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Search Results for " muscarinic receptor antagonist "

Targets Recommended: AChR

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抑制剂 & 化合物

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同位素标记化合物

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Cat. No.	Product Name
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

Cat. No.	Product Name	Target	Signaling Pathways
T0218	Biperiden Bipariden,Akineton,KL 373,比哌立登,Biperidine	AChR	Neuroscience
	Biperiden (Bipariden) 是中枢 M1胆碱受体阻断剂，有抗帕金森症活性。
T9771	Velufenacin	AChR	Neuroscience
	Velufenacin 是一种毒蕈碱型受体 (muscarinic receptor) 的拮抗剂。
T23297	(S)-(+)-Dimethindene maleate	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(S)-(+)-Dimethindene maleate 是一种可口服且具有选择性毒蕈碱 M2 受体和组胺 H1 受体拮抗剂，抑制毒蕈碱 M1，M3 和 M4 受体。
T13385	Zamifenacin fumarate 扎非那星富马酸盐,UK-76654 fumarate	AChR	Neuroscience
	Zamifenacin fumarate (UK-76654 fumarate) 是肠道选择性毒蕈碱M3受体的有效拮抗剂，可显著降低肠易激综合症的结肠蠕动。
T10914L	Cyclodrine Cyclopent	AChR	Neuroscience
	Cyclodrine (Cyclopent) 是一种胆碱能 (毒蕈碱，烟碱) 受体 (mAChR 和 nAChR) 拮抗剂。
T7895	Syn-Ake acetate 类蛇毒三肽,Dipeptide diaminobutyroyl benzylamide	AChR	Neuroscience
	Syn-Ake acetate (Dipeptide diaminobutyroyl benzylamide) 是一种毒蕈碱乙酰胆碱受体拮抗剂。
T6364	Desfesoterodine 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine	AChR	Neuroscience
	Desfesoterodine (5-HMT) 是选择性毒蕈碱受体拮抗剂，Kb 和pA2分别为 0.84 nM 和 9.14。它可改善大鼠脑梗死诱导膀胱过度活动，是 Tolterodine 和 Fesoterodine 的主要药理活性代谢产物。
T5655	mAChR-IN-1 hydrochloride	AChR	Neuroscience
	mAChR-IN-1 hydrochloride 是一种毒蕈碱胆碱能受体抑制剂，IC50值为17nM。
T1542	Pirenzepine dihydrochloride Pirenzepine HCl,Bisvanil,Tabe,盐酸哌仑西平,LS519	AChR	Neuroscience
	Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 毒蕈碱受体拮抗剂，可抑制胃液分泌。
T31207	GSK233705 Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B	AChR	Neuroscience
	GSK233705 (Darotropium bromide) 是一种毒蕈碱受体拮抗剂，可用来与预防和治疗人类的慢性阻塞性肺病(COPD)和哮喘。
T1534	Darifenacin hydrobromide 氢溴酸达非那新,Darifenacin HBr,UK-88525	AChR	Neuroscience
	Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂，pKi 为 8.9。
T23508	VU 0255035	AChR	Neuroscience
	VU 0255035 是高度选择性、竞争性和血脑屏障通透性的毒蕈碱 M1 受体拮抗剂，IC50为 130 nM，可减少毛果芸香碱诱导的小鼠癫痫发作。
T28722	SCH 57790 SCH57790,SCH-57790	AChR	Neuroscience
	SCH 57790 是一种新型且具有选择性的毒蕈碱 M（2）受体拮抗剂，可释放乙酰胆碱并增强实验动物的认知能力，可用于治疗阿尔茨海默病。
T16989	Tarafenacin D-tartrate SVT-40776 D-tartrate	AChR	Neuroscience
	Tarafenacin D-tartrate (SVT-40776 D-tartrate) 是一种具有选择和高效性的毒蕈碱乙酰胆碱 M3 受体拮抗剂，可用于研究膀胱过度活动症和支气管疾病。
T29687	Afacifenacin Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR	Neuroscience
	Afacifenacin (SMP-986) fumarate 是一种 M3 毒蕈碱受体选择性拮抗剂，可用于研究缺血性心脏病，尿失禁和膀胱炎和其他疾病。
T7079	Batefenterol GSK961081,TD-5959	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Batefenterol (TD-5959) 是一种毒蕈碱受体拮抗剂和β2-肾上腺素受体激动剂，对 hM2、hM3和β2-肾上腺素受体有高亲和力，Ki 值分别为 1.4、1.3 和 3.7 nM。
T0099	Tolterodine tartrate Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定	AChR	Neuroscience
	Tolterodine tartrate (PNU-200583E) 是毒蕈碱受体的有效拮抗剂。它在体内显示出对膀胱和唾液腺的选择性。
TP1902L1	G-Protein antagonist peptide acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	G-Protein antagonist peptide acetate 是一种 substance P 相关肽，可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide acetate 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活，并通过 β-肾上腺素受体抑制 Gs 的激活。
T8147	Solifenacin 索利那新,YM905 free base	AChR	Neuroscience
	Solifenacin (YM905 free base) 是一种新型的毒蕈碱受体拮抗剂，对 M1、M2和 M3受体的 pKi 值分别为 7.6、6.9 和 8.0。
T1179	Tiotropium bromide Tiopropium,噻托溴铵,BA679 BR	AChR	Neuroscience
	Tiotropium bromide (BA679 BR) 是一种毒蕈碱乙酰胆碱受体拮抗剂，可阻断乙酰胆碱配体的结合。
T10000	(±)-Tazifylline	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(±)-Tazifylline 是一种选择性的长效组胺 H1 受体拮抗剂。 Tazifylline 对 H2 受体、α- 和 β-肾上腺素能受体、5-羟色胺和毒蕈碱受体亚型的亲和力要低得多。
T14345	Atropine methyl bromide 甲溴阿托品,Methylatropine bromide	AChR	Neuroscience
	Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic examination. Compared to atropine, it demonstrates reduced penetration into the central nervous system[1][2]. Its high polarity makes it particularly effective in relieving pyloric spasm in infants.
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T5051	Isopropamide Iodide	AChR	Neuroscience
	Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病，尤其是胃酸过多和运动过度。
T12489L	Pimethixene maleate Pimetixene maleate	Dopamine Receptor; 5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂，具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A，5-HT2A，5-HT2B，5-HT2C，组胺 H1，多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2，可用于研究儿童干咳和刺激性咳嗽。
T72226L	PF-4348235 HCl PF-4348235 HCl（1017857-38-3 Free base）,β2AR/M-receptor agonist-2 HCl	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	PF-4348235 HCl (β2AR/M-receptor agonist-2 HCl) 是毒蕈碱M3 受体拮抗剂（Ki：0.73 nM）和 β2 肾上腺素受体激动剂 (MABA，EC50：3.7 nM)。PF-4348235 HCl 也是一种支气管扩张剂，可用于研究慢性阻塞性肺疾病 (COPD) 等心血管疾病和呼吸道疾病。
T1006	Propantheline bromide Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl	AChR	Neuroscience
	Propantheline bromide (Pro-Banthine) 是一种抗毒蕈碱剂，用于研究多汗症，遗尿，胃肠和膀胱痉挛。
T4494	CLOZAPINE N-OXIDE 氯氮平N-氧化,氯氮平N-氧化物	Dopamine Receptor; 5-HT Receptor; AChR; Drug Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	Clozapine N-oxide 是 Clozapine 的主要代谢产物，具有血脑屏障渗透性。Clozapine N-oxide 是一种 DREADDs 激动剂，可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide 也是一种多巴胺拮抗剂和选择性毒蕈碱 M4 受体激动剂。
T6426	Buclizine dihydrochloride 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Buclizine dihydrochloride (Buclina) 是可口服的一种哌嗪组胺 H1 受体拮抗剂，主要具有止吐和抗眩晕活性。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T68599	Orphenadrine Orphenadrine (free base)	Sodium Channel; NMDAR; AChR	Membrane transporter/Ion channel; Neuroscience
	Orphenadrine 是一种非竞争性的 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，以浓度依赖性方式抑制克隆的 HERG 通道，在 HEK 细胞中产生0.85μM 的 IC。Orphenadrine 是中枢和外周毒蕈碱受体的拮抗剂，通过孔残基 Y652或 F656突变阻断衰减。 Orphenadrine 具有抗痉挛、镇痛和抗胆碱能活性，对在体外和体内对谷氨酸神经毒性具有保护作用。Orphenadrine 对钠离子通道具有抑制作用，可用来治疗帕金森。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T23452	Telenzepine dihydrochloride	Others	Others
	muscarinic M1 receptor antagonist
T22709	DAU 5884 hydrochloride	Others	Others
	muscarinic M3 receptor antagonist
T23124	PD 102807	Others	Others
	M4 muscarinic receptor antagonist
T25697	Levophencynonate Levo-phencynonate	Others	Others
	Levophencynonate is a muscarinic receptor antagonist.
T25697L	Levophencynonate HCl Levophencynonate hydrochloride,R-(-)-Phencynonate hydrochloride	Others	Others
	Levophencynonate HCl is a muscarinic receptor antagonist.
T22876	J 104129 fumarate	Others	Others
	M3 muscarinic receptor antagonist
T23379	Solifenacin hydrochloride	Others	Others
	Solifenacin Hcl is a muscarinic receptor antagonist.
T2278L	Piboserod hydrochloride SB 207266 hydrochloride,Piboserod HCl,SB 207266A	Others	Others
	Piboserod HCl is a selective antagonist of 5-HT4 and muscarinic receptor.
T27199	Doxacurium Chloride BW A 938U,BWA938U,Nuromax,BW-A-938U	Others	Others
	Doxacurium Chloride is a muscarinic acetylcholine receptor M2 antagonist.
T29047	UH-AH 37 UH-AH-37,UH-AH37	Others	Others
	UH-AH 37 is a antagonist of human muscarinic acetylcholine receptor.
T71591	3-Quinuclidinyl xanthene-9-carboxylate	Others	Others
	3-Quinuclidinyl xanthene-9-carboxylate is a Muscarinic receptor antagonist.
T71014	Aprophit	Others	Others
	Aprophit is a muscarinic antagonist that has been shown to selectively acylate muscarinic receptor proteins.
T15211	Elucaine	Others	Others
	Elucaine is an antagonist of the muscarinic acetylcholine receptor. It has anti-ulcerative activity.
T13372	YM-58790 hydrochloride	Others	Others
	YM-58790 hydrochloride is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).
T24882	Tiemonium iodide Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin	Others	Others
	Tiemonium iodide is a muscarinic receptor antagonist. It is also an anticholinergic and a parasympatholytic.
T12680	(±)-Darifenacin (±)-UK-88525	Others	Others
	(±)-Darifenacin is the racemate of Darifenacin. Darifenacin is a selective antagonist of M3 muscarinic receptor.
T26373	(R)-Mequitazine V-0162,V0162,V 0162	Others	Others
	(R)-Mequitazine, a muscarinic acetylcholine receptor (M-AChRs) antagonist, is used potentially for the treatment of asthma.
T26604	Alvameline Tartrate LU-25-109T,LU 25 109T,LU-25109T,LU 25109T	Others	Others
	Alvameline Tartrate, a muscarinic M1 receptor agonist and M2/M3 receptor antagonist, is used potentially for treatment of urinary incontinence.

