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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35902	Milbemycin A4 oxime	Others	Others
	Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, ...
T35746	Milbemycin A3	Others	Others
	Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are rep...

化合物

Milbemycin A4 oxime

Cat.No: T35902

Target: Others

Milbemycin A3

Cat.No: T35746

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN7268	Milbemycin A4 Antibiotic B 41A4,Milbemycin α3	Others	Others
	Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.
TN7559	Milbemectin Milbemycin A3 (~30%) and Milbemycin A4 (~70%) Mixture	Others	Others
	Milbemectin is composed of 30% milbemycin A3 and 70% milbemycin A4, exhibiting acaricidal and nematocidal properties effective against adult spider mites, their eggs, and C. elegans, with IC50 values of 5.3, 41.1, and 9.5 µg/ml, respectively. It functions as an allosteric agonist of the Drosophila RDL GABA receptor, and demonstrates efficacy against the pinewood nematode, B. xylophilus, with an LC20 of 0.0781 mg/liter.
T1381	Milbemycin oxime	Others; Antibiotic; Parasite	Microbiology/Virology; Others
	Milbemycin oxime 是一种大环内酯，具有广谱抗寄生虫活性。它由 Milbemycin A4 和 A3 组成。它可结合谷氨酸门控的氯离子通道，可作用于肠道线虫，肺和心脏蠕虫。

天然产物

Milbemycin A4

Cat.No: TN7268

Synonym: Antibiotic B 41A4,Milbemycin α3

Target: Others

Cat.No: TN7559

Synonym: Milbemycin A3 (~30%) and Milbemycin A4 (~70%) Mixture

Target: Others

Milbemycin oxime

Cat.No: T1381

Target: Others, Antibiotic, Parasite

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