100 nM)。它可用于研究炎性疾病。
T15052	Dapansutrile	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Dapansutrile 是一种口服有活性的 NLRP3 炎性小体选择性抑制剂。它具有抗炎特性，可用于研究缓解疼痛。
T8828	CP 424174	IL Receptor	Immunology/Inflammation
	CP 424174 是一种具有可逆性的 IL-1β抑制剂(IC50:210 nM)，也能够间接性抑制 NLRP3。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T20731	Brilliant blue G-250 酸性蓝 90,BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) 是一种可视化的染料，常用于 SDS-PAGE 分离蛋白质，染色过程简单，定量高。在 Bradford 蛋白质分析中，它能够与蛋白质结合，通过595 nm 处的吸光度确定蛋白质浓度。它也是一种安全的 P2×7R 选择性拮抗剂，有望使 NLRP3炎症体失活。
T27841	Lobeglitazone Sulfate CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD	Immunology/Inflammation; NF-κB
	Lobeglitazone Sulfate（CKD-501 Sulfate）是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。
T25548	JC124 JC 124,JC-124	NOD	Immunology/Inflammation; NF-κB
	JC124 是 NLRP3 炎症小体的抑制剂，具有神经保护和抗炎活性。
T60442	NLRP3/AIM2-IN-3	NOD; AIM2	Immunology/Inflammation; NF-κB
	NLRP3/AIM2-IN-3 是一种独特的分子，能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂，对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解，其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用，抑制了 ASC 的寡聚。
T13375	YQ128	IL Receptor; NOD-like Receptor (NLR); NOD; Interleukin	Immunology/Inflammation; NF-κB
	YQ128 是选择性 NLRP3 炎性体抑制剂(IC50:0.30 µM)。它能显著的、选择性抑制 IL-1β的产生，但不影响 TNF-α 的产生。它能够透过血脑屏障到达中枢神经系统。它具有抗炎作用。
T61392	NLRP3-IN-10 ZVN26391	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-10 (ZVN26391) 是强效的 NLRP3 抑制剂，抑制 IL-1β 释放的 IC50 为 251.1 nM。NLRP3-IN-10 通过减弱 ASC 斑点形成来抑制 NLRP3炎症小体激活。
T60404	NLRP3/AIM2-IN-2	AIM2	Immunology/Inflammation
	NLRP3/AIM2-IN-2是一种新型强效抑制剂，对依赖于 NLRP3和 AIM2炎症体的热扩散具有不同物种特异性影响，IC50为0.2392 ± 0.0233 μ M。
T3701	MCC950 CP-456773	NOD	Immunology/Inflammation; NF-κB
	MCC950 (CP-456773) 是NLRP3的选择性抑制剂，能够作用于BMDMs(IC50:7.5 nM) 和 HMDMs(IC50:8.1 nM)。
T77675	TNKS-2-IN-1	PARP; Wnt/beta-catenin; Antibiotic	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; Stem Cells
	TNKS-2-IN-1 是一种 TNKS-2 抑制剂。TNKS-2-IN-1 对 TNKS-1 和 TNKS-2有抑制作用，IC50 分别为 259 nM 和 1100 nM。TNKS-2-IN-1 具有抗菌活性，对大肠杆菌和金黄色葡萄球菌具有抑制作用。TNKS-2-IN-1 抑制 NLRP3 炎症小体（IC505μM）通过抑制ATP刺激的J1A.774细胞释放IL-1β。
T9222L	Emlenoflast sodium MCC7840 sodium	NOD	Immunology/Inflammation; NF-κB
	Emlenoflast sodium (MCC7840 sodium)是磺酰脲类化合物，是一种选择性NLRP3炎症小体 (NLRP3 inflammasome) 的抑制剂，对NLRP3炎症小体的IC50值小于 100 nM，可用于炎性疾病的研究。
T78168	NLRP3-IN-17	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-17为一种高效、选择性且具有口服活性的NLRP3炎性体抑制剂，IC50为7 nM。该化合物在小鼠模型中显著抑制NLRP3依赖的IL-1β分泌，适用于慢性炎症疾病的研究。
T78894	NLRP3-IN-21	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-21（compound L38）是一款NLRP3炎症体抑制剂，具抗炎特性。此化合物能够抑制gasdermin D裂解、防止ASC寡聚化，并阻止NLRP3炎症小体的组装，从而遏制NLRP3炎症小体的激活及焦亡过程。
