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Search Results for " nlrp1 "
Targets Recommended: NOD

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T79906 ADS032

BT-032

NOD Immunology/Inflammation; NF-κB
ADS032 (BT-032)是一种 NLRP1NLRP3 抑制剂,具有抗炎活性,抑制 NLRP1NLRP3 的激活,抑制 Nigericin 引起的IL-1β产生,可用于研究呼吸道炎症或感染。
T6887 MCC950 sodium

CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950

NOD-like Receptor (NLR); NOD Immunology/Inflammation; NF-κB
MCC950 sodium (CP-456773 sodium) 是一种炎症小体 NLRP3 的抑制剂 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs),具有高效选择性。MCC950 sodium 对其他炎症小体,如 AIM2、 NLRC4 或 NLRP1 没有作用。
T3701 MCC950

CP-456773

NOD Immunology/Inflammation; NF-κB
MCC950 (CP-456773) 是NLRP3的选择性抑制剂,能够作用于BMDMs(IC50:7.5 nM) 和 HMDMs(IC50:8.1 nM)。
T16159 Muramyl dipeptide

MDP

NOD Immunology/Inflammation; NF-κB
Muramyl dipeptide (MDP) 是合成的免疫反应肽,由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达,直接促进成骨细胞分化,通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子,也是NLRP1激动剂。

化合物

ADS032
Cat.No: T79906
Synonym: BT-032
Target: NOD
MCC950 sodium
Cat.No: T6887
Synonym: CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950
Target: NOD-like Receptor (NLR), NOD
MCC950
Cat.No: T3701
Synonym: CP-456773
Target: NOD
Muramyl dipeptide
Cat.No: T16159
Synonym: MDP
Target: NOD
Cat. No. Product Name Species Expression System
TMPH-01738 NLRP1 Protein, Human, Recombinant (GST)

Caspase recruitment domain-containing protein 7,Nucleotide-b...

Human E. coli
NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000.
TMPH-02521 PYCARD Protein, Mouse, Recombinant (His & Myc)

Pycard,PYD and CARD domain-containing protein,Apoptosis-asso...

Mouse E. coli
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved ...

重组蛋白

NLRP1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01738
Species: Human
Expression System: E. coli
PYCARD Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02521
Species: Mouse
Expression System: E. coli
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