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Search Results for " n-methyltransferase "

Targets Recommended: Histone Methyltransferase Antifolate Histamine Receptor

34

抑制剂 & 化合物

4

天然产物

24

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8548	Metoprine	Histone Methyltransferase; Antifolate; Histamine Receptor	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂，具有抗肿瘤活性。它是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。
T8381	Amodiaquine	Others; Histone Methyltransferase; Parasite	Chromatin/Epigenetic; Microbiology/Virology; Others
	Amodiaquine 是一种合成的4-氨基喹啉类抗疟剂，是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂，有抗炎活性，可特异性结合Nurr1的配体结合域，EC50约为20 μM。
T2038	RG108 N-Phthalyl-L-tryptophan	DNA Methyltransferase	Chromatin/Epigenetic
	RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂，IC50为115 nM。它阻断 DNA 甲基转移酶的活性位点，可引起抑癌基因的去甲基化和再激活。
T7157	XY1 N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲	Histone Methyltransferase	Chromatin/Epigenetic
	XY1是 SGC707的类似物，SGC707是选择性PRMT3抑制剂，IC50值为31 nM。
T2352	AMI-1	Histone Methyltransferase	Chromatin/Epigenetic
	AMI1 是一种有效的、可逆的、细胞渗透性的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 和 3.0 μM。它通过阻断肽-底物结合对 PRMTs 发挥抑制作用。
T0381	Amodiaquine dihydrochloride dihydrate Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase; Parasite; Histamine Receptor	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) 是一种具有口服活性的组胺 N-甲基转移酶抑制剂，也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM。它是 4-氨基喹啉衍生物，具有抗疟和抗炎特性。
T22956	LY 78335 1-(2,3-Dichlorophenyl)ethanamine hydrochloride	Others	Others
	LY 78335 (1-(2,3-Dichlorophenyl)ethanamine hydrochloride) 是一种苯乙醇胺-N-甲基转移酶 (PNMT) 抑制剂。
T10363	Arazine N-Acetyl-S-farnesyl-L-cysteine	Others	Others
	Arazine (N-Acetyl-S-farnesyl-L-cysteine) 可以成为异戊二烯基半胱氨酸甲基转移酶的底物通过与异戊二烯化 G 蛋白或其受体位点竞争。 Arazine 是 G 蛋白和 GPCR 信号传导的细胞渗透性调节剂。
T8106	JBSNF-000088 JBSNF000088	Others	Others
	JBSNF-000088 是一种烟酰胺的类似物，是一种 NNMT(烟酰胺 N-甲基转移酶) 抑制剂，可作用于人 NNMT (IC50:1.8 µm)、猴 NNMT(IC50:2.8 µm) 和小鼠 NNMT (IC50:5.0 µm)。在代谢性疾病的动物模型中，它能够抑制 NNMT 活性，降低 MNA 水平并驱动胰岛素增敏，调节葡萄糖和减轻体重。
T7697	BIX-01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP，可诱导坏死性凋亡和自噬，具有抗肿瘤活性。
T8760	NNMTi 5-Amino-1-methylquinolinium	Others	Others
	NNMTi (5-Amino-1-methylquinolinium) 是烟酰胺 N -甲基转移酶的抑制剂 (IC50=1.2 μM)，可选择性地结合 NNMT 底物结合位点残基。它能诱导体外成肌细胞分化，提高老年小鼠肌肉干细胞融合和再生能力。
T1959	BIX-01294 trihydrochloride BIX 01294	Histone Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂，IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬，具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。
T72947	JBSNF-000028 JBSNF-000028 free base	Others	Others
	JBSNF-000028 是一种具有口服活性和有效性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，对人 NNMT (hNNMT)、猴 NNMT (mkNNMT) 和小鼠 NNMT (mNNMT) 具有抑制作用， IC50 分别为 0.033 μM、0.19 μM 和 0.21 μM。JBSNF-000028 可驱动胰岛素敏化、葡萄糖调节和体重减，可用于研究代谢紊乱。
T27831	Lifibrate	Others	Others
	Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT), and phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT).
T24604	PDAT Propyl Dimethyl Amino Tryptamine	Others	Others
	PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.
T68694	Quinacrine acetate	Others	Others
	Quinacrine acetate is a histamine N-methyltransferase inhibitor.
T23367	SKF 91488 dihydrochloride	Others	Others
	histamine N-methyltransferase inhibitor
T71922	MS2734	Others	Others
	MS2734 is a novel Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT).
T27924	LY 87130 LY87130,LY-87130	Others	Others
	LY 87130 is a phenylethanolamine-N-methyltransferase inhibitor.
T27872	LY 134046 LY-134046,LY134046,Lilly 134046	Others	Others
	LY 134046 is an inhibitor of phenylethanolamine-N-methyltransferase (PNMT).
T37693	N-acetyl-S-geranylgeranyl-L-Cysteine	Others	Others
	N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.
T70105	Chlorpromazine Sulfone Hydrochloride	Others	Others
	Chlorpromazine Sulfone Hydrochloride is a metabolite of Chlorpromazine -- an anti-emetic and anti-psychotic agent. It may also be used as a potential N-methyltransferase inhibitor.
T36802	Bisubstrate Inhibitor 78	Others	Others
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when us...
T26744	BAY-598 R-isomer BAY598 R-isomer,BAY 598 R-isomer	Others	Others
	BAY-598 R-异构体是BAY589的R-异构体，它可用作参考化合物。它是是赖氨酸N-甲基转移酶（SMYD2）的抑制剂，对SMYD2比蛋白酶激活的受体1（PAR1）具有选择性。
T83949	DC 432	Others	Others
	DC 432是一种强效的N-terminal methyltransferase 1/2 (NTMT1/2) (IC50= 54 nM)肽模拟抑制剂，含有BM30肽和额外五个精氨酸残基。在HCT116细胞中，DC 432处理能够降低调节染色体凝缩1和SET蛋白的N端甲基化水平。该化合物具有细胞渗透性。
T28114	MS2177 MS 2177,MS-2177	Others	Others
	MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2
T22242	Amodiaquine hydrochloride	Others	Others
	Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂，是一种有效的口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂，Ki 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM，具有抗炎作用。
T78163	JBSNF-000028 TFA	Others	Others
	JBSNF-000028 TFA是一种口服活性烟酰胺N-甲基转移酶(NNMT)抑制剂，其IC50值针对人NNMT (hNNMT)、猴NNMT (mkNNMT) 和小鼠NNMT (mNNMT) 分别为0.033 μM、0.19 μM和0.21 μM。
T78164	JBSNF-000028 hydrochloride	Others	Others
	JBSNF-000028 hydrochloride为口服活性烟酰胺N-甲基转移酶(NNMT)抑制剂，对hNNMT、mkNNMT及mNNMT的IC50值分别为0.033 μM、0.19 μM和0.21 μM。
T82011	JBSNF-000028 free base	Others	Others
	JBSNF-000028是一种烟酰胺N-甲基转移酶(NNMT)抑制剂，具有口服活性，其针对人类NNMT(hNNMT)、猕猴NNMT(mkNNMT)和小鼠NNMT(mNNMT)的IC50值分别为0.033 μM、0.19 μM和0.21 μM。
T64189	NNMT-IN-3	Others	Others
	NNMT-IN-3 (compound 14) 是一种有效的、选择性的烟酰胺 N-甲基转移酶 (NNMT) 抑制剂，在无细胞和基于细胞的实验中的 IC50 值分别为 1.1 nM 和 0.4 μM。NNMT-IN-3 能够用于肥胖、癌症、II 型糖尿病及骨骼肌减少症等疾病的研究。
T83713	DC432 TFA
	DC432是一种细胞内可渗透的肽类抑制剂，针对N-末端Xaa-Pro-Lys N-甲基转移酶1 (NTMT1; IC50 = 0.054 µM)。该化合物与NTMT1和NTMT2有结合作用（Kds分别为0.3和1 µM），并在10和50 µM的浓度下，通过细胞外实验抑制NTMT1对调节染色体凝缩1 (RCC1) N-末端二甲基化。DC432（100 µM）在HCT116细胞中减少了RCC1 SPKRIA基序的三甲基化。
T81661	NNMT-IN-4	Others	Others
	NNMT-IN-4（compound 38），一种选择性、非竞争性且具有膜通透性的烟酰胺N-甲基转移酶（NNMT）抑制剂，在体外生化及细胞实验中的IC50值为42 nM和38 nM。该抑制剂展现出良好的PK/PD关系和安全性，同时具备优秀的口服生物利用度和药物制剂性质，适合作为NNMT活性研究的体内化学探针。
T81432	PNMT-IN-1	Others	Others
	PNMT-IN-1（Inhibitor 4）是一种高特异性的PNMT抑制剂，具有1.2 nM的Ki值和81 nM的IC50值。它对DNMT1和DNMT3b也表现出活性，IC50值分别为61 μM和17 μM，并且对肾上腺素具有拮抗效果。PNMT-IN-1属于第二代抑制剂。

