33
13
23
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36420 |
IM-156 acetate
HL271 acetate |
Others | Others |
IM-156 acetate 是一种 NADH 脱氢酶(IC50=2.2μM)和 AMP-激活蛋白激酶α(AMPKα)的激活剂,是一种可口服且具有生物利用的线粒体氧化磷酸化(OxPhos)抑制剂。IM-156 acetate 可增加 AMPKα活性,抑制氯己酮诱导的大鼠腹膜纤维化,抑制肿瘤生长 。 | |||
T73486 |
RIG012
|
Others | Others |
RIG012 是一种有效的 RIG-I 抑制剂,用 NADH 偶联 ATPase 测得 IC50 值 为 0.71 μM。RIG012 对 IFN-β 和 ISG hRsad2 表达有抑制作用。 | |||
T7575L1 |
[Sar1, Ile8]-Angiotensin II acetate
|
RAAS | Endocrinology/Hormones |
[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶,并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用,包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。 | |||
T20067 |
WST-1
WST 1 |
||
WST-1 是一种具有细胞毒性的水溶性四唑盐,诱导细胞内线粒体脱氢酶进行 NADH 依赖性酶解反应,释放出水溶性甲基苯产物。WST-1 可通过检测吸收值来检测细胞增殖和细胞活性,可用于WST-1平板测定法测定超氧化物歧化酶活性。 | |||
T60774 |
NITD-916
NITD916,NITD 916 |
Antibiotic | Microbiology/Virology |
NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂,IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物, 与 InhA 和 NADH 形成三元复合物,阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。 | |||
T9558 |
KL-11743
|
transporter | Metabolism |
KL-11743 是葡萄糖竞争性 I 类葡萄糖转运蛋白抑制剂,口服有活性,能够抑制GLUT1 (IC50:115 nM) 、GLUT2 (IC50:137 nM) 、GLUT3 (IC50:90 nM) 及GLUT4 (IC50:68 nM) 。它能够特异性阻断葡萄糖代谢,也可与电子传递抑制剂协同作用诱导细胞死亡。 | |||
T22223 |
3PO
|
Glucokinase; Autophagy | Autophagy; Metabolism |
3PO 是一种 PFKFB3 的小分子抑制剂,IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖,IC50在1.4到24 μM 之间。它抑制葡萄糖摄取,并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。 | |||
T16342 |
KL1333
NQO1 activator 1 |
NADPH; Mitochondrial Metabolism | Metabolism |
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。 | |||
T71866 |
Cochlioquinone B
|
Others | Others |
Cochlioquinone B is a phytotoxin that inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from heart mitochondria. | |||
T36875 |
Sartorypyrone D
|
Others | Others |
Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.1It inhibits NADH fumarate reductase (NFRD; IC50= 1.7 μM inA. suummitochondria) and NADH oxidase (IC50= 3 μM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andM. smegmatisin disc assays. 1.Kaifuchi, S., Mori, M., Nonaka, K., et al.Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897J. Antibiot. (Tokyo)68(6)403-4... | |||
T70935 |
Phenoxan
|
Others | Others |
Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase. | |||
T76207 |
Glucose dehydrogenase (GDH)
|
||
Glucose dehydrogenase (GDH)是一种氧化还原酶,催化β-D-葡萄糖氧化成β-D-葡糖酸-1,5-内酯,同时将辅助因子NADP+还原至NADPH,或以较小程度还原NAD+至NADH。此酶能接收NAD+和NADP+作为辅助因子,适用于NADH与NADPH的再生。 | |||
T61192 |
CBR-6672
|
Others | Others |
CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1]. | |||
T76206 |
beta-Galactose dehydrogenase
|
||
beta-Galactose dehydrogenase 能够将半乳糖转化为半乳糖酸内酯,并同时将 NAD 还原为具有荧光性的 NADH,适用于半乳糖的定量测定。 | |||
T61035 |
CBR-3465
|
Others | Others |
CBR-3465 是结核分枝杆菌 (Mtb) II 型 NADH 脱氢酶的有效抑制剂。CBR-3465 抑制结核分枝杆菌的 MIC 值为 0.16 μM。 | |||
T68317 |
VJ115
|
Others | Others |
VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy... | |||
T75289 |
NAD sodium
|
Others | Others |
NAD sodium(β-Nicotinamide Adenine Dinucleotide sodium)为NAD的同类物,能在有机底物氧化反应中被还原为β-烟酰胺腺嘌呤二核苷酸(NADH)。此外,NAD sodium转化成的NADH能传递至线粒体内,间接促进ATP的生成。 | |||
T76116 |
L-Lactate dehydrogenase
|
Others | Others |
L-Lactate dehydrogenase (L-乳酸脱氢酶) 是一种氧化还原酶。L-Lactate dehydrogenase 在体内催化 NADH 将丙酮酸还原为 L-乳酸。 | |||
T83800 |
6-Biotin-17-NAD+ sodium
6-Biotin-17-Nicotinamide adenine dinucleotide,β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide |
||
6-Biotin-17-NAD+ 是信号分子及酶辅因子NAD+的生物素化衍生物,已应用于高通量筛选(HTS)中,用于测定线粒体复合物I(又称NADH脱氢酶)的活性。 | |||
T78360 |
Glyceraldehyde phosphate dehydrogenase
GAPDH,G3PDH,GADPH |
Others | Others |
