Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62585 |
NAS-181
|
Others | Others |
NAS-181 是一种选择性大鼠 5-羟色胺 1B (r5-HT1B) 的有效拮抗剂 (Ki: 47 nM)。NAS-181 可以加强大鼠脑区 5-HTP 的积累。 | |||
T69959 |
NAS-181 free base
|
Others | Others |
NAS-181 free base is a 5-HT(1B) receptor antagonist. | |||
T23055 |
NAS181
NAS-181 |
Others | Others |
rat 5-HT1B receptor antagonist | |||
T69958 |
Tofacitinib maleate
|
Others | Others |
Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively. |