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Search Results for " myosin "

Targets Recommended: Myosin Myosin

53

抑制剂 & 化合物

2

天然产物

24

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T72060	Myosin V-IN-1	Myosin	Cytoskeletal Signaling
	Myosin V-IN-1是一种有效且具有选择性的 Myosin V 抑制剂，Ki 值为 6 μM。Myosin V-IN-1 抑制肌动蛋白 V 发生作用，通过选择性抑制肌动球蛋白复合物释放 ADP 来减缓肌动蛋白激活的肌球蛋白 V ATP 酶。
T21550	Blebbistatin (±)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Blebbistatin ((±)-Blebbistatin) 是一种选择性的非肌肉肌球蛋白 II 抑制剂，可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合，并保留了细胞连接的完整性和屏障功能。Blebbistatin 是 MYH9 抑制剂。
T6038	(-)-Blebbistatin (S)-(-)-Blebbistatin	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	(-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。(-)-Blebbistatin 是一种肌球蛋白 II 抑制剂 (IC50=0.5-5 μM)，具有有效性和选择性。(-)-Blebbistatin 可以用于抑制心肌肌球蛋白、非肌肉肌球蛋白II和骨骼肌肌球蛋白。
T78375	Myosin H Chain Fragment, mouse
	MyosinH Chain Fragment, mouse, 来自α-肌球蛋白重链肽的片段，旨在诱导实验性自身免疫性心肌炎(EAM)小鼠模型。
T15050	Danicamtiv MYK-491,SAR 440181	Myosin	Cytoskeletal Signaling
	Danicamtiv (MYK-491) 是一种正性肌力药物，也是一种心肌肌球蛋白的选择性变构激活剂，可增加心脏收缩功能并保持机械效率。
T80046	Myosin H Chain Fragment, mouse acetate
	MyosinH Chain Fragment, mouse acetate salt，一种α-肌球蛋白重链肽的肽段，用于诱导实验性自身免疫性心肌炎(EAM)的小鼠模型。
T16104	ML-9	Myosin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。
T2006	Omecamtiv mecarbil CK-1827452	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	Omecamtiv mecarbil (CK-1827452) 是一种心脏特异性的肌球蛋白激活剂，用于研究心脏相关疾病。
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T9258	Aficamten	Others	Others
	Aficamten 是一种可研究肥厚型心肌病的新型心肌肌球蛋白抑制剂，IC50为 1.4 μM。
T81732	Myosin light chain kinase fragment 11-19 amide MLCK(11-19) amide
	Myosinlight chain kinase fragment 11-19 amide (MLCK(11-19) amide) 为MLCK专一性多肽抑制剂，具抑制低渗透压刺激下Ca2+入细胞的能力，并可应用于人类宫颈癌研究。
T7134	Mavacamten MYK-461,SAR439152	Myosin	Cytoskeletal Signaling
	Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂，在牛心脏和人心脏中的IC50值分别为 490和711 nM。
T7648	HA-100	Myosin; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。
T7144	BTS N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂，可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。
T3050	ML-7 hydrochloride ML-7 HCl,ML-7盐酸盐	Serine/threonin kinase; Myosin; YAP; PKA; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	ML-7 hydrochloride (ML-7 HCl) 是一种可渗透细胞的、可逆的、有效的、ATP 竞争性的肌球蛋白轻链激酶(MLCK) 特异性抑制剂，IC50为300 nM。它还抑制平滑肌肌球蛋白轻链激酶、PKA 和 PKC。
T20792	W-7 hydrochloride N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl	CaMK; Apoptosis; Myosin; PDE	Apoptosis; Cytoskeletal Signaling; Metabolism; Neuroscience
	W-7 hydrochloride (W-7 HCl) 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶，IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡，具有抗癌活性。
T67952	JB062	Myosin	Cytoskeletal Signaling
	JB062是一种针对非肌肉肌球蛋白(nonmusclemyosin)的抑制剂，其IC50值对骨骼肌肌球蛋白为1.6μM、心肌肌球蛋白为5.4μM，而对平滑肌肌球蛋白II大于100μM。此化合物对人类癌细胞显示出细胞毒性，对正常细胞则无此作用。JB062在肌肉痉挛、慢性肌肉骨骼疼痛及肥厚型心肌病研究中有潜在应用价值。
