1364
1000+
9
7
110
Cat. No. | Product Name | ||
---|---|---|---|
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; | |||
L2500 | 人内源代谢化合物库 | 499 compounds | |
499 种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选; | |||
L2530 | 小鼠代谢化合物库 | 218 compounds | |
218 种小鼠代谢化合物的集合,可用于高通量筛选和高内涵筛选; | |||
L5800 | 药物代谢杂质库 | 197 compounds | |
197 种药物异构体/代谢产物的特有集合,可用于高通量、高内涵筛选; | |||
L6001 | Mini真菌代谢天然产物筛选库 | Inquiry | |
L2570 | 人代谢物化合物库 | 4454 compounds | |
4454 种人代谢物的独特集合,用于高通量、高内涵筛选; | |||
L2501 | 人内源代谢化合物库 Plus | 1283 compounds | |
1283种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选。 | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L2560 | 代谢化合物库 | 2320 compounds | |
2320 种代谢途径相关的化合物,可用于高通量和高内涵筛选。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21059 |
Ticagrelor metabolite M5
Ticagrelor metabolite M5,,T437700,替格瑞洛杂质H,AR-C133913XX |
P2Y Receptor | GPCR/G Protein; Neuroscience |
Ticagrelor metabolite M5 (T437700) 是 Ticagrelor 的代谢物,是 P2Y12 受体的第一个可逆口服拮抗剂。与氯吡格雷相比,替格瑞洛对 ADP 受体具有更快和更一致的抑制作用。替格瑞洛用于治疗急性冠状动脉综合征(ACS)。 | |||
T16045 |
Methotrexate metabolite
DAMPA,甲喋呤杂质E |
Antifolate; Drug Metabolite | Cell Cycle/Checkpoint; Metabolism |
Methotrexate metabolite (DAMPA) (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用,被用作免疫抑制剂。 | |||
T10738 |
Abemaciclib metabolite M20
CDK4/6-IN-4,LSN3106726 |
CDK | Cell Cycle/Checkpoint |
Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。 | |||
T13133 |
Tetrabenazine Metabolite
(-)-β-Dihydrotetrabenazine,(-)-β-HTBZ |
Monoamine Transporter | Membrane transporter/Ion channel |
Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂,是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力,其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。 | |||
T10814 |
Cinacalcet metabolite M4
3-三氟甲基苯丙胺,Rarechem AL BW 1078 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cinacalcet metabolite M4 (Rarechem AL BW 1078) 是 Cinacalcet 的代谢物。Cinacalcet 是具有活性的 Ca receptor 激动剂,可用于心血管疾病。 | |||
T5401 |
GSK2983559 active metabolite
GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1 |
RIP kinase | Apoptosis; NF-κB |
GSK2983559 active metabolite (RIPK2-IN-1) 是一种受体相互作用蛋白-2 激酶抑制剂。 | |||
T12309 |
Omeprazole metabolite Omeprazole sulfone
Omeprazole sulphone,Omeprazole sulfone |
Others; Proton pump | Membrane transporter/Ion channel; Others |
Omeprazole sulfone 是Omeprazole的代谢物,能够抑制质子泵。 | |||
T37181 |
Avanafil metabolite M4
Avanafil metabolite M4 |
Others | Others |
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16 , as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. | |||
T36661 |
Iloperidone metabolite P95
Iloperidone metabolite P95 |
Others | Others |
Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone . It binds to the serotonin (5-HT) receptor subtype 5-HT2A and α1-, α2B-, and α2C-adrenergic receptors with mean Ki values of 7.08, 21.38, 83.18, and 47.86 nM, respectively, but does not cross the blood-brain barrier. | |||
T36662 |
Imidafenacin Metabolite M4
Imidafenacin Metabolite M4 |
Others | Others |
Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007) | |||
T11445 |
GNF179 (Metabolite)
GNF179 Metabolite |
Others | Others |
GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral bioavailability. | |||
T10220 |
LSN2839567
Abemaciclib metabolite M2 |
CDK | Cell Cycle/Checkpoint |
LSN2839567 (Abemaciclib metabolite M2) 是 Abemaciclib 的活性代谢物,是一种强效的 CDK4 和 CDK6 抑制剂(IC50s:1-3 nM),具有抗癌活性。LSN2839567 抑制 CDK9。LSN2839567 以浓度依赖性方式抑制细胞生长和细胞周期进程,可用于研究乳腺癌和肺癌。 | |||
T12229 |
Niraparib metabolite M1
尼拉帕尼代谢物,M1 metabolite of niraparib,Niraparib carboxylic acid metabolite M1 |
Others | Others |