T62808	NLRP3-IN-6	Others	Others
	NLRP3-IN-6 (Compound 34) 是一种 NLRP3 炎性体的选择性抑制剂。
T61826	NLRP3-IN-4	Others	Others
	NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis.
T62809	NLRP3-IN-7	Others	Others
	NLRP3-IN-7 (Compound 36) 是一种 NLRP3炎性体的选择性抑制剂，能够 NLRP3 炎性体的组装。
T26432	A68930 A 68930,A70108,A-68930,A 70108,A-70108	Others	Others
	A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.
T9655	NBC 6	Others	Others
	NLRP3-IN-NBC6 是一种有效的选择性 NLRP3炎性小体抑制剂，IC50为574 nM，其作用独立于 Ca2+。NLRP3-IN-NBC6 抑制 Nigericin 诱导的 THP-1 细胞炎症反应和 Imiquimod 诱导的 LPS-primed 的骨髓源性巨噬细胞 (BMDMs) 释放 IL-1β。
T38360	NBC 19	Others	Others
	Potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release. Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID:28943355 \|Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID:29618797
T39552	NLRP3-IN-5 NLRP3-IN-5	Others	Others
	NLRP3-IN-5, a compound disclosed in WO2016131098, is an inhibitor of NLRP3 inflammasome. It consists of the chemical structure N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide.
T73015	NLRP3-IN-16	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-16为高效、选择性NLRP3炎症小体抑制剂。其抑制IL-1β释放的IC50为0.131 μM，适用于炎症相关研究。
T71314	GL-V9	Others	Others
	GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.
T78613	Selnoflast calcium RO-7486967 calcium	NOD-like Receptor (NLR)	Immunology/Inflammation
	Selnoflast calcium (example 6) 作为一种NLRP3抑制剂。
T81665	NLRP3-IN-23	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-23 (Compound 15C) 是 NLRP3 炎症体激发的抑制剂，特别针对血红素介导机制。该化合物在 0.1μM 浓度时能显著抑制血红素诱导的 NLRP3 炎症体激活。
T73034	NLRP3-IN-12	Others	Others
	NLRP3-IN-12 是一种特异性的 NLRP3炎症小体抑制剂。NLRP3-IN-12 通过靶向 NLRP3蛋白抑制 IL-1β 的释放，IC50值为 0.45 μM。NLRP3-IN-12 可用于研究炎症性肠病。
T79696	JT001 sodium NLRP3-IN-19 sodium	NOD-like Receptor (NLR)	Immunology/Inflammation
	JT001（NLRP3-IN-19）sodium是一种高效、特异的口服NLRP3抑制剂，能够阻断NLRP3炎症小体的聚集，从而抑止细胞因子释放并防止细胞焦亡。此化合物主要应用于非酒精性脂肪肝炎和肝纤维化的研究领域。
T78822	JT002	NOD-like Receptor (NLR)	Immunology/Inflammation
	JT002为口服活性的NLRP3炎性体抑制剂，能够抑制NLRP3依赖性促炎细胞因子（如IL-1β、IL-1α、IL-18）的生成以及细胞焦亡（pyroptosis），阻断NLRP3炎性体复合物的形成。此外，JT002可有效减少小鼠气道高反应性，并降低气道中中性粒细胞的聚集。
T38106	JC-171	Others	Others
	JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1]. JC-171 (0-100 μM) blocks NLRP3 inflammasome activation and IL-1β production in primary macrophages dose dependently[1]. ...
T68225	Fc 11a-2	Others	Others
	Fc 11a-2 是一种苯并咪唑化合物，一种具有口服活性且有效的NLRP3炎症小体 (NLRP3inflammasome) 抑制剂。Fc 11a-2 通过抑制caspase-1的激活进而抑制 IL-1b/IL-18 的激活来抑制NLRP3炎性体的形成。Fc 11a-2 可防止Dextran sulfate sodium(DSS) 诱导的小鼠实验性结肠炎。
T73014	NLRP3-IN-15	Others	Others
	NLRP3-IN-15 是一种有效的、选择性的 NLRP3炎症小体抑制剂 (KD: 5.87 μM)。NLRP3-IN-15 抑制 IL-1β 释放，IC50为 0.131 μM。NLRP3-IN-15可用于炎症研究。