化合物

Cat.No: T8548

Target: Histone Methyltransferase, Antifolate, Histamine Receptor

Cat.No: T8381

Target: Others, Histone Methyltransferase, Parasite

Cat.No: T2038

Synonym: N-Phthalyl-L-tryptophan

Target: DNA Methyltransferase

Cat.No: T7157

Synonym: N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲

Target: Histone Methyltransferase

Cat.No: T2352

Target: Histone Methyltransferase

Amodiaquine dihydrochloride dihydrate

Cat.No: T0381

Synonym: Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate

Target: Histone Methyltransferase, Parasite, Histamine Receptor

Cat.No: T22956

Synonym: 1-(2,3-Dichlorophenyl)ethanamine hydrochloride

Target: Others

Cat.No: T10363

Synonym: N-Acetyl-S-farnesyl-L-cysteine

Target: Others

Cat.No: T8106

Synonym: JBSNF000088

Target: Others

Cat.No: T7697

Target: Histone Methyltransferase, Autophagy

Cat.No: T8760

Synonym: 5-Amino-1-methylquinolinium

Target: Others

BIX-01294 trihydrochloride

Cat.No: T1959

Synonym: BIX 01294

Target: Histone Methyltransferase, Autophagy

Cat.No: T72947

Synonym: JBSNF-000028 free base

Target: Others

Cat.No: T27831

Target: Others

Cat.No: T24604

Synonym: Propyl Dimethyl Amino Tryptamine

Target: Others

Quinacrine acetate

Cat.No: T68694

Target: Others

SKF 91488 dihydrochloride

Cat.No: T23367

Target: Others

Cat.No: T71922

Target: Others

Cat.No: T27924

Synonym: LY87130,LY-87130

Target: Others

Cat.No: T27872

Synonym: LY-134046,LY134046,Lilly 134046

Target: Others

N-acetyl-S-geranylgeranyl-L-Cysteine

Cat.No: T37693

Target: Others

Chlorpromazine Sulfone Hydrochloride

Cat.No: T70105

Target: Others

Bisubstrate Inhibitor 78

Cat.No: T36802

Target: Others

BAY-598 R-isomer

Cat.No: T26744

Synonym: BAY598 R-isomer,BAY 598 R-isomer

Target: Others

Cat.No: T83949

Target: Others

Cat.No: T28114

Synonym: MS 2177,MS-2177

Target: Others

Amodiaquine hydrochloride

Cat.No: T22242

Target: Others

JBSNF-000028 TFA

Cat.No: T78163

Target: Others

JBSNF-000028 hydrochloride

Cat.No: T78164

Target: Others

JBSNF-000028 free base

Cat.No: T82011

Target: Others

Cat.No: T64189

Target: Others

Cat.No: T83713

Cat.No: T81661

Target: Others

Cat.No: T81432

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1354	N-Acetyl-5-hydroxytryptamine Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin	Trk receptor; Endogenous Metabolite	Metabolism; Tyrosine Kinase/Adaptors
	N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体，能够有效激活TrkB 受体。
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。
T4909	N-Acetyl-DL-methionine N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-DL-methionine 是内源性代谢产物的一种。
T4120	N-Methylsarcosine N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG	Endogenous Metabolite	Metabolism
	N-Methylsarcosine (Dimethylglycine) 被用作运动性能增强剂和免疫兴奋剂。它也被用于治疗自闭症、癫痫和线粒体疾病。它也被用作慢性阻塞性肺疾病(COPD)患者蛋白质降解的生物标志物。此外，它被用作鉴定、区分和表征氨基酸甲基转移酶的底物。它在甘氨酸基离子液体和乳化剂的发展中起着重要的作用。

