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Search Results for " nf2 "

Targets Recommended: DYRK

9

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40187	GNF2133	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GNF2133 是一种有效的特异性 DYRK1A 抑制剂，IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。
T79446	INF200	NOD-like Receptor (NLR)	Immunology/Inflammation
	INF200（compound 5）是一种磺酰脲衍生的抑制剂，既能抑制NLRP3也能抑制NLRP3介导的焦亡(pyroptosis)。在HFD诱导的大鼠模型上，INF200对心脏代谢表现出有益效果，并且在(10 μM)浓度下减少了人巨噬细胞中IL-1β的释放，表现出抗炎特性。它还能改善血糖控制和脂质水平，降低全身炎症和心功能障碍的标志物（尤其是BNP水平）。此外，INF200在血流动力学评估中还可提升心肌损伤后的缺血/再灌注损伤(IRI)恢复。
TP2274	NF279 NF 279	Others	Others
	P2X1 antagonist
T63040	GNF2133 hydrochloride	Others	Others
	GNF2133 hydrochloride 是一种选择性的、有效的、口服具有活力的 DYRK1A 抑制剂，能够作用于 DYRK1A (IC50: 0.0062 μM) 和 GSK3β (IC50> 50 μM)。GNF2133 hydrochloride 对大鼠和人原代 β 细胞表现出良好的增殖能力和功效。GNF2133 hydrochloride 明显提升葡萄糖处理能力，增多胰岛素分泌。GNF2133 hydrochloride 具有潜力进行 1 型糖尿病的研究。
T69638	VT-105 VT 105	Others	Others
	VT-105 是一种强效的选择性 TEAD 自棕榈酰化抑制剂，可抑制 NF2 缺陷间皮瘤的增殖和肿瘤生长。
T79427	LM-41	YAP	Stem Cells
	LM-41是一种衍生自Flufenamic acid的TEAD抑制剂，能有效下调CTGF、Cyr61、Axl和NF2的表达水平。此外，LM-41抑制了人类MDA-MB-231乳腺癌细胞的迁移。
T79428	AF-2112	YAP	Stem Cells
	AF-2112为Flufenamic acid衍生物，作为TEAD抑制剂，能显著抑制CTGF、Cyr61、Axl及NF2基因表达。
T68934	VT101 free base	Others	Others
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T71424	VT-102 free base	Others	Others
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.

化合物

Cat.No: T40187

Target: DYRK

Cat.No: T79446

Target: NOD-like Receptor (NLR)

Cat.No: TP2274

Synonym: NF 279

Target: Others

GNF2133 hydrochloride

Cat.No: T63040

Target: Others

Cat.No: T69638

Synonym: VT 105

Target: Others

Cat.No: T79427

Target: YAP

Cat.No: T79428

Target: YAP

VT101 free base

Cat.No: T68934

Target: Others

VT-102 free base

Cat.No: T71424

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02781	Merlin Protein, Mouse, Recombinant (His & Trx) Moesin-ezrin-radixin-like protein,Schwannomin,Neurofibromin-...	Mouse	E. coli
	Merlin Protein, Mouse, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 55.9 kDa and the accession number is P46662.
TMPH-01662	Merlin Protein, Human, Recombinant (His) Merlin,Moesin-ezrin-radixin-like protein,Schwannomin,Neurofi...	Human	E. coli
	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress...
TMPY-01026	Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His) AI747498,α 2 Antiplasmin/SerpinF2...	Mouse	HEK293 Cells
	Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q5ND36.
TMPY-04860	Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His) α 2 Antiplasmin/SerpinF2,serpin p...	Rat	HEK293 Cells
	Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.6 kDa and the accession number is Q68FT8.
TMPY-01398	Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His) serpin peptidase inhibitor, clade F, member 2,α-	Human	HEK293 Cells
	Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.2 kDa and the accession number is P08697-1.
TMPH-02051	RNF207 Protein, Human, Recombinant (His & Myc) RNF207,RING finger protein 207	Human	E. coli
	RNF207 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

重组蛋白

Merlin Protein, Mouse, Recombinant (His & Trx)

Cat.No: TMPH-02781

Species: Mouse

Expression System: E. coli

Merlin Protein, Human, Recombinant (His)

Cat.No: TMPH-01662

Species: Human

Expression System: E. coli

Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01026

Species: Mouse

Expression System: HEK293 Cells

Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04860

Species: Rat

Expression System: HEK293 Cells

Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01398

Species: Human

Expression System: HEK293 Cells

RNF207 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02051

Species: Human

Expression System: E. coli

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