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Cat. No. | Product Name | Target | Signaling Pathways |
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T0106 |
Methazolamide
L584601,醋甲唑胺,CL 8490 |
Carbonic Anhydrase | Metabolism |
Methazolamide (CL 8490) 是一种磺胺衍生物,用作碳酸酐酶 (carbonic anhydrase) 抑制剂,对人 carbonic anhydrase II 的 Ki=为 14 nM。它是降低眼压的药物,能够抑制由青光眼及其他眼病引起的眼压升高的作用。 | |||
T71917 |
FFK29
|
Others | Others |
FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their e... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T70186 |
Methazolamide-d6
|
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Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED50 value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and re... |