Niraparib metabolite M1 is niraparib metabolite, niraparib is a novel poly(ADP-Ribose) polymerase (PARP) inhibitor. | |||
T20723 |
LGE-899
Sonidegib metabolite M48,LGE 899 |
Drug Metabolite | Metabolism |
LGE-899 (Sonidegib metabolite M48) 是 Sonidegib 的主要代谢物,是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。 | |||
T68375 |
KD026-metabolite
|
Others | Others |
KD026-metabolite, is a metabolite of KD-026. KD026, also known as SLx-4090, is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes. | |||
T37638 |
Tofacitinib metabolite-1
|
Others | Others |
Tofacitinib metabolite-1, a derivative of Tofacitinib, which is a JAK inhibitor, is employed in studies focused on the pharmacokinetics and metabolism of tofacitinib[1][2]. | |||
T37180 |
Avanafil metabolite M16
|
Others | Others |
Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M16 and avanafil metabolite M4 , as well as minor metabolites. | |||
T11893L |
Lurasidone metabolite 14326 hydrochloride
Lurasidone metabolite 14326 hydrochloride (186204-33-1 free base) |
Others | Others |
Lurasidone metabolite 14326 hydrochloride, an active metabolite of the atypical antipsychotic Lurasidone, maintains its significant function in pharmacological efficacy. | |||
T39345 |
Lopinavir Metabolite M-1
|
Others | Others |
Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties associated with Lopinavir Metabolite M-1. | |||
T70178 |
Sonidegib metabolite M25
|
Others | Others |
Sonidegib metabolite M25 is a smoothened (SMO) antagonist. | |||
T2687 |
Omeprazole sulfide
Omeprazole metabolite Omeprazole sulfide,Ufiprazole,奥美拉唑硫醚 |
Proton pump; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Omeprazole sulfide (Ufiprazole) 是 Omeprazole 的代谢物。 | |||
T12735 |
Ritonavir metabolite
Desthiazolylmethyloxycarbonyl Ritonavir,利托那韦代谢物 |
Others | Others |
Ritonavir metabolite is a Ritonavir metabolite, which is a inhibitor of HIV protease. | |||
T11893 |
Lurasidone metabolite 14326
|
Others | Others |
Lurasidone metabolite 14326, an active metabolite of the atypical antipsychotic Lurasidone, functions effectively in the body. | |||
T37645 |
Dasatinib metabolite M6
达沙替尼羧酸 |
Others | Others |
Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib, a potent and orally active inhibitor of both Bcr-Abl and Src family tyrosine kinases[1]. | |||
T35815 |
Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
|
Others | Others |
Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 μM for DPP-4 in human Caco-2 cells. It is formed from hydrolysis of the cyano group on vildagliptin. | |||
T23950 |
Dacomitinib metabolite M2
Dacomitinib cysteine conjugate,UNII-SOA52D3NLL |
Others | Others |
Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M. | |||
T12689 |
Ramelteon metabolite M-II
|
Others | Others |
Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin. | |||
T10358L |
AR-13324 M1 metabolite
|
Others | Others |
AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate. | |||
T33659 |
Nicardipine pyridine metabolite II
|
Others | Others |
Nicardipine pyridine metabolite II is a biaoctive chemical. | |||
T13525 |
Abiraterone metabolite 1
3β-OH-5α-Abi |
Others | Others |
Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone inhibits CYP17A1, blocks androgen synthesis, and prolongs survival in prostate cancer. | |||
T71932 |
MAM2201 N-pentanoic acid metabolite
|
Others | Others |
MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 -- a cannabinoid receptor agonist. | |||
T11641 |
N-Desmethyl imatinib
Imatinib metabolite N-Desmethyl imatinib,Norimatinib,N-去甲基伊马替尼 |
Bcr-Abl; PDGFR; c-Kit; Drug Metabolite | Angiogenesis; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors |
N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) 是 Imatinib 的代谢物。Imatinib 是一个靶向 c-Kit、v-Abl 和 PDGFR 的多靶点抑制剂。 | |||
T13760 |
Lurasidone Metabolite 14283 hydrochloride
|
Others | Others |
Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. | |||
T12211 |
Netupitant metabolite Monohydroxy Netupitant
Monohydroxy Netupitant |
Others | Others |
Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. | |||
T12213 |
Netupitant metabolite Netupitant N-oxide
Netupitant N-oxide |
Others | Others |
Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite. | |||
T11637 |
Iloperidone metabolite Hydroxy Iloperidone
P88,伊潘立酮代谢物,Hydroxy Iloperidone |
Others | Others |
Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. It is a metabolite of Iloperidone. | |||
T12212 |
Netupitant metabolite N-desmethyl Netupitant
N-desmethyl Netupitant |
Others | Others |
N-desmethyl Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. | |||
T10686 |
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
4-Hydroxyphenyl Carvedilol,4-Hydroxycarvedilol |
Others | Others |
4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol. Carvedilol is a beta-blocker/alpha-1 blocker. | |||
T11114 |
Duloxetine metabolite Para-Naphthol Duloxetine
度洛西汀代谢物,Para-Naphthol duloxetine |
Others | Others |
Para-Naphthol Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI),is a metabolite of Duloxetine. | |||
T73909 |
Abemaciclib metabolite M18
LSN3106729 |
Ligands for Target Protein for PROTAC | PROTAC |
Abemaciclibmetabolite M18 (LSN3106729) 是一种CDK抑制剂,具有抗肿瘤活性。作为Abemaciclib的代谢物,Abemaciclibmetabolite M18 能与CRBN配体结合,用于设计PROTAC CDK4/6降解剂。 | |||
T19175 |
Acetaminophen metabolite 3-hydroxy-acetaminophen
对乙酰氨基酚代谢物,3-Hydroxyacetaminophen |
Others | Others |
3-hydroxy-acetaminophen is a metabolite of Acetaminophen. Acetaminophen is a pain medicine. | |||
T83676 |
Tianeptine Metabolite MC5 sodium
|
||
Tianeptine metabolite MC5是一种来自非典型抗抑郁化合物tianeptine的活性代谢物,通过β-氧化形成。此代谢物在使用表达人类μ-阿片受体(MOR)而非人类δ-阿片受体(DOR;EC50s = 0.454和 >100 µM, 分别)的HEK293T细胞进行的生物发光共振能量转移(BRET)试验中,特异性诱导G蛋白激活。在野生型小鼠上,30 mg/kg剂量的Tianeptine metabolite MC5可减少强迫游泳测试中的静止时间,但在MOR敲除小鼠中则不会,表明其具有MOR依赖的抗抑郁样活性。 | |||
T19667 |
R-138727
Prasugrel active metabolite |
Others | Others |
R-138727 is a novel P2Y12 receptor inhibitor. | |||
T84618 |
tetranor-PGFM
tetranor-Prostaglandin F Metabolite |
Others | Others |
Tetranor-PGFM, the principal urinary metabolite of PGF2α, is excreted at rates of 7-13 µg per day in healthy females and 11-59 µg per 24 hours in healthy males. During pregnancy, female urinary levels of tetranor-PGFM increase 2 to 5-fold, returning to normal shortly after childbirth. | |||
T84724 |
γ-CEHC
γ-Tocopherol Metabolite |
Others | Others |
γ-CEHC, a metabolite of γ-tocopherol, is predominantly excreted through urine, primarily in its conjugated form as glucuronide [1], rather than through bile. | |||
T32000 |
GSK-1071306
Pazopanib metabolite M27 |
Others | Others |
GSK-1071306 is a bio-active chemical. | |||
T32828 |
LNC-119
Sonidegib metabolite M16,LNC119 |
Others | Others |
LNC-119 is an aminosteroid. | |||
T30191 |
Atecegatran
metabolite of AZD0837,atecegatran metoxil |
Others | Others |
Atecegatran 常被当作一种抗凝血剂属于,可用来治疗心血管疾病。 | |||
T30302 |
BAY-751098
UNII-58I22S7HYD,Regorafenib metabolite M4;UNII-58I22S7HYD,Regorafenib metabolite M4,BAY751098 |
Others | Others |
BAY-751098 is a bio-active chemical. | |||
T11987 |
Mebeverine alcohol
Mebeverine metabolite Mebeverine alcohol |
Others | Others |
Mebeverine alcohol is a metabolite of Mebeverine. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16338 |