天然产物

N-Acetyl-5-hydroxytryptamine

Cat.No: T1354

Synonym: Normelatonin,N-乙酰-5-羟色胺,O-Demethylmelatonin,N-Acetylserotonin

Target: Trk receptor, Endogenous Metabolite

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

N-Acetyl-DL-methionine

Cat.No: T4909

Synonym: N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸

Target: Others, Endogenous Metabolite

N-Methylsarcosine

Cat.No: T4120

Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00313	tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His) tRNA (guanine-N(7)-)-met...	Brugia malayi	E. coli
	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 36.3 kDa and the accession number is A8NFF0.
TMPJ-01118	GNMT Protein, Human, Recombinant (His) GNMT,Glycine N-Methyltran	Human	E. coli
	Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau...
TMPH-01529	INMT Protein, Human, Recombinant (His & SUMO) Thioether S-methyltransferase,INMT,Aromati...	Human	E. coli
	Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds.
TMPK-01308	TAG-72 Protein, Canine, Recombinant (His) mRNA-methyltransferase,mRNA (gua<...	Canine	E. coli
	The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA synthesis and a potential target for antiviral, antifungal, and antiprotozoal drug discovery.
TMPH-01681	METTL4 Protein, Human, Recombinant (His & Myc) METTL4,Methyltransferase-like protein 4,	Human	E. coli
	METTL4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 61.5 kDa and the accession number is Q8N3J2.
TMPJ-01114	GAMT Protein, Human, Recombinant (His) Guanidinoacetate N-methyltran...	Human	E. coli
	GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of ...
TMPY-02340	HNMT Protein, Human, Recombinant (GST) HMT,HNMT-S1,HNMT-S2,histamine	Human	E. coli
	HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ...
TMPH-02564	CARNMT1 Protein, Mouse, Recombinant (His & SUMO) Carnosine N-methyltransf...	Mouse	E. coli
	N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
TMPH-02708	HNMT Protein, Mouse, Recombinant (His & Myc) Hnmt,Histamine N-methyltran	Mouse	E. coli
	Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. HNMT Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.1 kDa and the accession number is Q91VF2.
TMPY-01284	METTL11A Protein, Human, Recombinant (GST) C9orf32,AD-003,METTL11A,HOMT1A,N-terminal ...	Human	E. coli
	METTL11A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A024R8E4.
TMPY-01285	METTL11A Protein, Human, Recombinant C9orf32,METTL11A,NTM1A,N-terminal...	Human	E. coli
	METTL11A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.5 kDa and the accession number is A0A024R8E4.
TMPH-01970	EEF2KMT Protein, Human, Recombinant (His) FAM86A,Protein-lysine N-methyltra...	Human	E. coli
	Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. EEF2KMT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 kDa and the accession number is Q96G04.
TMPY-02420	HEMK2 Protein, Human, Recombinant (His) N-6 adenine-specific DNA...	Human	E. coli
	N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to the eukaryotic/archaeal PrmC-related family. The encoded enzyme may be involved in the methylation of release factor I during translation termination. N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activi...
TMPH-01526	KMT2E Protein, Human, Recombinant (His & Myc) Inactive histone-lysine N	Human	E. coli
	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPH-01484	SMYD3 Protein, Human, Recombinant (His & Myc) Zinc finger MYND domain-...	Human	E. coli
	SMYD3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-01708	DOT1L Protein, Human, Recombinant DOT1,KMT4,DOT1-like histone H3K79 methyltran	Human	E. coli
	Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 family. In contrast to other lysine histone methyltransferase, DOT1L does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones. DOT1L is an histone methyltransferase. It methylates 'Lys-79' of histone H3. Nucleosome...
TMPY-01229	SETD7 Protein, Human, Recombinant (His) SET7/9,SET domain containin	Human	E. coli
	Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysi...
TMPY-01657	SUV420H2 Protein, Human, Recombinant (His & GST) suppressor of variegation 4-20 homolog 2 (Drosophil...	Human	E. coli
	Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-lysine methyltransferase family and Suvar4-2 subfamily. SUV42H2 is a histone methyltransferase that specifically trimethylates 'Lys-2' of histone H4. H4 'Lys-2' trimethylation represents a specific tag for epigenetic transcriptional repression. SUV42H2 mainly functions in pericentr...
TMPY-01383	PRMT6 Protein, Human, Recombinant (His & Flag) protein arginine methyltran	Human	HEK293 Cells
	Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H...
TMPH-02635	EEF1AKMT2 Protein, Mouse, Recombinant (His) Methyltransferase-like protein 10,Eef1akmt...	Mouse	E. coli
	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. EEF1AKMT2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 32.9 kDa and the accession number is Q9D853.
TMPH-02227	ERG Protein, Human, Recombinant (His) Transcriptional regulator ERG,Tran	Human	P. pastoris (Yeast)
	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. ERG Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.6 kDa and the accession number is P11308.
TMPY-01661	METTL1 Protein, Human, Recombinant (His) methyltransferase like 1,TRMT8,TRM8,YDL201w,C12orf1	Human	E. coli
	tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. METTL1 gene has been identified by its sequence similarity to the yeast ORF YDL21w. The human cDNA and the genomic structure of METTL1 have been analyzed. The transcript contains 1292 nucleotides and codes for a protein of 276 amino acids. The METTL1 gene product shows high sequen...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST) SET and MYND domain cont...	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg...
TMPY-01270	PRMT3 Protein, Human, Recombinant (GST) HRMT1L3,protein arginine methyltr...	Human	E. coli
	Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3 gene. Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. In human cells, the PRMT fam...