化合物

Cat.No: T0218

Synonym: Bipariden,Akineton,KL 373,比哌立登,Biperidine

Target: AChR

Cat.No: T9771

Target: AChR

(S)-(+)-Dimethindene maleate

Cat.No: T23297

Target: AChR, Histamine Receptor

Zamifenacin fumarate

Cat.No: T13385

Synonym: 扎非那星富马酸盐,UK-76654 fumarate

Target: AChR

Cat.No: T10914L

Synonym: Cyclopent

Target: AChR

Syn-Ake acetate

Cat.No: T7895

Synonym: 类蛇毒三肽,Dipeptide diaminobutyroyl benzylamide

Target: AChR

Desfesoterodine

Cat.No: T6364

Synonym: 5-HMT,(R)-5-Hydroxymethyl Tolterodine,(R)-5-羟甲基托特罗定,PNU-200577,5-HM,5-hydroxymethyl Tolterodine

Target: AChR

mAChR-IN-1 hydrochloride

Cat.No: T5655

Target: AChR

Pirenzepine dihydrochloride

Cat.No: T1542

Synonym: Pirenzepine HCl,Bisvanil,Tabe,盐酸哌仑西平,LS519

Target: AChR

Cat.No: T31207

Synonym: Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B

Target: AChR

Darifenacin hydrobromide

Cat.No: T1534

Synonym: 氢溴酸达非那新,Darifenacin HBr,UK-88525

Target: AChR

Cat.No: T23508

Target: AChR

Cat.No: T28722

Synonym: SCH57790,SCH-57790

Target: AChR

Tarafenacin D-tartrate

Cat.No: T16989

Synonym: SVT-40776 D-tartrate

Target: AChR

Cat.No: T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Cat.No: T7079

Synonym: GSK961081,TD-5959

Target: Adrenergic Receptor, AChR

Tolterodine tartrate

Cat.No: T0099

Synonym: Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定

Target: AChR

G-Protein antagonist peptide acetate

Cat.No: TP1902L1

Target: Adrenergic Receptor

Cat.No: T8147

Synonym: 索利那新,YM905 free base

Target: AChR

Tiotropium bromide

Cat.No: T1179

Synonym: Tiopropium,噻托溴铵,BA679 BR

Target: AChR

(±)-Tazifylline

Cat.No: T10000

Target: Histamine Receptor

Atropine methyl bromide

Cat.No: T14345

Synonym: 甲溴阿托品,Methylatropine bromide

Target: AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Isopropamide Iodide