Glyceraldehyde phosphate dehydrogenase是一种酶,既是抗胸腺细胞剂也是抗凋亡剂的靶点,它负责催化过羟基自由基对还原型烟酰胺腺嘌呤二核苷酸(NADH)的链氧化反应。 | |||
T37502 |
sn-Glycerol 3-phosphate lithium
|
Others | Others |
sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway. This process involves the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH, which is generated during glycolysis. | |||
T20016 |
Diuron
HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron |
Others | Others |
Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,500 ppm, dietary) increases the inc | |||
T27568 |
IACS-010759 hydrochloride
IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759 |
Others | Others |
IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I | |||
T79252 |
Apoptosis inducer 13
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Apoptosisinducer 13(Compound Ru4)能够诱导癌细胞进入凋亡并抑制其迁移与侵袭。该化合物能促进NADH向NAD+的转化,同时提升细胞内ROS的水平。 | |||
T37583 |
XTT (sodium salt hydrate)
|
||
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas... | |||
T73478 |
ME-143
NV-143 |
Others | Others |
ME-143为第二代特异性NADH氧化酶抑制剂,针对结直肠癌细胞中WNT/β-catenin通路展现抑制作用。该化合物在体外及体内显示出广泛的抗癌活性。 | |||
T38230 |
Iromycin A
|
Others | Others |
Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH oxidation in beef heart submitochondrial particles (IC50 = 0.461 μM for iromycin A). | |||
T73032 |
MtInhA-IN-1
|
Others | Others |
MtInhA-IN-1是一种口服活性的选择性结核分枝杆菌NADH依赖性烯酰基载体蛋白还原酶(MtInhA)抑制剂,IC50值为0.23 μM。对结核分枝杆菌H37Rv菌株,其MIC为0.4 μM。 | |||
T37070 |
Pyridomycin
|
Others | Others |
Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml). | |||
T83865 |
HP661
|
Others | Others |
HP661是一种针对线粒体复合物I(也称为NADH脱氢酶)的抑制剂,对复合物I具有选择性,以1 µM的浓度抑制其77.6%,而对复合物III抑制率为28.1%,对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力(IC50分别为10.6、29.7和15.1 nM),相较于氧化磷酸化水平低的NCI H358人类肺癌细胞(IC50 >10,000 nM)以及非癌性人类胰腺正常上皮细胞(HPNE)和MRC-5人类胎肺成纤维细胞(两者的IC50均>10,000 nM)。当以每天两次,每次30 mg/kg的剂量给药时,HP661在H460小鼠异种移植模型中减少肿瘤体积,并对trametinib引导的肿瘤生长减少产生加成效应。 | |||
T83866 |
LCC-12 formate
|
Others | Others |
LCC-12是一种铜(II)螯合剂,为二甲双胍的衍生物。作为单体,它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下,LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平,以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外,同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。 | |||
T37692 |
Piericidin B
|
Others | Others |
Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respiration in isolated rat liver mitochondria and isolated cockroach (P. americana) muscle mitochondria.2,3Topical application of piericidin B (4 μg/insect) induces mortality in 87.5% of houseflies (M. domestica).1It induces 93.3, 100, and 100% mortality in rice stem borer (C. simple... | |||
T35712 |
Debutyldronedarone hydrochloride
SR35021 hydrochloride |
Others | Others |
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5283 |
NADH disodium salt
Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠 |
Others; Endogenous Metabolite | Metabolism; Others |
NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用,包括糖酵解,柠檬酸循环和β-氧化。 | |||
T8347 |
Rifamycin S
|
Reactive Oxygen Species; ROS; Antibacterial; Antibiotic | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂,是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化,可研究肺结核和麻风病。 | |||
TN1774 |
Isobavachromene
|
Others; Antibacterial | Microbiology/Virology; Others |
Isobavachromene 是一种抗菌剂。 | |||
T7989 |
Trimethyl phosphate
|
Others | Others |
Trimethyl phosphate 是一种有机磷化合物,是催化磷酸化化合物水解的酶的抑制剂,已被用作合成肽和其他蛋白质的反应物,用作合成有机和无机化合物的催化剂,以及用作合成药物的试剂。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 是一种转递氢离子的辅酶,参与细胞中的氧化还原反应。NAD+ 参与糖酵解、柠檬酸循环、脂肪酸氧化等。NAD+ 接受来自其他分子的电子形成 NADH,然后又作为还原剂来给电子。 | |||
T19343L |
Glycerol 3-phosphate biscyclohexylammonium salt
|
Endogenous Metabolite | Metabolism |
