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Search Results for " myelin basic protein "

17

抑制剂 & 化合物

1

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1650	Myelin Basic Protein Myelin Basic Protein MBP
	Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.
T21618L	Myelin Basic Protein (87-99) Acetate Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)	Others	Others
	Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) 是一种致脑炎肽，可诱导碱性蛋白特异性 T 细胞增殖。它导致外周血单核细胞中的 Th1 极化，这与多发性硬化症 (MS) 有牵连。
TP1092	Myelin Basic Protein (MBP) (68-82), guinea pig MBP (68-82), guinea pig,豚鼠髓磷脂碱性蛋白片段68-82	Others	Others
	Myelin Basic Protein (MBP) (68-82), guinea pig 是一种髓鞘碱性蛋白 (MBP) 的片段。
T76021	Myelin Basic Protein TFA	Others	Others
	Myelin Basic Protein (MHP4-14) TFA 是一种合成肽，包含髓鞘碱性蛋白的残基4-14，是一种非常有选择性的 PKC 底物 (Km=7 μM)。Myelin Basic Protein TFA 不被环腺苷酸依赖性蛋白激酶、酪蛋白激酶 I 和 II、Ca2+/钙调素依赖性蛋白激酶 II 或磷酸化酶激酶磷酸化，可常规用于测定粗组织提取物中低背景的蛋白激酶 C。
T81734	Myelin Basic Protein (1-11)
	Myelin Basic Protein (1-11) 是髓鞘碱性蛋白 (MBP) 的一个致脑炎表位，并且常用于诱导实验性自身免疫性脑脊髓炎 (EAE)。
T78370	Myelin Basic Protein(87-99) TFA
	Myelin Basic Protein(87-99) TFA 为诱导神经碱性蛋白特异性T细胞增殖的致脑肽。该化合物能在外周血单核细胞中诱导Th1极化，与多发性硬化症(MS)的发病机制相关。
T83684	Myelin Basic Protein Peptide (mouse, bovine) TFA Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
	Myelin基础蛋白(MBP)肽是PKC的肽底物，相比PKA、酪蛋白激酶1(CK1)、CK2、磷酸化酶激酶及钙/钙调蛋白依赖性蛋白激酶(CaMKII)，它对PKC有选择性。MBP肽已用于监测原发性人类肾动脉平滑肌细胞中的PKC活性。
T82020	J5 peptide Myelin basic protein (85-99) antagonist
	J5 peptide是MBP抑制剂，竞争性阻断MBP85-99与HLA-DR2的结合。该肽段能减轻PLP139-151/MBP85-99诱导的小鼠实验性自身免疫性脑脊髓炎(EAE)。J5 peptide主要用于研究炎症和免疫疾病。
T82877	Biotin-myelin basic protein (94-102)
	Biotin-myelin basic protein (94-102) 是一种多肽片段，承担着在神经系统中促进髓鞘形成的关键角色。作为细胞膜肌动蛋白结合蛋白，髓鞘碱性蛋白（Myelin basic protein）对于维持神经纤维多层髓鞘的紧密附着至关重要，并有可能参与传递细胞外信号，以促进少突胶质细胞的细胞骨架与髓鞘的联结。
TP1887L1	[Ala107]-MBP (104-118) acetate [Ala107]-MBP (104-118) acetate(99026-77-4 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	[Ala107]-MBP (104-118) acetate ([Ala107]-MBP )(99026-77-4 free base) 是牛髓鞘碱性蛋白 (MBP) 的合成肽类似物。 PKC 的非竞争性抑制剂 (IC50 = 46 - 145 mM)。
TP1888	[Ala113]MBP(104-118) [Ala113]-MBP (104-118)
	Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).
TP1755	Ac-MBP (1-11) Ac-MBP 1-11
	Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].
TP1887	[Ala107]MBP(104-118) [Ala107]-MBP (104-118)
	Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).
T81841	MBP (146-170)
	MBP (146-170)，即髓磷脂碱性蛋白，主要用于多发性硬化症(MS)的科学研究。
T37929	14-dehydro Zymostenol	Others	Others
	14-dehydro Zymostenol is a precursor to cholesterol .1It increases the percentage of myelin basic protein-positive (MBP+) oligodendrocytes formed from oligodendrocyte precursor cells when used at concentrations of 5.8 and 17 μM.2 1.Lutsky, B.N., and Schroepfer, G.J., Jr.Studies on the enzymic conversion of 5α-cholesta-8,14-dien-3β-ol to cholesterolJ. Biol. Chem.245(23)6449-6455(1970) 2.Hubler, Z., Allimuthu, D., Bederman, I., et al.Accumulation of 8,9-unsaturated sterols drives oligodendrocyte f...
T82547	Dirucotide MBP8298
	Dirucotide (MBP8298) 是一种合成的肽，含有17个氨基酸，其序列与人类髓鞘碱性蛋白的部分序列一致。该化合物主要用于多发性硬化症（MS）等中枢神经系统自身免疫性疾病的研究。
T83690	[Leu144, Arg147]-PLP (139-151) TFA [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
	[Leu144,Arg147]-PLP (139-151)是髓鞘脂蛋白(PLP)的一种突变肽段，包含位于144和147位置的色氨酸到亮氨酸以及组氨酸到精氨酸的替换。使用[Leu144, Arg147]-PLP (139-151)（50 µg）乳化于完全弗氏佐剂(CFA)免疫后，能增加小鼠脾脏中的IL-4水平。它在体外抑制Th1细胞激活，但在体内不抑制，其中它诱导调节性T细胞的产生。用[Leu144, Arg147]-PLP (139-151)预免疫可以延迟由脑炎肽PLP (178-191)、髓磷脂少突细胞蛋白(MOG) (92-106)或髓鞘基础蛋白(MBP)在小鼠中诱导的实验性自身免疫性脑炎(EAE)的发病。

