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Search Results for " mrgprx2 "

Targets Recommended: Others

17

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40273	MrgprX2 antagonist-2 MrgprX2 antagonist-2	Others	Others
	MrgprX2 antagonist-2 is a potent antagonist of MrgprX2. It holds potential for investigating skin inflammatory disorders.
T40270	MrgprX2 antagonist-1 MrgprX2 antagonist-1	Others	Others
	MrgprX2 antagonist-1, is a novel MrgprX2 antagonist compound. It exhibits potential for exploration in studying cutaneous inflammatory disorders.
T40268	MrgprX2 antagonist-4 MrgprX2 antagonist-4	Others	Others
	MrgprX2 antagonist-4 and compound B-51 E117, is a potent MrgprX2 antagonist. It specifically targets and inhibits the MrgprX2 receptor, making it suitable for investigating various inflammatory skin disorders.
T40176	MrgprX2 antagonist-5 MrgprX2 antagonist-5	Others	Others
	MrgprX2 antagonist-5, which acts as a potent antagonist of MrgprX2. It exhibits the ability to effectively inhibit the activity of MrgprX2, making it an ideal candidate for research related to inflammatory skin disorders.
T40271	MrgprX2 antagonist-3 MrgprX2 antagonist-3	Others	Others
	MrgprX2 antagonist-3 is a potent inhibitor of MrgprX2. It holds promising potential for investigating skin inflammatory disorders.
T63812	MrgprX2 antagonist-8	MRGPR	GPCR/G Protein
	MrgprX2 antagonist-8 是 MrgprX2 拮抗剂，能够用于研究炎症性疾病。
T63394	MrgprX2 antagonist-6	Others	Others
	MrgprX2 antagonist-6 是一种高效抗过敏剂，对肥大细胞脱颗粒具有抑制作用。
T63766	MrgprX2 antagonist-7	Others	Others
	MrgprX2 antagonist-7 是一种抗过敏剂，具有明显的抗过敏效果，能够抑制肥大细胞脱颗粒。
T29221	(R)-ZINC-3573 ZINC 3573	MRGPR	GPCR/G Protein
	(R)-ZINC-3573是一种有效且高选择性的MRGPRX2探针。(R)-ZINC-3573激活人肥大细胞系中的内源性MRGPRX2，诱导细胞脱粒和钙释放。
T80080	PAMP-12 (unmodified) (TFA)
	PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂，展现出高效性（EC50=20-50 nM）。该化合物为内源性肽，能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。
T80727	ZINC49534341	Others	Others
	ZINC49534341是一种MRGPRX2拮抗剂，其Ki值为32纳摩尔(nM)。
T41187	(S)-ZINC-3573	Others	Others
	(S)-ZINC 3573 is a negative control for (R)-ZINC 3573. (S)-ZINC 3573 displays no activity at MRGPRX2 at concentrations below 100 μM.
TP1490	Proadrenomedullin (1-20), human
	Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena
TP1880	PAMP-12(human, porcine) PAMP-12 (human, porcine)
	Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.
T78027	PAMP-12 (unmodified)
	PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂，其EC50值为20-50 nM。作为内源性肽，它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。
TP1946	QWF
	Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching
T83697	PAMP-12 (human, mouse, rat, porcine, bovine) TFA Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
	Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段，源自人体肾上腺髓质，对应人类PAMP-20的9-20氨基酸，涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中，PAMP-12抑制forskolin诱导的cAMP积累（EC50 = 57.2 nM），特异性诱导表达MRGPRX2的CHO细胞的钙离子动员（EC50 = 41 nM），而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应（在1 µM浓度下）。PAMP-12还能作为烟碱型乙酰胆碱受体（nAChRs）的拮抗剂，抑制carbachol诱导的儿茶酚胺释放（IC50 = 1.3 µM）及钙和钠的流入（IC50分别为0.39 µM和0.87 µM），但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入（IC50 >1 µM），在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时，PAMP-12能降低平均动脉血压。

化合物

MrgprX2 antagonist-2

Cat.No: T40273

Synonym: MrgprX2 antagonist-2

Target: Others

MrgprX2 antagonist-1

Cat.No: T40270

Synonym: MrgprX2 antagonist-1

Target: Others

MrgprX2 antagonist-4

Cat.No: T40268

Synonym: MrgprX2 antagonist-4

Target: Others

MrgprX2 antagonist-5

Cat.No: T40176

Synonym: MrgprX2 antagonist-5

Target: Others

MrgprX2 antagonist-3

Cat.No: T40271

Synonym: MrgprX2 antagonist-3

Target: Others

MrgprX2 antagonist-8

Cat.No: T63812

Target: MRGPR

MrgprX2 antagonist-6

Cat.No: T63394

Target: Others

MrgprX2 antagonist-7

Cat.No: T63766

Target: Others

Cat.No: T29221

Synonym: ZINC 3573

Target: MRGPR

PAMP-12 (unmodified) (TFA)

Cat.No: T80080

Cat.No: T80727

Target: Others

Cat.No: T41187

Target: Others

Proadrenomedullin (1-20), human

Cat.No: TP1490

PAMP-12(human, porcine)

Cat.No: TP1880

Synonym: PAMP-12 (human, porcine)

PAMP-12 (unmodified)

Cat.No: T78027

Cat.No: TP1946

PAMP-12 (human, mouse, rat, porcine, bovine) TFA

Cat.No: T83697

Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His) Mas-related G-protein coupled receptor member X2,	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c...

重组蛋白

MRGPRX2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01640

Species: Human

Expression System: E. coli

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