T67951	JB061	Myosin	Cytoskeletal Signaling
	JB061是一种非肌肉肌球蛋白II抑制剂，针对心肌肌球蛋白、骨骼肌肌球蛋白和平滑肌肌球蛋白II的IC50分别为4.4 μM、9.1 μM和>100 μM。其对ATP酶活性的抑制作用较弱（IC50>200 μM）。此外，JB061对COS-7细胞显示出细胞毒性，IC50值为39 μM。
T12360	para-Nitroblebbistatin p-Nitroblebbistatin	Myosin	Cytoskeletal Signaling
	para-Nitroblebbistatin (p-Nitroblebbistatin) 是无细胞毒性、无荧光、光稳定、特异性的肌球蛋白 II (Myosin II) 抑制剂。para-Nitroblebbistatin 可用于肌球蛋白 II 在生理学、发育和细胞生物学中特殊作用的相关研究。
T72023	JB002	Myosin	Cytoskeletal Signaling
	JB002为一种肌球蛋白 II 抑制剂，IC50值不大于10 μM。适用于研究肌肉痉挛、慢性肌肉骨骼疼痛及肥厚型心肌病。
T26078	Rhodblock 6 Rhodblock6,Rhodblock-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rhodblock 6 是一种 Rho 激酶 (ROCK) 抑制剂，可抑制磷酸化 MRLC（肌球蛋白调节轻链）定位,通过特异性抑制 Rho 激酶的活性发挥作用。
T24214	Phenamacril JS39919,苯那普利,JS399 19	Myosin; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Phenamacril (JS39919) 是一种氰基丙烯酸酯类杀菌剂，对镰刀菌，特别是禾谷镰刀菌有很强的抑制作用。它是一种特异性镰刀菌肌球蛋白 I 抑制剂。
T12503	(+)-Blebbistatin	Others	Others
	(+)-Blebbistatin 是 (–)-Blebbistatin 的非活性对映异构体。 (–)-Blebbistatin 是一种选择性肌球蛋白 II ATPase 抑制剂。
T24612	Pentachloropseudilin PClP,Antibiotic A 15104 Y	Myosin; Antibiotic; TGF-beta/Smad	Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Pentachloropseudilin (PClP) 是一种可逆的变构 1 型肌球蛋白抑制剂，具有抗菌活性，抑制 Myo1s 和 5 类肌球蛋白。Pentachloropseudilin 抑制生长因子-β (TGF-β) ，可阻断克氏锥虫对宿主细胞的侵袭。
T62447	Paltimatrectinib PBI-200,PPI-5278	Trk receptor; Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Paltimatrectinib (PBI-200) 是一种高效的酪氨酸激酶 (tyrosine kinase) 抑制剂，具有抗癌活性，抑制肌球蛋白相关激酶 A (TrkA) 。Paltimatrectinib 可用于研究膀胱癌、乳腺癌和结直肠癌。
T13492	3,5-Diiodothyropropionic acid C082182,Ditpa cpd,3,5-二碘甲腺丙酸	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	3,5-Diiodothyropropionic acid (C082182) 是一种甲状腺激素类似物，能够诱导 α-肌球蛋白重链 mRNA 表达。它可与甲状腺激素受体结合，作用于 TRα1 (Ka:2.40 M-1) 和 TRβ1 (Ka:4.06 M-1) 。
TP1890L1	MLCK inhibitor peptide 18 acetate MLCK inhibitor peptide 18 acetate(224579-74-2 free base)	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	MLCK inhibitor peptide 18 acetate(224579-74-2 free base) 是肌球蛋白轻链激酶的选择性竞争性抑制剂 (IC50 = 50 nM)。显示出比 CaM 激酶 II 高 4000 倍的选择性，并且不抑制 PKA。细胞可渗透。
T30778	CCG-257081 MRTF/SRF-IN-1,CCG257081,CCG 257081	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-257081 (MRTF/SRF-IN-1) 是心肌素相关转录因子和血清反应因子 (MRTF/SRF) 的抑制剂,通过抑制 Rho/MRTF/SRF 通路来发挥作用。CCG-257081 已在多个小鼠模型中显示出预防博莱霉素诱导的纤维化的功效。CCG-257081 可用于预防癌症和纤维化的研究。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T1433	Ritodrine hydrochloride DU21220,盐酸利托君,Ritodrine HCl,NSC 291565	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T14069	A-3 hydrochloride	CaMK; Casein Kinase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors
	A-3 hydrochloride 是一种细胞可渗透的、可逆的、ATP 竞争性非选择性拮抗剂。它抑制 PKA 、酪蛋白激酶 II 和肌球蛋白轻链激酶，Ki 值分别为4.3 µM、5.1 µM 和7.4 µM。它还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。
T16145	MS-444 BE-34776	Others	Others