Glycerol 3-phosphate biscyclohexylammonium salt 是胞质甘油 3-磷酸脱氢酶途径中产生的,即利用 NADH 还原二羟丙酮磷酸的过程。 | |||
T81570 |
Paecilaminol
FKI-0550 |
||
Paecilaminol (FKI-0550) 为一种高效的 NADH 富马酸还原酶 (NADH-fumarate reductase) 抑制剂,其对蛔虫 (Ascaris suum) NADH 富马酸还原酶展现了 5.1 μM 的 IC50 值。 | |||
T74201 |
3′-Hydroxy-4′-O-methylglabridin
|
Others | Others |
3′-Hydroxy-4′-O-methylglabridin 是一种抗氧化剂,可有效防止 NADH 依赖的过氧化。 | |||
T19343 |
sn-Glycerol 3-phosphate
Glycerol 3-phosphate,SN-甘油3-磷酸 锂盐,sn-Glycerol 3-phosphate lithium salt |
Endogenous Metabolite | Metabolism |
sn-Glycerol 3-phosphate 是一种人内源性化合物,由NADH 还原磷酸二羟基丙酮而产生。 | |||
T40529 |
(R)-(-)-1,2-Propanediol
|
Others | Others |
(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is derived from glucose through the expression of NADH-linked glycerol dehydrogenase genes in Escherichia coli. | |||
T80016 |
Aurachin D
|
Antibiotic | Microbiology/Virology |
Aurachin D为一种具备抑菌活性的抗生素,对革兰氏阳性细菌及部分真菌种类显示出抑制效果,能够阻断牛心脏亚线粒体颗粒中的NADH氧化过程。 | |||
TN3069 |
4beta-Carboxy-19-nortotarol
|
NADPH-oxidase | Immunology/Inflammation |
4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion. | |||
T37714 |
Fuscin
|
Others | Others |
Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00673 |
NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His)
NAD-capped RNA hydrolase NudC,nudC,NADH pyrophospha... |
E. coli | E. coli |
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates. NADH pyrophosphatase Protein, E. coli O157:H7, Recombina... | |||
TMPH-03192 |
NAD2 Protein, Psoroptes ovis, Recombinant (His)
NADH-ubiquinone oxidoreductase chain 2,NADH |
Psoroptes ovis | E. coli |
N/A. NAD2 Protein, Psoroptes ovis, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 32.7 kDa and the accession number is A0A075XDS2. | |||
TMPH-03008 |
ENR Protein, Mycobacterium tuberculosis, Recombinant (His)
FAS-II enoyl-ACP reductase,Enoyl-ACP reductase,Enoyl-[acyl-c... |
Mycobacterium tuberculosis | E. coli |
ENR Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.6 kDa and the accession number is P9WGR0. | |||
TMPH-01744 |
NOX1 Protein, Human, Recombinant (His)
NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH ... |
Human | E. coli |
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t... | |||
TMPY-02801 |
PHGDH Protein, Human, Recombinant (His)
phosphoglycerate dehydrogenase,HEL-S-113,3PGDH,NLS1,PHGDHD,P... |
Human | E. coli |
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PH... | |||
TMPH-01691 |
TOMM40 Protein, Human, Recombinant (GST)
Mitochondrial import receptor subunit TOM40 homolog,p38.5,Pr... |
Human | E. coli |
Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. | |||
TMPY-03755 |
Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)
GPDH-C,HTGTI,GPD-C,glycerol-3-phosphate dehydrogenase 1 (sol... |
Human | E. coli |
GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. It also reduces nicotine adenine dinucleotide... | |||
TMPH-00161 |
MDH Protein, Bacillus methanolicus, Recombinant (His)
Type 3 alcohol dehydrogenase,mdh,NAD-dependent methanol dehy... |
Bacillus methanolicus | P. pastoris (Yeast) |
Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 42.4 kDa and the accession number is P31005. | |||
TMPH-00162 |
MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO)
NAD-dependent methanol dehydrogenase,Type 3 alcohol dehydrog... |
Bacillus methanolicus | E. coli |
Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 59.9 kDa and the accession number is P31005. | |||
TMPH-01302 |
HSD17B1 Protein, Human, Recombinant (His & Myc)
Placental 17-beta-hydroxysteroid dehydrogenase,Short chain d... |
Human | E. coli |
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. HSD17B1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 42.3 kDa and the accession number is P14061. | |||