T73013	NLRP3-IN-14	Others	Others
	NLRP3-IN-14 是一种有效的、选择性的 NLRP3炎症小体抑制剂 (KD: 5.87 μM)。NLRP3-IN-14 抑制 IL-1β 释放，IC50为 0.131 μM。NLRP3-IN-14可用于炎症研究。
T78639	Oxidized ATP trisodium salt oATP trisodium salt	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Oxidized ATP (oATP) trisodium salt 是一种P2 受体广泛抑制剂，其不可逆地阻断P2X7R活化并抑制CRP引发的NLRP3炎性体激活，常用于动脉粥样硬化研究。
T84683	NPBA	Others	Others
	NPBA为K2P通道TASK-3 (KCNK9)的激动剂，并对串联孔域弱内向整流K+通道(TWIK2)具有阻断作用。此外，NPBA能够抑制巨噬细胞中NLRP3炎性体的激活。
T62221	NLRP3-IN-8	Others	Others
	NLRP3-IN-8 (compound 27) 是具有口服活性的、与 NLRP3直接结合的 NLRP3炎性体抑制剂，对 IL-1β 的 IC50值为1.23 μM. NLRP3-IN-8 对肝微粒体具有良好的代谢稳定性 (t1/2= 138.63 min)，几乎没有毒性 (against L02: IC50> 100 μM) 。
T79695	NLRP3-IN-19 NLRP3-IN-19	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-19（JT001）是一种高效、特异性且具有口服活性的NLRP3抑制剂，能够阻断NLRP3炎症小体的组装，抑制细胞因子释放，并预防细胞焦亡。该化合物适用于非酒精性脂肪性肝炎和肝纤维化研究。
T69745	GDC-2394	Others	Others
	GDC-2394 是一种口服有效、选择性的 NLRP3抑制剂，同时也抑制 IL-1β，IC50为 0.4 μM (human IL-1β) 和 0.1 μM (mouse IL-1β)。GDC-2394 抑制 NLRP3诱导的 caspase-1活性，但不抑制 NLRC4 依赖的炎症小体激活。
T60356	Stavudine sodium	Others	Others
	Stavudine (d4T) sodium 是一种口服活性核苷逆转录酶抑制剂 (NRTI)，具有抗HIV-1和HIV-2的活性。Stavudine sodium 还抑制线粒体 DNA (mtDNA) 的复制。Stavudine sodium 降低 NLRP3 炎症小体激活并调节淀粉样 β 自噬。Stavudine sodium 诱导细胞凋亡。
T76111	Hexokinase (ScHEX1)	Others	Others
	Hexokinase(ScHEX1) 是一种糖酵解酶己糖激酶，收到 N-乙酰氨基葡萄糖的抑制。N-乙酰氨基葡萄糖对 Hexokinase(ScHEX1) 的抑制导致其与线粒体外膜分离，而导致 NLRP3炎症小体激活。
T79585	Anti-inflammatory agent 50	NF-κB	NF-κB
	Anti-inflammatory agent 50 (compound a1)是Fusidic acid的衍生物，有效抑制NO、IL-6及TNF-α等炎症因子，调控炎症介质及抑制MAPK、NF-κB和NLRP3炎症小体信号通路，从而减轻急性肺损伤。
T82621	D359-0396	NOD-like Receptor (NLR)	Immunology/Inflammation
	D359-0396 是一种口服活性的 NLRP3 炎性体抑制剂，能有效抑制巨噬细胞焦亡（pyroptosis）以及 IL-1β 的释放，并阻止 NLRP3 和 ASC 的寡聚化，抑制 GSDMD 的裂解。该化合物在动物模型中能减轻小鼠的 EAE 症状，并提高感染性休克后的小鼠存活率。
T79733	NLRP3-IN-20	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3-IN-20（compound 11）是一款口服活性的NLRP3炎症小体抑制剂，其抑制IL-1β分泌的IC50值为25 nM。该化合物展现出卓越的药代动力学性质，并在非酒精性脂肪性肝炎、致命性感染性休克以及结肠炎模型中证明了其显著疗效。
T81637	NT-0796	NOD-like Receptor (NLR)	Immunology/Inflammation
	NT-0796为一种选择性穿透中枢神经系统的NLRP3炎性体抑制剂，其PBMC方法中的IC50值为0.32 nM。该化合物为异丙酯类，能够在细胞内转化为NDT-197959（羧酸活性物）。NT-0796在神经炎症疾病研究中显示出潜力。
T78061	Peptide5 TFA	Gap Junction Protein	Cytoskeletal Signaling
	Peptide5 TFA，一种connexin 43模拟肽，能够降低动物脊髓损伤后的肿胀、抑制星形胶质细胞增生和神经元死亡。该化合物还可抑制NLRP3炎症小体，具有抗炎作用。
T81579	P2X7 receptor antagonist-4	Others	Others
	P2X7 receptor antagonist-4（Compound 14a）是一种选择性P2X7R拮抗剂，其对人类和小鼠P2X7R的IC50值分别为64.7 nM和10.1 nM。该化合物能有效抑制NLRP3炎性体的激活，并在脓毒症模型小鼠中减少肾损伤，降低caspase-1、gasdermin D、IL-1β和IL-18的表达。
T71651	GSK1370319A	Others	Others
	GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-relate...

