24
3
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77353 |
MyD88-IN-1
|
IL Receptor; NF-κB; TLR; MyD88 | Immunology/Inflammation; NF-κB |
MyD88-IN-1 是一种有效的 MyD88 抑制剂。MyD88-IN-1 具有抗炎活性,可抑制 Toll 样受体 (TLR) 和白细胞介素-1 (IL-1) 受体家族成员下游炎症信号通路 ,包括NF-κB 通路。MyD88-IN-1 可用于研究癌症和治疗炎症。 | |||
T9765 |
TJ-M2010-5
|
MyD88 | Immunology/Inflammation |
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。 | |||
T13932 |
TLR1
N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺 |
Others; MyD88 | Immunology/Inflammation; Others |
TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物,能够阻碍 IL-1 受体介导的反应。 | |||
T9203 |
JH-X-119-01
|
IRAK | Immunology/Inflammation; NF-κB |
JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM),在浓度达到 10 μM 时,也不会对 IRAK4 产生抑制作用。 | |||
T9027 |
CA-4948
Emavusertib |
IRAK; FLT | Angiogenesis; Immunology/Inflammation; NF-κB; Tyrosine Kinase/Adaptors |
CA-4948 (Emavusertib) 是一种IRAK4抑制剂,也是一种FLT3抑制剂,具有抗肿瘤作用。 | |||
TQ0181 |
Resatorvid
CLI-095,TAK-242,瑞沙托维 |
TNF; TLR; Autophagy; Interleukin | Apoptosis; Autophagy; Immunology/Inflammation |
Resatorvid (TAK-242) 是一种 Toll 样受体 4 (TLR4) 的抑制剂,具有选择性。Resatorvid 直接与 Cys747 结合,阻止 TLR4 与 TIRAP 结合,从而阻止下游信号转导。Resatorvid 具有抗肿瘤活性、抗炎活性和神经保护作用。 | |||
T13063 |
T6167923
|
MyD88 | Immunology/Inflammation |
T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好,破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性,并且改善抗炎活性,对 IFN-γ,IL-1β,IL-6 和 TNF-α 的 IC50分别为 2.7 μM,2.9 μM,2.66 μM 和 2.66 μM。 | |||
T27034 |
CL075
3M002,CL-075 |
NF-κB; TLR; MyD88 | Immunology/Inflammation; NF-κB |
CL075 (3M002) 是一种选择性TLR8 激动剂。CL075具有免疫调节活性,通过触发 MyD88 依赖性信号通路,激活 NF-κB 和 IRF7 引发炎症性细胞因子和 I 型干扰素 (IFN) 的产生。 | |||
T61931 |
IRAK4-IN-10
|
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-10 是一种高效的 IRAK4 抑制剂(IC50:1.5 nM),具有潜在的抗癌和抗炎活性。IRAK4-IN-10 阻断 MyD88 信号传导,可用研究自身免疫性疾病和癌症。 | |||
T41142 |
EM 163
|
IL Receptor; p38 MAPK; MyD88 | Immunology/Inflammation; MAPK |
EM 163是一种 TIR-TIR 相互作用抑制剂,它是MyD88蛋白的TIR(Toll/白细胞介素-1受体)结构域拟态。EM 163针对IL-1受体中的TIR 结构域,阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B(SEB)引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中,EM 163阻断p38的激活和IL-1β对化学诱导的长期电位(LTP)引发的蛋白质合成的抑制作用。 | |||
T16937 |
ST 2825
|
Others | Others |
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 inhibition of IL-1β-mediated activation of NF-κB transcriptional activity. | |||
T69722 |
TSI-13-48
|
Others | Others |
TSI-13-48 is a MyD88 inhibitor. | |||
T68261 |
T5996207
|
Others | Others |
T5996207 is a inhibitor of MyD88-dependent signaling pathways | |||
T69733 |
LM9
|
Others | Others |
LM9 is a MyD88 inhibitor which prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages. | |||
T11674 |
IRAK4-IN-6
|
Others | Others |
IRAK4-IN-6 是一种选择性的、口服有效的IRAK 抑制剂,IC50为 4 nM,靶向 MyD88 L265P 突变型弥漫性大 B 细胞淋巴瘤。 | |||
T69719 |
TSI-13-57
|
Others | Others |
TSI-13-57 is a MyD88 inhibitor. | |||
T75223 |
RDR 02308
|