	MS-444 suppresses the activity of purified smooth muscle myosin light chain kinase (MLCK) (IC50: 10 μM).
T69639	Sevasemten	Others	Others
	Sevasemten为骨骼肌肌球蛋白(Myosin)的变构抑制剂，具有选择性抑制作用，其IC50值对骨骼肌球蛋白 ≤ 10 μM，而对心脏肌球蛋白则 >100 μM。
T33451	ML 7 ML7,ML-7	Others	Others
	ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury.
T70626	MS 347a	Others	Others
	MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).
T62804	YQ456	Others	Others
	YQ456 是一种新型的肌球蛋白小分子抑制剂，能够高亲和力的结合肌球蛋白 (KD: 37 nM)，抗侵袭能力强 (IC50: 110 nM) 。
T23992	Diazobenzenesulfonic acid Diazobenzenesulphonate,diazobenzene sulfonic acid,DASA,Diazobenzene sulfonate,Diazobenzenesulfonate	Others	Others
	Diazobenzenesulfonic acid is a whiter or reddish crystalline acid derivative of sulfanilic acid. It is a desensitizer (inhibitor) of allosteric effect for myosin ATPase 13.
T24272	KT5926 KT 5926,KT-5926	Others	Others
	KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation.
TP1710	Calmodulin Binding Peptide 1
	Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1].
T36335	(S)-nitro-Blebbistatin	Others	Others
	(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. H...
T62833	Myoferlin inhibitor 1	Others	Others
	Myoferlin inhibitor 1 是一种新型抗胰腺癌转移药物，能够肌球蛋白发挥作用。
T85155	(S)-3'-hydroxy Blebbistatin (−)-3'-hydroxy Blebbistatin,meta-hydroxy-Blebbistatin,m-hydroxy-Blebbistatin	Others	Others
	(S)-3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (–)-blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S)-3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm). It effectively inhibits the Mg-ATPase activity and in vitro ...
TP1890	MLCK inhibitor peptide 18
	Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
T63641	(3S,4R)-PF-6683324	Others	Others
	(3S,4R)-PF-6683324 是原肌球蛋白相关激酶 (Trk) 抑制剂，对疼痛和癌症表现出研究潜力。
T36400	para-amino-Blebbistatin	Others	Others
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...
T73439	MPH-220	Others	Others
	MPH-220是一种口服活性的、选择性骨骼肌myosin-2抑制剂，能够促进肌肉松弛。作为一种抗痉挛药物，它用于研究痉挛和肌肉僵硬。
T17189	U-46619 9,11-Methanoepoxy PGH2	Progesterone Receptor; PPAR	DNA Damage/DNA Repair; Metabolism; Others
	U-46619是一种有效的TXA2激动剂，是一种血栓素A2类似物（内过氧化物），有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。
T16103	ML-9 Free Base	Others	Others
	ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) acti
T85257	(S)-3'-amino Blebbistatin meta-amino Blebbistatin,(−)-3'-amino Blebbistatin,m-amino Blebbistatin	Others	Others
	"(S)-3'-amino Blebbistatin, retaining the active stereochemistry of the less stable and more phototoxic (–)-blebbistatin, serves as a refined selective cell-permeable inhibitor of non-muscle myosin II ATPases. This compound efficaciously inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across several species with IC50s ranging from 0.5-5 µM, and exhibits minimal inhibition against smooth muscle myosin (IC50= 80 µM). Its primary functions include obstructing ...