化合物

Cat.No: T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Cat.No: T9222

Synonym: MCC7840

Target: NOD-like Receptor (NLR), NOD

Cat.No: T15052

Target: NOD-like Receptor (NLR), NOD

Cat.No: T8828

Target: IL Receptor

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

Brilliant blue G-250

Cat.No: T20731

Synonym: 酸性蓝 90,BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G

Target: P2X Receptor

Lobeglitazone Sulfate

Cat.No: T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: NOD

Cat.No: T25548

Synonym: JC 124,JC-124

Target: NOD

NLRP3/AIM2-IN-3

Cat.No: T60442

Target: NOD, AIM2

Cat.No: T13375

Target: IL Receptor, NOD-like Receptor (NLR), NOD, Interleukin

Cat.No: T61392

Synonym: ZVN26391

Target: NOD

NLRP3/AIM2-IN-2

Cat.No: T60404

Target: AIM2

Cat.No: T3701

Synonym: CP-456773

Target: NOD

Cat.No: T77675

Target: PARP, Wnt/beta-catenin, Antibiotic

Emlenoflast sodium

Cat.No: T9222L

Synonym: MCC7840 sodium

Target: NOD

Cat.No: T78168

Target: NOD-like Receptor (NLR)

Cat.No: T78894

Target: NOD-like Receptor (NLR)

Cat.No: T62808

Target: Others

Cat.No: T61826

Target: Others

Cat.No: T62809

Target: Others

Cat.No: T26432

Synonym: A 68930,A70108,A-68930,A 70108,A-70108

Target: Others

Cat.No: T9655

Target: Others

Cat.No: T38360

Target: Others

Cat.No: T39552

Synonym: NLRP3-IN-5

Target: Others

Cat.No: T73015

Target: NOD-like Receptor (NLR)

Cat.No: T71314

Target: Others

Selnoflast calcium

Cat.No: T78613

Synonym: RO-7486967 calcium

Target: NOD-like Receptor (NLR)

Cat.No: T81665

Target: NOD-like Receptor (NLR)

Cat.No: T73034

Target: Others

Cat.No: T79696

Synonym: NLRP3-IN-19 sodium

Target: NOD-like Receptor (NLR)

Cat.No: T78822

Target: NOD-like Receptor (NLR)

Cat.No: T38106

Target: Others

Cat.No: T68225

Target: Others

Cat.No: T73014

Target: Others

Cat.No: T73013

Target: Others

Oxidized ATP trisodium salt

Cat.No: T78639

Synonym: oATP trisodium salt

Target: P2X Receptor

Cat.No: T84683

Target: Others

Cat.No: T62221

Target: Others

Cat.No: T79695

Synonym: NLRP3-IN-19

Target: NOD-like Receptor (NLR)

Cat.No: T69745

Target: Others

Stavudine sodium

Cat.No: T60356

Target: Others

Hexokinase (ScHEX1)

Cat.No: T76111

Target: Others

Anti-inflammatory agent 50

Cat.No: T79585

Target: NF-κB

Cat.No: T82621

Target: NOD-like Receptor (NLR)

Cat.No: T79733

Target: NOD-like Receptor (NLR)

Cat.No: T81637

Target: NOD-like Receptor (NLR)