Norgestimate metabolite Norelgestromin
17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮 |
Drug Metabolite | Metabolism |
Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) 是norgestimate 的一种活性代谢物。它是用于避孕贴片的甾体孕激素,与雌激素乙炔雌二醇结合使用。 | |||
Fr13756 |
Isonicotinic acid
|
Endogenous Metabolite; Drug Metabolite | Metabolism |
Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。 | |||
T10815 |
Cinnamoylglycine
|
Endogenous Metabolite | Metabolism |
Cinnamoylglycine 是肉桂酸和的甘氨酸结合物,是人体尿液代谢物。它被用作的尿液标志物,能够作为在抗生素研究期之后定殖耐药性的标志物。 | |||
T13539 |
Allopurinol riboside
|
Others; Endogenous Metabolite; Parasite; Drug Metabolite | Metabolism; Microbiology/Virology; Others |
Allopurinol riboside 是别嘌醇的代谢产物,具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用,Ki 为 277 μM。 | |||
T12287 |
Octadecanedioic acid
|
Endogenous Metabolite | Metabolism |
Octadecanedioic acid 是内源性代谢物的一种,是一种长链二羧酸,曾在雷氏综合征的血清游离脂肪酸中被发现。 | |||
T10021 |
1-Methylxanthine
|
Endogenous Metabolite | Metabolism |
1-Methylxanthine 是咖啡因衍生物,是咖啡因和茶碱 (1,3-二甲基黄嘌呤,TP) 在人体尿代谢产物,能够提高肿瘤细胞的放射敏感性。 | |||
T8153 |
glycohyodeoxycholic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物,能够预防胆结石的形成。 | |||
T13719 |
Hexadecanal
Palmitaldehyde,十六醛 |
Endogenous Metabolite | Metabolism |
Hexadecanal (Palmitaldehyde) 是存在于动物体内的游离脂肪醛。 | |||
T0647 |
Tryptamine
|
Dehydrogenase; 5-HT Receptor; Endogenous Metabolite; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tryptamine 是一种在动物、植物和真菌中发现的单胺生物碱。它含有吲哚环结构,结构类似于色氨酸。在哺乳动物的大脑中发现了微量这种物质,并被认为是一种神经递质或神经调节剂。 | |||
T0069 |
Uracil
|
Others; Endogenous Metabolite | Metabolism; Others |
Uracil 是普遍存在的天然嘧啶衍生物,是 RNA 核酸中的四个碱基之一。 | |||
T8165 |
Erythrodiol
|
Endogenous Metabolite; ABC | Membrane transporter/Ion channel; Metabolism |
Erythrodiol 是一种橄榄油的成分,能够选择性抑制ABCA1蛋白的降解来促进胆固醇外流,有用于动脉粥样硬化的研究潜力。 | |||
TN1740 |
Homoeriodictyol
高胜草酚,高圣草酚 |
5-HT Receptor; transporter; Sodium Channel; Drug Metabolite | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Homoeriodictyol 是 Eriocitrin 的代谢物,属于黄酮类。Eriocitrin 是强效抗氧化剂。 | |||
T0586 |
Lactose
|
Others; Endogenous Metabolite | Metabolism; Others |
Lactose 是半乳糖和葡萄糖衍生的二糖,是大多数物种乳汁中的主要糖分,能够调节人类肠道的微生物菌群。 | |||
TN1490 |
Chrysoeriol
|
ERK; p38 MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Chrysoeriol 是一种天然黄酮,可从热带植物Coronopus didymus 中提取获得,具有强大的抗氧化功能,能够抑制脂质的过氧化。 | |||
T8272 |
Trierucin
|
Others; Endogenous Metabolite | Metabolism; Others |
Trierucin 是一种从种子油中提取的三芥酸甘油三酯。 | |||
T19792 |
1,3,7-Trimethyluric acid
|
Others | Others |
1,3,7-Trimethyluric acid 是咖啡因的代谢产物。其与咖啡因的代谢比可以反映 CYP3A 活性的变化情况。 | |||
T20446 |
Creosol
|
Endogenous Metabolite | Metabolism |
Creosol 是内源性代谢产物的一种。 | |||
T4799 |
Indole
|
Others; Endogenous Metabolite | Metabolism; Others |
Indole 它具有双环结构,由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中,有强烈的粪便气味。然而,在非常低的浓度下,它有一种花香,是许多花香(如橙花)和香水的成分。 | |||
T15720 |
Lathosterol
|
Endogenous Metabolite | Metabolism |
Lathosterol 是胆固醇样分子,其血清浓度是全身胆固醇合成的指标。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
T5352 |
GLYCODEOXYCHOLIC ACID
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycodeoxycholic Acid 是内源性代谢产物的一种,是一种存在于黑链霉菌、布氏锥虫和隐单胞菌中的天然产物,可诱导阻塞性胆汁淤积症患者的肝细胞坏死和自噬。 | |||
T37508 |
Meconin
|
Endogenous Metabolite | Metabolism |
Meconine 是一种人内源性代谢产物。 | |||
T8068 |
o-Toluic acid
|
Others | Others |
O-toluic acid 是一种在 2 号位被甲基取代的苯甲酸,可用作一种外源性的代谢物。 | |||
TN6833 |
octanal
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
octanal 是一种具有抗氧化和抗菌活性的天然产物。 | |||
T37298 |
Spinacine
|
Endogenous Metabolite | Metabolism |
Spinacine 是人内源性代谢产物。 | |||
T2228 |
