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16

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38120	4-MUNANA 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt
	4-MUNANA(4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt) 是用于神经氨酸酶 (neuraminidase) 活性测定的荧光底物，是神经氨酸酶底物类似物。
T36904	Nanangenine B	Others	Others
	Nanangenine B is a drimane sesquiterpene that has been found inAspergillus.1It is active againstB. subtilis(IC50= 62 μg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50= 38 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)
T36906	Nanangenine G	Others	Others
	Nanangenine G is a drimane sesquiterpene that has been found inAspergillus.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 47 μg/ml). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)
T29362	2-Norbornanamine, 2-ethyl-N-methyl-	Others	Others
	2-Norbornanamine, 2-ethyl-N-methyl- is a Drug / Therapeutic Agent.
T71110	Nanatinostat TFA	Others	Others
	Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor...
T29366	2-Norbornanamine, N,N,2,3-tetramethyl-	Others	Others
	2-Norbornanamine, N,N,2,3-tetramethyl- is a Drug / Therapeutic Agent.
T29363	2-Norbornanamine, N,2,3-trimethyl-	Others	Others
	2-Norbornanamine, N,2,3-trimethyl- is a Drug / Therapeutic Agent.
T29361	2-Norbornanamine, 2,3-dimethyl-	Others	Others
	2-Norbornanamine, 2,3-dimethyl- is a Drug / Therapeutic Agent.
T29365	2-Norbornanamine, N,3,3-trimethyl-	Others	Others
	2-Norbornanamine, N,3,3-trimethyl- is a Drug / Therapeutic Agent.
T16270	Nanatinostat CHR-3996	Others	Others
	Nanatinostat is an effective and class I selective inhibitor of histone deacetylase (IC50: 8 nM).
T16269	Nanaomycin A	DNA Methyltransferase; Dehydrogenase; Parasite	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的特异性抑制剂 (IC50 = 500 nM)。
T29364	2-Norbornanamine, N,2-dimethyl-	Others	Others
	2-Norbornanamine, N,2-dimethyl- is a Drug / Therapeutic Agent.
T71925	Isonanangenine B	Others	Others
	Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.
T36905	Nanangenine F	Others	Others
	Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg/ml, respectively). 1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019)
T61221	Antiparasitic agent-8	Others	Others
	Antiparasitic agent-8 (Compound 9) exhibits potent antiparasitic activity against Hymenolepis nana, while demonstrating low levels of cytotoxicity [1].
T38274	Papyracillic Acid	Others	Others
	Papyracillic acid is a fungal metabolite and a derivative of penicillic acid originally isolated fromL. papyraceumand has antibiotic, antifungal, and phytotoxic activities.1,2It is active against the bacteriaX. campestrisandB. subtilisand the fungusC. tropicalisin a disc assay when used at a concentration of 5 μg/disc.2Papyracillic acid (1 mg/ml) induces necrotic lesion formation in a panel of 10 plants. 1.Shan, R., Anke, H., Stadler, M., et al.Papyracillic acid, a new penicillic acid analogue f...

化合物

Cat.No: T38120

Synonym: 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid sodium salt

Nanangenine B

Cat.No: T36904

Target: Others

Nanangenine G

Cat.No: T36906

Target: Others

2-Norbornanamine, 2-ethyl-N-methyl-

Cat.No: T29362

Target: Others

Nanatinostat TFA

Cat.No: T71110

Target: Others

2-Norbornanamine, N,N,2,3-tetramethyl-

Cat.No: T29366

Target: Others

2-Norbornanamine, N,2,3-trimethyl-

Cat.No: T29363

Target: Others

2-Norbornanamine, 2,3-dimethyl-

Cat.No: T29361

Target: Others

2-Norbornanamine, N,3,3-trimethyl-

Cat.No: T29365

Target: Others

Cat.No: T16270

Synonym: CHR-3996

Target: Others

Cat.No: T16269

Target: DNA Methyltransferase, Dehydrogenase, Parasite

2-Norbornanamine, N,2-dimethyl-

Cat.No: T29364

Target: Others

Isonanangenine B

Cat.No: T71925

Target: Others

Nanangenine F

Cat.No: T36905

Target: Others

Antiparasitic agent-8

Cat.No: T61221

Target: Others

Papyracillic Acid

Cat.No: T38274

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1638	N-Acetylneuraminic acid 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	N-Acetylneuraminic acid (Acide aceneuramique) 是一种九碳唾液酸单糖，通常存在于细胞膜上的糖蛋白和哺乳动物细胞中的神经节苷脂等糖脂中。它可用于神经传递、白细胞外渗、病毒或细菌感染以及碳水化合物-蛋白质识别。
TN4662	Nonanal	Others	Others
	Nonanal 是木材腐烂真菌的生长因子。 Nonanal 是松梢甲虫的潜在引诱剂。

天然产物

N-Acetylneuraminic acid

Cat.No: T1638

Synonym: 唾液酸,Acide aceneuramique,N-乙酰神经氨酸,NeuAc,Lactaminic acid

Target: Others, Influenza Virus, Endogenous Metabolite

Cat.No: TN4662

Target: Others

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