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Search Results for " methyl-cpg-binding protein mbd2 "
Targets Recommended: DNA Alkylator/Crosslinker

1

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8554 KCC-07

DNA Alkylator/Crosslinker DNA Damage/DNA Repair
KCC-07 是一种甲基-CpG 结合域蛋白 2 (MBD2) 的选择性、强效和脑渗透抑制剂,具有抗癌活性。它阻止 MBD2 与甲基化 DNA 结合并激活脑特异性血管生成抑制剂 1,诱导抗增殖 BAI1/p53/p21 信号传导。

化合物

KCC-07
Cat.No: T8554
Synonym:
Target: DNA Alkylator/Crosslinker
Cat. No. Product Name Species Expression System
TMPH-01677 MBD2 Protein, Human, Recombinant (His & KSI)

Methyl-CpG-binding domain pro...

Human E. coli
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

重组蛋白

MBD2 Protein, Human, Recombinant (His & KSI)
Cat.No: TMPH-01677
Species: Human
Expression System: E. coli
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