化合物

Myosin V-IN-1

Cat.No: T72060

Target: Myosin

Cat.No: T21550

Synonym: (±)-Blebbistatin

Target: ATPase, Myosin

(-)-Blebbistatin

Cat.No: T6038

Synonym: (S)-(-)-Blebbistatin

Target: ATPase, Myosin

Myosin H Chain Fragment, mouse

Cat.No: T78375

Cat.No: T15050

Synonym: MYK-491,SAR 440181

Target: Myosin

Myosin H Chain Fragment, mouse acetate

Cat.No: T80046

Cat.No: T16104

Target: Myosin, Akt

Omecamtiv mecarbil

Cat.No: T2006

Synonym: CK-1827452

Target: ATPase, Myosin

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Cat.No: T9258

Target: Others

Myosin light chain kinase fragment 11-19 amide

Cat.No: T81732

Synonym: MLCK(11-19) amide

Cat.No: T7134

Synonym: MYK-461,SAR439152

Target: Myosin

Cat.No: T7648

Target: Myosin, PKA, PKC

Cat.No: T7144

Synonym: N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide

Target: ATPase, Myosin

ML-7 hydrochloride

Cat.No: T3050

Synonym: ML-7 HCl,ML-7盐酸盐

Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC

W-7 hydrochloride

Cat.No: T20792

Synonym: N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl

Target: CaMK, Apoptosis, Myosin, PDE

Cat.No: T67952

Target: Myosin

Cat.No: T67951

Target: Myosin

para-Nitroblebbistatin

Cat.No: T12360

Synonym: p-Nitroblebbistatin

Target: Myosin

Cat.No: T72023

Target: Myosin

Cat.No: T26078

Synonym: Rhodblock6,Rhodblock-6

Target: ROCK

Cat.No: T24214

Synonym: JS39919,苯那普利,JS399 19

Target: Myosin, Antifungal

(+)-Blebbistatin

Cat.No: T12503

Target: Others

Pentachloropseudilin

Cat.No: T24612

Synonym: PClP,Antibiotic A 15104 Y

Target: Myosin, Antibiotic, TGF-beta/Smad

Paltimatrectinib

Cat.No: T62447

Synonym: PBI-200,PPI-5278

Target: Trk receptor, Tyrosine Kinases

3,5-Diiodothyropropionic acid

Cat.No: T13492

Synonym: C082182,Ditpa cpd,3,5-二碘甲腺丙酸

Target: Thyroid hormone receptor(THR)

MLCK inhibitor peptide 18 acetate

Cat.No: TP1890L1

Synonym: MLCK inhibitor peptide 18 acetate(224579-74-2 free base)

Target: Serine/threonin kinase

Cat.No: T30778

Synonym: MRTF/SRF-IN-1,CCG257081,CCG 257081

Target: Rho, Ras

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Ritodrine hydrochloride

Cat.No: T1433

Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Target: Adrenergic Receptor

A-3 hydrochloride

Cat.No: T14069

Target: CaMK, Casein Kinase, PKA, PKC

Cat.No: T16145

Synonym: BE-34776

Target: Others

Cat.No: T69639

Target: Others

Cat.No: T33451

Synonym: ML7,ML-7

Target: Others

Cat.No: T70626

Target: Others

Cat.No: T62804

Target: Others

Diazobenzenesulfonic acid

Cat.No: T23992

Synonym: Diazobenzenesulphonate,diazobenzene sulfonic acid,DASA,Diazobenzene sulfonate,Diazobenzenesulfonate

Target: Others

Cat.No: T24272

Synonym: KT 5926,KT-5926

Target: Others

Calmodulin Binding Peptide 1

Cat.No: TP1710

(S)-nitro-Blebbistatin

Cat.No: T36335

Target: Others

Myoferlin inhibitor 1

Cat.No: T62833

Target: Others

(S)-3'-hydroxy Blebbistatin

Cat.No: T85155

Synonym: (−)-3'-hydroxy Blebbistatin,meta-hydroxy-Blebbistatin,m-hydroxy-Blebbistatin