TMPK-00571 |
OSMR Protein, Canine, Recombinant (His)
OSMRB,IL-31R-β,OSMR,OSMRBMGC150626,OSMR β,IL-31R subunit β,I... |
Canine | HEK293 Cells |
OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. OSMR Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mole... | |||
TMPJ-00956 |
MDH2 Protein, Human, Recombinant (His)
MDH2,Malate dehydrogenase,mitochondrial |
Human | HEK293 Cells |
Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and takes part in the malate-aspartate shuttle that functions in the metabolic coordination between cytosol and mitochondria. MDH2 is highly expressed in the adrenal system, small intestine, heart and panc... | |||
TMPJ-00724 |
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I... |
Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. | |||
TMPH-00916 |
ADH1B Protein, Human, Recombinant (His & SUMO)
ADH2,Alcohol dehydrogenase subunit beta,All-trans-retinol de... |
Human | E. coli |
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. ADH1B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli... | |||
TMPK-00493 |
OSMR Protein, Cynomolgus, Recombinant (His)
OSMR,IL-31R-β,PLCA1,IL-31RB,OSMRBMGC150626,IL-31R subunit β,... |
Cynomolgus | HEK293 Cells |
OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. OSMR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted ... | |||
TMPJ-01009 |
BLVRA Protein, Human, Recombinant (His)
Biliverdin reductase A,BVR,BVR A,BLVR,BLVRA,Biliverdin-IX α-... |
Human | E. coli |
Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. BLVRA acts on biliverdin by reducing its double-bond between the pyrrole rings into a single-bond. It accomplishes this using NADPH + H+ ... | |||
TMPJ-00797 |
LDHB Protein, Human, Recombinant (His)
LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH Heart Subu... |
Human | E. coli |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver.... | |||
TMPY-03497 |
AKR1C2 Protein, Human, Recombinant (His)
AKR1C2,HBAB,SRXY8,AKR1C-pseudo,aldo-keto reductase family 1,... |
Human | E. coli |
AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene ... | |||
TMPY-01812 |
Enoyl-ACP Reductase Protein, E. coli, Recombinant (His)
b1288,JW1281,gts,ECK1283,qmeA,envM |
E. coli | E. coli |
Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI subfamily. Microorganisms produce many kinds of antibiotics which function in an antagonistic capacity in nature where they have much competition. Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FABI is an enoyl-ACP... | |||
TMPY-02599 |
MDH1 Protein, Rat, Recombinant (His)
malate dehydrogenase 1, NAD (soluble) |
Rat | E. coli |
Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramers with subunit molecular weights of 30-35 kDa. MDH has been isolated from different sources including archaea, eubacteria, fungi, plants, and mammals. MDH catalyzes the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in... | |||
TMPY-02519 |
BLVRB Protein, Human, Recombinant (His)
HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1 |
Human | E. coli |
Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i... | |||
TMPH-02617 |
COX5A Protein, Mouse, Recombinant (His & SUMO)
Cytochrome c oxidase subunit 5A, mitochondrial,COX5A,Cytochr... |
Mouse | E. coli |
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over t... | |||
TMPY-01869 |
SIRT1 Protein, Human, Recombinant (His)
SIR2L1,sirtuin 1 |
Human | E. coli |
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 also deacetylates TAF1B and there... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T35520 |
Aflatoxin G1-13C17
Aflatoxin G1-13C17 |
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Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase... |