Adipic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Adipic acid 是一种生产尼龙的前体。它被发现与 HMG-CoA 裂解酶缺乏症,肉毒碱激酶缺乏症,中链酰基脱氢酶缺乏症相关,这些都是天生代谢异常导致的。 | |||
T2724 |
Caryophyllene oxide
|
Others; Endogenous Metabolite | Metabolism; Others |
Caryophyllene oxide 是一种天然产物,源自Annona squamosa L. bark. ,有缓解疼痛和抗炎特性。 | |||
T8086 |
Decyl aldehyde
|
Others; Endogenous Metabolite | Metabolism; Others |
Decyl aldehyde 是细菌荧光素酶底物,是十碳醛。 | |||
T5665 |
Geraniol
|
Others; Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology; Others |
Geraniol 对糖尿病引起的心脏功能障碍起保护作用,抑制氧化应激。 | |||
T8049 |
Pentadecanoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Pentadecanoic acid 是一个具有 15 个碳主链的饱和脂肪酸。 | |||
T5812 |
Zinc Phytate
|
Others | Others |
Zinc Phytate 存在于食物中,对人类吸收营养有重要意义。 | |||
T8031 |
Terephthalic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Terephthalic acid 是一种三种酞酸盐的异构体,是聚酯 PET 的前体,能够用于制作服装和塑料。 | |||
T5228 |
Nicotinuric acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Nicotinuric acid 是一种酰基甘氨酸,通常是脂肪酸的次要代谢物。 酰基甘氨酸是通过甘氨酸 N-酰基转移酶的作用产生的。 | |||
T4794 |
Glutaric acid
|
Endogenous Metabolite | Metabolism |
Glutaric acid 是一种 C5 二羧酸,是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。 | |||
T4809 |
Pyrimidine
嘧啶,Metadiazine |
Others; Endogenous Metabolite | Metabolism; Others |
Pyrimidine (Metadiazine) 是内源性代谢产物的一种。 | |||
T12095 |
Monomethyl fumarate
|
GPR; Drug Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism |
Monomethyl fumarate 是 Dimethyl fumarate 的活性代谢产物。Monomethyl fumarate 是一种 GPR109A 激动剂。Monomethyl fumarate 是一种 GPR109A 激动剂具有用于多种神经保护途径和其他视网膜疾病模型的潜力。 | |||
TN6752 |
Dimethyl sulfone
|
Endogenous Metabolite | Metabolism |
Dimethyl sulfone 是内源性代谢产物的一种。 | |||
T13581 |
Biotin sulfone
|
Endogenous Metabolite | Metabolism |
Biotin sulfone 是一个被分离的天然生物素代谢物。 | |||
T36790 |
(Ethoxymethyl)benzene
|
Endogenous Metabolite | Metabolism |
(Ethoxymethyl)benzene 是一种人内源性代谢产物。 | |||
T37501 |
Ethoxyacetic acid
|
Endogenous Metabolite | Metabolism |
Ethoxyacetic acid 是一种人内源性代谢产物。 | |||
T5565 |
Undecanedioic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
Undecanedioic acid 是存在于人体主动脉的部分区域中,其中晚期动脉粥样硬化病变与细胞间基质大分子相关,特别是与弹性蛋白相关。 | |||
T19418 |
Methionine sulfoxide
|
Endogenous Metabolite | Metabolism |
Methionine sulfoxide 是具有特性氧的甲硫氨酸的氧化产物,能够用作体内氧化应激的生物标记。 | |||
T7331 |
Ursocholic acid
|
Endogenous Metabolite | Metabolism |
Ursocholic acid 是存在于哺乳动物胆汁中的胆酸,通过小鼠肠道菌群转化为脱氧胆酸。脱氧胆酸是7α-羟化类固醇脱氢酶和肝细胞核因子1α的抑制剂。 | |||
TQ0284 |
Hydroxyphenyllactic acid
|
Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology |
Hydroxyphenyllactic acid 是具有抗真菌活性的代谢物。 | |||
T5985 |
Glycolic acid
|
Tyrosinase; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
Glycolic acid 是一种酪氨酸酶抑制剂,可以抑制黑色素的形成,从而减淡皮肤的颜色。 | |||
T7602 |
Theaflavin
|
Influenza Virus; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Theaflavin 是在红茶中发现的一种多酚类黄酮,具有如抗氧化、抗癌、抗炎和抗病毒多种生物活性。 | |||
T8034 |
Dimethyl Trisulfide
|
Others; Endogenous Metabolite | Metabolism; Others |
Dimethyl trisulfide 是存在于大蒜,洋葱,西兰花和类似植物中的有机三硫化物。它是一种氰化物解毒剂。 | |||
T5074 |
Cholesteryl palmitate
|
Others; Endogenous Metabolite | Metabolism; Others |
Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。 | |||
T10005L |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium
|
Endogenous Metabolite | Metabolism |
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium 是一种人内源性代谢物,是一种磷酸酯。 | |||
T5737 |
euphol
|
Others; Lipase; Endogenous Metabolite | Metabolism; Others |
Euphol 是从Euphorbia tirucalli 的汁液中分离出来的四环三萜醇,具有抗炎和免疫调节作用,口服具有活力。 它通过能够逆机制抑制单酰基甘油脂肪酶 (MGL) 的特性,IC50=315 nM。 外周 MGL 抑制能够调节内源性大麻素系统从而阻止炎症性疼痛的发展。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00844 |
HSD11B2 Protein, Human, Recombinant (His)
HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,Short ch... |
Human | P. pastoris (Yeast) |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. HSD11B2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P80365. | |||
TMPY-03414 |
ABHD10 Protein, Human, Recombinant (aa 53-306, His)
ABHD10,abhydrolase domain containing 10 |
Human | Baculovirus Insect Cells |
Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG). It is known that AcMPAG, which may be an immunotoxic metabolite, is deglucuronidated in human liver. AcMPAG deglucuronidation activity was detected in both human liver cytosol (HLC) and microsomes (HLM). By purification from HLC with column chromatographic purification steps, the en... | |||
TMPY-00320 |
APOA1BP Protein, Human, Recombinant (His)
YJEFN1,apolipoprotein A-I binding protein,AIBP |
Human | HEK293 Cells |
APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites.Pathogenic biallelic mutations in NAXE in children from four families with (sub-) acute-onset ataxia, cerebellar edema, spinal myelopathy, and skin lesions. | |||
TMPH-00843 |
HSD11B1 Protein, Human, Recombinant (His & SUMO)
7-oxosteroid reductase,11-beta-hydroxysteroid dehydrogenase ... |
Human | E. coli |
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. HSD11B1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P28845. | |||
TMPH-02615 |
CBS Protein, Mouse, Recombinant (His)
Cystathionine beta-synthase,Serine sulfhydrase,Beta-thionase... |
Mouse | E. coli |
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | |||
TMPH-01597 |
KYAT1 Protein, Human, Recombinant (His & SUMO)
Kynurenine aminotransferase 1,KYAT1,Glutamine--phenylpyruvat... |
Human | E. coli |
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl... | |||
TMPY-02420 |
HEMK2 Protein, Human, Recombinant (His)
N-6 adenine-specific DNA methyltransferase 1 (putative),HEMK... |
Human | E. coli |
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to the eukaryotic/archaeal PrmC-related family. The encoded enzyme may be involved in the methylation of release factor I during translation termination. N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activi... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23983 |
Deutetrabenazine metabolite M4
SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4 |
||
Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake | |||
T19407 |
Lurasidone Metabolite 14326 D8
|
Others | Others |
Lurasidone Metabolite 14326 D8 is the deuterium labeled Lurasidone Metabolite 14326. | |||
T19406 |
Lurasidone Metabolite 14283 D8
|
Others | Others |
Lurasidone Metabolite 14283 D8 is the deuterium labeled Lurasidone Metabolite 14283. | |||
TMIH-0519 |
Selexipag Active Metabolite-d7
|
||
Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药,是 Selexipag 的活性代谢物,用于治疗肺动脉高压。 | |||
TMIH-0067 |
Acalabrutinib Metabolite 27-d4
|
||
Acalabrutinib Metabolite 27-d4 是 Acalabrutinib Metabolite 27 的氘代化合物。 | |||
TMIH-0316 |
Lurasidone Inactive Metabolite 14326-d8
5β/6β-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers) |
||
Lurasidone Inactive Metabolite 14326-d8 是 Lurasidone Inactive Metabolite 14326 的氘代化合物。Lurasidone Inactive Metabolite 14326 的 CAS 号为 186204-33-1。 | |||
TMIH-0155 |
Prasugrel Metabolite Derivative-13C-d3
Mixture of Diastereomers-13C-d3 |
||
Prasugrel Metabolite Derivative-13C-d3 是 Prasugrel Metabolite Derivative 的 13C 和氘代化合物。 | |||
TMIH-0315 |
Lurasidone Inactive Metabolite 14283-d8
5α/6α-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers) |
||
Lurasidone Inactive Metabolite 14283-d8 是 Lurasidone Inactive Metabolite 14283 的氘代化合物。Lurasidone Inactive Metabolite 14283 的 CAS 号为 186204-31-9。 | |||
