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Search Results for " ng-25 "

Targets Recommended: MAPK

9

抑制剂 & 化合物

6

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T5643	NG25	MAPK	MAPK
	NG25 是TAK1(IC50:149 nM)和MAP4K2(IC50:21.7 nM)的双抑制剂。
T36779	NG 25 (hydrochloride hydrate)	Others	Others
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv...
T69898	NG25 trihydrochloride	Others	Others
	NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration...
T35857	Actinopyrone A	Others	Others
	Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities. It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis. Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL. Intravenous administration of actinopyrone A (30 μg/kg) increases coron...
T35423	7-oxo Staurosporine	Others	Others
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits gr...
T37488	10(S),17(S)-DiHDHA	Others	Others
	Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stere...
T36844	Inostamycin A	Others	Others
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...
T36486	Benpyrine	Others	Others
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T35701	FSL-1 TFA
	FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2]. FSL-1 significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].FSL-1 (50 ng/mL, 24 hours) induce...

化合物

Cat.No: T5643

Target: MAPK

NG 25 (hydrochloride hydrate)

Cat.No: T36779

Target: Others

NG25 trihydrochloride

Cat.No: T69898

Target: Others

Cat.No: T35857

Target: Others

7-oxo Staurosporine

Cat.No: T35423

Target: Others

10(S),17(S)-DiHDHA

Cat.No: T37488

Target: Others

Cat.No: T36844

Target: Others

Cat.No: T36486

Target: Others

Cat.No: T35701

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00360	G6B Protein, Human, Recombinant (His) G6b,G6b-B,NG31,chromosome 6 open reading f...	Human	HEK293 Cells
	G6B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is O95866-1.
TMPY-00126	G6B Protein, Human, Recombinant (hFc) G6b-B,chromosome 6 open reading frame 25,<...	Human	HEK293 Cells
	G6B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.2 kDa and the accession number is O95866-1.
TMPK-00754	LY6G6D Protein, Human, Recombinant (His & Strep-II) C6orf23,MEGT1,Protein Ly6-D,NG25,G6D,Ly6-D	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (His & Strep-II) is ex...
TMPK-00753	LY6G6D Protein, Human, Recombinant (His) C6orf23,Ly6-D,NG25,G6D,Protein Ly6-D,MEGT1	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (His) is expressed in ...
TMPK-01332	LY6G6D Protein, Cynomolgus, Recombinant (His) Ly6-D,C6orf23,G6D,MEGT1,NG25,Protein Ly6-D	Cynomolgus	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Cynomolgus, Recombinant (His) is expresse...
TMPK-00752	LY6G6D Protein, Human, Recombinant (hFc) G6D,MEGT1,C6orf23,NG25,Protein Ly6-D,Ly6-D	Human	HEK293 Cells
	LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (hFc) is expressed in ...

重组蛋白

G6B Protein, Human, Recombinant (His)

Cat.No: TMPY-00360

Species: Human

Expression System: HEK293 Cells

G6B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00126

Species: Human

Expression System: HEK293 Cells

LY6G6D Protein, Human, Recombinant (His & Strep-II)

Cat.No: TMPK-00754

Species: Human

Expression System: HEK293 Cells

LY6G6D Protein, Human, Recombinant (His)

Cat.No: TMPK-00753

Species: Human

Expression System: HEK293 Cells

LY6G6D Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01332

Species: Cynomolgus

Expression System: HEK293 Cells

LY6G6D Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00752

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35775	HT-2 Toxin-13C22 HT-2 Toxin-13C22
	HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human...

同位素标记化合物

HT-2 Toxin-13C22

Cat.No: T35775

Synonym: HT-2 Toxin-13C22

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