Cat.No: T78061

Target: Gap Junction Protein

P2X7 receptor antagonist-4

Cat.No: T81579

Target: Others

Cat.No: T71651

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T20089	ATP Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite	Metabolism
	ATP (Adenosine triphosphate) 可为细胞提供能量，参与整体能量平衡，维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子，以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T2812	ATP disodium salt hydrate ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐	Others; Endogenous Metabolite	Metabolism; Others
	ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。同时，它是也是免疫和炎症中重要的内源性信号分子。
T1352	ATP disodium salt Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate	P2X Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。
T6S1367	Procyanidin B2 原花青素 B2,Proanthocyanidin B2	Reactive Oxygen Species; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质，具有抗肿瘤，抗氧化等活性。
TQ0165	Arglabin 阿格拉宾,(+)-Arglabin	NOD-like Receptor (NLR); Transferase; NOD; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Arglabin ((+)-Arglabin) 是从青蒿中分离出的一种天然产物，是一种 NLRP3 炎性体抑制剂，具有抗动脉粥样硬化和抗癌作用。
T3092	Nigericin sodium salt 尼日利亚菌素,尼日利亚菌素钠盐	Potassium Channel; NOD-like Receptor (NLR); Antibacterial; Antibiotic; NOD	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Nigericin sodium salt 属于抗生素，是一种 NLRP3 激活剂，也是一种阳离子离子载体。Nigericin sodium 可以触发 NALP3 炎性体的激活，可抑制高尔基体功能并抑制革兰氏阳性菌的生长。
T5716	4'-Methoxyresveratrol 白藜芦醇-4'-甲醚,4'-O-Methylresveratrol	advanced glycation end products	Others
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) 是一种多酚类化合物，来源于双翅目植物中，具有抗雄激素、抗真菌和抗炎症作用。它能抑制 RAGE- 介导的 MAPK/NF-κB 信号通路，并激活 NLRP3 炎性体，从而缓解 AGE- 诱导的炎症。
T36051	Lipoxin A4 LXA4	Endogenous Metabolite; Interleukin	Immunology/Inflammation; Metabolism
	Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类花生酸介质，具有抗炎作用。Lipoxin A4 通过抑制 Nrf2 来减弱 MSU 晶体诱导的 NLRP3 炎症小体激活，通过 FPR2-IRF 途径调节 M1/M2 巨噬细胞极化。Lipoxin 抑制氧化应激和炎症。
T72580	Isoandrographolide	Others	Others
	Isoandrographolide 具有诱导细胞分化和保肝活性。Isoandrographolide 可抑制 NLRP3炎症小体激活并减轻小鼠矽肺。
T38838	QS-21 Stimulon,QS-21	Others	Others
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.

天然产物

Cat.No: T9352

Target: Others

Cat.No: T20089

Synonym: Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate

Target: Endogenous Metabolite

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

ATP disodium salt hydrate

Cat.No: T2812

Synonym: ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐

Target: Others, Endogenous Metabolite

ATP disodium salt

Cat.No: T1352

Synonym: Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate

Target: P2X Receptor, Endogenous Metabolite

Cat.No: T6S1367

Synonym: 原花青素 B2,Proanthocyanidin B2

Target: Reactive Oxygen Species, NOD

Cat.No: TQ0165

Synonym: 阿格拉宾,(+)-Arglabin

Target: NOD-like Receptor (NLR), Transferase, NOD, Autophagy

Nigericin sodium salt

Cat.No: T3092

Synonym: 尼日利亚菌素,尼日利亚菌素钠盐

Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD

4'-Methoxyresveratrol

Cat.No: T5716

Synonym: 白藜芦醇-4'-甲醚,4'-O-Methylresveratrol

Target: advanced glycation end products

Cat.No: T36051

Synonym: LXA4

Target: Endogenous Metabolite, Interleukin

Isoandrographolide

Cat.No: T72580

Target: Others

Cat.No: T38838

Synonym: Stimulon,QS-21

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01228	MARCO Protein, Human, Recombinant (His) Ly112,SCARA2,AI323439,MARCO	Human	HEK293 Cells
	Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in macrophages; therefore, in the absence of MARCO, macrophages are more susceptible to a greater inflammatory response by particulates known to cause NLRP3 inflammasome activation and the effect is due to increased LMP.
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc) Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ...
TMPH-01502	Humanin Protein, Human, Recombinant (GST) Humanin,Humanin mitochondrial,MT-RNR2	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....
TMPH-01503	Humanin Protein, Human, Recombinant (hFc) MT-RNR2,Humanin,Humanin mitochondrial	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....

重组蛋白

MARCO Protein, Human, Recombinant (His)

Cat.No: TMPK-01228

Species: Human

Expression System: HEK293 Cells

PYCARD Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02521

Species: Mouse

Expression System: E. coli

Humanin Protein, Human, Recombinant (GST)

Cat.No: TMPH-01502

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01503

Species: Human

Expression System: HEK293 Cells

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