TMIH-0198 |
DM-3411-d8
Brexpiprazole Metabolite |
||
DM-3411-d8 是 DM-3411 的氘代化合物。DM-3411 的 CAS 号为 913611-97-9。Brexpiprazole是人5-HT1A和多巴胺受体的部分激动剂,Ki分别为0.12 和 0.3 nM。它也是5-HT2A受体的拮抗剂,Ki为 0.47 nM,可作为非典型抗精神病药。 | |||
TMIH-0023 |
1-[3-carboxypropyl]-3,7-dimethylxanthine-d6
pentoxyfylline metabolite 1-d6 |
||
1-[3-carboxypropyl]-3,7-dimethylxanthine-d6 是 1-[3-carboxypropyl]-3,7-dimethylxanthine 的氘代化合物。 | |||
TMIH-0021 |
1-(5-hydroxyhexyl)-3,7-dimethylxanthine-d6
pentoxyfylline metabolite 2-d6 |
||
1-(5-hydroxyhexyl)-3,7-dimethylxanthine-d6 是 1-(5-hydroxyhexyl)-3,7-dimethylxanthine 的氘代化合物。 | |||
T12571 |
PSI-6206 13C,d3
Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3 |
Others | Others |
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor. | |||
T19451 |
N-Desmethyl imatinib-d8
Norimatinib D8,Imatinib metabolite N-Desmethyl imatinib D8,N-Desmethyl imatinib D8 |
Others | Others |
N-Desmethyl imatinib D8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib. | |||
T9087 |
Creatine-d3 hydrate
CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物 |
Endogenous Metabolite | Metabolism |
Creatine-d3 hydrate (CREATINE-(METHYL-D3) MONOHYDRATE) 是一种氘标记的肌酸水合物。其中肌酸水合物在肌肉和脑细胞的能量代谢中起着关键作用。 | |||
T71142 |
Tebuconazole-d9
|
||
Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... | |||
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
T19442 |
N-acetyl Dapsone (D4')
MADDS D4' |
Others | Others |
N-acetyl Dapsone (D4') is the deuterium-labeled metabolite of Dapsone. | |||
T19275 |
Desbutyl Lumefantrine D9
Desbutyl-benflumetol D9 |
Others | Others |
Desbutyl Lumefantrine D9, a deuterium-labeled metabolite of Lumefantrine, exhibits the incorporation of deuterium atoms. | |||
T19441 |
N-acetyl Dapsone D4
MADDS D4 |
Others | Others |
N-Acetyl Dapsone D4 is a deuterium-labeled metabolite of N-Acetyl Dapsone, derived from Dapsone. | |||
T12445 |
Phenolic acid
|
Others | Others |
Phenolic acid is an endogenous metabolite. | |||
T19434 |
Monohydroxy Netupitant D6
|
Others | Others |
Monohydroxy Netupitant D6 is a metabolite of Netupitant. | |||
T12144 |
N-Desethyl Oxybutynin-d5 hydrochloride
N-Desethyl Oxybutynin D5 hydrochloride |
Others | Others |
N-Desethyl Oxybutynin D5 hydrochloride is the the active metabolite Oxybutynin, is deuterium labeled N-Desethyl Oxybutynin hydrochloride. | |||
T19452 |
N-desmethyl Netupitant D6
|
Others | Others |
N-desmethyl Netupitant D6 is the deuterium labeled N-desmethyl Netupitant, which is a Netupitant metabolite. | |||
T19109 |
25-Hydroxy VD2-D6
|
Others | Others |
25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2. | |||
TMID-0140 |
2-Methoxyestrone-1,4,16,16-d4
|
||
2-Methoxyestrone-1,4,16,16-d4 是 2-Methoxyestrone 的氘代化合物。2-Methoxyestrone 的 CAS 号为 362-08-3。2-Methoxyestrone 是甲氧基苯二酚雌激素,也是雌酮代谢物,其 pKa=10.81。 | |||
T19273 |
Debutyldronedarone D7
SR-35021 D7 |
Others | Others |
Debutyldronedarone D7 is deuterium-labeled Debutyldronedarone, which is the main circulating active metabolite of dronedarone in the body. | |||
T19162 |
7-Desmethyl-agomelatine D3
|
Others | Others |
7-Desmethyl-agomelatine D3 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine. | |||
T11036 |
Diacetolol D7
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Diacetolol D7 is deuterium-labeled diacetone Roller. Diacetol is the main metabolite of Acetolol. Diacetololβ-adrenoceptor shielding and anti-arrhythmic agent. | |||
T19474 |
Netupitant N-oxide D6
|
Others | Others |
Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide. | |||
T11585 |
Hydroxy Itraconazole D8
R-63373 D8 |
Others | Others |