化合物

Myelin Basic Protein

Cat.No: TP1650

Synonym: Myelin Basic Protein MBP

Myelin Basic Protein (87-99) Acetate

Cat.No: T21618L

Synonym: Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)

Target: Others

Myelin Basic Protein (MBP) (68-82), guinea pig

Cat.No: TP1092

Synonym: MBP (68-82), guinea pig,豚鼠髓磷脂碱性蛋白片段68-82

Target: Others

Myelin Basic Protein TFA

Cat.No: T76021

Target: Others

Myelin Basic Protein (1-11)

Cat.No: T81734

Myelin Basic Protein(87-99) TFA

Cat.No: T78370

Myelin Basic Protein Peptide (mouse, bovine) TFA

Cat.No: T83684

Synonym: Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide

Cat.No: T82020

Synonym: Myelin basic protein (85-99) antagonist

Biotin-myelin basic protein (94-102)

Cat.No: T82877

[Ala107]-MBP (104-118) acetate

Cat.No: TP1887L1

Synonym: [Ala107]-MBP (104-118) acetate(99026-77-4 free base)

Target: PKC

[Ala113]MBP(104-118)

Cat.No: TP1888

Synonym: [Ala113]-MBP (104-118)

Cat.No: TP1755

Synonym: Ac-MBP 1-11

[Ala107]MBP(104-118)

Cat.No: TP1887

Synonym: [Ala107]-MBP (104-118)

Cat.No: T81841

14-dehydro Zymostenol

Cat.No: T37929

Target: Others

Cat.No: T82547

Synonym: MBP8298

[Leu144, Arg147]-PLP (139-151) TFA

Cat.No: T83690

Synonym: [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

Cat. No.	Product Name	Target	Signaling Pathways
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。

天然产物

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01563	PMP2 Protein, Human, Recombinant (His) MP2,FABP8,peripheral myelin protein 2,P2,M...	Human	E. coli
	Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells ...
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His) kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...	Human	HEK293 Cells
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh...
TMPY-04407	LOK Protein, Human, Recombinant (His) serine/threonine kinase 10,PRO2729,LOK	Human	E. coli
	Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste2 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK1 is si...

重组蛋白

PMP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01563

Species: Human

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02759

Species: Human

Expression System: HEK293 Cells

LOK Protein, Human, Recombinant (His)

Cat.No: TMPY-04407

Species: Human

Expression System: E. coli

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