Others | Others |
RDR 02308 是 TLR4-MyD88结合抑制剂,可抑制全长β-lactamase。 | |||
T61734 |
IRAK4-IN-9
|
Others | Others |
IRAK4-IN-9 (compound 73) is a highly potent inhibitor of IRAK4, displaying an impressive IC50 value of 1.5 nM. By blocking MyD88-dependent signaling, IRAK4-IN-9 exhibits promising potential for the investigation of inflammatory diseases, autoimmune diseases, and cancer [1]. | |||
T63262 |
IRAK4-IN-15
|
Others | Others |
IRAK4-IN-15 是选择性的、有效的 IRAK4 抑制剂 (IC50: 0.002 μM),具有良好的人类 PK 预测且具有低内在清除率。IRAK4-IN-15 与 Acalabrutinib 联用对 MyD88/CD79 双突变体 ABC-DLBCL 的表现出强大的协同体外活性。 | |||
T70145 |
LYRM03
|
Others | Others |
LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries. | |||
T70595 |
Artemisinin B
|
Others | Others |
Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases. | |||
T79485 |
IRAK4-IN-27
|
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-27(Compound 22)为高效选择性IRAK4抑制剂,具IC50值8.7 nM。该化合物能够抑制含MYD88L265P突变的DLBCL细胞系生长并促进其细胞凋亡(apoptosis),适用于弥漫大B细胞淋巴瘤(DLBCL)的研究。 | |||
T74664 |
KTX-582
|
PROTACs | PROTAC |
KTX-582为一有效IRAK4降解剂,DC50对IRAK4及Ikaros分别为4 nM与5 nM。KTX-582能诱导MYD88MTDLBCL细胞凋亡(apoptosis),在淋巴瘤模型中有效促进体内肿瘤消退。 | |||
T63278 |
IRAK4-IN-14
|
Others | Others |
IRAK4-IN-14 是选择性的、有效的、口服具有活力的 IRAK4 抑制剂 (IC50: 0.003 μM),在大鼠和小鼠中具有出良好的 PK 参数。IRAK4-IN-14 与 Acalabrutinib 联合使用对 MyD88/CD79 双突变体 ABC-DLBCL 表现出协同体外作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3898 |
Schaftoside
夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside |
Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy | Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction |
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达,还降低 Drp1 表达和磷酸化,并减少线粒体分裂,具有抗氧化和抗癌活性。 | |||
T5S0167 |
Atractylenolide I
白术内酯 I,白术内酯I;苍术内酯I |
IL Receptor; TNF; TLR; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。 | |||
T27191 |
D-Mannuronic Acid
|
||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01723 |
MYD88 Protein, Human, Recombinant (His)
Myeloid differentiation primary response protein MyD |
Human | E. coli |
MYD88 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q99836. | |||
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPH-02937 |
TLR11 Protein, Mouse, Recombinant (His & Myc)
Toll-like receptor 11,Toll-like receptor 12,Tlr11 |
Mouse | E. coli |
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR11 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q6R5P0. | |||
TMPH-02211 |
TLR7 Protein, Human, Recombinant (His & Myc)
TLR7,Toll-like receptor 7 |
Human | E. coli |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed i... | |||
TMPH-02212 |
TLR8 Protein, Human, Recombinant (His)
TLR8,Toll-like receptor 8 |
Human | P. pastoris (Yeast) |
Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-con... | |||
TMPH-03267 |
CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f... |
Rat | E. coli |
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ... |