Hydroxy Itraconazole D8 is the deuterium-labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole, which is a triazole antifungal agent. | |||
T31109 |
CTP-499
|
||
CTP499, a selective PDE inhibitor, and the deuterium-containing agent is an HDX analogue and a metabolite of hexantheobromine that slows the progression of type 2 diabetic nephropathy in patients with macroalbuminuria. | |||
T19447 |
N-Demethyl Ivabradine D6 Hydrochloride
|
Others | Others |
N-Demethyl Ivabradine D6 Hydrochloride salt is the deuterium labeled N-Demethyl Ivabradine, which is a Ivabradine metabolite. | |||
T10663 |
Calcitriol-d6
Calcitriol D6,骨化三醇 D6 |
Others | Others |
Calcitriol D6 is the deuterated form of Calcitriol, which is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor. | |||
T19489 |
O-Desmethyl gefitinib D8
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma. | |||
TMIJ-0093 |
Keto Pioglitazone-d4
|
||
Keto Pioglitazone-d4 是 Keto Pioglitazone 的氘代化合物。Keto Pioglitazone 的 CAS 号为 146062-45-5。 | |||
T19088 |
13-cis Acitretin D3
Isoacitretin D3,13-cis Acitretin D3 |
Others | Others |
13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid. | |||
T19311 |
Enzalutamide carboxylic acid D6
MDV3100 carboxylic acid D6 |
Others | Others |
Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide. Enzalutamide carboxylic acid D6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). | |||
T10149 |
4-Hydroxypropranolol-d7 hydrochloride
(±)-4-hydroxy Propranolol D7 hydrochloride,4-Hydroxypropranolol D7 hydrochloride |
Others | Others |
4-Hydroxypropranolol D7 hydrochloride is deuterium-labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors | |||
T11817 |
Lansoprazole Sulfide D4
|
Proton pump | Membrane transporter/Ion channel |
Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. | |||
T10144 |
4-Hydroxyatomoxetine D3
|
Others | Others |
4-Hydroxyatomoxetine D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor. | |||
T10113 |
3-Hydroxy agomelatine D3
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). | |||
TMID-0062 |
Ethyl-β-D-glucuronide-d5
|
||
Ethyl-β-D-glucuronide-d5 是 Ethyl-β-D-glucuronide 的氘代化合物。Ethyl-β-D-glucuronide 的 CAS 号为 17685-04-0。 | |||
TMIJ-0128 |
4’-Hydroxy Diclofenac-d4
|
||
4’-Hydroxy Diclofenac-d4 是 4’-Hydroxy Diclofenac 的氘代化合物。4’-Hydroxy Diclofenac 的 CAS 号为 64118-84-9。 | |||
T19119 |
3-Hydroxy Midostaurin-D5
CGP52421-D5 |
Others | Others |
3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma). | |||
TMIJ-0008 |
3-Amino-2-Oxazolidinone-d4
Aoz-d4 |
||
3-Amino-2-Oxazolidinone-d4 是 3-Amino-2-Oxazolidinone 的氘代化合物。3-Amino-2-Oxazolidinone 的 CAS 号为 80-65-9。3-Amino-2-oxazolidinone 是一种呋喃唑烷酮的代谢物 (metabolite),可用作检测呋喃唑烷酮残留的一个指标。 | |||
T10118 |
3-O-Methyltolcapone D7
Ro 40-7591 D7 |
Transferase | Metabolism |
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P | |||
T10351 |
Aprocitentan D4
ACT-132577 D4 |
Others | Others |
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5). | |||
TMID-0220 |
4’-Hydroxy Diclofenac-d4 (Major)
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4’-Hydroxy Diclofenac-d4 (Major) 是 4’-Hydroxy Diclofenac 的氘代化合物。4’-Hydroxy Diclofenac 的 CAS 号为 64118-84-9。 | |||
T10611 |
Brexpiprazole S-oxide D8
DM-3411 D8 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM). | |||
TMID-0039 |
Hydroxy Dimetridazole-d3
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Hydroxy Dimetridazole-d3 是 Hydroxy Dimetridazole 的氘代化合物。Hydroxy Dimetridazole 的 CAS 号为 936-05-0。Hydroxy Dimetridazole 是Dimetridazol的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物,可用于对抗原生动物感染。 | |||
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