Target: Others

MLCK inhibitor peptide 18

Cat.No: TP1890

(3S,4R)-PF-6683324

Cat.No: T63641

Target: Others

para-amino-Blebbistatin

Cat.No: T36400

Target: Others

Cat.No: T73439

Target: Others

Cat.No: T17189

Synonym: 9,11-Methanoepoxy PGH2

Target: Progesterone Receptor, PPAR

Cat.No: T16103

Target: Others

(S)-3'-amino Blebbistatin

Cat.No: T85257

Synonym: meta-amino Blebbistatin,(−)-3'-amino Blebbistatin,m-amino Blebbistatin

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
TN1533	Cucurbitacin A	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

天然产物

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: TN1533

Target: ROCK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01729	Myosin-9/MYH9 Protein, Human, Recombinant (GST) Myosin-9,MYH9,Myosin heavy chain 9,Myo...	Human	E. coli
	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis. Promotes cell motility in conjunction with S100A4. During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10. Myosin-...
TMPH-00285	Myosin-1 Protein, Bovine, Recombinant (His & Myc) Myosin heavy chain 2x,MYH1,Myosin heavy ch...	Bovine	E. coli
	Muscle contraction. Myosin-1 Protein, Bovine, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is Q9BE40.
TMPH-01727	Myosin-6/MYH6 Protein, Human, Recombinant (His) Myosin heavy chain 6,Myosin heavy chain, c...	Human	P. pastoris (Yeast)
	Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 76.8 kDa and the accession number is P13533.
TMPH-01728	Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) Myosin-6,MYH6,Myosin heavy chain, cardiac ...	Human	E. coli
	Muscle contraction. Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 80.8 kDa and the accession number is P13533.
TMPH-01726	MYL6 Protein, Human, Recombinant (GST) 17 kDa myosin light chain,Myosin light cha...	Human	E. coli
	Regulatory light chain of myosin. Does not bind calcium. MYL6 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.7 kDa and the accession number is P60660.
TMPH-01725	MYL3 Protein, Human, Recombinant (GST) Ventricular myosin alkali light chain,Ventricular/s...	Human	E. coli
	Regulatory light chain of myosin. Does not bind calcium. MYL3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 48.8 kDa and the accession number is P08590.
TMPH-00379	MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) Mylk,Telokin,Myosin light chain kinase, smooth musc...	Chicken	E. coli
	Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 52.9 kDa and the accession number is P11799.
TMPH-03753	MYLK Protein, Human, Recombinant (His) MYLK,Myosin light chain kinase, smooth muscle,Telok...	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...
TMPH-01730	MYBPC3 Protein, Human, Recombinant (His & SUMO) C-protein, cardiac muscle isoform,Myosin-binding pr...	Human	E. coli
	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q14896.
TMPH-01004	Beclin-1 Protein, Human, Recombinant (His) Protein GT197,GT197,Coiled-coil myosin-like BCL2-in...	Human	E. coli
	Beclin-1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 57.9 kDa and the accession number is Q14457.
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO) Beclin-1,GT197,Coiled-coil myosin-like BCL2-interac...	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential f...
TMPH-01731	MYBPC2 Protein, Human, Recombinant (His) C-protein, skeletal muscle fast isoform,Myosin-bind...	Human	E. coli
	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. MYBPC2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.5 kDa and the accession number is Q14324.
TMPH-02847	CNPY2 Protein, Mouse, Recombinant (His & Myc) MIR-interacting saposin-like protein,Tmem4,Transmembrane pro...	Mouse	E. coli
	Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
TMPY-03957	Troponin C Protein, Human, Recombinant TN-C,CMD1Z,TNNC,TNC,CMH13,troponin C type 1 (slow)	Human	E. coli
	Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which...
TMPY-03261	CNPY2 Protein, Human, Recombinant (His) canopy FGF signaling regulator 2,HP10390,ZSIG9,MSAP,TMEM4	Human	HEK293 Cells
	CNPY2 is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. CNPY2 enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain. It is expressed in different tissues, including brain. Overexpression of CNPY2 enhanced the motility of glioma cells measured in matrigel invasion chambers and using a scratch assay. Downregulation of CNPY2 by RNA interference significantly decreased glioma cell migration and...
TMPY-02760	CALML3 Protein, Human, Recombinant (His) calmodulin-like 3,CLP	Human	E. coli
	Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its pote...
TMPJ-01261	PPP1R14A Protein, Human, Recombinant (His) 17 kDa PKC-Potentiated Inhibitory Protein of PP1,CPI17,PPP1R...	Human	E. coli
	Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA su...
TMPY-04327	VEGFB Protein, Human, Recombinant (hFc) VRF,血管内皮生长因子,vascular endothelial growth factor B,VEGFL	Human	HEK293 Cells
	Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I...
TMPY-03434	BMF Protein, Human, Recombinant (His) Bcl2 modifying factor	Human	E. coli
	BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular d...
TMPY-03607	Cofilin Protein, Human, Recombinant (His) CFL,HEL-S-15,cofilin 1 (non-muscle)	Human	E. coli
	CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a...
TMPY-03501	Optineurin Protein, Human, Recombinant (His & GST) optineurin,HIP7,ALS12,HYPL,TFIIIA-INTP,FIP2,NRP,GLC1E	Human	Baculovirus Insect Cells
	OPTN (Optineurin) is a Protein Coding gene. The Optineurin gene encodes the coiled-coil containing protein optineurin. Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerization, optineurin can act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the ...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST) PRAK,MAPKAP-K5,MK-5,mitogen-activated protein kinase-activat...	Human	Baculovirus Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator...
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) death-associated protein kinase 3,DLK,ZIP,ZIPK	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT...
TMPY-03504	CBFB Protein, Human, Recombinant (His) core-binding factor, β subunit,core-binding factor, beta sub...	Human	E. coli
	CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBFB is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enh...