Cat.No: T5051

Target: AChR

Pimethixene maleate

Cat.No: T12489L

Synonym: Pimetixene maleate

Target: Dopamine Receptor, 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T72226L

Synonym: PF-4348235 HCl（1017857-38-3 Free base）,β2AR/M-receptor agonist-2 HCl

Target: Adrenergic Receptor, AChR

Propantheline bromide

Cat.No: T1006

Synonym: Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl

Target: AChR

CLOZAPINE N-OXIDE

Cat.No: T4494

Synonym: 氯氮平N-氧化,氯氮平N-氧化物

Target: Dopamine Receptor, 5-HT Receptor, AChR, Drug Metabolite

Buclizine dihydrochloride

Cat.No: T6426

Synonym: 盐酸安其敏,Longifene,Buclina,Buclizine HCl,UCB-4445

Target: 5-HT Receptor, AChR, Histamine Receptor

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Cat.No: T68599

Synonym: Orphenadrine (free base)

Target: Sodium Channel, NMDAR, AChR

Cat.No: T38192

Target: Others

Telenzepine dihydrochloride

Cat.No: T23452

Target: Others

DAU 5884 hydrochloride

Cat.No: T22709

Target: Others

Cat.No: T23124

Target: Others

Levophencynonate

Cat.No: T25697

Synonym: Levo-phencynonate

Target: Others

Levophencynonate HCl

Cat.No: T25697L

Synonym: Levophencynonate hydrochloride,R-(-)-Phencynonate hydrochloride

Target: Others

J 104129 fumarate

Cat.No: T22876

Target: Others

Solifenacin hydrochloride

Cat.No: T23379

Target: Others

Piboserod hydrochloride

Cat.No: T2278L

Synonym: SB 207266 hydrochloride,Piboserod HCl,SB 207266A

Target: Others

Doxacurium Chloride

Cat.No: T27199

Synonym: BW A 938U,BWA938U,Nuromax,BW-A-938U

Target: Others

Cat.No: T29047

Synonym: UH-AH-37,UH-AH37

Target: Others

3-Quinuclidinyl xanthene-9-carboxylate

Cat.No: T71591

Target: Others

Cat.No: T71014

Target: Others

Cat.No: T15211

Target: Others

YM-58790 hydrochloride

Cat.No: T13372

Target: Others

Tiemonium iodide

Cat.No: T24882

Synonym: Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin

Target: Others

(±)-Darifenacin

Cat.No: T12680

Synonym: (±)-UK-88525

Target: Others

(R)-Mequitazine

Cat.No: T26373

Synonym: V-0162,V0162,V 0162

Target: Others

Alvameline Tartrate

Cat.No: T26604

Synonym: LU-25-109T,LU 25 109T,LU-25109T,LU 25109T

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T21532	Anisodamine 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine	AChR	Neuroscience
	Anisodamine (6-beta-Hydroxyhyoscyamine) 是毒蕈碱和烟碱胆碱受体的拮抗剂，对毒蕈碱受体的亲和力与东莨菪碱和阿托品相似。 Anisodamine 改善休克状态下的微循环，可用于有机磷中毒的研究。

天然产物

Cat.No: T21532

Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

Target: AChR

Cat. No.	Product Name	Target	Signaling Pathways
T12973	Solifenacin D5 hydrochloride	Others	Others
	Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is an antagonist of muscarinic receptor(pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively).
TMIJ-0235	rac-Tolterodine-d14 Tartrate
	rac-Tolterodine-d14 Tartrate 是 rac-Tolterodine Tartrate 的氘代化合物。rac-Tolterodine Tartrate 的 CAS 号为 124937-52-6。Tolterodine Tartrate 是毒蕈碱受体的有效拮抗剂。它在体内显示出对膀胱和唾液腺的选择性。

同位素标记化合物

Solifenacin D5 hydrochloride

Cat.No: T12973

Target: Others

rac-Tolterodine-d14 Tartrate

Cat.No: TMIJ-0235

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