重组蛋白

tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His)

Cat.No: TMPH-00313

Species: Brugia malayi

Expression System: E. coli

GNMT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01118

Species: Human

Expression System: E. coli

INMT Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01529

Species: Human

Expression System: E. coli

TAG-72 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01308

Species: Canine

Expression System: E. coli

METTL4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01681

Species: Human

Expression System: E. coli

GAMT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01114

Species: Human

Expression System: E. coli

HNMT Protein, Human, Recombinant (GST)

Cat.No: TMPY-02340

Species: Human

Expression System: E. coli

CARNMT1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02564

Species: Mouse

Expression System: E. coli

HNMT Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02708

Species: Mouse

Expression System: E. coli

METTL11A Protein, Human, Recombinant (GST)

Cat.No: TMPY-01284

Species: Human

Expression System: E. coli

METTL11A Protein, Human, Recombinant

Cat.No: TMPY-01285

Species: Human

Expression System: E. coli

EEF2KMT Protein, Human, Recombinant (His)

Cat.No: TMPH-01970

Species: Human

Expression System: E. coli

HEMK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02420

Species: Human

Expression System: E. coli

KMT2E Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01526

Species: Human

Expression System: E. coli

SMYD3 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01484

Species: Human

Expression System: E. coli

DOT1L Protein, Human, Recombinant

Cat.No: TMPY-01708

Species: Human

Expression System: E. coli

SETD7 Protein, Human, Recombinant (His)

Cat.No: TMPY-01229

Species: Human

Expression System: E. coli

SUV420H2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01657

Species: Human

Expression System: E. coli

PRMT6 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPY-01383

Species: Human

Expression System: HEK293 Cells

EEF1AKMT2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02635

Species: Mouse

Expression System: E. coli

ERG Protein, Human, Recombinant (His)

Cat.No: TMPH-02227

Species: Human

Expression System: P. pastoris (Yeast)

METTL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01661

Species: Human

Expression System: E. coli

SMYD3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01268

Species: Human

Expression System: Baculovirus Insect Cells

PRMT3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01270

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0028	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 1-Methylhistamine-d3 Dihydrochloride
	2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl 是 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的氘代化合物。2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl 的 CAS 号为 6481-48-7。1-Methylhistamine dihydrochloride 是组胺代谢物。

同位素标记化合物

2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl

Cat.No: TMIH-0028

Synonym: 1-Methylhistamine-d3 Dihydrochloride

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