重组蛋白

Myosin-9/MYH9 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01729

Species: Human

Expression System: E. coli

Myosin-1 Protein, Bovine, Recombinant (His & Myc)

Cat.No: TMPH-00285

Species: Bovine

Expression System: E. coli

Myosin-6/MYH6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01727

Species: Human

Expression System: P. pastoris (Yeast)

Myosin-6/MYH6 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01728

Species: Human

Expression System: E. coli

MYL6 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01726

Species: Human

Expression System: E. coli

MYL3 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01725

Species: Human

Expression System: E. coli

MLCK Protein, Chicken, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00379

Species: Chicken

Expression System: E. coli

MYLK Protein, Human, Recombinant (His)

Cat.No: TMPH-03753

Species: Human

Expression System: E. coli

MYBPC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01730

Species: Human

Expression System: E. coli

Beclin-1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01004

Species: Human

Expression System: E. coli

Beclin-1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02538

Species: Mouse

Expression System: E. coli

MYBPC2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01731

Species: Human

Expression System: E. coli

CNPY2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02847

Species: Mouse

Expression System: E. coli

Troponin C Protein, Human, Recombinant

Cat.No: TMPY-03957

Species: Human

Expression System: E. coli

CNPY2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03261

Species: Human

Expression System: HEK293 Cells

CALML3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02760

Species: Human

Expression System: E. coli

PPP1R14A Protein, Human, Recombinant (His)

Cat.No: TMPJ-01261

Species: Human

Expression System: E. coli

VEGFB Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04327

Species: Human

Expression System: HEK293 Cells

BMF Protein, Human, Recombinant (His)

Cat.No: TMPY-03434

Species: Human

Expression System: E. coli

Cofilin Protein, Human, Recombinant (His)

Cat.No: TMPY-03607

Species: Human

Expression System: E. coli

Optineurin Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03501

Species: Human

Expression System: Baculovirus Insect Cells

PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04425

Species: Human

Expression System: Baculovirus Insect Cells

ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04385

Species: Human

Expression System: Baculovirus Insect Cells

CBFB Protein, Human, Recombinant (His)

Cat.No: TMPY-03504

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0010	Mavacamten-d6
	Mavacamten-d6 是 Mavacamten 的氘代化合物。Mavacamten 的 CAS 号为 1642288-47-8。MYK-461 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂，在牛心脏和人心脏中的IC50值分别为 490和711 nM。

同位素标记化合物

Cat.No: TMID-0010

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